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GET1
HPA
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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

                                          • CELL LINE

                                          • STRUCTURE

                                          • INTERACTION

                                          • GET1
                                          SINGLE CELL LYMPH NODE Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS CELL TYPE MARKERS
                                          Cell types
                                          Blood and immune cells
                                          Mesenchymal cells
                                          Endothelial and mural cells
                                          Methods
                                          LYMPH NODE DETAIL SUMMARY
                                          Vascular endothelial cellsLymphatic endothelial cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsCDCNK-cells0246810nCPMEndothelial and mural cellsMesenchymal cellsBlood and immune cells
                                          SINGLE CELL TYPE - LYMPH NODEi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 Naive T-cells (CD4+)
                                          c-1 Memory B-cells
                                          c-2 Memory B-cells
                                          c-3 Effector T-cells (CD8+)
                                          c-4 Memory B-cells
                                          c-5 Naive T-cells (CD4+)
                                          c-6 Naive B-cells
                                          c-7 Regulatory T-cells
                                          c-8 Naive T-cells (CD4+)
                                          c-9 Naive T-cells (CD8+)
                                          c-10 Memory B-cells
                                          c-11 Memory B-cells
                                          c-12 Plasma cells (cycling)
                                          c-13 Plasma cells
                                          c-14 Innate lymphoid cells
                                          c-15 Effector T-cells (CD8+)
                                          c-16 Monocytes
                                          c-17 Macrophages
                                          c-18 NKT-cells
                                          c-19 Neutrophils
                                          c-20 NK-cells
                                          c-21 Mast cells
                                          c-22 NK-cells
                                          c-23 Conventional dendritic cell
                                          c-24 Macrophages
                                          c-25 Mixed NKT-cells
                                          c-26 Fibroblasts
                                          c-27 Lymphatic endothelial cells
                                          c-28 Venous endothelial cells
                                          c-29 Conventional dendritic cell
                                          c-30 Lymphoid DC
                                          c-31 Arterial endothelial cells
                                          c-32 Plasmacytoid DCs
                                          SINGLE CELL TYPE TABULA SAPIENS - LYMPH NODEi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 180
                                          c-0 B cell
                                          c-1 Cd8-positive alpha-beta t c
                                          c-2 T cell
                                          c-3 Type i nk t cell
                                          c-4 Cd4-positive alpha-beta t c
                                          c-5 Innate lymphoid cell
                                          c-6 Regulatory t cell
                                          c-7 Plasma cell
                                          c-8 Neutrophil
                                          c-9 Classical monocyte
                                          c-10 Nk cell
                                          c-11 Macrophage
                                          c-12 Endothelial cell
                                          c-13 Cd141-positive myeloid dend...
                                          c-14 Cd1c-positive myeloid dendr...
                                          c-15 Intermediate monocyte
                                          c-16 Hematopoietic stem cell
                                          c-17 Non-classical monocyte
                                          c-18 Mast cell
                                          c-19 Plasmacytoid dendritic cell
                                          c-20 Stromal cell
                                          c-21 Erythrocyte
                                          c-22 Mature conventional dendrit...
                                          c-23 Naive b cell
                                          c-24 Memory b cell
                                          c-25 Naive thymus-derived cd4-po...
                                          c-26 Cd4-positive, alpha-beta me...
                                          c-27 Cd8-positive, alpha-beta me...
                                          c-28 Mature nk t cell
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1PECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1COL1A1DCNFBLN2PDGFRACPA3TPSAB1TPSB2CEACAM8CSF3RCXCR2FCGR3BFCN1IL1BS100A8S100A9VCANCD14FCGR3AC1QBC1QCHLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RAGATA3HPGDSIL9RNCR2RORCBANK1CD19MS4A1CD27TNFRSF13BDERL3IGHA1CLEC9AIRF8CD1CCLEC10ACCR7LAMP3CLEC4CIL3RAIRF7GZMANKG7PRF1T-cells c-0B-cells c-1B-cells c-2T-cells c-3B-cells c-4T-cells c-5B-cells c-6T-cells c-7T-cells c-8T-cells c-9B-cells c-10B-cells c-11Plasma cells c-12Plasma cells c-13Innate lymphoid cells c-14T-cells c-15Monocytes c-16Macrophages c-17T-cells c-18Neutrophils c-19NK-cells c-20Mast cells c-21NK-cells c-22CDC c-23Macrophages c-24T-cells c-25Fibroblasts c-26Lymphatic endothelial cells c-27Vascular endothelial cells c-28CDC c-29CDC c-30Vascular endothelial cells c-31PDCs c-32Current geneVascular endothelial cellsLymphatic endothelial cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsCDCPDCsNK-cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1PECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1COL1A1DCNFBLN2PDGFRACPA3TPSAB1TPSB2CEACAM8CSF3RCXCR2FCGR3BFCN1IL1BS100A8S100A9VCANCD14FCGR3AC1QBC1QCHLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RAGATA3HPGDSIL9RNCR2RORCBANK1CD19MS4A1CD27TNFRSF13BDERL3IGHA1CLEC9AIRF8CD1CCLEC10ACCR7LAMP3CLEC4CIL3RAIRF7GZMANKG7PRF1B cell c-0Cd8-positive alpha-beta t cell c-1T cell c-2Type i nk t cell c-3Cd4-positive alpha-beta t cell c-4Innate lymphoid cell c-5Regulatory t cell c-6Plasma cell c-7Neutrophil c-8Classical monocyte c-9Nk cell c-10Macrophage c-11Endothelial cell c-12Cd141-positive myeloid dendritic cell c-13Cd1c-positive myeloid dendritic cell c-14Intermediate monocyte c-15Hematopoietic stem cell c-16Non-classical monocyte c-17Mast cell c-18Plasmacytoid dendritic cell c-19Stromal cell c-20Erythrocyte c-21Mature conventional dendritic cell c-22Naive b cell c-23Memory b cell c-24Naive thymus-derived cd4-positive, alpha-beta t cell c-25Cd4-positive, alpha-beta memory t cell c-26Cd8-positive, alpha-beta memory t cell c-27Mature nk t cell c-28Current geneVascular endothelial cellsLymphatic endothelial cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsCDCPDCsNK-cells00.250.50.751-4-2024
                                           

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