The Single Cell Resource
The Single Cell resource of the Human Protein Atlas presents comprehensive data on gene expression across various human tissues and cell types, utilizing single cell RNA sequencing (scRNAseq), cell sorting, single nuclei RNA sequencing (snRNAseq), and bulk RNAseq correlation analyses. The resource provides insights into mRNA and protein expression patterns, gene specificity, and expression clustering with single cell types, immune cells and brain single nuclei. The Single Cell Resource includes four main datasets:
- The Single cell type section, providing the expression profiles across 81 cell types from 31 human tissues, and cell type specificity based on gene expression.
- The Tissue cell type section, providing the predicted cell-type expression specificity based on bulk RNAseq
- The Single nuclei brain section, providing more details regarding cell type specificity within the brain, based on single nuclei RNAseq
- The Immune cell section, providing expression comparison between sorted immune cells
Learn more about each of these four parts down below, and explore the details of each dataset, or serach for a gene and browse the expression details side by side across the different datasets on the gene summary pages. More information about the content, the generation and analysis of the data in this resource can be found under respective link or here for single cell type, tissue cell type, single nuclei brain and immune cell. Additionally, each focused section is based on different datasets, see more details here for single cell type, tissue cell type (using GTEx RNAseq data), single nuclei brain and immune cell.
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Single cell type
Providing the mRNA expression profiles of protein-coding genes from 31 human tissues including peripheral blood mononuclear cells (PBMCs) across single cell types. The scRNAseq analysis is based on publicly available genome-wide expression data and comprises all protein-coding genes in 557 individual cell type clusters corresponding to 15 different cell type groups and 81 individual cell types.
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Single nuclei brain
Providing the mRNA expression profiles of protein-coding genes in cluster cell types across 11 different brain regions. The snRNAseq analysis is based on publicly available genome-wide expression data from over 2,5 milion brain cells, described by 34 cluster cell types, representing the cell of the brain.
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Transcription factor landscape
Explore the expression landscape of the 1485 transcription factors throughout human cell types representing both normal tissue and cell types, as well as cancer cell lines.
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