Single cell type - TSTD3 - The Human Protein Atlas

TSTD3

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TSTD3
Gene descriptionⁱ Full gene name according to HGNC.	Thiosulfate sulfurtransferase like domain containing 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.45
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TSTD3 is part of cluster 69 Neurons - Neuronal signaling with confidenceⁱ 0.93
331 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DPF3	Double PHD fingers 3	0.6532	76
FIGN	Fidgetin, microtubule severing factor	0.6067	69
TTC28	Tetratricopeptide repeat domain 28	0.5801	69
PDE7B	Phosphodiesterase 7B	0.5734	69
ASIC1	Acid sensing ion channel subunit 1	0.5648	76
PARD3B	Par-3 family cell polarity regulator beta	0.5601	47
NPAS3	Neuronal PAS domain protein 3	0.5586	69
ZBTB20	Zinc finger and BTB domain containing 20	0.5522	69
L3MBTL4	L3MBTL histone methyl-lysine binding protein 4	0.5515	69
EPHB1	EPH receptor B1	0.5118	47
SOBP	Sine oculis binding protein homolog	0.5096	69
NCAM2	Neural cell adhesion molecule 2	0.5037	69
SGCD	Sarcoglycan delta	0.5024	76
GALNT13	Polypeptide N-acetylgalactosaminyltransferase 13	0.4990	69
APOL5	Apolipoprotein L5	0.4980	69

IMMUNE CELLS

TSTD3 is part of cluster 20 Non-specific - DNA binding with confidenceⁱ 1
266 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RNF103-CHMP3	RNF103-CHMP3 readthrough	0.9524	20
NPIPB13	Nuclear pore complex interacting protein family, member B13	0.9524	20
LRRC37A3	Leucine rich repeat containing 37 member A3	0.9524	20
ZNF208	Zinc finger protein 208	0.9524	34
MPV17L	MPV17 mitochondrial inner membrane protein like	0.9524	20
THRB	Thyroid hormone receptor beta	0.9524	20
ZNF724	Zinc finger protein 724	0.9286	34
PRRC2C	Proline rich coiled-coil 2C	0.9286	20
SLC3A1	Solute carrier family 3 member 1	0.9048	20
ZNF233	Zinc finger protein 233	0.9048	24
UBN2	Ubinuclein 2	0.9048	20
IL4R	Interleukin 4 receptor	0.9048	34
TBC1D8B	TBC1 domain family member 8B	0.9048	20
MORC4	MORC family CW-type zinc finger 4	0.9048	20
GNAZ	G protein subunit alpha z	0.9048	20

Adipocytes	6.8 nTPM
Breast	6.8 nTPM
Adipose tissue	6.7 nTPM

Alveolar cells type 1	5.2 nTPM
Lung	5.2 nTPM

Alveolar cells type 2	7.0 nTPM
Lung	7.0 nTPM

B-cells	11.3 nTPM
Esophagus	23.6 nTPM
Kidney	20.8 nTPM
Bone marrow	17.6 nTPM
Liver	14.5 nTPM
Salivary gland	14.0 nTPM
PBMC	12.3 nTPM
Stomach	10.5 nTPM
Adipose tissue	7.8 nTPM
Spleen	7.5 nTPM
Lymph node	7.4 nTPM
Thymus	4.8 nTPM
Skin	3.4 nTPM
Lung	2.7 nTPM

Basal keratinocytes	4.9 nTPM
Tongue	5.0 nTPM
Skin	4.7 nTPM

Ciliated cells	9.1 nTPM
Bronchus	10.5 nTPM
Endometrium	10.0 nTPM
Fallopian tube	8.8 nTPM
Lung	7.1 nTPM

Club cells	8.4 nTPM
Bronchus	9.5 nTPM
Prostate	8.6 nTPM
Lung	7.2 nTPM

Endothelial cells	9.0 nTPM
Heart muscle	17.5 nTPM
Liver	15.1 nTPM
Placenta	14.8 nTPM
Ovary	14.4 nTPM
Testis	9.8 nTPM
Skeletal muscle	9.8 nTPM
Prostate	9.6 nTPM
Skin	8.2 nTPM
Esophagus	8.2 nTPM
Endometrium	7.5 nTPM
Tongue	7.4 nTPM
Vascular	7.3 nTPM
Breast	7.0 nTPM
Salivary gland	6.3 nTPM
Pancreas	5.2 nTPM
Thymus	5.0 nTPM
Fallopian tube	4.8 nTPM
Lung	4.5 nTPM

Enteroendocrine cells	15.5 nTPM
Rectum	23.5 nTPM
Small intestine	13.7 nTPM
Colon	9.3 nTPM

Fibroblasts	12.2 nTPM
Prostate	18.5 nTPM
Heart muscle	17.3 nTPM
Vascular	17.3 nTPM
Skeletal muscle	15.0 nTPM
Adipose tissue	15.0 nTPM
Salivary gland	14.8 nTPM
Liver	14.2 nTPM
Skin	13.5 nTPM
Esophagus	12.6 nTPM
Thymus	10.3 nTPM
Breast	10.0 nTPM
Fallopian tube	9.5 nTPM
Pancreas	8.7 nTPM
Placenta	7.8 nTPM
Lung	6.7 nTPM
Stomach	4.3 nTPM

Granulocytes	6.9 nTPM
Tongue	9.7 nTPM
Lung	6.6 nTPM
Fallopian tube	4.6 nTPM

Intestinal goblet cells	9.6 nTPM
Rectum	12.2 nTPM
Small intestine	10.4 nTPM
Colon	6.2 nTPM

Lymphatic endothelial cells	14.3 nTPM
Ovary	21.8 nTPM
Fallopian tube	6.7 nTPM

Macrophages	4.0 nTPM
Skin	7.8 nTPM
Testis	7.4 nTPM
Kidney	7.1 nTPM
Pancreas	6.2 nTPM
Skeletal muscle	5.7 nTPM
Prostate	5.1 nTPM
Tongue	4.5 nTPM
Salivary gland	4.0 nTPM
Vascular	4.0 nTPM
Breast	3.6 nTPM
Thymus	3.5 nTPM
Adipose tissue	3.0 nTPM
Bone marrow	3.0 nTPM
Spleen	3.0 nTPM
Esophagus	2.6 nTPM
Fallopian tube	2.0 nTPM
Endometrium	1.8 nTPM
Lung	1.7 nTPM
Stomach	0.0 nTPM

Paneth cells	8.6 nTPM
Rectum	11.7 nTPM
Colon	7.2 nTPM
Small intestine	6.9 nTPM

Astrocytes	77.7 nTPM
Brain	77.7 nTPM

Bipolar cells	12.5 nTPM
Eye	12.5 nTPM

Cholangiocytes	19.1 nTPM
Liver	19.1 nTPM

Collecting duct cells	21.4 nTPM
Kidney	21.4 nTPM

Plasma cells	4.5 nTPM
Fallopian tube	7.1 nTPM
Liver	5.5 nTPM
Esophagus	5.2 nTPM
Spleen	5.1 nTPM
Salivary gland	4.9 nTPM
Thymus	4.1 nTPM
Stomach	2.5 nTPM
Bone marrow	1.5 nTPM

Schwann cells	10.9 nTPM
Vascular	15.1 nTPM
Esophagus	12.0 nTPM
Adipose tissue	5.5 nTPM

Serous glandular cells	6.0 nTPM
Salivary gland	7.6 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	12.8 nTPM
Vascular	19.7 nTPM
Prostate	18.9 nTPM
Ovary	18.5 nTPM
Liver	17.0 nTPM
Salivary gland	16.4 nTPM
Skin	13.3 nTPM
Skeletal muscle	12.1 nTPM
Tongue	12.0 nTPM
Fallopian tube	10.9 nTPM
Esophagus	10.8 nTPM
Lung	10.6 nTPM
Placenta	10.2 nTPM
Adipose tissue	9.6 nTPM
Thymus	9.3 nTPM
Breast	8.1 nTPM
Endometrium	7.6 nTPM

T-cells	5.9 nTPM
Kidney	13.3 nTPM
PBMC	12.4 nTPM
Bone marrow	9.8 nTPM
Salivary gland	8.9 nTPM
Lymph node	6.7 nTPM
Prostate	6.2 nTPM
Tongue	6.1 nTPM
Skeletal muscle	6.0 nTPM
Spleen	5.9 nTPM
Endometrium	5.8 nTPM
Adipose tissue	5.3 nTPM
Liver	5.2 nTPM
Esophagus	4.9 nTPM
Fallopian tube	4.6 nTPM
Vascular	4.4 nTPM
Colon	3.9 nTPM
Stomach	3.3 nTPM
Skin	3.2 nTPM
Lung	2.6 nTPM
Breast	2.5 nTPM
Thymus	1.9 nTPM

Undifferentiated cells	9.4 nTPM
Small intestine	12.5 nTPM
Rectum	8.8 nTPM
Colon	6.9 nTPM

Amygdala excitatory	57.4 nTPM
Thalamus	83.9 nTPM
Basal ganglia	60.2 nTPM
Cerebral cortex	55.9 nTPM
Amygdala	50.7 nTPM
Hippocampus	47.6 nTPM
Hypothalamus	46.2 nTPM

Astrocyte	156.2 nTPM
Amygdala	191.2 nTPM
Hypothalamus	184.0 nTPM
Spinal cord	167.1 nTPM
Hippocampus	159.1 nTPM
Midbrain	155.1 nTPM
Thalamus	154.4 nTPM
Basal ganglia	151.2 nTPM
Cerebral cortex	150.2 nTPM
Pons	142.2 nTPM
Medulla oblongata	141.6 nTPM
Cerebellum	122.6 nTPM

Bergmann glia	142.7 nTPM
Medulla oblongata	174.8 nTPM
Cerebellum	132.4 nTPM
Pons	120.8 nTPM

Central nervous system macrophage	81.1 nTPM
Basal ganglia	96.6 nTPM
Hypothalamus	94.8 nTPM
Amygdala	92.4 nTPM
Medulla oblongata	83.3 nTPM
Midbrain	82.1 nTPM
Thalamus	80.4 nTPM
Pons	78.5 nTPM
Cerebellum	75.9 nTPM
Hippocampus	75.8 nTPM
Spinal cord	70.4 nTPM
Cerebral cortex	61.8 nTPM

Cerebellar inhibitory	77.3 nTPM
Spinal cord	96.2 nTPM
Midbrain	86.2 nTPM
Cerebellum	77.5 nTPM
Medulla oblongata	70.7 nTPM
Pons	56.1 nTPM

Cge interneuron	83.3 nTPM
Amygdala	94.1 nTPM
Basal ganglia	91.8 nTPM
Cerebral cortex	90.0 nTPM
Hypothalamus	85.9 nTPM
Hippocampus	81.6 nTPM
Midbrain	78.5 nTPM
Thalamus	61.0 nTPM

Choroid plexus epithelial cell	121.0 nTPM
Basal ganglia	135.1 nTPM
Medulla oblongata	131.3 nTPM
Thalamus	117.8 nTPM
Hippocampus	99.8 nTPM

Committed oligodendrocyte precursor	81.8 nTPM
Hypothalamus	102.4 nTPM
Basal ganglia	96.9 nTPM
Cerebellum	96.7 nTPM
Thalamus	81.5 nTPM
Medulla oblongata	78.8 nTPM
Spinal cord	77.3 nTPM
Pons	77.0 nTPM
Amygdala	75.0 nTPM
Midbrain	74.8 nTPM
Hippocampus	70.1 nTPM
Cerebral cortex	69.7 nTPM

Deep-layer corticothalamic and 6b	52.3 nTPM
Basal ganglia	60.6 nTPM
Midbrain	58.8 nTPM
Amygdala	52.7 nTPM
Cerebral cortex	51.0 nTPM
Hippocampus	46.2 nTPM
Hypothalamus	44.7 nTPM

Deep-layer intratelencephalic	61.0 nTPM
Basal ganglia	74.7 nTPM
Amygdala	67.3 nTPM
Cerebral cortex	60.5 nTPM
Hippocampus	59.0 nTPM
Hypothalamus	43.4 nTPM

Deep-layer near-projecting	60.8 nTPM
Hippocampus	77.4 nTPM
Basal ganglia	65.6 nTPM
Cerebral cortex	60.9 nTPM
Amygdala	57.6 nTPM
Hypothalamus	42.6 nTPM

Eccentric medium spiny neuron	77.0 nTPM
Hippocampus	83.3 nTPM
Amygdala	80.0 nTPM
Hypothalamus	78.8 nTPM
Cerebral cortex	77.5 nTPM
Basal ganglia	73.8 nTPM
Thalamus	68.9 nTPM

Endothelial cell	100.9 nTPM
Hippocampus	128.2 nTPM
Spinal cord	124.3 nTPM
Cerebellum	109.2 nTPM
Thalamus	109.0 nTPM
Pons	96.1 nTPM
Midbrain	95.5 nTPM
Medulla oblongata	94.4 nTPM
Hypothalamus	94.3 nTPM
Cerebral cortex	92.1 nTPM
Basal ganglia	86.7 nTPM
Amygdala	80.5 nTPM

Ependymal cell	121.0 nTPM
Hypothalamus	165.1 nTPM
Hippocampus	137.1 nTPM
Amygdala	133.7 nTPM
Spinal cord	130.3 nTPM
Thalamus	118.2 nTPM
Basal ganglia	117.4 nTPM
Medulla oblongata	99.0 nTPM
Midbrain	95.9 nTPM
Pons	91.9 nTPM