Single cell type - MPV17L - The Human Protein Atlas

MPV17L

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPV17L
Gene descriptionⁱ Full gene name according to HGNC.	MPV17 mitochondrial inner membrane protein like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late primary spermatocytes - Meiotic division & transition (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late primary spermatocytes, Thymic myoid cells, Conjunctival goblet cells, Innate lymphoid cells, Breast lactating cells, Endometrial secretory cells, Megakaryocyte-Erythroid progenitors)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.90
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not detected
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Spermatogenic cell types, Stromal cells, Goblet cells, Innate lymphoid cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Not detected

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MPV17L is part of cluster 53 Late primary spermatocytes - Meiotic division & transition with confidenceⁱ 1
303 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFSF11	TNF superfamily member 11	0.5766	92
MORC1	MORC family CW-type zinc finger 1	0.5717	92
LZTFL1	Leucine zipper transcription factor like 1	0.5483	92
DBF4	DBF4 zinc finger	0.5336	53
CHST13	Carbohydrate sulfotransferase 13	0.5208	53
ZMYND12	Zinc finger MYND-type containing 12	0.5075	53
PTH2	Parathyroid hormone 2	0.5059	92
IL23R	Interleukin 23 receptor	0.4806	92
RPL10L	Ribosomal protein L10 like	0.4738	53
ADAM30	ADAM metallopeptidase domain 30	0.4682	53
CCDC110	Coiled-coil domain containing 110	0.4577	53
PABPC3	Poly(A) binding protein cytoplasmic 3	0.4565	53
FAM170A	Family with sequence similarity 170 member A	0.4527	53
CCT6B	Chaperonin containing TCP1 subunit 6B	0.4507	53
IL3	Interleukin 3	0.4455	92

IMMUNE CELLS

MPV17L is part of cluster 20 Non-specific - DNA binding with confidenceⁱ 1
266 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NPR3	Natriuretic peptide receptor 3	0.9762	20
TSTD3	Thiosulfate sulfurtransferase like domain containing 3	0.9524	20
CTCFL	CCCTC-binding factor like	0.9524	20
ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase	0.9524	20
BCLAF3	BCLAF1 and THRAP3 family member 3	0.9286	35
HYAL4	Hyaluronidase 4	0.9286	20
SCRG1	Stimulator of chondrogenesis 1	0.9286	20
SLC35F5	Solute carrier family 35 member F5	0.9286	14
PRRC2C	Proline rich coiled-coil 2C	0.9286	20
KCNC1	Potassium voltage-gated channel subfamily C member 1	0.9286	20
THRB	Thyroid hormone receptor beta	0.9286	20
GNAZ	G protein subunit alpha z	0.9048	20
RABGEF1	RAB guanine nucleotide exchange factor 1	0.9048	20
HMBOX1	Homeobox containing 1	0.9048	20
TBC1D8B	TBC1 domain family member 8B	0.9048	20

	Lacrimal acinar cells	Salivary acinar cells	Pancreatic acinar cells
Eye	0.0
Salivary gland		0.1
Pancreas			0.3
Mean exp	0.0	0.1	0.3

	Adipocytes
Heart muscle	0.0
Skeletal muscle	0.0
Adipose tissue	0.0
Mean exp	0.0

	Adrenal cortex cells	Adrenal medulla cells
Adrenal gland	0.0	0.0
Mean exp	0.0	0.0

	Alveolar cells type 1	Alveolar cells type 2	Transitional alveolar cells
Lung	0.0	0.0	0.0
Mean exp	0.0	0.0	0.0

	Esophageal apical cells
Esophagus	0.0
Mean exp	0.0

	B-cells
Brain	0.0
Eye	0.0
Lung	0.0
Salivary gland	0.0
Esophagus	0.0
Stomach	0.0
Liver	0.0
Kidney	0.0
Urinary bladder	0.0
Breast	0.0
Endometrium	0.0
Adipose tissue	0.0
Blood	0.0
Bone marrow	0.0
Lymph node	0.0
Spleen	0.0
Thymus	0.0
Mean exp	0.0

	Ocular epithelial cells	Mesothelial cells	Urothelial cells	Epicardial cells	Prostatic hillock cells
Eye	0.1
Urinary bladder			0.2
Prostate					0.1
Heart muscle				0.0
Adipose tissue		0.0
Thymus		0.0
Mean exp	0.1	0.0	0.2	0.0	0.1

	Respiratory basal cells	Esophageal basal cells	Salivary basal cells	Basal keratinocytes	Epididymal basal cells	Basal prostatic cells
Lung	0.6
Tongue				0.1
Salivary gland			0.2
Esophagus		0.0
Epididymis					0.0
Prostate						0.3
Skin				0.0
Mean exp	0.6	0.0	0.2	0.0	0.0	0.3

	Ependymal cells	Choroid plexus epithelial cells	Respiratory ciliated cells	Respiratory deuterosomal cells	Epididymal efferent duct ciliated cells	Fallopian tube ciliated cells	Endometrial ciliated cells
Brain	0.1	0.1
Lung			0.2	0.0
Epididymis					0.8
Fallopian tube						0.4
Endometrium							0.1
Mean exp	0.1	0.1	0.2	0.0	0.8	0.4	0.1

	Cdc	Pdcs
Lung		0.0
Breast	0.0	0.0
Endometrium		0.0
Adipose tissue	0.0
Skin	0.0
Blood		0.0
Lymph node	0.2
Mean exp	0.1	0.0

	Salivary duct cells	Cholangiocytes	Pancreatic duct cells	Renal collecting duct intercalated cells	Renal collecting duct principal cells	Renal connecting tubule cells	Epididymal efferent duct absorptive cells
Salivary gland	0.4
Liver		0.0
Pancreas			0.3
Kidney				0.0	0.0	0.0
Epididymis							1.0
Mean exp	0.4	0.0	0.3	0.0	0.0	0.0	1.0

	Vascular endothelial cells	Lymphatic endothelial cells
Brain	0.0
Eye	0.0	0.5
Pituitary gland	0.0
Lung	0.1	0.0
Tongue	0.0	0.0
Salivary gland	0.1	0.0
Esophagus	0.0	0.0
Stomach	0.0
Liver	0.0
Pancreas	0.0
Kidney	0.0	0.0
Urinary bladder	0.2	0.0
Testis	0.0	0.0
Epididymis	0.0
Prostate	0.0	0.0
Breast	0.0	0.0
Ovary	0.0	0.0
Fallopian tube	0.3	0.2
Endometrium	0.1	0.0
Placenta	0.0
Heart muscle	0.0
Skeletal muscle	0.0
Vasculature	0.1	0.0
Adipose tissue	0.0	0.0
Skin	0.0	0.0
Lymph node	0.0	0.0
Spleen		0.3
Thymus	0.1	0.0
Mean exp	0.0	0.0

	Enterocytes	Colonocytes
Small intestine	0.0
Colon		0.1
Rectum		0.1
Mean exp	0.0	0.1

	Neuroendocrine cells
Stomach	0.0
Small intestine	0.0
Colon	0.0
Rectum	0.0
Mean exp	0.0

	Erythrocyte progenitors	Erythrocytes
Blood		0.0
Bone marrow	0.4	0.0
Spleen		0.0
Mean exp	0.4	0.0

	Fibro-adipogenic progenitors
Skeletal muscle	0.0
Adipose tissue	0.0
Mean exp	0.0

	Fibroblasts
Brain	0.1
Eye	0.1
Lung	0.0
Tongue	0.4
Salivary gland	0.1
Esophagus	0.0
Stomach	0.2
Pancreas	0.2
Kidney	0.0
Urinary bladder	0.1
Epididymis	0.0
Prostate	0.0
Breast	0.1
Fallopian tube	0.5
Placenta	0.0
Heart muscle	0.0
Vasculature	0.2
Skin	0.3
Lymph node	0.7
Thymus	0.1
Mean exp	0.2

	Foveolar cells	Mucous neck cells	Parietal cells	Gastric chief cells
Stomach	0.6	0.0	0.0	0.0
Mean exp	0.6	0.0	0.0	0.0

	Submucosal glandular cells	Prostatic glandular cells	Prostatic club cells	Endometrial glandular cells
Lung	0.5
Esophagus	0.0
Prostate		0.1	0.1
Endometrium				0.0
Mean exp	0.3	0.1	0.1	0.0

	Astrocytes	Bergmann glia	Müller glia	Pituicytes/fscs	Oligodendrocyte progenitor cells	Oligodendrocytes	Schwann cells	Microglia
Brain	0.2	0.1			0.2	0.2		0.1
Eye			0.1				0.0
Pituitary gland				0.2
Tongue							0.0
Urinary bladder							0.0
Vasculature							0.3
Mean exp	0.2	0.1	0.1	0.2	0.2	0.2	0.1	0.1

	Conjunctival goblet cells	Goblet cells
Eye	1.9
Small intestine		0.0
Colon		0.2
Rectum		0.0
Mean exp	1.9	0.1

	Innate lymphoid cells
Lung	0.0
Salivary gland	4.8
Urinary bladder	3.2
Breast	0.0
Fallopian tube	0.0
Endometrium	1.0
Lymph node	3.0
Spleen	2.6
Thymus	1.1
Mean exp	1.7

	Respiratory ionocytes	Salivary ionocytes
Lung	0.0
Salivary gland		0.0
Mean exp	0.0	0.0

	Breast hormone-responsive cells	Endometrial luminal cells
Breast	0.6
Endometrium		0.0
Mean exp	0.6	0.0

	Mast cells
Eye	0.0
Lung	0.7
Tongue	0.0
Salivary gland	0.0
Stomach	0.0
Pancreas	0.0
Urinary bladder	0.3
Epididymis	0.0
Fallopian tube	0.0
Vasculature	0.0
Adipose tissue	0.0
Lymph node	0.0
Mean exp	0.1

Acinar cells - 0.3 nCPM

Adipocytes - 0.0 nCPM

Adrenal endocrine cells - 0.0 nCPM

Alveolar cells - 0.0 nCPM

Apical squamous epithelial cells - 0.0 nCPM

B-cells - 0.0 nCPM

Barrier epithelial cells - 0.2 nCPM

Basal cells - 0.6 nCPM

Ciliated cells - 0.8 nCPM

Dendritic cells - 0.1 nCPM

Ductal cells - 1.0 nCPM

Endothelial cells - 0.0 nCPM

Enterocytes - 0.1 nCPM

Enteroendocrine cells - 0.0 nCPM

Erythrocytes - 0.4 nCPM

Fibro-adipogenic progenitors - 0.0 nCPM

Fibroblasts - 0.2 nCPM

Gastric glandular cells - 0.6 nCPM

Glandular cells - 0.3 nCPM

Glial cells - 0.2 nCPM

Goblet cells - 1.9 nCPM

Hepatocytes - 0.3 nCPM

Innate lymphoid cells - 1.7 nCPM

Ionocytes - 0.0 nCPM

Leydig cells - 0.6 nCPM

Luminal cells - 0.6 nCPM

Mast cells - 0.1 nCPM

Megakaryocytes - 1.1 nCPM

Mononuclear phagocytes - 0.2 nCPM

Mural cells - 0.1 nCPM

Myocytes - 0.1 nCPM

Neuronal cells - 0.3 nCPM

Neutrophils - 0.0 nCPM

Nk-cells - 0.0 nCPM

Oocytes - 0.0 nCPM

Pancreatic islet cells - 0.1 nCPM

Pigment cells - 0.0 nCPM

Pituitary endocrine cells - 0.5 nCPM

Plasma cells - 0.0 nCPM

Platelets - 0.0 nCPM

Proliferating cells - 0.2 nCPM

Renal nephron cells - 0.0 nCPM

Reproductive supporting cells - 0.0 nCPM

Secretory cells - 1.5 nCPM

Secretory gland support - 0.0 nCPM

Smooth muscle cells - 0.3 nCPM

Spermatogenic cell types - 2.9 nCPM

Stellate cells - 0.0 nCPM

Stem cells - 0.0 nCPM

Stromal cells - 2.7 nCPM

Suprabasal cells - 0.0 nCPM

T-cells - 0.0 nCPM

Trophoblast cells - 0.0 nCPM

	Megakaryocyte progenitors	Megakaryocyte-erythroid progenitors	Megakaryocytes
Bone marrow	0.9	1.1	0.0
Mean exp	0.9	1.1	0.0

	Monocyte progenitors	Monocytes	Macrophages	Kupffer cells	Hofbauer cells
Brain		0.0	0.0
Eye		0.0	0.3
Pituitary gland			0.0
Lung		0.1	0.1
Tongue		0.0	0.0
Salivary gland		0.0	0.0
Esophagus			0.0
Stomach		0.0	0.0
Liver		0.0	0.8	0.0
Pancreas		0.0	0.0
Kidney			0.0
Urinary bladder		0.0	0.2
Testis			0.0
Prostate		0.0	0.2
Breast		0.0	0.0
Ovary			0.0
Fallopian tube		0.2	0.1
Endometrium			0.0
Placenta					0.0
Heart muscle			0.0
Skeletal muscle			0.0
Vasculature		0.2	0.2
Adipose tissue			0.1
Skin			0.0
Blood		0.2
Bone marrow	0.2	0.2	0.4
Lymph node		0.0	0.4
Thymus		0.1	1.0
Spleen		0.2	0.6
Mean exp	0.2	0.1	0.2	0.0	0.0

	Pericytes	Vascular smooth muscle cells
Brain	0.0	0.0
Eye	0.0	0.0
Pituitary gland	0.0
Lung	0.0	0.0
Tongue	0.0	0.0
Salivary gland	0.0	0.0
Stomach	0.0	0.0
Pancreas	0.0
Kidney	0.0	0.0
Urinary bladder	1.1	0.0
Testis	0.0
Epididymis	0.0	0.0
Prostate	0.0	0.0
Breast	0.0	0.0
Ovary	0.0	0.0
Fallopian tube	0.0	0.2
Placenta	0.0
Heart muscle	0.0	0.0
Skeletal muscle	0.0	0.0
Vasculature	0.0	0.2
Adipose tissue	0.0	0.0
Skin	1.1	0.0
Thymus	0.0	0.0
Mean exp	0.1	0.0

	Cardiomyocytes	Myonuclei
Heart muscle	0.0
Skeletal muscle		0.1
Mean exp	0.0	0.1

	Brain excitatory neurons	Brain inhibitory neurons	Retinal amacrine cells	Retinal horizontal cells	Retinal ganglion cells	Retinal bipolar cells	Rod photoreceptor cells	Cone photoreceptor cells	Other brain neurons
Brain	0.2	0.2							0.3
Eye			0.0	0.0	0.0	0.0	0.2	0.0
Mean exp	0.2	0.2	0.0	0.0	0.0	0.0	0.2	0.0	0.3

	Neutrophil progenitors	Neutrophils
Eye		0.0
Lung		0.0
Salivary gland		0.0
Urinary bladder		0.0
Prostate		0.0
Vasculature		0.0
Blood	0.0	0.0
Bone marrow	0.0	0.0
Lymph node		0.0
Spleen	0.0	0.0
Thymus	0.0	0.0
Mean exp	0.0	0.0

	Nk-cells
Brain	0.0
Eye	0.0
Lung	0.0
Salivary gland	0.0
Stomach	0.0
Colon	0.0
Liver	0.0
Kidney	0.0
Urinary bladder	0.0
Prostate	0.0
Fallopian tube	0.0
Endometrium	0.0
Vasculature	0.0
Blood	0.0
Bone marrow	0.0
Lymph node	0.0
Spleen	0.0
Thymus	0.0
Mean exp	0.0

	Melanocytes	Retinal pigment epithelial cells
Eye	0.0	0.0
Skin	0.0
Mean exp	0.0	0.0

	Corticotrophs	Gonadotrophs	Lactotrophs	Somatotrophs	Thyrotrophs
Pituitary gland	0.4	0.0	0.1	0.5	0.0
Mean exp	0.4	0.0	0.1	0.5	0.0

	Plasma cells
Eye	0.0
Lung	0.0
Salivary gland	0.0
Stomach	0.0
Liver	0.0
Urinary bladder	0.0
Breast	0.0
Fallopian tube	0.0
Blood	0.0
Bone marrow	0.0
Lymph node	0.0
Spleen	0.0
Thymus	0.0
Mean exp	0.0