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VPS37B
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                                          • VPS37B
                                          TISSUE PRIMARY DATA KIDNEY Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
                                          DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
                                          NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
                                          SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
                                          ANTIBODIES
                                          AND
                                          VALIDATION
                                          Dictionary
                                          Kidney
                                          Tissue proteome
                                          Kidney
                                          Tissue methods
                                          KIDNEY - Expression summary
                                          Protein expression
                                          Kidneyi

                                          On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

                                          h
                                          m
                                          l
                                          n
                                          Cells in glomeruli: Medium
                                          Cells in tubules: Medium
                                          RNA expressioni

                                          A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

                                          Scroll down to view mRNA expression data in more detail.

                                          Consensus:27.8 nTPM
                                          HPA:9.9 nTPM
                                          GTEx:27.8 nTPM
                                          FANTOM5:50.0 Scaled Tags Per Million
                                          KIDNEY - SINGLE CELL RNA EXPRESSION
                                          Explore single cell type data
                                          Renal collecting duct intercalated cellsRenal collecting duct principal cellsRenal connecting tubule cellsPodocytesProximal tubule cellsLoop of henle epithelial cellsPapillary tip epithelial cellsDistal convoluted tubule cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMacrophagesT-cellsB-cellsNK-cells050100150200250300nCPM

                                          KIDNEY - Antibody stainingi

                                          Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

                                          Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

                                          Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

                                          Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

                                          Antibody HPA038217Antibody HPA038218
                                          Cells in glomeruli MediumLow
                                          Cells in tubules HighMedium





                                          KIDNEY - HPA RNA-seqi

                                          The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

                                          Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

                                          Average nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          9.9
                                          overview
                                          Female, age 58
                                          Kidney sample 55
                                          nTPM: 14.8
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          20

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 67
                                          Kidney sample 56
                                          nTPM: 12.4
                                          Cell types%
                                          Cells in tubules:
                                          70

                                          Cells in glomeruli:
                                          15

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          5

                                          overview
                                          Female, age 55
                                          Kidney sample 57
                                          nTPM: 14
                                          Cell types%
                                          Cells in tubules:
                                          80

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          5

                                          overview
                                          Male, age 46
                                          Kidney sample 58
                                          nTPM: 12.3
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          25

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          10

                                          overview
                                          Female, age 57
                                          Kidney sample 358
                                          nTPM: 3.4
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 78
                                          Kidney sample 377
                                          nTPM: 9.2
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 73
                                          Kidney sample 380
                                          nTPM: 6.8
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Female, age 59
                                          Kidney sample 394
                                          nTPM: 8.2
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 48
                                          Kidney sample 414
                                          nTPM: 8.1
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          5

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          25


                                          KIDNEY - GTEx RNA-seqi

                                          RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

                                          Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

                                          Max subtype nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          27.8
                                          GTEx sample id Sample description nTPM
                                          19.923.027.514.235.705101520253035404550556065
                                          19.923.027.514.235.705101520253035404550556065
                                          Kidney - Cortex
                                          Average nTPM: 24.7
                                          Samples: 104

                                          Max nTPM: 66.7
                                          Min nTPM: 14.2
                                          Std nTPM: 8.1
                                          Median nTPM: 23.0
                                          GTEX-1I1GP-1926-SM-CNNQU 50-59 years, male 66.7
                                          GTEX-1N2EF-1426-SM-EXUSH 60-69 years, male 59.9
                                          GTEX-16XZZ-2226-SM-HAV34 60-69 years, male 51.8
                                          GTEX-13O1R-2526-SM-5N9FW 60-69 years, male 41.1
                                          GTEX-13O3O-1726-SM-GJ3RL 60-69 years, female 39.7
                                          GTEX-14C39-2126-SM-664OH 40-49 years, male 39.2
                                          GTEX-1GN1U-2126-SM-AHZ4J 50-59 years, female 35.7
                                          GTEX-11GS4-2326-SM-5A5KS 60-69 years, male 34.8
                                          GTEX-11TTK-1926-SM-5PNW8 60-69 years, female 34.1
                                          GTEX-ZXG5-2026-SM-HAUZV 60-69 years, male 32.2
                                          GTEX-1JJ6O-2526-SM-AHZ3J 60-69 years, male 30.9
                                          GTEX-1F48J-2226-SM-7MXTN 50-59 years, female 30.8
                                          GTEX-1OJC4-2326-SM-DTXA5 50-59 years, female 30.2
                                          GTEX-1JMLX-1526-SM-AHZ3N 50-59 years, male 30.1
                                          GTEX-O5YV-1226-SM-EV795 60-69 years, female 29.9
                                          GTEX-15DYW-2026-SM-6AJBD 60-69 years, female 29.5
                                          GTEX-1LG7Y-2726-SM-D5OVW 50-59 years, male 29.0
                                          GTEX-16Z82-2826-SM-HAUZZ 60-69 years, male 28.6
                                          GTEX-12696-0926-SM-5FQTV 60-69 years, male 28.2
                                          GTEX-13RTJ-2226-SM-5S2Q1 60-69 years, male 28.2
                                          GTEX-1QP6S-1526-SM-EXUSG 40-49 years, male 28.2
                                          GTEX-ZE9C-1426-SM-4WKGM 60-69 years, male 28.1
                                          GTEX-1C6VQ-2326-SM-7IGN1 50-59 years, male 28.0
                                          GTEX-13112-2126-SM-5GCO4 50-59 years, male 27.6
                                          GTEX-P4QS-1126-SM-3NMD5 60-69 years, male 27.6
                                          GTEX-145MN-0326-SM-5QGQI 30-39 years, male 27.5
                                          GTEX-1CB4J-1926-SM-7MGX8 60-69 years, male 27.5
                                          GTEX-ZC5H-1726-SM-5HL7X 40-49 years, female 27.5
                                          GTEX-1497J-0826-SM-5NQAJ 60-69 years, male 27.1
                                          GTEX-1GF9W-1326-SM-7P8PX 60-69 years, male 26.8
                                          GTEX-1GMR3-2426-SM-7MXV2 40-49 years, male 26.8
                                          GTEX-1HBPI-2026-SM-CE6RZ 50-59 years, male 26.8
                                          GTEX-T5JC-1526-SM-4DM68 20-29 years, male 26.5
                                          GTEX-1NV8Z-2226-SM-EXOJ2 60-69 years, male 26.4
                                          GTEX-14C5O-2026-SM-5YYB1 60-69 years, male 26.3
                                          GTEX-1HCVE-2126-SM-HL9UO 50-59 years, male 26.2
                                          GTEX-1PWST-2226-SM-EVR3G 70-79 years, male 25.8
                                          GTEX-13FHP-2126-SM-GIN8J 50-59 years, male 25.6
                                          GTEX-NFK9-1826-SM-HL9T3 40-49 years, male 25.6
                                          GTEX-ZDXO-0226-SM-4WKH7 60-69 years, male 25.5
                                          GTEX-1O9I2-1926-SM-F2TBQ 50-59 years, male 25.4
                                          GTEX-1GTWX-1826-SM-9QEHG 60-69 years, male 25.3
                                          GTEX-1QAET-2126-SM-F2TBS 50-59 years, male 24.7
                                          GTEX-WL46-1926-SM-GNIN6 50-59 years, male 24.4
                                          GTEX-ZYFG-1626-SM-5GZYY 60-69 years, female 24.4
                                          GTEX-12WSG-0826-SM-5EQ5A 50-59 years, female 24.0
                                          GTEX-QLQW-1626-SM-CMKFE 30-39 years, male 23.7
                                          GTEX-13OVL-1826-SM-5KLZR 50-59 years, male 23.6
                                          GTEX-16XZY-1026-SM-HAV39 70-79 years, male 23.6
                                          GTEX-1BAJH-1826-SM-731DA 70-79 years, male 23.5
                                          GTEX-Y5V5-1226-SM-EYYVP 60-69 years, female 23.4
                                          GTEX-1A3MW-2226-SM-73KUX 60-69 years, female 23.1
                                          GTEX-14JG1-2326-SM-HAUZ5 40-49 years, male 22.9
                                          GTEX-14PJ2-1826-SM-HL9UB 50-59 years, male 22.6
                                          GTEX-1GF9V-1926-SM-9JGHE 60-69 years, male 22.5
                                          GTEX-REY6-1826-SM-EAZAT 60-69 years, male 22.4
                                          GTEX-11OF3-1326-SM-5N9FJ 60-69 years, male 22.2
                                          GTEX-1H3VY-1926-SM-9JGHJ 50-59 years, male 22.2
                                          GTEX-ZLFU-0926-SM-5P9F8 40-49 years, male 22.2
                                          GTEX-RN64-1626-SM-48FD7 50-59 years, male 22.1
                                          GTEX-ZYT6-2226-SM-5GIC9 30-39 years, male 22.0
                                          GTEX-17F96-1926-SM-7MGWY 70-79 years, male 21.6
                                          GTEX-17HHY-2326-SM-7KFSR 50-59 years, male 21.6
                                          GTEX-1KWVE-0826-SM-CXZKO 30-39 years, male 21.6
                                          GTEX-S33H-1426-SM-EZ6L7 30-39 years, male 21.6
                                          GTEX-13OW6-1826-SM-5N9F9 50-59 years, male 21.5
                                          GTEX-1E2YA-1626-SM-7MGXS 50-59 years, male 21.3
                                          GTEX-1MUQO-2526-SM-E9TJN 60-69 years, male 21.2
                                          GTEX-Y5V6-2026-SM-5IFHO 60-69 years, male 21.2
                                          GTEX-XPVG-0526-SM-4B65N 50-59 years, male 20.9
                                          GTEX-1IL2V-1826-SM-ARU7R 70-79 years, male 20.8
                                          GTEX-15CHQ-2126-SM-6871M 60-69 years, male 20.7
                                          GTEX-13OVI-1126-SM-5KLZF 60-69 years, female 20.5
                                          GTEX-15DCD-1926-SM-HAV33 70-79 years, female 20.5
                                          GTEX-1IKK5-0926-SM-A9G2U 60-69 years, male 20.3
                                          GTEX-1ICLY-2026-SM-GA913 50-59 years, male 20.2
                                          GTEX-1R9PO-1626-SM-E6CPT 60-69 years, female 20.0
                                          GTEX-1399S-0526-SM-5IJG8 30-39 years, female 19.9
                                          GTEX-14E6D-2526-SM-5YYA9 50-59 years, male 19.9
                                          GTEX-1N2DW-1826-SM-EAZ54 50-59 years, male 19.7
                                          GTEX-16MT8-1926-SM-7EPGL 60-69 years, female 19.6
                                          GTEX-1HCU7-1826-SM-A9G2A 50-59 years, male 19.6
                                          GTEX-ZVZP-0926-SM-5GIDB 50-59 years, male 19.5
                                          GTEX-13NYB-1726-SM-5N9G2 40-49 years, male 18.8
                                          GTEX-1JMPZ-1226-SM-ARU8Y 30-39 years, male 18.6
                                          GTEX-1EKGG-2226-SM-7IGOA 60-69 years, male 18.5
                                          GTEX-17F97-1926-SM-7IGM4 50-59 years, male 18.3
                                          GTEX-1JJE9-1026-SM-HL9TH 70-79 years, male 18.2
                                          GTEX-W5X1-1626-SM-H7OGO 40-49 years, female 18.0
                                          GTEX-147F4-2626-SM-5Q5CS 50-59 years, male 17.9
                                          GTEX-1K9T9-1826-SM-CXZK2 50-59 years, female 17.8
                                          GTEX-1JMQK-1926-SM-CJI3B 60-69 years, male 17.7
                                          GTEX-1LH75-1326-SM-F2I1R 50-59 years, female 17.7
                                          GTEX-1117F-2126-SM-GIN9G 60-69 years, female 17.6
                                          GTEX-1HB9E-1826-SM-D4P33 50-59 years, male 17.2
                                          GTEX-QDT8-1726-SM-EYYV6 30-39 years, female 17.2
                                          GTEX-1RQEC-2426-SM-F2I1J 60-69 years, male 17.0
                                          GTEX-QDVN-1726-SM-HL9TO 50-59 years, male 17.0
                                          GTEX-1H3NZ-2126-SM-9WPQ6 60-69 years, male 16.5
                                          GTEX-1J1OQ-1426-SM-AHZ3P 40-49 years, female 15.7
                                          GTEX-1JMQJ-1726-SM-E9U4V 50-59 years, male 15.3
                                          GTEX-1A8FM-2026-SM-7P8RN 50-59 years, female 15.2
                                          GTEX-T6MN-1826-SM-EXOHN 50-59 years, male 14.3
                                          GTEX-1AX8Z-2326-SM-731CR 60-69 years, male 14.2
                                          Show allShow less
                                          23.325.529.919.032.7051015202530354045
                                          23.325.529.919.032.7051015202530354045
                                          Kidney - Medulla
                                          Average nTPM: 27.8
                                          Samples: 11

                                          Max nTPM: 49.9
                                          Min nTPM: 19.0
                                          Std nTPM: 7.9
                                          Median nTPM: 25.5
                                          GTEX-T5JC-1626-SM-EZ6KW 20-29 years, male 49.9
                                          GTEX-QEG5-2026-SM-H6Q6I 20-29 years, male 32.7
                                          GTEX-RU72-1926-SM-EAZ3F 50-59 years, female 30.4
                                          GTEX-QEG4-1526-SM-GPRWK 30-39 years, male 29.3
                                          GTEX-R55E-2026-SM-EZ6L1 20-29 years, male 26.1
                                          GTEX-P4QS-1226-SM-HPAG8 60-69 years, male 25.5
                                          GTEX-TKQ2-0626-SM-EZ6LB 50-59 years, male 24.5
                                          GTEX-S33H-1526-SM-GQ1CB 30-39 years, male 23.4
                                          GTEX-SIU8-1926-SM-H7OG4 50-59 years, male 23.1
                                          GTEX-N7MS-1526-SM-HAUZP 60-69 years, male 21.9
                                          GTEX-T6MN-1926-SM-GOQYD 50-59 years, male 19.0
                                          Show allShow less

                                          KIDNEY - FANTOM5 CAGEi

                                          RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

                                          Max subtype Scaled Tags Per Millioni

                                          Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

                                          50.0
                                          FANTOM5 sample id Sample description Scaled Tags Per Million
                                          Kidney
                                          Scaled Tags Per Million: 50.0
                                          FF:10017-101C8 60,62,63 years, female 50.0

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