Single cell type - ZNF606 - The Human Protein Atlas

ZNF606

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF606
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 606
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Rod photoreceptor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.52
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF606 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF75A	Zinc finger protein 75a	0.6468	55
ZFP14	ZFP14 zinc finger protein	0.6271	55
HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2	0.6234	55
ZNF441	Zinc finger protein 441	0.6194	55
ZNF274	Zinc finger protein 274	0.6098	55
ZNF665	Zinc finger protein 665	0.6022	55
ZNF268	Zinc finger protein 268	0.5808	55
POLM	DNA polymerase mu	0.5633	55
ZNF671	Zinc finger protein 671	0.5594	55
ZNF397	Zinc finger protein 397	0.5504	55
ZNF550	Zinc finger protein 550	0.5492	55
ELMOD3	ELMO domain containing 3	0.5448	55
LRIG2	Leucine rich repeats and immunoglobulin like domains 2	0.5448	55
RIC3	RIC3 acetylcholine receptor chaperone	0.5380	55
MTMR4	Myotubularin related protein 4	0.5350	55

IMMUNE CELLS

ZNF606 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.92
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF717	Zinc finger protein 717	1.0000	24
SHISAL2A	Shisa like 2A	0.9762	24
KLF13	KLF transcription factor 13	0.9524	24
ZNF814	Zinc finger protein 814	0.9524	24
ZC3H6	Zinc finger CCCH-type containing 6	0.9524	24
LYG2	Lysozyme g2	0.9524	24
FANCF	FA complementation group F	0.9524	24
ZNF571	Zinc finger protein 571	0.9524	24
RPUSD2	RNA pseudouridine synthase domain containing 2	0.9524	24
ZNF382	Zinc finger protein 382	0.9524	24
MRNIP	MRN complex interacting protein	0.9524	24
ZNF419	Zinc finger protein 419	0.9286	43
DHX36	DEAH-box helicase 36	0.9286	24
RP9	RP9 pre-mRNA splicing factor	0.9286	24
TUT1	Terminal uridylyl transferase 1, U6 snRNA-specific	0.9286	24

Adipocytes	4.0 nTPM
Adipose tissue	4.7 nTPM
Breast	3.2 nTPM

Alveolar cells type 1	3.3 nTPM
Lung	3.3 nTPM

Alveolar cells type 2	2.1 nTPM
Lung	2.1 nTPM

Astrocytes	8.7 nTPM
Brain	8.7 nTPM

B-cells	9.9 nTPM
Bone marrow	25.4 nTPM
PBMC	21.6 nTPM
Lymph node	14.9 nTPM
Thymus	12.0 nTPM
Spleen	11.9 nTPM
Lung	9.4 nTPM
Stomach	9.3 nTPM
Salivary gland	8.4 nTPM
Esophagus	5.9 nTPM
Liver	4.8 nTPM
Adipose tissue	3.3 nTPM
Skin	1.7 nTPM
Kidney	0.0 nTPM

Ciliated cells	10.7 nTPM
Bronchus	16.1 nTPM
Lung	11.2 nTPM
Fallopian tube	8.1 nTPM
Endometrium	7.3 nTPM

Club cells	4.8 nTPM
Bronchus	5.6 nTPM
Prostate	4.7 nTPM
Lung	3.9 nTPM

Endothelial cells	5.4 nTPM
Heart muscle	14.3 nTPM
Esophagus	9.0 nTPM
Testis	8.2 nTPM
Breast	7.0 nTPM
Ovary	6.4 nTPM
Prostate	6.3 nTPM
Vascular	6.3 nTPM
Thymus	5.6 nTPM
Pancreas	5.2 nTPM
Skeletal muscle	4.9 nTPM
Salivary gland	4.6 nTPM
Placenta	4.0 nTPM
Liver	3.8 nTPM
Lung	3.3 nTPM
Endometrium	2.8 nTPM
Skin	2.5 nTPM
Fallopian tube	2.2 nTPM
Tongue	1.6 nTPM

Enteroendocrine cells	1.2 nTPM
Colon	1.8 nTPM
Rectum	1.7 nTPM
Small intestine	0.0 nTPM

Fibroblasts	3.8 nTPM
Liver	8.3 nTPM
Heart muscle	6.5 nTPM
Placenta	5.8 nTPM
Esophagus	5.4 nTPM
Salivary gland	4.2 nTPM
Vascular	3.8 nTPM
Thymus	3.5 nTPM
Prostate	3.3 nTPM
Skeletal muscle	3.0 nTPM
Stomach	2.9 nTPM
Breast	2.9 nTPM
Adipose tissue	2.6 nTPM
Fallopian tube	2.6 nTPM
Pancreas	2.5 nTPM
Lung	1.8 nTPM
Skin	1.7 nTPM

Granulocytes	6.4 nTPM
Tongue	9.7 nTPM
Lung	5.0 nTPM
Fallopian tube	4.4 nTPM

Intestinal goblet cells	5.5 nTPM
Small intestine	10.3 nTPM
Rectum	3.7 nTPM
Colon	2.5 nTPM

Lymphatic endothelial cells	4.6 nTPM
Ovary	5.5 nTPM
Fallopian tube	3.7 nTPM

Macrophages	2.3 nTPM
Bone marrow	7.1 nTPM
Esophagus	6.4 nTPM
Prostate	3.2 nTPM
Breast	3.1 nTPM
Thymus	2.9 nTPM
Salivary gland	2.5 nTPM
Skin	2.2 nTPM
Pancreas	2.1 nTPM
Vascular	2.1 nTPM
Lung	1.9 nTPM
Fallopian tube	1.7 nTPM
Tongue	1.6 nTPM
Skeletal muscle	1.5 nTPM
Adipose tissue	1.5 nTPM
Testis	1.2 nTPM
Endometrium	1.2 nTPM
Kidney	0.9 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	2.0 nTPM
Small intestine	3.5 nTPM
Rectum	2.7 nTPM
Colon	0.0 nTPM

Basal prostatic cells	4.3 nTPM
Prostate	4.3 nTPM

Bipolar cells	13.0 nTPM
Eye	13.0 nTPM

Cone photoreceptor cells	17.0 nTPM
Eye	17.0 nTPM

Plasma cells	2.9 nTPM
Esophagus	5.2 nTPM
Stomach	4.6 nTPM
Thymus	4.6 nTPM
Spleen	3.1 nTPM
Fallopian tube	2.6 nTPM
Liver	1.5 nTPM
Bone marrow	1.5 nTPM
Salivary gland	0.4 nTPM

Schwann cells	3.3 nTPM
Vascular	7.8 nTPM
Adipose tissue	2.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.3 nTPM
Tongue	4.4 nTPM
Salivary gland	4.2 nTPM

Smooth muscle cells	3.8 nTPM
Thymus	5.6 nTPM
Ovary	5.4 nTPM
Adipose tissue	4.9 nTPM
Esophagus	4.8 nTPM
Vascular	4.6 nTPM
Prostate	4.3 nTPM
Endometrium	3.9 nTPM
Breast	3.7 nTPM
Lung	3.5 nTPM
Skeletal muscle	3.4 nTPM
Placenta	3.3 nTPM
Liver	3.0 nTPM
Tongue	2.7 nTPM
Salivary gland	2.6 nTPM
Fallopian tube	2.6 nTPM
Skin	1.9 nTPM

T-cells	4.6 nTPM
PBMC	15.0 nTPM
Lymph node	8.9 nTPM
Bone marrow	6.8 nTPM
Thymus	6.5 nTPM
Prostate	6.4 nTPM
Kidney	6.2 nTPM
Spleen	5.1 nTPM
Salivary gland	4.8 nTPM
Liver	4.7 nTPM
Fallopian tube	4.5 nTPM
Vascular	4.0 nTPM
Stomach	3.6 nTPM
Lung	3.4 nTPM
Skin	3.2 nTPM
Breast	2.9 nTPM
Endometrium	2.7 nTPM
Tongue	2.6 nTPM
Esophagus	2.4 nTPM
Adipose tissue	1.6 nTPM
Skeletal muscle	1.1 nTPM
Colon	1.0 nTPM

Undifferentiated cells	2.2 nTPM
Rectum	2.8 nTPM
Small intestine	2.6 nTPM
Colon	1.3 nTPM

Amygdala excitatory	14.2 nTPM
Hypothalamus	19.4 nTPM
Amygdala	14.9 nTPM
Cerebral cortex	14.6 nTPM
Hippocampus	13.7 nTPM
Basal ganglia	11.5 nTPM
Thalamus	11.3 nTPM

Astrocyte	24.0 nTPM
Hypothalamus	30.1 nTPM
Amygdala	27.7 nTPM
Cerebellum	25.7 nTPM
Midbrain	25.0 nTPM
Basal ganglia	23.3 nTPM
Hippocampus	22.9 nTPM
Medulla oblongata	22.7 nTPM
Pons	22.6 nTPM
Thalamus	22.5 nTPM
Spinal cord	22.0 nTPM
Cerebral cortex	19.4 nTPM

Bergmann glia	22.6 nTPM
Medulla oblongata	27.7 nTPM
Cerebellum	24.2 nTPM
Pons	15.8 nTPM

Central nervous system macrophage	14.5 nTPM
Amygdala	17.8 nTPM
Cerebral cortex	16.0 nTPM
Midbrain	16.0 nTPM
Hippocampus	15.4 nTPM
Hypothalamus	15.4 nTPM
Thalamus	14.7 nTPM
Medulla oblongata	14.4 nTPM
Cerebellum	14.2 nTPM
Basal ganglia	14.1 nTPM
Pons	11.8 nTPM
Spinal cord	9.7 nTPM

Cerebellar inhibitory	14.2 nTPM
Midbrain	15.6 nTPM
Cerebellum	15.4 nTPM
Spinal cord	13.7 nTPM
Medulla oblongata	13.3 nTPM
Pons	13.0 nTPM

Cge interneuron	14.7 nTPM
Thalamus	15.9 nTPM
Hypothalamus	15.5 nTPM
Cerebral cortex	15.0 nTPM
Amygdala	14.7 nTPM
Basal ganglia	14.5 nTPM
Hippocampus	13.8 nTPM
Midbrain	13.8 nTPM

Choroid plexus epithelial cell	30.5 nTPM
Basal ganglia	48.5 nTPM
Thalamus	27.4 nTPM
Medulla oblongata	26.8 nTPM
Hippocampus	19.4 nTPM

Committed oligodendrocyte precursor	24.6 nTPM
Spinal cord	51.5 nTPM
Amygdala	27.6 nTPM
Hippocampus	27.2 nTPM
Cerebellum	23.8 nTPM
Hypothalamus	23.2 nTPM
Cerebral cortex	22.8 nTPM
Midbrain	22.7 nTPM
Thalamus	21.4 nTPM
Pons	19.5 nTPM
Basal ganglia	18.1 nTPM
Medulla oblongata	12.9 nTPM

Deep-layer corticothalamic and 6b	14.3 nTPM
Basal ganglia	14.7 nTPM
Hypothalamus	14.6 nTPM
Cerebral cortex	14.4 nTPM
Midbrain	14.4 nTPM
Amygdala	14.3 nTPM
Hippocampus	13.4 nTPM

Deep-layer intratelencephalic	14.3 nTPM
Hypothalamus	15.7 nTPM
Basal ganglia	14.6 nTPM
Amygdala	14.0 nTPM
Cerebral cortex	13.9 nTPM
Hippocampus	13.1 nTPM

Deep-layer near-projecting	14.7 nTPM
Amygdala	16.8 nTPM
Basal ganglia	16.1 nTPM
Hypothalamus	15.8 nTPM
Cerebral cortex	14.8 nTPM
Hippocampus	10.1 nTPM

Eccentric medium spiny neuron	14.8 nTPM
Basal ganglia	15.6 nTPM
Amygdala	15.4 nTPM
Hypothalamus	14.9 nTPM
Cerebral cortex	14.5 nTPM
Thalamus	14.3 nTPM
Hippocampus	14.1 nTPM

Endothelial cell	14.3 nTPM
Cerebellum	18.6 nTPM
Hippocampus	18.6 nTPM
Hypothalamus	17.4 nTPM
Medulla oblongata	17.4 nTPM
Basal ganglia	16.8 nTPM
Amygdala	13.4 nTPM
Midbrain	13.2 nTPM
Spinal cord	12.1 nTPM
Thalamus	11.9 nTPM
Pons	9.4 nTPM
Cerebral cortex	9.0 nTPM

Ependymal cell	42.5 nTPM
Hypothalamus	54.4 nTPM
Amygdala	49.5 nTPM
Thalamus	46.6 nTPM
Basal ganglia	44.9 nTPM
Midbrain	44.4 nTPM
Hippocampus	42.5 nTPM
Medulla oblongata	38.6 nTPM
Pons	38.5 nTPM
Spinal cord	23.0 nTPM