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GET1
HPA
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Blood group antigen proteins
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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

                                          • CELL LINE

                                          • STRUCTURE

                                          • INTERACTION

                                          • GET1
                                          SINGLE CELL SMALL INTESTINE Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS CELL TYPE MARKERS
                                          Cell types
                                          Glandular epithelial cells
                                          Stem and proliferating cells
                                          Endocrine cells
                                          Specialized epithelial cells
                                          Blood and immune cells
                                          Methods
                                          SMALL INTESTINE DETAIL SUMMARY
                                          Neuroendocrine cellsPaneth cellsEnterocytesGoblet cellsEnteric transient amplifying cellsEnteric stem cells0246810nCPMEndocrine cellsSpecialized epithelial cellsGlandular epithelial cellsStem and proliferating cells
                                          SINGLE CELL TYPE - SMALL INTESTINEi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 Enterocytes
                                          c-1 Goblet cells
                                          c-2 Enterocytes
                                          c-3 Enterocytes
                                          c-4 Enterocytes
                                          c-5 Enterocytes
                                          c-6 TA cells (intermediate prog...
                                          c-7 Enterocytes
                                          c-8 Enterocytes
                                          c-9 TA cells (intermediate prog...
                                          c-10 Enteric stem cells
                                          c-11 TA cells (intermediate prog...
                                          c-12 Early goblet cells
                                          c-13 Enterocytes (Best 4+)
                                          c-14 Enteroendocrine cells
                                          c-15 Paneth cells
                                          c-16 N cells
                                          c-17 NK-cells
                                          SINGLE CELL TYPE TABULA SAPIENS - SMALL INTESTINEi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 350
                                          c-0 Cd4-positive, alpha-beta t ...
                                          c-1 Enterocyte of epithelium of...
                                          c-2 Neutrophil
                                          c-3 Transit amplifying cell of ...
                                          c-4 Small intestine goblet cell
                                          c-5 Cd8-positive, alpha-beta t ...
                                          c-6 B cell
                                          c-7 Monocyte
                                          c-8 Paneth cell of epithelium o...
                                          c-9 Intestinal tuft cell
                                          c-10 Plasma cell
                                          c-11 Mast cell
                                          c-12 Fibroblast
                                          c-13 Intestinal enteroendocrine ...
                                          c-14 Gut endothelial cell
                                          c-15 Intestinal crypt stem cell ...
                                          c-16 Intestinal crypt stem cell
                                          c-17 Immature enterocyte
                                          c-18 Goblet cell
                                          c-19 Mature enterocyte
                                          c-20 Duodenum glandular cell
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1CHGACHGBNEUROD1SYPNTSPYYDEFA5DEFA6REG3AANPEPFABP2RBP2BEST4CA7OTOP2FCGBPMUC2TFF3GZMANKG7PRF1CCND1MKI67MYCPCNAASCL2LGR5OLFM4Enterocytes c-0Goblet cells c-1Enterocytes c-2Enterocytes c-3Enterocytes c-4Enterocytes c-5Enteric transient amplifying cells c-6Enterocytes c-7Enterocytes c-8Enteric transient amplifying cells c-9Enteric stem cells c-10Enteric transient amplifying cells c-11Goblet cells c-12Enterocytes c-13Neuroendocrine cells c-14Paneth cells c-15Neuroendocrine cells c-16NK-cells c-17Current geneNeuroendocrine cellsPaneth cellsEnterocytesGoblet cellsNK-cellsEnteric transient amplifying cellsEnteric stem cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1CHGACHGBNEUROD1SYPNTSPYYDEFA5DEFA6REG3AANPEPFABP2RBP2BEST4CA7OTOP2FCGBPMUC2TFF3GZMANKG7PRF1CCND1MKI67MYCPCNAASCL2LGR5OLFM4Cd4-positive, alpha-beta t cell c-0Enterocyte of epithelium of small intestine c-1Neutrophil c-2Transit amplifying cell of small intestine c-3Small intestine goblet cell c-4Cd8-positive, alpha-beta t cell c-5B cell c-6Monocyte c-7Paneth cell of epithelium of small intestine c-8Intestinal tuft cell c-9Plasma cell c-10Mast cell c-11Fibroblast c-12Intestinal enteroendocrine cell c-13Gut endothelial cell c-14Intestinal crypt stem cell of small intestine c-15Intestinal crypt stem cell c-16Immature enterocyte c-17Goblet cell c-18Mature enterocyte c-19Duodenum glandular cell c-20Current geneNeuroendocrine cellsPaneth cellsEnterocytesGoblet cellsNK-cellsEnteric transient amplifying cellsEnteric stem cells00.250.50.751-4-2024
                                           

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