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GET1
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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

                                          • CELL LINE

                                          • STRUCTURE

                                          • INTERACTION

                                          • GET1
                                          SINGLE CELL LIVER Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS TISSUE CELL TYPE CELL TYPE MARKERS
                                          Cell types
                                          Specialized epithelial cells
                                          Blood and immune cells
                                          Endothelial and mural cells
                                          Mesenchymal cells
                                          Methods
                                          Cell type enrichment
                                          Liver
                                          Methods
                                          LIVER DETAIL SUMMARY
                                          CholangiocytesHepatocytesVascular endothelial cellsHepatic stellate cellsMonocytesMacrophagesKupffer cellsT-cellsB-cellsPlasma cellsNK-cells0246810nCPMSpecialized epithelial cellsEndothelial and mural cellsMesenchymal cellsBlood and immune cells
                                          SINGLE CELL TYPE - LIVERi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 Hepatocytes
                                          c-1 Hepatocytes
                                          c-2 CD8+ T-cells
                                          c-3 CD4+ T-cells
                                          c-4 Resident NK-cells (CXCR6+)
                                          c-5 Hepatocytes
                                          c-6 Hepatocytes
                                          c-7 Macrophages
                                          c-8 Hepatocytes
                                          c-9 Cytotoxic NK-cells (GZMB+)
                                          c-10 Liver sinusoidal ECs (STAB2
                                          c-11 Monocytes
                                          c-12 Liver sinusoidal ECs (PLVAP...
                                          c-13 Kupffer cells
                                          c-14 Venous endothelial cells
                                          c-15 Plasma cells
                                          c-16 B-cells
                                          c-17 Hepatocytes (CFHR1+, CYP2A7
                                          c-18 Hepatocytes (CFHR1+, CYP2A7
                                          c-19 Cholangiocytes
                                          c-20 Hepatic stellate cells
                                          c-21 Resident NK-cells (CXCR6+)
                                          c-22 Cytotoxic NK-cells (GZMB+)
                                          c-23 Cholangiocytes (LGALS2+)
                                          SINGLE CELL TYPE TABULA SAPIENS - LIVERi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 180
                                          c-0 Macrophage
                                          c-1 Monocyte
                                          c-2 Endothelial cell of hepatic...
                                          c-3 Liver dendritic cell
                                          c-4 Nk cell
                                          c-5 Fibroblast
                                          c-6 Hepatocyte
                                          c-7 Intrahepatic cholangiocyte
                                          c-8 T cell
                                          c-9 Neutrophil
                                          c-10 Plasma cell
                                          c-11 Erythrocyte
                                          c-12 Endothelial cell
                                          TISSUE CELL TYPE - LIVERi

                                          The plot below shows the enrichment prediction score for each cell type profiled in the tissue. This score is the mean correlation between the selected gene and the 3 reference transcripts selected to represent each cell type profiled within the tissue. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type. Hover the mouse pointer over the symbols or cell type names to see the mean correlation values.

                                          Category
                                          Alphabetical
                                          Enrichment
                                          Hepatocytes_1Hepatocytes_2CholangiocytesNK-cells (Liver)Erythroid cellsSinusoid Endothelial cellsVascular endothelial cellsHepatic stellate cellsKupffer cellsNeutrophilsT-cellsPlasma cells0.30.40.50.60.70.80.91.0EnrichmentSpecialized epithelial cellsBlood and immune cellsEndothelial and mural cellsMesenchymal cells
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          TISSUE CELL TYPE
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1ELF3KRT19MUC5BALBFGAHPXPECAM1VWFACKR1POSTNMRC1STAB1STAB2ACTA2COL1A1PDGFRAFCN1IL1BS100A8S100A9VCANC1QBC1QCCD5LTIMD4CD3DCD3GCD4CD8AIL7RBANK1CD19MS4A1DERL3IGHA1GZMANKG7PRF1CXCR6Hepatocytes c-0Hepatocytes c-1T-cells c-2T-cells c-3NK-cells c-4Hepatocytes c-5Hepatocytes c-6Macrophages c-7Hepatocytes c-8NK-cells c-9Vascular endothelial cells c-10Monocytes c-11Vascular endothelial cells c-12Kupffer cells c-13Vascular endothelial cells c-14Plasma cells c-15B-cells c-16Hepatocytes c-17Hepatocytes c-18Cholangiocytes c-19Hepatic stellate cells c-20NK-cells c-21NK-cells c-22Cholangiocytes c-23Current geneCholangiocytesHepatocytesVascular endothelial cellsHepatic stellate cellsMonocytesMacrophagesKupffer cellsT-cellsB-cellsPlasma cellsNK-cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1ELF3KRT19MUC5BALBFGAHPXPECAM1VWFACKR1POSTNMRC1STAB1STAB2ACTA2COL1A1PDGFRAFCN1IL1BS100A8S100A9VCANC1QBC1QCCD5LTIMD4CD3DCD3GCD4CD8AIL7RBANK1CD19MS4A1DERL3IGHA1GZMANKG7PRF1CXCR6Macrophage c-0Monocyte c-1Endothelial cell of hepatic sinusoid c-2Liver dendritic cell c-3Nk cell c-4Fibroblast c-5Hepatocyte c-6Intrahepatic cholangiocyte c-7T cell c-8Neutrophil c-9Plasma cell c-10Erythrocyte c-11Endothelial cell c-12Current geneCholangiocytesHepatocytesVascular endothelial cellsHepatic stellate cellsMonocytesMacrophagesKupffer cellsT-cellsB-cellsPlasma cellsNK-cells00.250.50.751-4-2024
                                          GET1 ADH6CMBLSLC10A1AOX1APOFC8AEPCAMKRT7SPINT1KLRF1NCR1SH2D1BAHSPCA1SLC4A1CLEC1BEHD3GPR182ARAP3ECSCRRHOJDCNISLROLFML3IGSF6LST1SIGLEC1CSF3RFPR1S100A8CD3DCD3ECD6IGKCIGLC1JCHAINADH6CMBLSLC10A1AOX1APOFC8AEPCAMKRT7SPINT1KLRF1NCR1SH2D1BAHSPCA1SLC4A1CLEC1BEHD3GPR182ARAP3ECSCRRHOJDCNISLROLFML3IGSF6LST1SIGLEC1CSF3RFPR1S100A8CD3DCD3ECD6IGKCIGLC1JCHAINCurrent geneHepatocytes_1Hepatocytes_2CholangiocytesNK-cells (Liver)Erythroid cellsSinusoid Endothelial cellsVascular endothelial cellsHepatic stellate cellsKupffer cellsNeutrophilsT-cellsPlasma cells<00.250.50.751
                                           

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