Single cell type - SLC35B1 - The Human Protein Atlas

SLC35B1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC35B1
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 35 member B1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.29
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC35B1 is part of cluster 77 Plasma cells - Protein processing with confidenceⁱ 1
324 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYDGF	Myeloid derived growth factor	0.7444	77
MANF	Mesencephalic astrocyte derived neurotrophic factor	0.7437	77
SDF2L1	Stromal cell derived factor 2 like 1	0.7268	77
GMPPB	GDP-mannose pyrophosphorylase B	0.7120	77
SRPRB	SRP receptor subunit beta	0.6871	77
CLPTM1L	CLPTM1 like	0.6796	61
TMEM208	Transmembrane protein 208	0.6774	77
SSR3	Signal sequence receptor subunit 3	0.6762	77
HSPA5	Heat shock protein family A (Hsp70) member 5	0.6741	77
SEC13	SEC13 homolog, nuclear pore and COPII coat complex component	0.6623	77
SEC11C	SEC11 homolog C, signal peptidase complex subunit	0.6581	77
PDIA6	Protein disulfide isomerase family A member 6	0.6573	77
DNAJB11	DnaJ heat shock protein family (Hsp40) member B11	0.6560	77
DERL1	Derlin 1	0.6503	77
SEC61A1	SEC61 translocon subunit alpha 1	0.6466	77

IMMUNE CELLS

SLC35B1 is part of cluster 13 Non-specific - Mitochondria with confidenceⁱ 0.99
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARHGAP31	Rho GTPase activating protein 31	1.0000	13
TBC1D10B	TBC1 domain family member 10B	1.0000	13
KDELR1	KDEL endoplasmic reticulum protein retention receptor 1	1.0000	13
AHCY	Adenosylhomocysteinase	0.9762	13
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.9762	13
PHB2	Prohibitin 2	0.9762	13
NCKIPSD	NCK interacting protein with SH3 domain	0.9762	13
MRPL24	Mitochondrial ribosomal protein L24	0.9762	13
HINT2	Histidine triad nucleotide binding protein 2	0.9762	13
TMEM39B	Transmembrane protein 39B	0.9762	13
SLC23A2	Solute carrier family 23 member 2	0.9762	13
UBE2K	Ubiquitin conjugating enzyme E2 K	0.9762	13
SPAG6	Sperm associated antigen 6	0.9762	13
AKR7A2	Aldo-keto reductase family 7 member A2	0.9762	13
BLTP2	Bridge-like lipid transfer protein family member 2	0.9524	13

Adipocytes	31.7 nTPM
Breast	37.2 nTPM
Adipose tissue	26.3 nTPM

Alveolar cells type 1	71.7 nTPM
Lung	71.7 nTPM

Alveolar cells type 2	91.9 nTPM
Lung	91.9 nTPM

Astrocytes	10.2 nTPM
Brain	10.2 nTPM

B-cells	17.2 nTPM
Skin	32.2 nTPM
Lung	29.5 nTPM
Adipose tissue	24.3 nTPM
Salivary gland	18.7 nTPM
Stomach	17.7 nTPM
Thymus	17.6 nTPM
Lymph node	15.7 nTPM
PBMC	15.4 nTPM
Liver	14.5 nTPM
Spleen	14.0 nTPM
Bone marrow	13.9 nTPM
Kidney	10.4 nTPM
Esophagus	0.0 nTPM

Ciliated cells	29.0 nTPM
Lung	35.0 nTPM
Bronchus	31.6 nTPM
Fallopian tube	30.6 nTPM
Endometrium	18.9 nTPM

Club cells	41.8 nTPM
Lung	54.2 nTPM
Bronchus	49.4 nTPM
Prostate	21.7 nTPM

Dendritic cells	45.3 nTPM
Adipose tissue	51.1 nTPM
PBMC	39.6 nTPM

Endothelial cells	34.7 nTPM
Pancreas	69.8 nTPM
Lung	62.3 nTPM
Placenta	51.7 nTPM
Breast	42.2 nTPM
Fallopian tube	42.2 nTPM
Skin	36.9 nTPM
Testis	32.0 nTPM
Skeletal muscle	31.9 nTPM
Thymus	31.6 nTPM
Heart muscle	29.5 nTPM
Esophagus	29.3 nTPM
Tongue	27.9 nTPM
Endometrium	27.6 nTPM
Ovary	26.3 nTPM
Liver	25.2 nTPM
Vascular	24.6 nTPM
Salivary gland	18.0 nTPM
Prostate	16.4 nTPM

Enteroendocrine cells	48.7 nTPM
Small intestine	61.8 nTPM
Colon	59.1 nTPM
Rectum	25.2 nTPM

Fibroblasts	33.6 nTPM
Pancreas	94.0 nTPM
Lung	71.8 nTPM
Placenta	41.9 nTPM
Thymus	41.6 nTPM
Breast	34.5 nTPM
Heart muscle	32.7 nTPM
Fallopian tube	30.4 nTPM
Prostate	26.4 nTPM
Vascular	24.6 nTPM
Skin	24.5 nTPM
Adipose tissue	23.2 nTPM
Skeletal muscle	22.6 nTPM
Salivary gland	22.2 nTPM
Esophagus	19.9 nTPM
Liver	19.0 nTPM
Stomach	8.6 nTPM

Granulocytes	22.8 nTPM
Fallopian tube	27.7 nTPM
Lung	26.2 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	52.5 nTPM
Colon	103.8 nTPM
Rectum	27.0 nTPM
Small intestine	26.8 nTPM

Lymphatic endothelial cells	36.5 nTPM
Ovary	43.6 nTPM
Fallopian tube	29.3 nTPM

Macrophages	32.9 nTPM
Pancreas	78.1 nTPM
Lung	53.1 nTPM
Thymus	52.9 nTPM
Testis	39.1 nTPM
Kidney	36.3 nTPM
Breast	35.5 nTPM
Endometrium	34.4 nTPM
Fallopian tube	32.7 nTPM
Bone marrow	32.4 nTPM
Prostate	31.4 nTPM
Skin	30.1 nTPM
Adipose tissue	28.3 nTPM
Skeletal muscle	26.9 nTPM
Vascular	25.2 nTPM
Tongue	22.7 nTPM
Salivary gland	22.5 nTPM
Stomach	18.0 nTPM
Spleen	16.0 nTPM
Esophagus	10.3 nTPM

Basal keratinocytes	27.3 nTPM
Tongue	33.8 nTPM
Skin	20.9 nTPM

Basal prostatic cells	22.4 nTPM
Prostate	22.4 nTPM

Basal respiratory cells	55.4 nTPM
Bronchus	55.4 nTPM

Basal squamous epithelial cells	20.6 nTPM
Esophagus	20.6 nTPM

Paneth cells	33.5 nTPM
Colon	36.2 nTPM
Small intestine	34.5 nTPM
Rectum	29.6 nTPM

Plasma cells	136.2 nTPM
Liver	192.3 nTPM
Thymus	182.4 nTPM
Spleen	157.3 nTPM
Fallopian tube	145.4 nTPM
Bone marrow	120.8 nTPM
Stomach	115.6 nTPM
Salivary gland	92.7 nTPM
Esophagus	83.2 nTPM

Schwann cells	30.7 nTPM
Vascular	34.5 nTPM
Adipose tissue	33.6 nTPM
Esophagus	24.0 nTPM

Serous glandular cells	53.9 nTPM
Salivary gland	63.7 nTPM
Tongue	44.2 nTPM

Smooth muscle cells	25.4 nTPM
Placenta	56.9 nTPM
Lung	36.4 nTPM
Salivary gland	29.3 nTPM
Thymus	29.3 nTPM
Esophagus	27.6 nTPM
Liver	27.2 nTPM
Fallopian tube	26.7 nTPM
Skeletal muscle	26.1 nTPM
Breast	25.5 nTPM
Endometrium	22.0 nTPM
Tongue	21.0 nTPM
Ovary	19.0 nTPM
Skin	17.7 nTPM
Vascular	16.3 nTPM
Adipose tissue	14.9 nTPM
Prostate	10.9 nTPM

Suprabasal keratinocytes	40.3 nTPM
Tongue	58.2 nTPM
Skin	22.4 nTPM

T-cells	28.0 nTPM
Breast	41.6 nTPM
Skin	40.7 nTPM
Stomach	37.3 nTPM
Liver	35.7 nTPM
Colon	35.1 nTPM
Skeletal muscle	34.8 nTPM
Fallopian tube	34.7 nTPM
Lung	31.5 nTPM
Kidney	29.3 nTPM
Adipose tissue	28.9 nTPM
Endometrium	26.0 nTPM
Tongue	24.5 nTPM
Prostate	24.1 nTPM
Vascular	24.1 nTPM
PBMC	22.1 nTPM
Esophagus	21.9 nTPM
Spleen	21.1 nTPM
Bone marrow	20.8 nTPM
Thymus	19.4 nTPM
Lymph node	17.4 nTPM
Salivary gland	17.4 nTPM

Undifferentiated cells	41.8 nTPM
Colon	59.4 nTPM
Small intestine	39.6 nTPM
Rectum	26.6 nTPM

Amygdala excitatory	13.9 nTPM
Basal ganglia	18.1 nTPM
Hippocampus	16.1 nTPM
Cerebral cortex	14.8 nTPM
Amygdala	13.4 nTPM
Thalamus	11.8 nTPM
Hypothalamus	9.4 nTPM

Astrocyte	15.4 nTPM
Cerebral cortex	19.2 nTPM
Midbrain	18.3 nTPM
Thalamus	18.2 nTPM
Pons	18.1 nTPM
Hippocampus	16.2 nTPM
Basal ganglia	15.2 nTPM
Medulla oblongata	14.6 nTPM
Cerebellum	14.5 nTPM
Spinal cord	14.0 nTPM
Amygdala	11.1 nTPM
Hypothalamus	9.8 nTPM

Bergmann glia	17.0 nTPM
Pons	24.5 nTPM
Cerebellum	15.9 nTPM
Medulla oblongata	10.7 nTPM

Central nervous system macrophage	13.1 nTPM
Cerebral cortex	15.5 nTPM
Thalamus	14.8 nTPM
Pons	14.6 nTPM
Hippocampus	14.4 nTPM
Medulla oblongata	14.4 nTPM
Cerebellum	14.0 nTPM
Midbrain	12.4 nTPM
Basal ganglia	12.3 nTPM
Hypothalamus	11.8 nTPM
Amygdala	10.2 nTPM
Spinal cord	10.0 nTPM

Cerebellar inhibitory	20.2 nTPM
Pons	21.4 nTPM
Cerebellum	20.6 nTPM
Medulla oblongata	20.1 nTPM
Midbrain	19.9 nTPM
Spinal cord	19.2 nTPM

Cge interneuron	17.5 nTPM
Basal ganglia	21.3 nTPM
Midbrain	20.5 nTPM
Cerebral cortex	19.5 nTPM
Hippocampus	18.9 nTPM
Thalamus	16.4 nTPM
Amygdala	15.7 nTPM
Hypothalamus	10.5 nTPM

Choroid plexus epithelial cell	13.9 nTPM
Hippocampus	16.6 nTPM
Basal ganglia	15.1 nTPM
Medulla oblongata	12.7 nTPM
Thalamus	11.0 nTPM

Committed oligodendrocyte precursor	18.9 nTPM
Spinal cord	29.4 nTPM
Pons	23.9 nTPM
Cerebellum	23.8 nTPM
Midbrain	21.8 nTPM
Medulla oblongata	19.4 nTPM
Cerebral cortex	17.7 nTPM
Hippocampus	17.1 nTPM
Basal ganglia	15.9 nTPM
Thalamus	15.1 nTPM
Hypothalamus	12.3 nTPM
Amygdala	11.8 nTPM

Deep-layer corticothalamic and 6b	19.9 nTPM
Midbrain	27.7 nTPM
Basal ganglia	24.6 nTPM
Cerebral cortex	23.1 nTPM
Hippocampus	19.4 nTPM
Amygdala	17.3 nTPM
Hypothalamus	7.2 nTPM

Deep-layer intratelencephalic	16.5 nTPM
Basal ganglia	20.7 nTPM
Cerebral cortex	19.8 nTPM
Hippocampus	17.0 nTPM
Amygdala	15.8 nTPM
Hypothalamus	9.2 nTPM

Deep-layer near-projecting	20.2 nTPM
Basal ganglia	27.6 nTPM
Cerebral cortex	25.2 nTPM
Hippocampus	22.1 nTPM
Amygdala	20.3 nTPM
Hypothalamus	5.6 nTPM

Eccentric medium spiny neuron	16.3 nTPM
Basal ganglia	18.5 nTPM
Hypothalamus	16.4 nTPM
Cerebral cortex	16.1 nTPM
Amygdala	16.0 nTPM
Thalamus	15.8 nTPM
Hippocampus	15.3 nTPM