Single cell type - ZNF154 - The Human Protein Atlas

ZNF154

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF154
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 154
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Dendritic cells, Astrocytes, Rod photoreceptor cells, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.65
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (eosinophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Dendritic cells, Astrocytes, Rod photoreceptor cells, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (eosinophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF154 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF549	Zinc finger protein 549	0.6855	55
ZNF441	Zinc finger protein 441	0.6311	55
ZNF134	Zinc finger protein 134	0.6288	55
ZNF671	Zinc finger protein 671	0.5905	55
ZNF26	Zinc finger protein 26	0.5377	55
NIPSNAP3B	Nipsnap homolog 3B	0.5316	2
GNG7	G protein subunit gamma 7	0.5053	73
PNOC	Prepronociceptin	0.5047	73
ZNF606	Zinc finger protein 606	0.5036	55
TNFRSF13C	TNF receptor superfamily member 13C	0.4897	73
P2RX5	Purinergic receptor P2X 5	0.4831	73
ZNF418	Zinc finger protein 418	0.4750	68
MED17	Mediator complex subunit 17	0.4734	55
ZNF256	Zinc finger protein 256	0.4721	55
ZIK1	Zinc finger protein interacting with K protein 1	0.4710	30

IMMUNE CELLS

ZNF154 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 0.95
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CEP295	Centrosomal protein 295	0.9762	21
USHBP1	USH1 protein network component harmonin binding protein 1	0.9524	21
RFX3	Regulatory factor X3	0.9524	21
MAGEF1	MAGE family member F1	0.9524	21
SECISBP2	SECIS binding protein 2	0.9524	21
MT-ND2	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2	0.9286	22
PRELID3A	PRELI domain containing 3A	0.9286	21
ENSG00000291303	Novel protein	0.9048	24
ERMN	Ermin	0.9048	21
SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	0.9048	22
NUPR1	Nuclear protein 1, transcriptional regulator	0.9048	21
SHOX	Short stature homeobox	0.9048	21
ZNF646	Zinc finger protein 646	0.8810	21
ZNF431	Zinc finger protein 431	0.8810	21
CNR2	Cannabinoid receptor 2	0.8810	22

Adipocytes	1.9 nTPM
Adipose tissue	3.2 nTPM
Breast	0.6 nTPM

Alveolar cells type 1	0.1 nTPM
Lung	0.1 nTPM

Alveolar cells type 2	0.4 nTPM
Lung	0.4 nTPM

B-cells	7.0 nTPM
Liver	19.3 nTPM
Adipose tissue	11.9 nTPM
Bone marrow	11.6 nTPM
Salivary gland	9.3 nTPM
Spleen	8.9 nTPM
Thymus	6.7 nTPM
Lymph node	6.4 nTPM
Stomach	6.3 nTPM
Lung	5.4 nTPM
PBMC	4.6 nTPM
Kidney	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	0.2 nTPM
Tongue	0.3 nTPM
Skin	0.0 nTPM

Ciliated cells	1.3 nTPM
Fallopian tube	3.4 nTPM
Bronchus	1.2 nTPM
Endometrium	0.4 nTPM
Lung	0.2 nTPM

Club cells	2.1 nTPM
Bronchus	2.5 nTPM
Prostate	2.3 nTPM
Lung	1.5 nTPM

Dendritic cells	11.9 nTPM
Adipose tissue	13.0 nTPM
PBMC	10.8 nTPM

Endothelial cells	2.8 nTPM
Heart muscle	8.7 nTPM
Endometrium	5.5 nTPM
Liver	5.0 nTPM
Salivary gland	4.6 nTPM
Ovary	4.5 nTPM
Placenta	3.4 nTPM
Vascular	3.0 nTPM
Skeletal muscle	2.6 nTPM
Thymus	2.6 nTPM
Prostate	2.4 nTPM
Tongue	2.1 nTPM
Testis	1.5 nTPM
Lung	1.5 nTPM
Breast	0.9 nTPM
Esophagus	0.8 nTPM
Fallopian tube	0.4 nTPM
Skin	0.1 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	1.1 nTPM
Liver	5.9 nTPM
Placenta	3.2 nTPM
Heart muscle	1.8 nTPM
Lung	1.8 nTPM
Prostate	1.3 nTPM
Vascular	0.7 nTPM
Skeletal muscle	0.6 nTPM
Esophagus	0.5 nTPM
Skin	0.4 nTPM
Adipose tissue	0.4 nTPM
Salivary gland	0.4 nTPM
Thymus	0.3 nTPM
Breast	0.2 nTPM
Fallopian tube	0.2 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Granulocytes	7.6 nTPM
Fallopian tube	11.9 nTPM
Lung	6.1 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	1.3 nTPM
Fallopian tube	2.7 nTPM
Ovary	0.0 nTPM

Macrophages	1.2 nTPM
Spleen	3.0 nTPM
Salivary gland	2.6 nTPM
Tongue	2.1 nTPM
Bone marrow	2.0 nTPM
Prostate	1.9 nTPM
Fallopian tube	1.7 nTPM
Adipose tissue	1.5 nTPM
Esophagus	1.3 nTPM
Breast	1.3 nTPM
Skin	1.1 nTPM
Skeletal muscle	0.8 nTPM
Thymus	0.8 nTPM
Lung	0.7 nTPM
Vascular	0.7 nTPM
Testis	0.6 nTPM
Endometrium	0.6 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Astrocytes	11.1 nTPM
Brain	11.1 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Cone photoreceptor cells	6.8 nTPM
Eye	6.8 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	3.2 nTPM
Fallopian tube	10.6 nTPM
Salivary gland	3.6 nTPM
Stomach	3.4 nTPM
Spleen	2.9 nTPM
Thymus	2.6 nTPM
Bone marrow	1.5 nTPM
Liver	1.0 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.5 nTPM
Adipose tissue	3.9 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.4 nTPM
Salivary gland	0.9 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.2 nTPM
Esophagus	6.0 nTPM
Ovary	5.1 nTPM
Liver	3.4 nTPM
Endometrium	3.1 nTPM
Adipose tissue	2.9 nTPM
Skeletal muscle	1.9 nTPM
Vascular	1.9 nTPM
Thymus	1.8 nTPM
Tongue	1.8 nTPM
Fallopian tube	1.7 nTPM
Placenta	1.6 nTPM
Salivary gland	1.4 nTPM
Lung	1.2 nTPM
Breast	1.1 nTPM
Skin	0.6 nTPM
Prostate	0.0 nTPM

T-cells	2.9 nTPM
Vascular	6.4 nTPM
Salivary gland	5.5 nTPM
Colon	4.9 nTPM
Fallopian tube	4.8 nTPM
Endometrium	4.0 nTPM
Prostate	3.8 nTPM
Thymus	3.8 nTPM
Skeletal muscle	3.4 nTPM
Lung	3.4 nTPM
Lymph node	3.0 nTPM
Bone marrow	2.6 nTPM
Spleen	2.5 nTPM
Tongue	2.3 nTPM
Stomach	2.2 nTPM
Liver	1.9 nTPM
Adipose tissue	1.8 nTPM
PBMC	1.2 nTPM
Breast	1.2 nTPM
Skin	1.1 nTPM
Kidney	0.9 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	10.4 nTPM
Hypothalamus	13.3 nTPM
Amygdala	11.1 nTPM
Basal ganglia	10.3 nTPM
Cerebral cortex	10.3 nTPM
Hippocampus	10.0 nTPM
Thalamus	7.7 nTPM

Astrocyte	15.2 nTPM
Amygdala	16.3 nTPM
Hypothalamus	16.2 nTPM
Thalamus	16.1 nTPM
Cerebellum	15.9 nTPM
Midbrain	15.7 nTPM
Basal ganglia	15.4 nTPM
Medulla oblongata	15.0 nTPM
Pons	14.9 nTPM
Cerebral cortex	14.7 nTPM
Hippocampus	14.1 nTPM
Spinal cord	13.3 nTPM

Bergmann glia	18.5 nTPM
Medulla oblongata	21.3 nTPM
Cerebellum	18.3 nTPM
Pons	15.8 nTPM

Central nervous system macrophage	1.3 nTPM
Cerebral cortex	2.5 nTPM
Hypothalamus	2.4 nTPM
Hippocampus	1.8 nTPM
Pons	1.2 nTPM
Spinal cord	1.2 nTPM
Thalamus	1.2 nTPM
Amygdala	1.1 nTPM
Basal ganglia	1.0 nTPM
Cerebellum	0.9 nTPM
Medulla oblongata	0.8 nTPM
Midbrain	0.7 nTPM

Cerebellar inhibitory	10.5 nTPM
Midbrain	11.2 nTPM
Spinal cord	11.0 nTPM
Cerebellum	10.2 nTPM
Medulla oblongata	10.1 nTPM
Pons	10.0 nTPM

Cge interneuron	11.1 nTPM
Hypothalamus	12.5 nTPM
Midbrain	12.4 nTPM
Amygdala	11.8 nTPM
Thalamus	10.9 nTPM
Hippocampus	10.5 nTPM
Basal ganglia	10.0 nTPM
Cerebral cortex	9.6 nTPM

Choroid plexus epithelial cell	21.3 nTPM
Basal ganglia	28.4 nTPM
Hippocampus	27.7 nTPM
Medulla oblongata	20.8 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	15.3 nTPM
Spinal cord	33.1 nTPM
Hippocampus	18.1 nTPM
Pons	16.8 nTPM
Amygdala	16.4 nTPM
Cerebellum	14.3 nTPM
Midbrain	13.4 nTPM
Basal ganglia	13.1 nTPM
Hypothalamus	12.3 nTPM
Cerebral cortex	12.0 nTPM
Medulla oblongata	11.6 nTPM
Thalamus	6.8 nTPM

Deep-layer corticothalamic and 6b	11.1 nTPM
Midbrain	13.3 nTPM
Hypothalamus	11.9 nTPM
Amygdala	11.1 nTPM
Basal ganglia	10.3 nTPM
Cerebral cortex	10.1 nTPM
Hippocampus	9.9 nTPM

Deep-layer intratelencephalic	9.9 nTPM
Amygdala	11.0 nTPM
Hypothalamus	10.4 nTPM
Basal ganglia	9.6 nTPM
Hippocampus	9.3 nTPM
Cerebral cortex	9.2 nTPM

Deep-layer near-projecting	10.0 nTPM
Hippocampus	12.7 nTPM
Amygdala	9.6 nTPM
Cerebral cortex	9.5 nTPM
Hypothalamus	9.4 nTPM
Basal ganglia	8.8 nTPM

Eccentric medium spiny neuron	12.9 nTPM
Thalamus	13.8 nTPM
Hippocampus	13.3 nTPM
Basal ganglia	13.1 nTPM
Hypothalamus	13.0 nTPM
Amygdala	12.8 nTPM
Cerebral cortex	11.7 nTPM

Endothelial cell	11.5 nTPM
Medulla oblongata	17.4 nTPM
Cerebellum	14.7 nTPM
Midbrain	13.2 nTPM
Hypothalamus	12.4 nTPM
Spinal cord	12.1 nTPM
Cerebral cortex	10.9 nTPM
Thalamus	10.2 nTPM
Basal ganglia	9.3 nTPM
Hippocampus	9.3 nTPM
Amygdala	8.9 nTPM
Pons	8.1 nTPM