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GET1
HPA
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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

                                          • CELL LINE

                                          • STRUCTURE

                                          • INTERACTION

                                          • GET1
                                          SINGLE CELL THYMUS Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS CELL TYPE MARKERS
                                          Cell types
                                          Blood and immune cells
                                          Mesenchymal cells
                                          Endothelial and mural cells
                                          Specialized epithelial cells
                                          Methods
                                          THYMUS DETAIL SUMMARY
                                          Mesothelial cellsMedullary thymic epithelial cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsThymic myoid cellsNeutrophil progenitorsNeutrophilsMonocytesMacrophagesT-cellsThymocytesInnate lymphoid cellsB-cellsPlasma cellsNK-cells0246810nCPMSpecialized epithelial cellsEndothelial and mural cellsMesenchymal cellsBlood and immune cells
                                          SINGLE CELL TYPE - THYMUSi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 T-cells (CD4+)
                                          c-1 Fibroblasts
                                          c-2 Memory B-cells
                                          c-3 Neutrophils
                                          c-4 Regulatory T-cells (CD4+)
                                          c-5 Naive T-cells (CD4+)
                                          c-6 Capillary endothelial cells
                                          c-7 Naive B-cells
                                          c-8 Cytotoxic T-cells (CD8+)
                                          c-9 Venous endothelial cells
                                          c-10 Monocytes
                                          c-11 Fibroblasts
                                          c-12 T-cells (CD4+)
                                          c-13 Vascular smooth muscle cell
                                          c-14 Arterial endothelial cells
                                          c-15 Macrophages
                                          c-16 Pericytes
                                          c-17 Late myelocytes
                                          c-18 Plasma cells
                                          c-19 T-cells (CD8+)
                                          c-20 NK-cells
                                          c-21 Fibroblasts
                                          c-22 T-cells (CD8+)
                                          c-23 Lymphatic endothelial cells
                                          c-24 ILCs
                                          c-25 Thymic myoid cells
                                          c-26 Thymocytes
                                          c-27 Mesothelial cells
                                          c-28 Mast cells
                                          c-29 MTEC
                                          c-30 Mast cells
                                          SINGLE CELL TYPE TABULA SAPIENS - THYMUSi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 130
                                          c-0 Cd4-positive helper t cell
                                          c-1 Naive regulatory t cell
                                          c-2 T follicular helper cell
                                          c-3 Cd8-positive, alpha-beta cy...
                                          c-4 Dn4 thymocyte
                                          c-5 B cell
                                          c-6 Medullary thymic epithelial...
                                          c-7 Fibroblast
                                          c-8 Macrophage
                                          c-9 Vascular associated smooth ...
                                          c-10 Plasma cell
                                          c-11 Vein endothelial cell
                                          c-12 Capillary endothelial cell
                                          c-13 Endothelial cell of artery
                                          c-14 Nk cell
                                          c-15 Erythrocyte
                                          c-16 Monocyte
                                          c-17 Endothelial cell of lymphat...
                                          c-18 Myeloid dendritic cell
                                          c-19 Dn3 thymocyte
                                          c-20 Dn1 thymic pro-t cell
                                          c-21 Innate lymphoid cell
                                          c-22 Cd8-positive, alpha-beta t ...
                                          c-23 Memory b cell
                                          c-24 Naive b cell
                                          c-25 Mesothelial cell
                                          c-26 Mature nk t cell
                                          c-27 Fast muscle cell
                                          c-28 Dendritic cell
                                          c-29 Immature natural killer cel
                                          c-30 Thymocyte
                                          c-31 Mast cell
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1ITLN1MSLNUPK3BEPCAMKRT14KRT17PECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1MYH11COL1A1DCNFBLN2PDGFRADESMYL1MYL11MYOD1CPA3TPSAB1TPSB2CAMPCEACAM8LTFCSF3RCXCR2FCGR3BFCN1IL1BS100A8S100A9VCANCD14C1QBC1QCHLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RADNTTFLT3KITGATA3HPGDSIL9RNCR2RORCBANK1CD19MS4A1CD27TNFRSF13BDERL3IGHA1GZMANKG7PRF1T-cells c-0Fibroblasts c-1B-cells c-2Neutrophils c-3T-cells c-4T-cells c-5Vascular endothelial cells c-6B-cells c-7T-cells c-8Vascular endothelial cells c-9Monocytes c-10Fibroblasts c-11T-cells c-12Vascular smooth muscle cells c-13Vascular endothelial cells c-14Macrophages c-15Pericytes c-16Neutrophil progenitors c-17Plasma cells c-18T-cells c-19NK-cells c-20Fibroblasts c-21T-cells c-22Lymphatic endothelial cells c-23Innate lymphoid cells c-24Thymic myoid cells c-25Thymocytes c-26Mesothelial cells c-27Mast cells c-28Medullary thymic epithelial cells c-29Mast cells c-30Current geneMesothelial cellsMedullary thymic epithelial cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsThymic myoid cellsMast cellsNeutrophil progenitorsNeutrophilsMonocytesMacrophagesT-cellsThymocytesInnate lymphoid cellsB-cellsPlasma cellsNK-cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1ITLN1MSLNUPK3BEPCAMKRT14KRT17PECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1MYH11COL1A1DCNFBLN2PDGFRADESMYL1MYL11MYOD1CPA3TPSAB1TPSB2CAMPCEACAM8LTFCSF3RCXCR2FCGR3BFCN1IL1BS100A8S100A9VCANCD14C1QBC1QCHLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RADNTTFLT3KITGATA3HPGDSIL9RNCR2RORCBANK1CD19MS4A1CD27TNFRSF13BDERL3IGHA1GZMANKG7PRF1Cd4-positive helper t cell c-0Naive regulatory t cell c-1T follicular helper cell c-2Cd8-positive, alpha-beta cytotoxic t cell c-3Dn4 thymocyte c-4B cell c-5Medullary thymic epithelial cell c-6Fibroblast c-7Macrophage c-8Vascular associated smooth muscle cell c-9Plasma cell c-10Vein endothelial cell c-11Capillary endothelial cell c-12Endothelial cell of artery c-13Nk cell c-14Erythrocyte c-15Monocyte c-16Endothelial cell of lymphatic vessel c-17Myeloid dendritic cell c-18Dn3 thymocyte c-19Dn1 thymic pro-t cell c-20Innate lymphoid cell c-21Cd8-positive, alpha-beta t cell c-22Memory b cell c-23Naive b cell c-24Mesothelial cell c-25Mature nk t cell c-26Fast muscle cell c-27Dendritic cell c-28Immature natural killer cell c-29Thymocyte c-30Mast cell c-31Current geneMesothelial cellsMedullary thymic epithelial cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsThymic myoid cellsMast cellsNeutrophil progenitorsNeutrophilsMonocytesMacrophagesT-cellsThymocytesInnate lymphoid cellsB-cellsPlasma cellsNK-cells00.250.50.751-4-2024
                                           

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