Single cell type - RBM26 - The Human Protein Atlas

RBM26

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RBM26
Gene descriptionⁱ Full gene name according to HGNC.	RNA binding motif protein 26
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Excitatory neurons, Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RBM26 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRPF40A	Pre-mRNA processing factor 40 homolog A	0.5037	39
SMARCAD1	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	0.5020	55
SFSWAP	Splicing factor SWAP	0.4902	55
DMTF1	Cyclin D binding myb like transcription factor 1	0.4781	55
SCFD1	Sec1 family domain containing 1	0.4764	55
RBM33	RNA binding motif protein 33	0.4763	78
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	0.4721	78
CNOT1	CCR4-NOT transcription complex subunit 1	0.4703	78
ZFP69B	ZFP69 zinc finger protein B	0.4695	34
NIPBL	NIPBL cohesin loading factor	0.4693	55
PDS5A	PDS5 cohesin associated factor A	0.4658	55
FBXO11	F-box protein 11	0.4629	29
TMEM161B	Transmembrane protein 161B	0.4587	55
ZNF407	Zinc finger protein 407	0.4576	76
RBM15	RNA binding motif protein 15	0.4562	55

IMMUNE CELLS

RBM26 is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.98
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRKX	Protein kinase cAMP-dependent X-linked catalytic subunit	1.0000	32
DNAJC21	DnaJ heat shock protein family (Hsp40) member C21	1.0000	32
FAM136A	Family with sequence similarity 136 member A	1.0000	32
TEC	Tec protein tyrosine kinase	0.9762	32
ARL16	ADP ribosylation factor like GTPase 16	0.9762	32
ZNF808	Zinc finger protein 808	0.9762	32
ZNF443	Zinc finger protein 443	0.9762	32
ZNF415	Zinc finger protein 415	0.9762	32
ZSCAN21	Zinc finger and SCAN domain containing 21	0.9762	32
NIPSNAP3B	Nipsnap homolog 3B	0.9762	32
PAN3	Poly(A) specific ribonuclease subunit PAN3	0.9762	32
DNAJC14	DnaJ heat shock protein family (Hsp40) member C14	0.9762	32
ZMYM5	Zinc finger MYM-type containing 5	0.9762	41
ZNF227	Zinc finger protein 227	0.9762	32
LATS1	Large tumor suppressor kinase 1	0.9762	32

Adipocytes	49.5 nTPM
Adipose tissue	57.3 nTPM
Breast	41.6 nTPM

Alveolar cells type 1	36.4 nTPM
Lung	36.4 nTPM

Alveolar cells type 2	54.2 nTPM
Lung	54.2 nTPM

Astrocytes	141.2 nTPM
Brain	141.2 nTPM

B-cells	67.7 nTPM
Adipose tissue	165.4 nTPM
Salivary gland	105.5 nTPM
PBMC	93.9 nTPM
Lymph node	84.5 nTPM
Bone marrow	71.5 nTPM
Spleen	67.4 nTPM
Lung	65.7 nTPM
Thymus	64.3 nTPM
Stomach	60.7 nTPM
Liver	43.5 nTPM
Skin	23.7 nTPM
Esophagus	23.6 nTPM
Kidney	10.4 nTPM

Ciliated cells	35.2 nTPM
Bronchus	41.4 nTPM
Lung	37.0 nTPM
Fallopian tube	34.1 nTPM
Endometrium	28.2 nTPM

Club cells	40.1 nTPM
Lung	44.1 nTPM
Prostate	43.5 nTPM
Bronchus	32.7 nTPM

Dendritic cells	75.3 nTPM
Adipose tissue	78.7 nTPM
PBMC	71.9 nTPM

Endothelial cells	45.9 nTPM
Heart muscle	73.4 nTPM
Liver	63.0 nTPM
Salivary gland	57.1 nTPM
Endometrium	55.4 nTPM
Vascular	55.3 nTPM
Ovary	54.3 nTPM
Prostate	53.8 nTPM
Testis	48.5 nTPM
Skeletal muscle	47.2 nTPM
Tongue	44.7 nTPM
Placenta	41.4 nTPM
Breast	39.5 nTPM
Esophagus	38.4 nTPM
Thymus	38.3 nTPM
Fallopian tube	36.3 nTPM
Lung	32.3 nTPM
Skin	29.7 nTPM
Pancreas	18.1 nTPM

Enteroendocrine cells	36.0 nTPM
Rectum	47.0 nTPM
Colon	33.5 nTPM
Small intestine	27.5 nTPM

Fibroblasts	42.0 nTPM
Liver	70.0 nTPM
Heart muscle	59.8 nTPM
Skeletal muscle	48.4 nTPM
Adipose tissue	48.3 nTPM
Vascular	47.8 nTPM
Salivary gland	46.3 nTPM
Breast	46.1 nTPM
Fallopian tube	42.5 nTPM
Prostate	40.9 nTPM
Esophagus	36.7 nTPM
Placenta	36.2 nTPM
Lung	36.2 nTPM
Thymus	32.9 nTPM
Skin	29.2 nTPM
Stomach	27.4 nTPM
Pancreas	23.1 nTPM

Granulocytes	64.7 nTPM
Tongue	77.6 nTPM
Fallopian tube	62.5 nTPM
Lung	53.9 nTPM

Intestinal goblet cells	37.5 nTPM
Small intestine	47.0 nTPM
Rectum	42.8 nTPM
Colon	22.9 nTPM

Lymphatic endothelial cells	43.0 nTPM
Ovary	43.6 nTPM
Fallopian tube	42.3 nTPM

Macrophages	46.1 nTPM
Adipose tissue	73.2 nTPM
Salivary gland	59.7 nTPM
Fallopian tube	57.5 nTPM
Skeletal muscle	56.3 nTPM
Spleen	52.1 nTPM
Bone marrow	49.7 nTPM
Endometrium	48.0 nTPM
Tongue	46.5 nTPM
Prostate	46.3 nTPM
Thymus	46.1 nTPM
Testis	45.9 nTPM
Vascular	42.6 nTPM
Esophagus	42.4 nTPM
Stomach	41.2 nTPM
Lung	39.1 nTPM
Breast	38.6 nTPM
Kidney	38.1 nTPM
Skin	33.4 nTPM
Pancreas	18.5 nTPM

Basal respiratory cells	26.0 nTPM
Bronchus	26.0 nTPM

Basal squamous epithelial cells	50.7 nTPM
Esophagus	50.7 nTPM

Bipolar cells	50.1 nTPM
Eye	50.1 nTPM

Cholangiocytes	30.5 nTPM
Liver	30.5 nTPM

Paneth cells	27.4 nTPM
Rectum	36.9 nTPM
Small intestine	34.5 nTPM
Colon	10.9 nTPM

Plasma cells	64.0 nTPM
Thymus	71.6 nTPM
Salivary gland	70.7 nTPM
Spleen	66.9 nTPM
Liver	64.1 nTPM
Esophagus	62.4 nTPM
Fallopian tube	61.4 nTPM
Stomach	59.1 nTPM
Bone marrow	55.9 nTPM

Schwann cells	43.1 nTPM
Adipose tissue	54.7 nTPM
Vascular	50.7 nTPM
Esophagus	24.0 nTPM

Serous glandular cells	63.9 nTPM
Tongue	70.7 nTPM
Salivary gland	57.2 nTPM

Smooth muscle cells	38.9 nTPM
Adipose tissue	55.7 nTPM
Endometrium	50.6 nTPM
Salivary gland	50.0 nTPM
Liver	47.5 nTPM
Prostate	45.6 nTPM
Skeletal muscle	44.7 nTPM
Vascular	44.2 nTPM
Tongue	43.1 nTPM
Fallopian tube	35.9 nTPM
Ovary	35.9 nTPM
Esophagus	32.4 nTPM
Breast	30.2 nTPM
Placenta	28.6 nTPM
Thymus	27.6 nTPM
Skin	25.2 nTPM
Lung	24.7 nTPM

Suprabasal keratinocytes	43.1 nTPM
Tongue	44.1 nTPM
Skin	42.1 nTPM

T-cells	57.9 nTPM
Adipose tissue	96.8 nTPM
Skeletal muscle	80.1 nTPM
Salivary gland	79.5 nTPM
Prostate	72.6 nTPM
PBMC	70.6 nTPM
Endometrium	68.7 nTPM
Fallopian tube	61.6 nTPM
Vascular	61.5 nTPM
Lymph node	58.4 nTPM
Tongue	57.2 nTPM
Lung	56.4 nTPM
Thymus	54.7 nTPM
Liver	54.4 nTPM
Breast	54.3 nTPM
Esophagus	48.7 nTPM
Spleen	45.1 nTPM
Colon	43.9 nTPM
Bone marrow	40.9 nTPM
Stomach	40.8 nTPM
Kidney	36.4 nTPM
Skin	34.0 nTPM

Undifferentiated cells	37.2 nTPM
Small intestine	41.0 nTPM
Rectum	38.8 nTPM
Colon	31.8 nTPM

Amygdala excitatory	338.4 nTPM
Amygdala	378.6 nTPM
Hypothalamus	360.1 nTPM
Basal ganglia	328.2 nTPM
Thalamus	325.8 nTPM
Cerebral cortex	319.9 nTPM
Hippocampus	317.7 nTPM

Astrocyte	294.6 nTPM
Amygdala	427.4 nTPM
Hippocampus	335.3 nTPM
Hypothalamus	328.3 nTPM
Cerebral cortex	320.4 nTPM
Basal ganglia	314.8 nTPM
Thalamus	287.3 nTPM
Pons	283.3 nTPM
Midbrain	269.0 nTPM
Medulla oblongata	254.8 nTPM
Cerebellum	217.4 nTPM
Spinal cord	202.5 nTPM

Bergmann glia	339.6 nTPM
Cerebellum	357.7 nTPM
Pons	335.2 nTPM
Medulla oblongata	326.1 nTPM

Central nervous system macrophage	298.7 nTPM
Amygdala	415.1 nTPM
Hypothalamus	360.6 nTPM
Basal ganglia	324.5 nTPM
Hippocampus	316.0 nTPM
Thalamus	306.0 nTPM
Midbrain	287.6 nTPM
Pons	265.1 nTPM
Cerebral cortex	264.9 nTPM
Cerebellum	257.2 nTPM
Medulla oblongata	248.1 nTPM
Spinal cord	240.2 nTPM

Cerebellar inhibitory	224.9 nTPM
Midbrain	241.7 nTPM
Medulla oblongata	237.0 nTPM
Pons	234.2 nTPM
Cerebellum	216.6 nTPM
Spinal cord	195.2 nTPM

Cge interneuron	237.1 nTPM
Amygdala	272.6 nTPM
Hypothalamus	260.5 nTPM
Thalamus	242.7 nTPM
Midbrain	241.1 nTPM
Basal ganglia	221.7 nTPM
Hippocampus	219.9 nTPM
Cerebral cortex	201.6 nTPM

Choroid plexus epithelial cell	244.2 nTPM
Basal ganglia	307.9 nTPM
Medulla oblongata	277.7 nTPM
Thalamus	208.3 nTPM
Hippocampus	183.0 nTPM

Committed oligodendrocyte precursor	245.1 nTPM
Amygdala	307.9 nTPM
Hypothalamus	307.9 nTPM
Thalamus	262.3 nTPM
Hippocampus	246.8 nTPM
Cerebral cortex	245.1 nTPM
Pons	233.7 nTPM
Basal ganglia	231.6 nTPM
Cerebellum	228.3 nTPM
Medulla oblongata	219.5 nTPM
Midbrain	206.6 nTPM
Spinal cord	206.0 nTPM

Deep-layer corticothalamic and 6b	334.8 nTPM
Amygdala	364.4 nTPM
Hippocampus	340.0 nTPM
Midbrain	339.5 nTPM
Hypothalamus	338.8 nTPM
Cerebral cortex	324.7 nTPM
Basal ganglia	301.1 nTPM

Deep-layer intratelencephalic	336.5 nTPM
Amygdala	390.1 nTPM
Hypothalamus	332.2 nTPM
Hippocampus	330.9 nTPM
Basal ganglia	320.0 nTPM
Cerebral cortex	309.2 nTPM

Deep-layer near-projecting	300.7 nTPM
Amygdala	354.9 nTPM
Hypothalamus	321.3 nTPM
Basal ganglia	289.8 nTPM
Cerebral cortex	281.0 nTPM
Hippocampus	256.3 nTPM

Eccentric medium spiny neuron	338.4 nTPM
Amygdala	370.4 nTPM
Thalamus	361.4 nTPM
Basal ganglia	344.6 nTPM
Hypothalamus	326.8 nTPM
Hippocampus	318.8 nTPM
Cerebral cortex	308.1 nTPM