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GET1
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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

                                          • CELL LINE

                                          • STRUCTURE

                                          • INTERACTION

                                          • GET1
                                          SINGLE CELL SKIN Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS TISSUE CELL TYPE CELL TYPE MARKERS
                                          Cell types
                                          Mesenchymal cells
                                          Blood and immune cells
                                          Endothelial and mural cells
                                          Specialized epithelial cells
                                          Squamous epithelial cells
                                          Pigment cells
                                          Muscle cells
                                          Glial cells
                                          Methods
                                          Cell type enrichment
                                          Skin
                                          Methods
                                          SKIN DETAIL SUMMARY
                                          Suprabasal keratinocytesMelanocytesBasal keratinocytesSmooth muscle cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMacrophagesT-cellsCDC0246810nCPMSquamous epithelial cellsPigment cellsSpecialized epithelial cellsMuscle cellsEndothelial and mural cellsMesenchymal cellsBlood and immune cells
                                          SINGLE CELL TYPE - SKINi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 Fibroblasts
                                          c-1 Fibroblasts
                                          c-2 Conventional dendritic cell
                                          c-3 Fibroblasts
                                          c-4 Vascular endothelial cells
                                          c-5 Basal keratinocytes
                                          c-6 T-cells (CD8+)
                                          c-7 Fibroblasts
                                          c-8 Suprabasal keratinocytes
                                          c-9 Vascular smooth muscle cell...
                                          c-10 Pericytes
                                          c-11 Vascular smooth muscle cell
                                          c-12 Lymphatic endothelial cells
                                          c-13 T-cells (CD8+)
                                          c-14 NK T-cells
                                          c-15 Tregs (CD4+)
                                          c-16 Macrophages
                                          c-17 Conventional dendritic cell
                                          c-18 Melanocytes
                                          c-19 GdT-cells
                                          c-20 Smooth muscle cells
                                          c-21 Lymphoid dendritic cells
                                          c-22 Mast cells
                                          c-23 Plasma cells
                                          c-24 Langerhans cells
                                          c-25 Non-myelinated schwann cell
                                          SINGLE CELL TYPE TABULA SAPIENS - SKINi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 250
                                          c-0 Macrophage
                                          c-1 Stromal cell
                                          c-2 Cd8-positive, alpha-beta me...
                                          c-3 Cd141-positive myeloid dend...
                                          c-4 T cell
                                          c-5 Nkt cell
                                          c-6 Mast cell
                                          c-7 Muscle cell
                                          c-8 Cd8-positive, alpha-beta cy...
                                          c-9 Cd1c-positive myeloid dendr...
                                          c-10 Endothelial cell
                                          c-11 Cd4-positive, alpha-beta me...
                                          c-12 Nk cell
                                          c-13 Naive thymus-derived cd8-po...
                                          c-14 Naive thymus-derived cd4-po...
                                          c-15 Melanocyte
                                          c-16 Regulatory t cell
                                          c-17 Epithelial cell
                                          c-18 Plasma cell
                                          c-19 Cd4-positive helper t cell
                                          c-20 Memory b cell
                                          c-21 Langerhans cell
                                          c-22 Naive b cell
                                          c-23 Smooth muscle cell
                                          c-24 Cell of skeletal muscle
                                          TISSUE CELL TYPE - SKINi

                                          The plot below shows the enrichment prediction score for each cell type profiled in the tissue. This score is the mean correlation between the selected gene and the 3 reference transcripts selected to represent each cell type profiled within the tissue. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type. Hover the mouse pointer over the symbols or cell type names to see the mean correlation values.

                                          Category
                                          Alphabetical
                                          Enrichment
                                          Fibroblasts_1Fibroblasts_2Keratinocyte (other)Keratinocyte (granular)MelanocytesHair cortex cellsInner root sheath cellsOuter root sheath cellsSebaceous gland cellsEccrine sweat gland cellsLangerhans cellsAdipocytes (Skin)Mitotic cells (Skin)Endothelial cellsSmooth muscle cellsMacrophagesMast cellsT-cellsPlasma cells0.30.40.50.60.70.80.91.0EnrichmentMesenchymal cellsSquamous epithelial cellsPigment cellsSpecialized epithelial cellsGlandular epithelial cellsBlood and immune cellsStem and proliferating cellsEndothelial and mural cellsMuscle cells
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          TISSUE CELL TYPE
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1S100BMBPMPZCDH19L1CAMIVLKRT1KRT10DCTMLANAPAX3COL17A1ITGA6TP63ACTG2DESMYH11PECAM1VWFLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1COL1A1DCNFBLN2PDGFRACPA3TPSAB1TPSB2C1QBC1QCHLA-DRAHLA-DRB1F13A1CD1ACD207MMP9CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RATRDCDERL3IGHA1CLEC9AIRF8CD1CCLEC10ACCR7LAMP3GZMANKG7PRF1Fibroblasts c-0Fibroblasts c-1CDC c-2Fibroblasts c-3Vascular endothelial cells c-4Basal keratinocytes c-5T-cells c-6Fibroblasts c-7Suprabasal keratinocytes c-8Vascular smooth muscle cells c-9Pericytes c-10Vascular smooth muscle cells c-11Lymphatic endothelial cells c-12T-cells c-13T-cells c-14T-cells c-15Macrophages c-16CDC c-17Melanocytes c-18T-cells c-19Smooth muscle cells c-20CDC c-21Mast cells c-22Plasma cells c-23Langerhans cells c-24Schwann cells c-25Current geneSchwann cellsSuprabasal keratinocytesMelanocytesBasal keratinocytesSmooth muscle cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMast cellsMacrophagesLangerhans cellsT-cellsPlasma cellsCDCNK-cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1S100BMBPMPZCDH19L1CAMIVLKRT1KRT10DCTMLANAPAX3COL17A1ITGA6TP63ACTG2DESMYH11PECAM1VWFLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1COL1A1DCNFBLN2PDGFRACPA3TPSAB1TPSB2C1QBC1QCHLA-DRAHLA-DRB1F13A1CD1ACD207MMP9CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RATRDCDERL3IGHA1CLEC9AIRF8CD1CCLEC10ACCR7LAMP3GZMANKG7PRF1Macrophage c-0Stromal cell c-1Cd8-positive, alpha-beta memory t cell c-2Cd141-positive myeloid dendritic cell c-3T cell c-4Nkt cell c-5Mast cell c-6Muscle cell c-7Cd8-positive, alpha-beta cytotoxic t cell c-8Cd1c-positive myeloid dendritic cell c-9Endothelial cell c-10Cd4-positive, alpha-beta memory t cell c-11Nk cell c-12Naive thymus-derived cd8-positive, alpha-beta t cell c-13Naive thymus-derived cd4-positive, alpha-beta t cell c-14Melanocyte c-15Regulatory t cell c-16Epithelial cell c-17Plasma cell c-18Cd4-positive helper t cell c-19Memory b cell c-20Langerhans cell c-21Naive b cell c-22Smooth muscle cell c-23Cell of skeletal muscle c-24Current geneSchwann cellsSuprabasal keratinocytesMelanocytesBasal keratinocytesSmooth muscle cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMast cellsMacrophagesLangerhans cellsT-cellsPlasma cellsCDCNK-cells00.250.50.751-4-2024
                                          GET1 CCDC80COL1A1COL3A1FBLN2OLFML3PODNDEGS1KRT1KRT10LCE1BLCE1CLCE2DMLANATYRTYRP1KRTAP2-1KRTAP2-2KRTAP2-4KRT25KRT71TCHHDACH1LHX2SLC4A3FADS1FADS2FAR2AQP5CHRM3SLC12A2CSF1RFCER1ALST1LIPEPLIN1TRARG1CENPFKIFC1TOP2AADGRL4DIPK2BMECOMACTG2CNN1MYH11C1QBCD163VSIG4GCSAMLMS4A2RGS13CD2CD3ECD96IGKCIGLC1JCHAINCCDC80COL1A1COL3A1FBLN2OLFML3PODNDEGS1KRT1KRT10LCE1BLCE1CLCE2DMLANATYRTYRP1KRTAP2-1KRTAP2-2KRTAP2-4KRT25KRT71TCHHDACH1LHX2SLC4A3FADS1FADS2FAR2AQP5CHRM3SLC12A2CSF1RFCER1ALST1LIPEPLIN1TRARG1CENPFKIFC1TOP2AADGRL4DIPK2BMECOMACTG2CNN1MYH11C1QBCD163VSIG4GCSAMLMS4A2RGS13CD2CD3ECD96IGKCIGLC1JCHAINCurrent geneFibroblasts_1Fibroblasts_2Keratinocyte (other)Keratinocyte (granular)MelanocytesHair cortex cellsInner root sheath cellsOuter root sheath cellsSebaceous gland cellsEccrine sweat gland cellsLangerhans cellsAdipocytes (Skin)Mitotic cells (Skin)Endothelial cellsSmooth muscle cellsMacrophagesMast cellsT-cellsPlasma cells<00.250.50.751
                                           

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