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                                          • SUMMARY

                                          • TISSUE

                                          • BRAIN

                                          • SINGLE CELL

                                          • SUBCELL

                                          • CANCER

                                          • BLOOD

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                                          • STRUCTURE

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                                          • GET1
                                          SINGLE CELL LUNG Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND BLOOD BONE MARROW BRAIN BREAST COLON ENDOMETRIUM EPIDIDYMIS ESOPHAGUS
                                          EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PITUITARY GLAND
                                          PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
                                          THYMUS THYROID GLAND TONGUE URINARY BLADDER VASCULATURE
                                          Single cell type
                                          Tabula sapiens
                                          Tissue cell type
                                          SINGLE CELL TYPE TABULA SAPIENS TISSUE CELL TYPE CELL TYPE MARKERS
                                          Cell types
                                          Blood and immune cells
                                          Specialized epithelial cells
                                          Endothelial and mural cells
                                          Glandular epithelial cells
                                          Mesenchymal cells
                                          Ciliated cells
                                          Glial cells
                                          Methods
                                          Cell type enrichment
                                          Lung
                                          Methods
                                          LUNG DETAIL SUMMARY
                                          Respiratory ciliated cellsRespiratory deuterosomal cellsAlveolar cells type 1Alveolar cells type 2Transitional alveolar cellsRespiratory ionocytesRespiratory basal cellsSubmucosal glandular cellsRespiratory secretory cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsPDCsNK-cells0246810nCPMCiliated cellsSpecialized epithelial cellsGlandular epithelial cellsEndothelial and mural cellsMesenchymal cellsBlood and immune cells
                                          SINGLE CELL TYPE - LUNGi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                          - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          - The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                          Cluster filter:
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 10
                                          c-0 Alveolar macrophages
                                          c-1 AT2
                                          c-2 Capillary endothelial cells
                                          c-3 Capillary endothelial cells
                                          c-4 Monocyte derived macrophage
                                          c-5 AT1
                                          c-6 Monocytes
                                          c-7 Alveolar macrophages
                                          c-8 Interstitial perivascular m...
                                          c-9 T-cells (CD8+)
                                          c-10 NK-cells
                                          c-11 Mast cells
                                          c-12 AT2
                                          c-13 AT0
                                          c-14 Venous endothelial cells
                                          c-15 Cytotoxic T-cells (CD8+)
                                          c-16 T-cells (CD4+)
                                          c-17 Cytotoxic T-cells (CD8+)
                                          c-18 Arterial endothelial cells
                                          c-19 Basal cells
                                          c-20 AT2 (proliferating)
                                          c-21 Club/Goblet cells
                                          c-22 Suprabasal cells
                                          c-23 Pericytes (STEAP4- LAMC3+)
                                          c-24 Neutrophils
                                          c-25 Alveolar fibroblasts
                                          c-26 Non classical monocyte
                                          c-27 Vascular smooth muscle cell
                                          c-28 Ciliated cells (proximal, B...
                                          c-29 Adventitial fibroblasts
                                          c-30 B-cells
                                          c-31 Ciliated cells (distal, GPC
                                          c-32 Regulatory T-cells (CD4+)
                                          c-33 Lymphatic endothelial cells
                                          c-34 Naive T-cells (CD4+)
                                          c-35 Peribroncheal fibroblasts
                                          c-36 Fibroblasts
                                          c-37 Submucosal gland mucous cel
                                          c-38 Suprabasal cells (Cycling)
                                          c-39 Plasma cells
                                          c-40 ILCs
                                          c-41 Pericytes (STEAP4+ LAMC3-)
                                          c-42 Deuterosomal cells
                                          c-43 Ionocytes
                                          c-44 Submucosal serous mucous ce
                                          c-45 CDC1 & Lymphoid DCs
                                          c-46 Mesothelial cells
                                          c-47 Plasmacytoid DCs
                                          c-48 Schwann cells
                                          SINGLE CELL TYPE TABULA SAPIENS - LUNGi

                                          RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot and a bar chart. This window shows single cell expression data generated by the https://tabula-sapiens.sf.czbiohub.org/about#consortium, that also offers UMAP visualization and cell type clusters for each tissue sample: https://tabula-sapiens.sf.czbiohub.org/organs, here integrate offering easy comparison to the HPA cluster method of single cell types.

                                          • UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. The cells are colored according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%)

                                          • The LEGEND shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

                                          Cell type color
                                          Cluster color
                                          Colored according to cell type group
                                          Colored according to clusters
                                          Read count filter: 0
                                           
                                          Cluster Cell type Expression (nCPM)
                                          0 1130
                                          c-0 Type ii pneumocyte
                                          c-1 Neutrophil
                                          c-2 Cd4-positive alpha-beta t c
                                          c-3 Cd8-positive alpha-beta t c
                                          c-4 Nk cell
                                          c-5 Bronchial vessel endothelia...
                                          c-6 Smooth muscle cell
                                          c-7 Adventitial cell
                                          c-8 Macrophage
                                          c-9 Respiratory mucous cell
                                          c-10 Basophil
                                          c-11 Classical monocyte
                                          c-12 Endothelial cell of artery
                                          c-13 Lung ciliated cell
                                          c-14 Dendritic cell
                                          c-15 Cd4-positive, alpha-beta t ...
                                          c-16 Respiratory goblet cell
                                          c-17 Basal cell
                                          c-18 Plasma cell
                                          c-19 B cell
                                          c-20 Cd8-positive, alpha-beta t ...
                                          c-21 Serous cell of epithelium o...
                                          c-22 Non-classical monocyte
                                          c-23 Capillary endothelial cell
                                          c-24 Capillary aerocyte
                                          c-25 Type i pneumocyte
                                          c-26 Vein endothelial cell
                                          c-27 Alveolar fibroblast
                                          c-28 Endothelial cell of lymphat...
                                          c-29 Bronchial smooth muscle cel
                                          c-30 Plasmacytoid dendritic cell
                                          c-31 Club cell
                                          c-32 Lung microvascular endothel...
                                          c-33 Vascular associated smooth ...
                                          c-34 Myofibroblast cell
                                          c-35 Pericyte cell
                                          c-36 Mesothelial cell
                                          c-37 Fibroblast
                                          c-38 Intermediate monocyte
                                          c-39 Pulmonary ionocyte
                                          TISSUE CELL TYPE - LUNGi

                                          The plot below shows the enrichment prediction score for each cell type profiled in the tissue. This score is the mean correlation between the selected gene and the 3 reference transcripts selected to represent each cell type profiled within the tissue. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type. Hover the mouse pointer over the symbols or cell type names to see the mean correlation values.

                                          Category
                                          Alphabetical
                                          Enrichment
                                          Respiratory ciliated cellsAlveolar cells type 1Alveolar cells type 2Mitotic cells (Lung)NK-cells (Lung)B-cells (Lung)Fibroblasts_1Fibroblasts_2Endothelial cellsSmooth muscle cellsMacrophagesNeutrophils_1Neutrophils_2Mast cellsT-cellsPlasma cells0.30.40.50.60.70.80.91.0EnrichmentCiliated cellsSpecialized epithelial cellsStem and proliferating cellsBlood and immune cellsMesenchymal cellsEndothelial and mural cellsMuscle cells
                                          CELL TYPE MARKERSi

                                          The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                          Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.

                                          Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                          SINGLE CELL TYPE
                                          TABULA SAPIENS
                                          TISSUE CELL TYPE
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1S100BMBPMPZCDH19L1CAMFOXJ1RSPH1SNTNTPPP3CDC20BSPOCK2UPK3BMFSD2ASFTPCSCGB3A2ITLN1MSLNBSNDCLCNKBDLK2PKP1TP63CLCA2SERPINB3AGR2CCL28KRT23TCN1WFDC2PRB3MUC5BBPIFB1SCGB3A1MUC5ACPECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1MYH11COL1A1DCNFBLN2PDGFRAMFAP5PI16LIMCH1COL15A1CPA3TPSAB1TPSB2CEACAM8CSF3RCXCR2FCGR3BFCN1IL1BS100A8S100A9VCANCD14FCGR3AC1QBC1QCCYP27A1FABP4MARCOFOLR2HLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RAGATA3HPGDSIL9RNCR2RORCBANK1CD19MS4A1DERL3IGHA1CLEC9AIRF8CCR7LAMP3CLEC4CIL3RAIRF7GZMANKG7PRF1Macrophages c-0Alveolar cells type 2 c-1Vascular endothelial cells c-2Vascular endothelial cells c-3Macrophages c-4Alveolar cells type 1 c-5Monocytes c-6Macrophages c-7Macrophages c-8T-cells c-9NK-cells c-10Mast cells c-11Alveolar cells type 2 c-12Transitional alveolar cells c-13Vascular endothelial cells c-14T-cells c-15T-cells c-16T-cells c-17Vascular endothelial cells c-18Respiratory basal cells c-19Alveolar cells type 2 c-20Respiratory secretory cells c-21Respiratory basal cells c-22Pericytes c-23Neutrophils c-24Fibroblasts c-25Monocytes c-26Vascular smooth muscle cells c-27Respiratory ciliated cells c-28Fibroblasts c-29B-cells c-30Respiratory ciliated cells c-31T-cells c-32Lymphatic endothelial cells c-33T-cells c-34Fibroblasts c-35Fibroblasts c-36Submucosal glandular cells c-37Respiratory basal cells c-38Plasma cells c-39Innate lymphoid cells c-40Pericytes c-41Respiratory deuterosomal cells c-42Respiratory ionocytes c-43Submucosal glandular cells c-44CDC c-45Mesothelial cells c-46PDCs c-47Schwann cells c-48Current geneSchwann cellsRespiratory ciliated cellsRespiratory deuterosomal cellsAlveolar cells type 1Alveolar cells type 2Transitional alveolar cellsMesothelial cellsRespiratory ionocytesRespiratory basal cellsSubmucosal glandular cellsRespiratory secretory cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsCDCPDCsNK-cells00.250.50.751-4-2024
                                          Max-norm
                                          Z-score
                                          Fraction of highest expression (≥1 nTPM)
                                          log2(nTPM+1) z-score
                                          GET1S100BMBPMPZCDH19L1CAMFOXJ1RSPH1SNTNTPPP3CDC20BSPOCK2UPK3BMFSD2ASFTPCSCGB3A2ITLN1MSLNBSNDCLCNKBDLK2PKP1TP63CLCA2SERPINB3AGR2CCL28KRT23TCN1WFDC2PRB3MUC5BBPIFB1SCGB3A1MUC5ACPECAM1VWFACKR1POSTNHEY1HEY2SEMA3GCA4RGCCLYVE1PROX1PDGFRBRGS5STEAP4ACTA2CNN1MYH11COL1A1DCNFBLN2PDGFRAMFAP5PI16LIMCH1COL15A1CPA3TPSAB1TPSB2CEACAM8CSF3RCXCR2FCGR3BFCN1IL1BS100A8S100A9VCANCD14FCGR3AC1QBC1QCCYP27A1FABP4MARCOFOLR2HLA-DRAHLA-DRB1F13A1CD3DCD3GCD4CD8AIL7RCTLA4FOXP3IL2RAGATA3HPGDSIL9RNCR2RORCBANK1CD19MS4A1DERL3IGHA1CLEC9AIRF8CCR7LAMP3CLEC4CIL3RAIRF7GZMANKG7PRF1Type ii pneumocyte c-0Neutrophil c-1Cd4-positive alpha-beta t cell c-2Cd8-positive alpha-beta t cell c-3Nk cell c-4Bronchial vessel endothelial cell c-5Smooth muscle cell c-6Adventitial cell c-7Macrophage c-8Respiratory mucous cell c-9Basophil c-10Classical monocyte c-11Endothelial cell of artery c-12Lung ciliated cell c-13Dendritic cell c-14Cd4-positive, alpha-beta t cell c-15Respiratory goblet cell c-16Basal cell c-17Plasma cell c-18B cell c-19Cd8-positive, alpha-beta t cell c-20Serous cell of epithelium of bronchus c-21Non-classical monocyte c-22Capillary endothelial cell c-23Capillary aerocyte c-24Type i pneumocyte c-25Vein endothelial cell c-26Alveolar fibroblast c-27Endothelial cell of lymphatic vessel c-28Bronchial smooth muscle cell c-29Plasmacytoid dendritic cell c-30Club cell c-31Lung microvascular endothelial cell c-32Vascular associated smooth muscle cell c-33Myofibroblast cell c-34Pericyte cell c-35Mesothelial cell c-36Fibroblast c-37Intermediate monocyte c-38Pulmonary ionocyte c-39Current geneSchwann cellsRespiratory ciliated cellsRespiratory deuterosomal cellsAlveolar cells type 1Alveolar cells type 2Transitional alveolar cellsMesothelial cellsRespiratory ionocytesRespiratory basal cellsSubmucosal glandular cellsRespiratory secretory cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMast cellsNeutrophilsMonocytesMacrophagesT-cellsInnate lymphoid cellsB-cellsPlasma cellsCDCPDCsNK-cells00.250.50.751-4-2024
                                          GET1 DNAH12ERICH3SNTNAGERCLIC5EMP2ACOXLCFTRSLC26A9ANLNTOP2ATPX2KLRF1NCR1SH2D1BCD19MS4A1TNFRSF13CCAMK2N1GPC3TCF21FBLN2PODNSERPINF1ERGESAMFLI1MYL9TAGLNTPM2C1QACTSDMS4A4AELANEMPOPRTN3AQP9FPR1GLT1D1CPA3RGS13SLC18A2CD2CD3DCD3GIGKCJCHAINMZB1DNAH12ERICH3SNTNAGERCLIC5EMP2ACOXLCFTRSLC26A9ANLNTOP2ATPX2KLRF1NCR1SH2D1BCD19MS4A1TNFRSF13CCAMK2N1GPC3TCF21FBLN2PODNSERPINF1ERGESAMFLI1MYL9TAGLNTPM2C1QACTSDMS4A4AELANEMPOPRTN3AQP9FPR1GLT1D1CPA3RGS13SLC18A2CD2CD3DCD3GIGKCJCHAINMZB1Current geneRespiratory ciliated cellsAlveolar cells type 1Alveolar cells type 2Mitotic cells (Lung)NK-cells (Lung)B-cells (Lung)Fibroblasts_1Fibroblasts_2Endothelial cellsSmooth muscle cellsMacrophagesNeutrophils_1Neutrophils_2Mast cellsT-cellsPlasma cells<00.250.50.751
                                           

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