Single cell type - RSBN1 - The Human Protein Atlas

RSBN1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RSBN1
Gene descriptionⁱ Full gene name according to HGNC.	Round spermatid basic protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.23
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RSBN1 is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TBCC	Tubulin folding cofactor C	0.6654	78
LEPROTL1	Leptin receptor overlapping transcript like 1	0.6611	78
TSPYL2	TSPY like 2	0.6410	78
CD40LG	CD40 ligand	0.6381	78
IL2	Interleukin 2	0.6373	78
PBX4	PBX homeobox 4	0.6353	78
IL7R	Interleukin 7 receptor	0.6328	78
EML4	EMAP like 4	0.6278	78
ZFP36L2	ZFP36 ring finger protein like 2	0.6278	78
ICOS	Inducible T cell costimulator	0.6270	78
ZNF831	Zinc finger protein 831	0.6230	78
CDKN1B	Cyclin dependent kinase inhibitor 1B	0.6227	78
PDCD1	Programmed cell death 1	0.6225	78
NSMCE3	NSE3 homolog, SMC5-SMC6 complex component	0.6101	78
CCR4	C-C motif chemokine receptor 4	0.5903	78

IMMUNE CELLS

RSBN1 is part of cluster 41 Basophils - Unknown function with confidenceⁱ 0.86
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZMYM5	Zinc finger MYM-type containing 5	1.0000	41
RBM26	RNA binding motif protein 26	0.9762	32
ZNF358	Zinc finger protein 358	0.9762	41
AKR1C3	Aldo-keto reductase family 1 member C3	0.9762	41
PRKX	Protein kinase cAMP-dependent X-linked catalytic subunit	0.9762	32
UBB	Ubiquitin B	0.9762	41
DNAJC21	DnaJ heat shock protein family (Hsp40) member C21	0.9762	32
BRD7	Bromodomain containing 7	0.9762	41
SPICE1	Spindle and centriole associated protein 1	0.9762	41
TEX30	Testis expressed 30	0.9762	41
DSN1	DSN1 component of MIS12 kinetochore complex	0.9762	41
FAM136A	Family with sequence similarity 136 member A	0.9762	32
BHLHE40	Basic helix-loop-helix family member e40	0.9762	41
BBOF1	Basal body orientation factor 1	0.9762	41
CASP8AP2	Caspase 8 associated protein 2	0.9762	41

Adipocytes	38.9 nTPM
Adipose tissue	39.1 nTPM
Breast	38.6 nTPM

Alveolar cells type 1	39.4 nTPM
Lung	39.4 nTPM

Alveolar cells type 2	38.0 nTPM
Lung	38.0 nTPM

Astrocytes	15.2 nTPM
Brain	15.2 nTPM

B-cells	57.8 nTPM
Esophagus	82.6 nTPM
Lymph node	79.7 nTPM
Salivary gland	79.3 nTPM
Adipose tissue	75.3 nTPM
Kidney	57.2 nTPM
Lung	56.3 nTPM
Thymus	54.0 nTPM
Stomach	52.3 nTPM
Spleen	50.0 nTPM
PBMC	47.7 nTPM
Liver	43.5 nTPM
Bone marrow	38.9 nTPM
Skin	33.9 nTPM

Ciliated cells	26.5 nTPM
Lung	29.5 nTPM
Fallopian tube	28.9 nTPM
Endometrium	28.1 nTPM
Bronchus	19.5 nTPM

Club cells	30.2 nTPM
Prostate	40.8 nTPM
Bronchus	25.9 nTPM
Lung	23.9 nTPM

Dendritic cells	61.1 nTPM
Adipose tissue	75.5 nTPM
PBMC	46.8 nTPM

Endothelial cells	39.4 nTPM
Prostate	52.8 nTPM
Heart muscle	51.5 nTPM
Ovary	49.2 nTPM
Skin	48.0 nTPM
Skeletal muscle	47.9 nTPM
Breast	47.5 nTPM
Esophagus	47.1 nTPM
Salivary gland	46.8 nTPM
Testis	45.5 nTPM
Fallopian tube	37.5 nTPM
Vascular	36.0 nTPM
Tongue	35.5 nTPM
Placenta	33.5 nTPM
Endometrium	33.1 nTPM
Thymus	33.0 nTPM
Lung	31.7 nTPM
Liver	16.4 nTPM
Pancreas	15.5 nTPM

Enteroendocrine cells	44.6 nTPM
Colon	60.5 nTPM
Small intestine	48.1 nTPM
Rectum	25.2 nTPM

Fibroblasts	39.8 nTPM
Prostate	70.0 nTPM
Esophagus	64.0 nTPM
Heart muscle	60.6 nTPM
Skin	47.6 nTPM
Salivary gland	46.9 nTPM
Breast	42.9 nTPM
Adipose tissue	40.4 nTPM
Fallopian tube	40.4 nTPM
Skeletal muscle	38.3 nTPM
Vascular	30.7 nTPM
Lung	30.4 nTPM
Liver	28.5 nTPM
Placenta	28.0 nTPM
Thymus	27.9 nTPM
Stomach	25.9 nTPM
Pancreas	13.9 nTPM

Granulocytes	51.4 nTPM
Lung	61.0 nTPM
Fallopian tube	49.6 nTPM
Tongue	43.7 nTPM

Intestinal goblet cells	51.5 nTPM
Colon	57.1 nTPM
Small intestine	53.7 nTPM
Rectum	43.7 nTPM

Lymphatic endothelial cells	31.0 nTPM
Fallopian tube	34.7 nTPM
Ovary	27.3 nTPM

Macrophages	29.0 nTPM
Skin	45.7 nTPM
Tongue	44.9 nTPM
Salivary gland	43.0 nTPM
Prostate	41.0 nTPM
Lung	35.4 nTPM
Breast	34.7 nTPM
Adipose tissue	34.5 nTPM
Esophagus	32.1 nTPM
Testis	31.0 nTPM
Thymus	26.2 nTPM
Skeletal muscle	25.4 nTPM
Fallopian tube	23.0 nTPM
Vascular	22.0 nTPM
Endometrium	21.5 nTPM
Bone marrow	21.3 nTPM
Pancreas	20.6 nTPM
Stomach	20.6 nTPM
Kidney	19.5 nTPM
Spleen	9.0 nTPM

Bipolar cells	78.4 nTPM
Eye	78.4 nTPM

Cholangiocytes	24.8 nTPM
Liver	24.8 nTPM

Collecting duct cells	19.4 nTPM
Kidney	19.4 nTPM

Cone photoreceptor cells	69.7 nTPM
Eye	69.7 nTPM

Paneth cells	53.7 nTPM
Colon	68.8 nTPM
Rectum	47.4 nTPM
Small intestine	44.9 nTPM

Plasma cells	27.6 nTPM
Esophagus	46.8 nTPM
Salivary gland	40.7 nTPM
Fallopian tube	37.6 nTPM
Stomach	26.0 nTPM
Liver	23.5 nTPM
Thymus	18.6 nTPM
Spleen	14.0 nTPM
Bone marrow	13.6 nTPM

Schwann cells	32.7 nTPM
Adipose tissue	39.0 nTPM
Vascular	35.0 nTPM
Esophagus	24.0 nTPM

Serous glandular cells	29.7 nTPM
Salivary gland	37.4 nTPM
Tongue	22.1 nTPM

Smooth muscle cells	43.5 nTPM
Lung	58.8 nTPM
Ovary	56.8 nTPM
Skin	55.1 nTPM
Skeletal muscle	53.8 nTPM
Adipose tissue	49.9 nTPM
Esophagus	48.1 nTPM
Fallopian tube	43.4 nTPM
Salivary gland	42.5 nTPM
Liver	42.0 nTPM
Breast	39.7 nTPM
Vascular	38.1 nTPM
Prostate	37.7 nTPM
Tongue	36.2 nTPM
Thymus	32.9 nTPM
Placenta	30.7 nTPM
Endometrium	29.8 nTPM

Suprabasal keratinocytes	55.6 nTPM
Skin	71.8 nTPM
Tongue	39.5 nTPM

T-cells	94.3 nTPM
Adipose tissue	197.2 nTPM
Thymus	114.6 nTPM
Salivary gland	113.2 nTPM
Fallopian tube	109.9 nTPM
Breast	107.4 nTPM
Skin	103.7 nTPM
Stomach	101.0 nTPM
Lung	100.7 nTPM
Esophagus	99.8 nTPM
Tongue	99.3 nTPM
Lymph node	97.7 nTPM
Skeletal muscle	95.3 nTPM
Prostate	91.9 nTPM
Vascular	90.5 nTPM
PBMC	77.8 nTPM
Liver	73.3 nTPM
Spleen	71.7 nTPM
Endometrium	66.5 nTPM
Bone marrow	58.0 nTPM
Kidney	55.9 nTPM
Colon	54.6 nTPM

Undifferentiated cells	41.4 nTPM
Rectum	42.9 nTPM
Small intestine	41.9 nTPM
Colon	39.3 nTPM

Amygdala excitatory	46.8 nTPM
Hypothalamus	54.7 nTPM
Basal ganglia	48.0 nTPM
Amygdala	45.8 nTPM
Hippocampus	45.4 nTPM
Thalamus	44.9 nTPM
Cerebral cortex	41.8 nTPM

Astrocyte	36.0 nTPM
Amygdala	50.2 nTPM
Basal ganglia	40.1 nTPM
Cerebral cortex	38.3 nTPM
Hypothalamus	36.9 nTPM
Hippocampus	36.5 nTPM
Thalamus	35.3 nTPM
Midbrain	34.3 nTPM
Pons	34.0 nTPM
Cerebellum	31.6 nTPM
Medulla oblongata	30.1 nTPM
Spinal cord	28.8 nTPM

Bergmann glia	53.8 nTPM
Medulla oblongata	59.7 nTPM
Pons	54.7 nTPM
Cerebellum	47.2 nTPM

Central nervous system macrophage	61.8 nTPM
Amygdala	83.5 nTPM
Thalamus	67.7 nTPM
Basal ganglia	65.3 nTPM
Hypothalamus	65.3 nTPM
Hippocampus	63.3 nTPM
Midbrain	62.2 nTPM
Medulla oblongata	56.4 nTPM
Pons	56.2 nTPM
Cerebral cortex	55.3 nTPM
Cerebellum	53.9 nTPM
Spinal cord	50.3 nTPM

Cerebellar inhibitory	43.8 nTPM
Midbrain	51.6 nTPM
Pons	48.6 nTPM
Medulla oblongata	45.8 nTPM
Cerebellum	42.6 nTPM
Spinal cord	30.2 nTPM

Cge interneuron	56.3 nTPM
Hypothalamus	67.6 nTPM
Amygdala	60.4 nTPM
Thalamus	60.1 nTPM
Hippocampus	53.1 nTPM
Basal ganglia	52.7 nTPM
Cerebral cortex	51.8 nTPM
Midbrain	48.5 nTPM

Choroid plexus epithelial cell	47.1 nTPM
Basal ganglia	68.5 nTPM
Medulla oblongata	53.8 nTPM
Hippocampus	38.8 nTPM
Thalamus	27.4 nTPM

Committed oligodendrocyte precursor	42.9 nTPM
Spinal cord	62.5 nTPM
Hypothalamus	54.6 nTPM
Amygdala	51.3 nTPM
Medulla oblongata	41.3 nTPM
Cerebral cortex	41.2 nTPM
Thalamus	39.2 nTPM
Hippocampus	38.8 nTPM
Cerebellum	38.1 nTPM
Basal ganglia	37.8 nTPM
Pons	37.2 nTPM
Midbrain	29.4 nTPM

Deep-layer corticothalamic and 6b	47.0 nTPM
Hypothalamus	59.7 nTPM
Amygdala	50.2 nTPM
Cerebral cortex	45.5 nTPM
Hippocampus	44.2 nTPM
Basal ganglia	42.3 nTPM
Midbrain	39.9 nTPM

Deep-layer intratelencephalic	50.3 nTPM
Hypothalamus	58.2 nTPM
Amygdala	55.5 nTPM
Hippocampus	50.6 nTPM
Cerebral cortex	44.5 nTPM
Basal ganglia	42.5 nTPM

Deep-layer near-projecting	48.2 nTPM
Hypothalamus	62.5 nTPM
Amygdala	47.8 nTPM
Hippocampus	47.5 nTPM
Cerebral cortex	43.7 nTPM
Basal ganglia	39.4 nTPM

Eccentric medium spiny neuron	53.1 nTPM
Hypothalamus	57.4 nTPM
Thalamus	55.0 nTPM
Amygdala	53.2 nTPM
Hippocampus	51.8 nTPM
Cerebral cortex	51.2 nTPM
Basal ganglia	49.8 nTPM