Single cell type - FAM136A - The Human Protein Atlas

FAM136A

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM136A
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 136 member A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.27
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FAM136A is part of cluster 77 Plasma cells - Protein processing with confidenceⁱ 1
324 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
YKT6	YKT6 v-SNARE homolog	0.5666	45
CCNC	Cyclin C	0.5579	45
P4HB	Prolyl 4-hydroxylase subunit beta	0.5392	77
SEC11C	SEC11 homolog C, signal peptidase complex subunit	0.5374	77
SLC35B1	Solute carrier family 35 member B1	0.5354	77
BHLHA15	Basic helix-loop-helix family member a15	0.5274	60
MYDGF	Myeloid derived growth factor	0.5224	77
ATAD3A	ATPase family AAA domain containing 3A	0.5202	39
SHCBP1	SHC binding and spindle associated 1	0.5147	61
SEC63	SEC63 homolog, protein translocation regulator	0.5130	75
H3C2	H3 clustered histone 2	0.5129	61
H3C8	H3 clustered histone 8	0.5110	61
SRM	Spermidine synthase	0.5087	61
GMPPB	GDP-mannose pyrophosphorylase B	0.5084	77
LRRC59	Leucine rich repeat containing 59	0.5067	77

IMMUNE CELLS

FAM136A is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.98
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRKX	Protein kinase cAMP-dependent X-linked catalytic subunit	1.0000	32
DNAJC21	DnaJ heat shock protein family (Hsp40) member C21	1.0000	32
RBM26	RNA binding motif protein 26	1.0000	32
ARL16	ADP ribosylation factor like GTPase 16	0.9762	32
RSBN1	Round spermatid basic protein 1	0.9762	41
ZNF808	Zinc finger protein 808	0.9762	32
ZNF443	Zinc finger protein 443	0.9762	32
ZNF415	Zinc finger protein 415	0.9762	32
ZSCAN21	Zinc finger and SCAN domain containing 21	0.9762	32
NIPSNAP3B	Nipsnap homolog 3B	0.9762	32
PAN3	Poly(A) specific ribonuclease subunit PAN3	0.9762	32
TEC	Tec protein tyrosine kinase	0.9762	32
DNAJC14	DnaJ heat shock protein family (Hsp40) member C14	0.9762	32
ZMYM5	Zinc finger MYM-type containing 5	0.9762	41
ZNF227	Zinc finger protein 227	0.9762	32

Adipocytes	17.0 nTPM
Breast	19.7 nTPM
Adipose tissue	14.2 nTPM

Alveolar cells type 1	81.7 nTPM
Lung	81.7 nTPM

Alveolar cells type 2	67.6 nTPM
Lung	67.6 nTPM

Astrocytes	8.4 nTPM
Brain	8.4 nTPM

B-cells	36.1 nTPM
Kidney	67.6 nTPM
Adipose tissue	45.7 nTPM
Salivary gland	42.3 nTPM
Skin	35.6 nTPM
Spleen	34.9 nTPM
Thymus	34.8 nTPM
Bone marrow	34.7 nTPM
Lymph node	32.5 nTPM
PBMC	30.8 nTPM
Lung	29.5 nTPM
Liver	29.0 nTPM
Stomach	28.7 nTPM
Esophagus	23.6 nTPM

Ciliated cells	32.2 nTPM
Endometrium	38.9 nTPM
Fallopian tube	33.8 nTPM
Lung	29.7 nTPM
Bronchus	26.4 nTPM

Club cells	42.1 nTPM
Bronchus	44.8 nTPM
Lung	44.4 nTPM
Prostate	37.1 nTPM

Dendritic cells	35.1 nTPM
PBMC	46.8 nTPM
Adipose tissue	23.5 nTPM

Endothelial cells	20.5 nTPM
Placenta	36.9 nTPM
Lung	30.7 nTPM
Endometrium	29.8 nTPM
Tongue	26.7 nTPM
Liver	23.9 nTPM
Skin	23.6 nTPM
Breast	21.1 nTPM
Ovary	20.3 nTPM
Fallopian tube	19.5 nTPM
Thymus	18.6 nTPM
Salivary gland	17.8 nTPM
Testis	17.1 nTPM
Heart muscle	16.4 nTPM
Vascular	16.2 nTPM
Pancreas	15.5 nTPM
Prostate	14.9 nTPM
Skeletal muscle	11.9 nTPM
Esophagus	8.7 nTPM

Enteroendocrine cells	41.5 nTPM
Colon	65.3 nTPM
Rectum	35.2 nTPM
Small intestine	24.0 nTPM

Fibroblasts	28.6 nTPM
Heart muscle	61.0 nTPM
Pancreas	60.5 nTPM
Placenta	50.8 nTPM
Lung	39.1 nTPM
Vascular	26.7 nTPM
Thymus	25.9 nTPM
Breast	24.2 nTPM
Adipose tissue	23.9 nTPM
Salivary gland	23.3 nTPM
Skin	22.4 nTPM
Esophagus	18.8 nTPM
Skeletal muscle	18.7 nTPM
Fallopian tube	17.6 nTPM
Stomach	17.3 nTPM
Prostate	17.2 nTPM
Liver	10.7 nTPM

Granulocytes	26.7 nTPM
Tongue	29.1 nTPM
Fallopian tube	25.6 nTPM
Lung	25.2 nTPM

Intestinal goblet cells	52.8 nTPM
Colon	67.2 nTPM
Rectum	49.8 nTPM
Small intestine	41.4 nTPM

Lymphatic endothelial cells	20.6 nTPM
Ovary	27.3 nTPM
Fallopian tube	13.9 nTPM

Macrophages	31.6 nTPM
Pancreas	51.4 nTPM
Kidney	47.8 nTPM
Lung	43.5 nTPM
Endometrium	41.8 nTPM
Breast	35.8 nTPM
Prostate	34.9 nTPM
Thymus	34.2 nTPM
Salivary gland	33.3 nTPM
Testis	31.0 nTPM
Fallopian tube	30.9 nTPM
Bone marrow	28.4 nTPM
Esophagus	28.3 nTPM
Tongue	28.3 nTPM
Adipose tissue	25.8 nTPM
Vascular	23.7 nTPM
Skeletal muscle	23.4 nTPM
Stomach	20.6 nTPM
Spleen	20.1 nTPM
Skin	16.7 nTPM

Basal keratinocytes	36.8 nTPM
Tongue	49.3 nTPM
Skin	24.4 nTPM

Basal prostatic cells	33.4 nTPM
Prostate	33.4 nTPM

Basal respiratory cells	39.5 nTPM
Bronchus	39.5 nTPM

Basal squamous epithelial cells	39.4 nTPM
Esophagus	39.4 nTPM

Paneth cells	44.4 nTPM
Rectum	59.3 nTPM
Small intestine	41.4 nTPM
Colon	32.6 nTPM

Plasma cells	105.7 nTPM
Thymus	146.9 nTPM
Liver	140.2 nTPM
Spleen	138.3 nTPM
Bone marrow	116.3 nTPM
Stomach	93.8 nTPM
Salivary gland	93.6 nTPM
Fallopian tube	75.3 nTPM
Esophagus	41.6 nTPM

Schwann cells	17.7 nTPM
Adipose tissue	42.2 nTPM
Vascular	11.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	81.7 nTPM
Salivary gland	106.0 nTPM
Tongue	57.4 nTPM

Smooth muscle cells	25.1 nTPM
Salivary gland	51.6 nTPM
Vascular	35.9 nTPM
Placenta	35.1 nTPM
Ovary	32.0 nTPM
Breast	28.6 nTPM
Endometrium	28.3 nTPM
Thymus	27.9 nTPM
Fallopian tube	27.6 nTPM
Skin	21.9 nTPM
Tongue	19.5 nTPM
Adipose tissue	19.4 nTPM
Prostate	18.2 nTPM
Esophagus	15.6 nTPM
Lung	14.1 nTPM
Liver	13.6 nTPM
Skeletal muscle	12.9 nTPM

Suprabasal keratinocytes	59.0 nTPM
Tongue	76.4 nTPM
Skin	41.7 nTPM

T-cells	36.3 nTPM
Colon	48.7 nTPM
Adipose tissue	48.1 nTPM
Prostate	47.4 nTPM
Fallopian tube	45.0 nTPM
Esophagus	43.8 nTPM
Kidney	42.6 nTPM
PBMC	40.6 nTPM
Endometrium	38.9 nTPM
Salivary gland	37.8 nTPM
Skeletal muscle	36.7 nTPM
Skin	36.4 nTPM
Liver	35.0 nTPM
Breast	34.8 nTPM
Tongue	30.3 nTPM
Lung	30.2 nTPM
Spleen	29.5 nTPM
Thymus	28.8 nTPM
Lymph node	28.3 nTPM
Bone marrow	27.3 nTPM
Stomach	26.5 nTPM
Vascular	25.7 nTPM

Undifferentiated cells	74.7 nTPM
Colon	95.3 nTPM
Small intestine	71.2 nTPM
Rectum	57.7 nTPM

Amygdala excitatory	10.9 nTPM
Thalamus	11.8 nTPM
Cerebral cortex	11.3 nTPM
Hypothalamus	11.0 nTPM
Hippocampus	10.7 nTPM
Basal ganglia	10.5 nTPM
Amygdala	10.2 nTPM

Astrocyte	11.0 nTPM
Cerebral cortex	13.5 nTPM
Thalamus	11.9 nTPM
Pons	11.7 nTPM
Hippocampus	11.5 nTPM
Midbrain	11.3 nTPM
Cerebellum	11.2 nTPM
Medulla oblongata	11.2 nTPM
Basal ganglia	10.7 nTPM
Amygdala	10.2 nTPM
Hypothalamus	9.5 nTPM
Spinal cord	8.6 nTPM

Bergmann glia	12.5 nTPM
Pons	12.9 nTPM
Medulla oblongata	12.8 nTPM
Cerebellum	11.7 nTPM

Central nervous system macrophage	16.3 nTPM
Cerebral cortex	19.2 nTPM
Cerebellum	18.3 nTPM
Medulla oblongata	18.1 nTPM
Pons	18.0 nTPM
Hippocampus	17.4 nTPM
Midbrain	16.8 nTPM
Basal ganglia	15.4 nTPM
Hypothalamus	14.6 nTPM
Spinal cord	14.4 nTPM
Amygdala	14.2 nTPM
Thalamus	12.6 nTPM

Cerebellar inhibitory	12.7 nTPM
Midbrain	15.2 nTPM
Pons	13.7 nTPM
Medulla oblongata	13.4 nTPM
Cerebellum	12.7 nTPM
Spinal cord	8.2 nTPM

Cge interneuron	14.4 nTPM
Midbrain	16.9 nTPM
Hippocampus	16.0 nTPM
Cerebral cortex	15.7 nTPM
Basal ganglia	14.7 nTPM
Thalamus	13.4 nTPM
Amygdala	13.1 nTPM
Hypothalamus	10.9 nTPM

Choroid plexus epithelial cell	16.8 nTPM
Hippocampus	25.0 nTPM
Medulla oblongata	15.1 nTPM
Thalamus	13.7 nTPM
Basal ganglia	13.3 nTPM

Committed oligodendrocyte precursor	11.4 nTPM
Medulla oblongata	24.5 nTPM
Midbrain	15.1 nTPM
Basal ganglia	13.7 nTPM
Hippocampus	13.2 nTPM
Cerebral cortex	11.4 nTPM
Cerebellum	11.1 nTPM
Thalamus	9.5 nTPM
Pons	8.0 nTPM
Hypothalamus	7.5 nTPM
Amygdala	7.3 nTPM
Spinal cord	3.7 nTPM

Deep-layer corticothalamic and 6b	14.5 nTPM
Basal ganglia	16.8 nTPM
Hippocampus	15.8 nTPM
Midbrain	15.5 nTPM
Cerebral cortex	14.6 nTPM
Amygdala	13.3 nTPM
Hypothalamus	11.0 nTPM

Deep-layer intratelencephalic	12.3 nTPM
Basal ganglia	14.4 nTPM
Cerebral cortex	13.8 nTPM
Hippocampus	12.0 nTPM
Amygdala	10.9 nTPM
Hypothalamus	10.3 nTPM

Deep-layer near-projecting	20.4 nTPM
Hippocampus	25.4 nTPM
Basal ganglia	23.0 nTPM
Cerebral cortex	21.5 nTPM
Hypothalamus	16.1 nTPM
Amygdala	15.9 nTPM

Eccentric medium spiny neuron	14.3 nTPM
Hypothalamus	17.2 nTPM
Basal ganglia	15.7 nTPM
Hippocampus	14.5 nTPM
Cerebral cortex	13.8 nTPM
Amygdala	12.8 nTPM
Thalamus	11.5 nTPM