Single cell type - ZNF549 - The Human Protein Atlas

ZNF549

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF549
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 549
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.52
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (NK-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (NK-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF549 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF154	Zinc finger protein 154	0.6855	55
ZNF773	Zinc finger protein 773	0.6404	55
PLAG1	PLAG1 zinc finger	0.5986	55
ZNF134	Zinc finger protein 134	0.5801	55
ZNF441	Zinc finger protein 441	0.5713	55
ARHGAP25	Rho GTPase activating protein 25	0.5634	73
ZNF671	Zinc finger protein 671	0.5599	55
SP4	Sp4 transcription factor	0.5506	55
ZNF329	Zinc finger protein 329	0.5285	55
ZNF439	Zinc finger protein 439	0.5259	55
ZNF606	Zinc finger protein 606	0.5252	55
ZNF419	Zinc finger protein 419	0.5240	55
RIC3	RIC3 acetylcholine receptor chaperone	0.5172	55
BCAS4	Breast carcinoma amplified sequence 4	0.5165	73
ZNF26	Zinc finger protein 26	0.5135	55

IMMUNE CELLS

ZNF549 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.9
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MZF1	Myeloid zinc finger 1	1.0000	24
SYNRG	Synergin gamma	1.0000	24
ATP6V1G2	ATPase H+ transporting V1 subunit G2	1.0000	24
MAGEE1	MAGE family member E1	1.0000	24
SDR42E1	Short chain dehydrogenase/reductase family 42E, member 1	1.0000	24
LDOC1	LDOC1 regulator of NFKB signaling	1.0000	24
PJA1	Praja ring finger ubiquitin ligase 1	1.0000	24
PLEKHA1	Pleckstrin homology domain containing A1	1.0000	24
ARL6	ADP ribosylation factor like GTPase 6	0.9762	24
CEP70	Centrosomal protein 70	0.9762	24
DPH5	Diphthamide biosynthesis 5	0.9762	24
ODF2L	Outer dense fiber of sperm tails 2 like	0.9762	24
CASD1	CAS1 domain containing 1	0.9762	24
C12orf29	Chromosome 12 open reading frame 29	0.9762	24
CLK4	CDC like kinase 4	0.9762	24

Adipocytes	2.4 nTPM
Breast	2.8 nTPM
Adipose tissue	2.0 nTPM

Alveolar cells type 1	0.9 nTPM
Lung	0.9 nTPM

Alveolar cells type 2	0.7 nTPM
Lung	0.7 nTPM

Astrocytes	5.6 nTPM
Brain	5.6 nTPM

B-cells	7.4 nTPM
Stomach	13.5 nTPM
Lung	10.7 nTPM
Bone marrow	10.0 nTPM
Liver	9.7 nTPM
Salivary gland	9.1 nTPM
Lymph node	8.3 nTPM
PBMC	7.7 nTPM
Thymus	7.6 nTPM
Esophagus	5.9 nTPM
Kidney	5.2 nTPM
Spleen	5.2 nTPM
Adipose tissue	2.1 nTPM
Skin	1.7 nTPM

Ciliated cells	2.9 nTPM
Fallopian tube	3.7 nTPM
Bronchus	2.9 nTPM
Lung	2.6 nTPM
Endometrium	2.3 nTPM

Club cells	1.8 nTPM
Prostate	1.9 nTPM
Lung	1.8 nTPM
Bronchus	1.7 nTPM

Endothelial cells	3.1 nTPM
Prostate	5.8 nTPM
Pancreas	5.2 nTPM
Salivary gland	4.6 nTPM
Ovary	4.4 nTPM
Vascular	4.3 nTPM
Liver	3.8 nTPM
Heart muscle	3.5 nTPM
Endometrium	3.2 nTPM
Thymus	3.1 nTPM
Tongue	2.8 nTPM
Fallopian tube	2.4 nTPM
Testis	2.1 nTPM
Esophagus	2.1 nTPM
Lung	2.0 nTPM
Placenta	1.7 nTPM
Skeletal muscle	1.6 nTPM
Skin	1.4 nTPM
Breast	0.9 nTPM

Enteroendocrine cells	3.0 nTPM
Rectum	5.0 nTPM
Small intestine	3.4 nTPM
Colon	0.7 nTPM

Fibroblasts	1.5 nTPM
Liver	3.6 nTPM
Skeletal muscle	2.2 nTPM
Esophagus	2.2 nTPM
Vascular	2.2 nTPM
Breast	1.9 nTPM
Fallopian tube	1.7 nTPM
Placenta	1.5 nTPM
Salivary gland	1.4 nTPM
Skin	1.3 nTPM
Prostate	1.3 nTPM
Heart muscle	1.2 nTPM
Pancreas	1.2 nTPM
Adipose tissue	1.2 nTPM
Thymus	1.0 nTPM
Lung	0.3 nTPM
Stomach	0.0 nTPM

Granulocytes	6.0 nTPM
Lung	6.6 nTPM
Fallopian tube	6.5 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	0.9 nTPM
Small intestine	1.5 nTPM
Rectum	0.7 nTPM
Colon	0.5 nTPM

Lymphatic endothelial cells	4.1 nTPM
Ovary	5.5 nTPM
Fallopian tube	2.7 nTPM

Macrophages	2.4 nTPM
Salivary gland	4.2 nTPM
Pancreas	4.1 nTPM
Bone marrow	4.1 nTPM
Prostate	3.9 nTPM
Thymus	3.5 nTPM
Skin	3.3 nTPM
Vascular	3.1 nTPM
Lung	2.7 nTPM
Esophagus	2.6 nTPM
Tongue	2.6 nTPM
Skeletal muscle	2.5 nTPM
Adipose tissue	2.2 nTPM
Fallopian tube	2.1 nTPM
Breast	1.4 nTPM
Testis	1.2 nTPM
Spleen	1.0 nTPM
Kidney	0.9 nTPM
Endometrium	0.6 nTPM
Stomach	0.0 nTPM

Paneth cells	3.0 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM
Rectum	1.9 nTPM

Basal squamous epithelial cells	0.2 nTPM
Esophagus	0.2 nTPM

Cone photoreceptor cells	6.8 nTPM
Eye	6.8 nTPM

Plasma cells	1.7 nTPM
Fallopian tube	3.2 nTPM
Liver	2.5 nTPM
Spleen	2.2 nTPM
Salivary gland	1.8 nTPM
Stomach	1.7 nTPM
Bone marrow	1.5 nTPM
Thymus	1.1 nTPM
Esophagus	0.0 nTPM

Schwann cells	1.2 nTPM
Vascular	2.1 nTPM
Adipose tissue	1.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	3.3 nTPM
Tongue	4.4 nTPM
Salivary gland	2.2 nTPM

Smooth muscle cells	2.8 nTPM
Lung	7.1 nTPM
Liver	4.2 nTPM
Adipose tissue	4.2 nTPM
Ovary	3.4 nTPM
Endometrium	3.1 nTPM
Salivary gland	3.1 nTPM
Fallopian tube	3.1 nTPM
Thymus	2.6 nTPM
Vascular	2.4 nTPM
Skeletal muscle	2.2 nTPM
Skin	1.9 nTPM
Breast	1.9 nTPM
Prostate	1.8 nTPM
Tongue	1.8 nTPM
Placenta	1.6 nTPM
Esophagus	0.0 nTPM

T-cells	5.1 nTPM
Salivary gland	8.2 nTPM
Fallopian tube	8.1 nTPM
Prostate	7.9 nTPM
Thymus	7.9 nTPM
Vascular	7.6 nTPM
Bone marrow	6.9 nTPM
Colon	6.8 nTPM
Lymph node	6.7 nTPM
Stomach	5.4 nTPM
Liver	5.0 nTPM
PBMC	4.9 nTPM
Tongue	4.8 nTPM
Lung	4.5 nTPM
Spleen	4.3 nTPM
Adipose tissue	4.1 nTPM
Skeletal muscle	3.8 nTPM
Breast	3.7 nTPM
Endometrium	3.3 nTPM
Esophagus	2.4 nTPM
Skin	1.1 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	1.0 nTPM
Small intestine	1.3 nTPM
Rectum	1.3 nTPM
Colon	0.5 nTPM

Amygdala excitatory	47.8 nTPM
Hypothalamus	70.1 nTPM
Amygdala	52.1 nTPM
Hippocampus	49.5 nTPM
Cerebral cortex	46.2 nTPM
Basal ganglia	37.7 nTPM
Thalamus	31.3 nTPM

Astrocyte	28.8 nTPM
Amygdala	39.7 nTPM
Hypothalamus	32.1 nTPM
Hippocampus	31.5 nTPM
Cerebral cortex	29.6 nTPM
Basal ganglia	27.9 nTPM
Cerebellum	27.7 nTPM
Thalamus	27.6 nTPM
Midbrain	27.3 nTPM
Spinal cord	24.6 nTPM
Pons	24.3 nTPM
Medulla oblongata	24.1 nTPM

Bergmann glia	22.2 nTPM
Cerebellum	27.2 nTPM
Medulla oblongata	23.4 nTPM
Pons	15.8 nTPM

Central nervous system macrophage	10.9 nTPM
Hypothalamus	16.1 nTPM
Medulla oblongata	12.2 nTPM
Hippocampus	11.3 nTPM
Basal ganglia	10.8 nTPM
Pons	10.6 nTPM
Spinal cord	10.6 nTPM
Cerebral cortex	10.2 nTPM
Thalamus	10.1 nTPM
Amygdala	9.8 nTPM
Cerebellum	9.5 nTPM
Midbrain	8.6 nTPM

Cerebellar inhibitory	30.7 nTPM
Spinal cord	44.0 nTPM
Medulla oblongata	30.6 nTPM
Midbrain	28.6 nTPM
Cerebellum	26.4 nTPM
Pons	23.9 nTPM

Cge interneuron	30.6 nTPM
Hypothalamus	39.9 nTPM
Amygdala	33.0 nTPM
Hippocampus	31.0 nTPM
Cerebral cortex	30.8 nTPM
Basal ganglia	28.2 nTPM
Thalamus	27.4 nTPM
Midbrain	23.8 nTPM

Choroid plexus epithelial cell	16.5 nTPM
Basal ganglia	21.8 nTPM
Medulla oblongata	16.9 nTPM
Thalamus	16.4 nTPM
Hippocampus	11.1 nTPM

Committed oligodendrocyte precursor	32.8 nTPM
Amygdala	51.9 nTPM
Cerebral cortex	41.8 nTPM
Hypothalamus	37.6 nTPM
Hippocampus	35.2 nTPM
Spinal cord	33.1 nTPM
Cerebellum	31.7 nTPM
Pons	30.1 nTPM
Basal ganglia	29.6 nTPM
Medulla oblongata	27.1 nTPM
Midbrain	25.2 nTPM
Thalamus	18.0 nTPM

Deep-layer corticothalamic and 6b	44.7 nTPM
Hypothalamus	58.5 nTPM
Amygdala	50.3 nTPM
Cerebral cortex	47.0 nTPM
Hippocampus	44.3 nTPM
Basal ganglia	41.7 nTPM
Midbrain	26.6 nTPM

Deep-layer intratelencephalic	45.1 nTPM
Hypothalamus	55.8 nTPM
Amygdala	47.8 nTPM
Hippocampus	43.6 nTPM
Cerebral cortex	40.8 nTPM
Basal ganglia	37.4 nTPM

Deep-layer near-projecting	40.7 nTPM
Hypothalamus	53.5 nTPM
Cerebral cortex	39.1 nTPM
Amygdala	38.0 nTPM
Basal ganglia	37.3 nTPM
Hippocampus	35.5 nTPM

Eccentric medium spiny neuron	50.0 nTPM
Hypothalamus	54.6 nTPM
Basal ganglia	54.2 nTPM
Thalamus	52.2 nTPM
Cerebral cortex	48.7 nTPM
Amygdala	47.0 nTPM
Hippocampus	43.1 nTPM

Endothelial cell	17.4 nTPM
Basal ganglia	26.1 nTPM
Amygdala	22.4 nTPM
Hypothalamus	22.3 nTPM
Hippocampus	21.2 nTPM
Pons	18.1 nTPM
Midbrain	17.0 nTPM
Thalamus	16.4 nTPM
Cerebellum	14.7 nTPM
Medulla oblongata	12.3 nTPM
Cerebral cortex	10.9 nTPM
Spinal cord	10.4 nTPM

Ependymal cell	16.8 nTPM
Amygdala	23.9 nTPM
Basal ganglia	20.2 nTPM
Hypothalamus	18.7 nTPM
Hippocampus	18.5 nTPM
Thalamus	17.0 nTPM
Medulla oblongata	16.7 nTPM
Midbrain	14.0 nTPM
Spinal cord	11.5 nTPM
Pons	10.6 nTPM