The single nuclei brain - Explore the expression profiles in single nuclei brain cell typesThis resource contains brain cell type expression profiles based on single-nuclei RNA sequencing (snRNAseq) data covering 11 brain regions, including 2,5 million cells. The snRNAseq analysis, is based on genome-wide expression data published by Siletti K et al. (2023), representing the human brain with over 3 million cells and 461 clusters. In the Human Protein Atlas, the data is represented by 34 superclusters. A specificity classification was conducted to determine the number of genes with an elevated expression in these 34 main clusters across the brain regions, as displayed in the pie chart and table on this page. Gene expression and clustering within these different clusters can be further explored at the Human Brain Cell Atlas v1.0, where individual cell types, regions and clusters are provided. The integration of this extensive brain snRNAseq data facilitates easy comparison to the cell type expression profiles across different datasets. The Single cell type resource enables comparison to โwhole bodyโ cell types, which includes integrated peripheral tissues and cerebral cortex snRNAseq data from Allen Brain Map. This Single nuclei brain data is expanding the brain cell details further, enabeling an in-depth comparison of clusters and regional variation across the human brain. More information about the specific content, data generation, and analysis methods can be found in the Methods Summary, and in data details. Explore the different knowledge summaries for cluster cell type by clicking the links in the table below, browse the list of genes with an elevated expression in different clusters by clicking the pie chart or bar chart below, or use the search function and find your favorite gene and see the regional expression overview for all the clusters. Additional links and background information can be found at the bottom of this page. Learn about:
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