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GET1
HPA
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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

                                          • CELL LINE

                                          • STRUCTURE

                                          • INTERACTION

                                          • GET1
                                          SINGLE CELL SKELETAL MUSCLE Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS TISSUE CELL TYPE CELL TYPE MARKERS
                                          Cell types
                                          Muscle cells
                                          Mesenchymal cells
                                          Stem and proliferating cells
                                          Blood and immune cells
                                          Endothelial and mural cells
                                          Methods
                                          Cell type enrichment
                                          Skeletal muscle
                                          Methods
                                          SKELETAL MUSCLE DETAIL SUMMARY
                                          MyonucleiVascular endothelial cellsPericytesVascular smooth muscle cellsAdipocytesFibro-adipogenic progenitorsMacrophagesMyosatellite cells0246810nCPMMuscle cellsEndothelial and mural cellsMesenchymal cellsBlood and immune cellsStem and proliferating cells
                                          SINGLE CELL TYPE - SKELETAL MUSCLEi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 Myonuclei (type I)
                                          c-1 Myonuclei (type I)
                                          c-2 Myonuclei (type I)
                                          c-3 Myonuclei (type I)
                                          c-4 Myonuclei (type I)
                                          c-5 Myonuclei (type I)
                                          c-6 Myonuclei (type I)
                                          c-7 Myonuclei (type IIa)
                                          c-8 Myonuclei (denervated)
                                          c-9 Fibro-adipogenic progenitor
                                          c-10 Myonuclei (type IIx)
                                          c-11 Myonuclei (type I)
                                          c-12 Myonuclei (denervated)
                                          c-13 Myonuclei (type IIa)
                                          c-14 Myosatellite cells
                                          c-15 Myonuclei (type I)
                                          c-16 Macrophages
                                          c-17 Myonuclei (denervated)
                                          c-18 Capillary endothelial cells
                                          c-19 Adipocytes
                                          c-20 Vascular smooth muscle cell
                                          c-21 Myonuclei (NMJ associated)
                                          c-22 Pericytes
                                          c-23 Arterial endothelial cells
                                          c-24 T-cells
                                          c-25 Venous endothelial cells
                                          c-26 NK & T-cells
                                          c-27 Mast cells
                                          SINGLE CELL TYPE TABULA SAPIENS - SKELETAL MUSCLEi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 160
                                          c-0 Endothelial cell of vascula...
                                          c-1 Capillary endothelial cell
                                          c-2 Endothelial cell of lymphat...
                                          c-3 Mesenchymal stem cell
                                          c-4 Endothelial cell of artery
                                          c-5 Pericyte cell
                                          c-6 Cd4-positive, alpha-beta t ...
                                          c-7 Skeletal muscle satellite s...
                                          c-8 Macrophage
                                          c-9 Cd8-positive, alpha-beta t ...
                                          c-10 T cell
                                          c-11 Smooth muscle cell
                                          c-12 Tendon cell
                                          c-13 Fast muscle cell
                                          c-14 Slow muscle cell
                                          c-15 Mast cell
                                          c-16 Erythrocyte
                                          c-17 Mesothelial cell
                                          c-18 Mature nk t cell
                                          TISSUE CELL TYPE - SKELETAL MUSCLEi

                                          The plot below shows the enrichment prediction score for each cell type profiled in the tissue. This score is the mean correlation between the selected gene and the 3 reference transcripts selected to represent each cell type profiled within the tissue. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type. Hover the mouse pointer over the symbols or cell type names to see the mean correlation values.

                                          Category
                                          Alphabetical
                                          Enrichment
                                          Skeletal myocytes_1Skeletal myocytes_2Skeletal myocytes_3Endothelial cellsSmooth muscle cellsFibroblastsMacrophagesNeutrophilsPlasma cells0.30.40.50.60.70.80.91.0EnrichmentMuscle cellsEndothelial and mural cellsMesenchymal cellsBlood and immune cells
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          TISSUE CELL TYPE
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1CKMMBMYH7TNNI1TNNT1MYH2MYH1ACHECHRNEETV4CHRNGRUNX1PECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1MYH11ADIPOQFABP4LIPEPLIN1CD34PDGFRATCF7L2CPA3TPSAB1TPSB2C1QBC1QCHLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RGZMANKG7PRF1PAX7Myonuclei c-0Myonuclei c-1Myonuclei c-2Myonuclei c-3Myonuclei c-4Myonuclei c-5Myonuclei c-6Myonuclei c-7Myonuclei c-8Fibro-adipogenic progenitors c-9Myonuclei c-10Myonuclei c-11Myonuclei c-12Myonuclei c-13Myosatellite cells c-14Myonuclei c-15Macrophages c-16Myonuclei c-17Vascular endothelial cells c-18Adipocytes c-19Vascular smooth muscle cells c-20Myonuclei c-21Pericytes c-22Vascular endothelial cells c-23T-cells c-24Vascular endothelial cells c-25NK-cells c-26Mast cells c-27Current geneMyonucleiVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsAdipocytesFibro-adipogenic progenitorsMast cellsMacrophagesT-cellsNK-cellsMyosatellite cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1CKMMBMYH7TNNI1TNNT1MYH2MYH1ACHECHRNEETV4CHRNGRUNX1PECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1MYH11ADIPOQFABP4LIPEPLIN1CD34PDGFRATCF7L2CPA3TPSAB1TPSB2C1QBC1QCHLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RGZMANKG7PRF1PAX7Endothelial cell of vascular tree c-0Capillary endothelial cell c-1Endothelial cell of lymphatic vessel c-2Mesenchymal stem cell c-3Endothelial cell of artery c-4Pericyte cell c-5Cd4-positive, alpha-beta t cell c-6Skeletal muscle satellite stem cell c-7Macrophage c-8Cd8-positive, alpha-beta t cell c-9T cell c-10Smooth muscle cell c-11Tendon cell c-12Fast muscle cell c-13Slow muscle cell c-14Mast cell c-15Erythrocyte c-16Mesothelial cell c-17Mature nk t cell c-18Current geneMyonucleiVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsAdipocytesFibro-adipogenic progenitorsMast cellsMacrophagesT-cellsNK-cellsMyosatellite cells00.250.50.751-4-2024
                                          GET1 MYH7MYL2TNNC1APOBEC2MYOZ3PKIATNNI2TNNT3TPM1ADGRL4ERGPECAM1ACTG2KCNMB1MYH11ISLRLUMSSC5DC1QAC1QBMS4A4AAQP9CSF3RVNN2IGKCIGLC1JCHAINMYH7MYL2TNNC1APOBEC2MYOZ3PKIATNNI2TNNT3TPM1ADGRL4ERGPECAM1ACTG2KCNMB1MYH11ISLRLUMSSC5DC1QAC1QBMS4A4AAQP9CSF3RVNN2IGKCIGLC1JCHAINCurrent geneSkeletal myocytes_1Skeletal myocytes_2Skeletal myocytes_3Endothelial cellsSmooth muscle cellsFibroblastsMacrophagesNeutrophilsPlasma cells<00.250.50.751
                                           

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