Single cell type - MT-ND2 - The Human Protein Atlas

MT-ND2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MT-ND2
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cardiomyocytes, Proximal enterocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.25
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Proximal enterocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MT-ND2 is part of cluster 68 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
262 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MT-ND1	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	0.8872	68
MT-ND4	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4	0.8338	68
MT-CO2	Mitochondrially encoded cytochrome c oxidase II	0.8022	68
MT-CO1	Mitochondrially encoded cytochrome c oxidase I	0.7955	68
MT-CYB	Mitochondrially encoded cytochrome b	0.7408	68
MT-ND3	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3	0.7296	68
MT-CO3	Mitochondrially encoded cytochrome c oxidase III	0.7289	71
HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.6476	68
MT-ATP6	Mitochondrially encoded ATP synthase membrane subunit 6	0.6461	71
MT-ND5	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5	0.6454	68
ATP5ME	ATP synthase membrane subunit e	0.6405	68
SDHA	Succinate dehydrogenase complex flavoprotein subunit A	0.6318	68
UQCRB	Ubiquinol-cytochrome c reductase binding protein	0.5992	68
MFN2	Mitofusin 2	0.5777	68
UQCRC2	Ubiquinol-cytochrome c reductase core protein 2	0.5764	39

IMMUNE CELLS

MT-ND2 is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 1
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SECISBP2	SECIS binding protein 2	0.9762	21
SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	0.9524	22
ZNF154	Zinc finger protein 154	0.9286	21
LCAT	Lecithin-cholesterol acyltransferase	0.9048	22
KMT2E	Lysine methyltransferase 2E (inactive)	0.9048	22
SERPINB2	Serpin family B member 2	0.9048	22
RNPC3	RNA binding region (RNP1, RRM) containing 3	0.9048	21
MAGEF1	MAGE family member F1	0.9048	21
PLAAT5	Phospholipase A and acyltransferase 5	0.9048	22
ABHD18	Abhydrolase domain containing 18	0.9048	22
ASRGL1	Asparaginase and isoaspartyl peptidase 1	0.9048	22
CDK15	Cyclin dependent kinase 15	0.9048	22
USHBP1	USH1 protein network component harmonin binding protein 1	0.9048	21
AVL9	AVL9 cell migration associated	0.9048	21
HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.9048	22

Adipocytes	1459.2 nTPM
Adipose tissue	1660.6 nTPM
Breast	1257.7 nTPM

Alveolar cells type 1	2348.7 nTPM
Lung	2348.7 nTPM

Alveolar cells type 2	2490.1 nTPM
Lung	2490.1 nTPM

Astrocytes	61.0 nTPM
Brain	61.0 nTPM

B-cells	2781.4 nTPM
Liver	9790.8 nTPM
Kidney	5870.6 nTPM
PBMC	5778.7 nTPM
Adipose tissue	3277.3 nTPM
Lung	2567.4 nTPM
Salivary gland	2078.3 nTPM
Thymus	1297.2 nTPM
Skin	1280.6 nTPM
Lymph node	1012.2 nTPM
Stomach	926.3 nTPM
Esophagus	837.8 nTPM
Spleen	757.2 nTPM
Bone marrow	683.5 nTPM

Basal keratinocytes	2477.2 nTPM
Skin	2996.5 nTPM
Tongue	1957.9 nTPM

Basal squamous epithelial cells	1771.5 nTPM
Esophagus	1771.5 nTPM

Ciliated cells	3135.6 nTPM
Bronchus	4396.1 nTPM
Lung	3791.0 nTPM
Fallopian tube	2186.1 nTPM
Endometrium	2169.3 nTPM

Club cells	2599.3 nTPM
Bronchus	2987.1 nTPM
Lung	2698.4 nTPM
Prostate	2112.5 nTPM

Dendritic cells	2274.2 nTPM
PBMC	2737.6 nTPM
Adipose tissue	1810.9 nTPM

Distal enterocytes	10570.7 nTPM
Rectum	12229.5 nTPM
Colon	8911.9 nTPM

Endothelial cells	2739.8 nTPM
Heart muscle	8617.7 nTPM
Liver	5676.0 nTPM
Testis	5400.4 nTPM
Ovary	4411.7 nTPM
Skeletal muscle	3792.0 nTPM
Placenta	2778.9 nTPM
Fallopian tube	2103.7 nTPM
Pancreas	1895.0 nTPM
Lung	1878.4 nTPM
Skin	1823.0 nTPM
Tongue	1666.6 nTPM
Prostate	1619.4 nTPM
Vascular	1617.9 nTPM
Salivary gland	1490.4 nTPM
Thymus	1394.6 nTPM
Breast	1109.0 nTPM
Endometrium	1065.0 nTPM
Esophagus	976.6 nTPM

Enteroendocrine cells	5438.7 nTPM
Colon	6061.2 nTPM
Small intestine	5722.9 nTPM
Rectum	4531.8 nTPM

Erythroid cells	3619.3 nTPM
Liver	6565.8 nTPM
Bone marrow	672.8 nTPM

Fibroblasts	2028.9 nTPM
Liver	5258.3 nTPM
Heart muscle	4353.4 nTPM
Skeletal muscle	3199.3 nTPM
Lung	2244.3 nTPM
Adipose tissue	2127.6 nTPM
Fallopian tube	2122.1 nTPM
Prostate	1779.5 nTPM
Salivary gland	1638.5 nTPM
Placenta	1601.4 nTPM
Skin	1590.8 nTPM
Pancreas	1445.0 nTPM
Vascular	1417.3 nTPM
Thymus	1296.3 nTPM
Breast	965.1 nTPM
Stomach	775.3 nTPM
Esophagus	648.9 nTPM

Bipolar cells	10536.6 nTPM
Eye	10536.6 nTPM

Cholangiocytes	6210.0 nTPM
Liver	6210.0 nTPM

Collecting duct cells	3436.5 nTPM
Kidney	3436.5 nTPM

Cone photoreceptor cells	6331.0 nTPM
Eye	6331.0 nTPM

Glandular and luminal cells	2246.9 nTPM
Endometrium	2246.9 nTPM

Granulocytes	4947.9 nTPM
Lung	7094.1 nTPM
Tongue	4826.3 nTPM
Fallopian tube	2923.2 nTPM

Intestinal goblet cells	12002.7 nTPM
Rectum	14983.2 nTPM
Small intestine	13525.2 nTPM
Colon	7499.6 nTPM

Lymphatic endothelial cells	3005.9 nTPM
Ovary	4871.7 nTPM
Fallopian tube	1140.0 nTPM

Macrophages	3034.6 nTPM
Lung	8313.7 nTPM
Testis	7513.1 nTPM
Adipose tissue	4432.2 nTPM
Skeletal muscle	4174.1 nTPM
Fallopian tube	3961.7 nTPM
Kidney	3791.4 nTPM
Vascular	2988.1 nTPM
Thymus	2519.0 nTPM
Skin	2516.1 nTPM
Pancreas	2298.1 nTPM
Salivary gland	2293.2 nTPM
Tongue	2032.7 nTPM
Prostate	1905.2 nTPM
Spleen	1779.4 nTPM
Breast	1685.2 nTPM
Stomach	1610.2 nTPM
Endometrium	1383.7 nTPM
Esophagus	1328.0 nTPM
Bone marrow	1132.0 nTPM

Paneth cells	8982.6 nTPM
Small intestine	10969.4 nTPM
Rectum	9949.6 nTPM
Colon	6028.7 nTPM

Plasma cells	1903.9 nTPM
Liver	7554.0 nTPM
Fallopian tube	2135.4 nTPM
Salivary gland	1748.6 nTPM
Stomach	977.1 nTPM
Esophagus	925.2 nTPM
Thymus	841.8 nTPM
Spleen	530.0 nTPM
Bone marrow	519.5 nTPM

Schwann cells	1656.2 nTPM
Adipose tissue	2295.1 nTPM
Vascular	2278.1 nTPM
Esophagus	395.4 nTPM

Serous glandular cells	3111.3 nTPM
Salivary gland	4715.7 nTPM
Tongue	1506.9 nTPM

Smooth muscle cells	2481.6 nTPM
Ovary	5851.3 nTPM
Liver	4387.9 nTPM
Skeletal muscle	3750.6 nTPM
Fallopian tube	3157.9 nTPM
Salivary gland	2747.6 nTPM
Skin	2604.5 nTPM
Placenta	2204.0 nTPM
Prostate	2123.2 nTPM
Tongue	1999.2 nTPM
Vascular	1991.4 nTPM
Adipose tissue	1887.3 nTPM
Breast	1871.4 nTPM
Lung	1755.2 nTPM
Thymus	1337.2 nTPM
Esophagus	1137.6 nTPM
Endometrium	899.2 nTPM

Suprabasal keratinocytes	2118.5 nTPM
Skin	2442.2 nTPM
Tongue	1794.7 nTPM

T-cells	2813.1 nTPM
Liver	9531.4 nTPM
Kidney	5958.6 nTPM
PBMC	5309.4 nTPM
Colon	5008.3 nTPM
Skeletal muscle	4111.8 nTPM
Adipose tissue	3919.0 nTPM
Fallopian tube	3210.7 nTPM
Lung	3062.9 nTPM
Vascular	2615.4 nTPM
Prostate	2570.2 nTPM
Tongue	2147.0 nTPM
Skin	2071.3 nTPM
Endometrium	1828.9 nTPM
Salivary gland	1644.3 nTPM
Breast	1401.0 nTPM
Thymus	1054.8 nTPM
Lymph node	823.3 nTPM
Stomach	807.1 nTPM
Esophagus	783.6 nTPM
Spleen	637.7 nTPM
Bone marrow	578.1 nTPM

Undifferentiated cells	8925.3 nTPM
Rectum	11342.6 nTPM
Small intestine	9714.4 nTPM
Colon	5718.9 nTPM

Amygdala excitatory	176.5 nTPM
Hypothalamus	354.4 nTPM
Basal ganglia	299.3 nTPM
Amygdala	139.6 nTPM
Hippocampus	94.5 nTPM
Thalamus	88.5 nTPM
Cerebral cortex	82.8 nTPM

Astrocyte	70.8 nTPM
Hypothalamus	113.1 nTPM
Basal ganglia	93.1 nTPM
Thalamus	90.3 nTPM
Cerebellum	80.8 nTPM
Hippocampus	68.7 nTPM
Cerebral cortex	68.2 nTPM
Amygdala	63.7 nTPM
Midbrain	58.6 nTPM
Spinal cord	54.7 nTPM
Pons	49.9 nTPM
Medulla oblongata	37.9 nTPM

Bergmann glia	37.2 nTPM
Medulla oblongata	42.6 nTPM
Cerebellum	35.8 nTPM
Pons	33.1 nTPM

Central nervous system macrophage	159.3 nTPM
Thalamus	238.3 nTPM
Amygdala	202.7 nTPM
Hippocampus	180.2 nTPM
Pons	177.9 nTPM
Midbrain	163.4 nTPM
Spinal cord	151.0 nTPM
Cerebral cortex	150.9 nTPM
Hypothalamus	133.4 nTPM
Basal ganglia	132.6 nTPM
Cerebellum	128.7 nTPM
Medulla oblongata	93.0 nTPM

Cerebellar inhibitory	181.8 nTPM
Midbrain	326.9 nTPM
Pons	251.0 nTPM
Cerebellum	180.9 nTPM
Spinal cord	82.5 nTPM
Medulla oblongata	67.8 nTPM

Cge interneuron	241.1 nTPM
Hypothalamus	346.8 nTPM
Thalamus	294.9 nTPM
Amygdala	240.2 nTPM
Basal ganglia	236.6 nTPM
Hippocampus	205.7 nTPM
Cerebral cortex	184.6 nTPM
Midbrain	179.1 nTPM

Choroid plexus epithelial cell	734.7 nTPM
Thalamus	1729.1 nTPM
Hippocampus	748.8 nTPM
Basal ganglia	234.8 nTPM
Medulla oblongata	225.9 nTPM