Single cell type - ZNF208 - The Human Protein Atlas

ZNF208

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF208
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 208
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Early spermatids, Granulosa cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.62
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Hippocampal CA4)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Early spermatids, Granulosa cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Hippocampal CA4)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZNF208 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF43	Zinc finger protein 43	0.5495	55
ANGEL2	Angel homolog 2	0.5291	55
ZNF676	Zinc finger protein 676	0.5283	31
CWC22	CWC22 spliceosome associated protein homolog	0.5040	55
ZNF354C	Zinc finger protein 354C	0.5016	55
OBI1	ORC ubiquitin ligase 1	0.4640	55
ICE1	Interactor of little elongation complex ELL subunit 1	0.4635	55
ZNF727	Zinc finger protein 727	0.4535	55
GXYLT2	Glucoside xylosyltransferase 2	0.4518	53
CEP162	Centrosomal protein 162	0.4240	18
ZNF234	Zinc finger protein 234	0.4206	55
ZNF721	Zinc finger protein 721	0.4141	55
KIAA1586	KIAA1586	0.4103	21
ZSCAN30	Zinc finger and SCAN domain containing 30	0.4058	55
BDP1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	0.4054	55

IMMUNE CELLS

ZNF208 is part of cluster 34 B-cells - Unknown function with confidenceⁱ 1
112 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF724	Zinc finger protein 724	0.9762	34
IL4R	Interleukin 4 receptor	0.9762	34
CDHR3	Cadherin related family member 3	0.9762	34
TSTD3	Thiosulfate sulfurtransferase like domain containing 3	0.9524	20
RNF103-CHMP3	RNF103-CHMP3 readthrough	0.9524	20
NPIPB13	Nuclear pore complex interacting protein family, member B13	0.9524	20
TMEM220	Transmembrane protein 220	0.9524	34
TBXA2R	Thromboxane A2 receptor	0.9524	34
AKT3	AKT serine/threonine kinase 3	0.9286	34
THRB	Thyroid hormone receptor beta	0.9286	20
AKAP6	A-kinase anchoring protein 6	0.9286	34
CFAP418	Cilia and flagella associated protein 418	0.9286	34
H2AC12	H2A clustered histone 12	0.9286	34
ACIN1	Apoptotic chromatin condensation inducer 1	0.9048	20
DSP	Desmoplakin	0.9048	34

Adipocytes	8.6 nTPM
Breast	9.1 nTPM
Adipose tissue	8.1 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

Astrocytes	10.8 nTPM
Brain	10.8 nTPM

B-cells	4.7 nTPM
Salivary gland	16.8 nTPM
Liver	9.7 nTPM
Spleen	6.7 nTPM
Lymph node	5.6 nTPM
PBMC	4.6 nTPM
Adipose tissue	4.5 nTPM
Thymus	3.9 nTPM
Stomach	3.8 nTPM
Bone marrow	3.5 nTPM
Skin	1.7 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	1.8 nTPM
Fallopian tube	6.8 nTPM
Endometrium	0.3 nTPM
Lung	0.2 nTPM
Bronchus	0.0 nTPM

Club cells	1.0 nTPM
Prostate	2.2 nTPM
Lung	0.7 nTPM
Bronchus	0.1 nTPM

Endothelial cells	7.9 nTPM
Vascular	15.2 nTPM
Prostate	13.3 nTPM
Salivary gland	12.5 nTPM
Heart muscle	11.9 nTPM
Breast	11.4 nTPM
Pancreas	10.3 nTPM
Thymus	10.2 nTPM
Tongue	10.1 nTPM
Skeletal muscle	9.4 nTPM
Testis	8.5 nTPM
Fallopian tube	7.9 nTPM
Ovary	4.9 nTPM
Esophagus	3.9 nTPM
Endometrium	3.1 nTPM
Placenta	2.8 nTPM
Lung	2.6 nTPM
Liver	2.5 nTPM
Skin	2.1 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	8.0 nTPM
Skeletal muscle	14.4 nTPM
Vascular	13.4 nTPM
Salivary gland	13.3 nTPM
Fallopian tube	13.1 nTPM
Prostate	9.9 nTPM
Heart muscle	9.5 nTPM
Breast	9.3 nTPM
Adipose tissue	9.1 nTPM
Lung	8.8 nTPM
Thymus	6.7 nTPM
Placenta	6.6 nTPM
Esophagus	4.8 nTPM
Stomach	2.9 nTPM
Liver	2.4 nTPM
Skin	2.1 nTPM
Pancreas	1.3 nTPM

Granulocytes	3.2 nTPM
Tongue	4.9 nTPM
Fallopian tube	4.2 nTPM
Lung	0.5 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	9.2 nTPM
Ovary	10.9 nTPM
Fallopian tube	7.6 nTPM

Macrophages	0.5 nTPM
Salivary gland	2.6 nTPM
Prostate	1.9 nTPM
Skeletal muscle	1.2 nTPM
Tongue	1.2 nTPM
Breast	0.9 nTPM
Vascular	0.7 nTPM
Adipose tissue	0.4 nTPM
Fallopian tube	0.4 nTPM
Thymus	0.2 nTPM
Lung	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal prostatic cells	7.8 nTPM
Prostate	7.8 nTPM

Basal squamous epithelial cells	1.6 nTPM
Esophagus	1.6 nTPM

Cytotrophoblasts	8.2 nTPM
Placenta	8.2 nTPM

Endometrial stromal cells	5.4 nTPM
Endometrium	5.4 nTPM

Plasma cells	0.5 nTPM
Fallopian tube	2.9 nTPM
Spleen	0.7 nTPM
Thymus	0.7 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	0.5 nTPM
Vascular	1.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.6 nTPM
Salivary gland	1.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	5.0 nTPM
Prostate	14.0 nTPM
Tongue	11.1 nTPM
Salivary gland	9.1 nTPM
Fallopian tube	9.0 nTPM
Vascular	7.2 nTPM
Endometrium	4.4 nTPM
Ovary	3.8 nTPM
Placenta	3.7 nTPM
Thymus	3.7 nTPM
Breast	3.2 nTPM
Skeletal muscle	3.0 nTPM
Lung	2.4 nTPM
Adipose tissue	2.2 nTPM
Liver	1.7 nTPM
Esophagus	1.2 nTPM
Skin	0.3 nTPM

T-cells	3.5 nTPM
Salivary gland	8.6 nTPM
Lung	7.1 nTPM
Adipose tissue	6.7 nTPM
Fallopian tube	6.7 nTPM
Thymus	6.3 nTPM
Vascular	4.8 nTPM
Prostate	4.6 nTPM
Skeletal muscle	3.8 nTPM
Kidney	3.5 nTPM
Lymph node	3.3 nTPM
Breast	3.3 nTPM
Spleen	3.0 nTPM
Bone marrow	2.3 nTPM
Tongue	2.1 nTPM
Colon	1.9 nTPM
Endometrium	1.8 nTPM
PBMC	1.6 nTPM
Stomach	0.8 nTPM
Liver	0.5 nTPM
Skin	0.4 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	15.2 nTPM
Thalamus	22.7 nTPM
Hippocampus	16.0 nTPM
Cerebral cortex	15.4 nTPM
Amygdala	14.2 nTPM
Basal ganglia	12.9 nTPM
Hypothalamus	10.1 nTPM

Astrocyte	8.7 nTPM
Thalamus	17.2 nTPM
Basal ganglia	16.4 nTPM
Cerebral cortex	13.1 nTPM
Hypothalamus	12.7 nTPM
Midbrain	10.8 nTPM
Hippocampus	6.1 nTPM
Amygdala	5.8 nTPM
Medulla oblongata	5.3 nTPM
Pons	4.7 nTPM
Cerebellum	2.5 nTPM
Spinal cord	1.4 nTPM

Bergmann glia	0.7 nTPM
Pons	1.4 nTPM
Cerebellum	0.8 nTPM
Medulla oblongata	0.0 nTPM

Central nervous system macrophage	8.6 nTPM
Amygdala	27.3 nTPM
Cerebral cortex	12.3 nTPM
Midbrain	9.2 nTPM
Thalamus	8.5 nTPM
Hippocampus	7.9 nTPM
Hypothalamus	7.1 nTPM
Cerebellum	6.3 nTPM
Medulla oblongata	5.4 nTPM
Pons	5.0 nTPM
Basal ganglia	4.9 nTPM
Spinal cord	0.9 nTPM

Cerebellar inhibitory	7.5 nTPM
Midbrain	9.3 nTPM
Medulla oblongata	8.5 nTPM
Cerebellum	8.2 nTPM
Pons	6.2 nTPM
Spinal cord	5.5 nTPM

Cge interneuron	4.2 nTPM
Amygdala	6.8 nTPM
Hippocampus	5.5 nTPM
Cerebral cortex	4.7 nTPM
Hypothalamus	3.7 nTPM
Midbrain	3.4 nTPM
Basal ganglia	2.6 nTPM
Thalamus	2.6 nTPM

Choroid plexus epithelial cell	6.1 nTPM
Hippocampus	8.3 nTPM
Thalamus	8.2 nTPM
Basal ganglia	5.9 nTPM
Medulla oblongata	1.9 nTPM

Committed oligodendrocyte precursor	24.1 nTPM
Midbrain	35.3 nTPM
Medulla oblongata	34.9 nTPM
Cerebral cortex	31.0 nTPM
Amygdala	26.5 nTPM
Pons	25.7 nTPM
Thalamus	25.2 nTPM
Hypothalamus	23.9 nTPM
Hippocampus	19.7 nTPM
Spinal cord	18.4 nTPM
Cerebellum	14.3 nTPM
Basal ganglia	10.4 nTPM

Deep-layer corticothalamic and 6b	13.0 nTPM
Hypothalamus	18.9 nTPM
Amygdala	17.2 nTPM
Cerebral cortex	14.0 nTPM
Basal ganglia	12.2 nTPM
Hippocampus	11.5 nTPM
Midbrain	4.4 nTPM

Deep-layer intratelencephalic	9.3 nTPM
Cerebral cortex	13.4 nTPM
Hippocampus	10.2 nTPM
Hypothalamus	9.8 nTPM
Amygdala	9.1 nTPM
Basal ganglia	4.0 nTPM

Deep-layer near-projecting	10.0 nTPM
Hypothalamus	17.3 nTPM
Hippocampus	13.3 nTPM
Cerebral cortex	9.9 nTPM
Amygdala	5.5 nTPM
Basal ganglia	3.7 nTPM

Eccentric medium spiny neuron	8.0 nTPM
Hypothalamus	12.4 nTPM
Cerebral cortex	9.0 nTPM
Amygdala	8.3 nTPM
Basal ganglia	7.8 nTPM
Thalamus	6.5 nTPM
Hippocampus	3.7 nTPM

Endothelial cell	13.1 nTPM
Basal ganglia	22.4 nTPM
Spinal cord	20.7 nTPM
Pons	18.1 nTPM
Cerebellum	13.9 nTPM
Hypothalamus	12.4 nTPM
Cerebral cortex	11.5 nTPM
Hippocampus	11.2 nTPM
Thalamus	10.7 nTPM
Midbrain	9.5 nTPM
Medulla oblongata	9.2 nTPM
Amygdala	4.5 nTPM

Ependymal cell	4.0 nTPM
Hypothalamus	8.0 nTPM
Basal ganglia	6.6 nTPM
Hippocampus	4.9 nTPM
Spinal cord	3.8 nTPM
Midbrain	3.2 nTPM
Amygdala	2.8 nTPM
Thalamus	2.8 nTPM
Pons	2.4 nTPM
Medulla oblongata	1.1 nTPM