Single cell type - PET100 - The Human Protein Atlas

PET100

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PET100
Gene descriptionⁱ Full gene name according to HGNC.	PET100 cytochrome c oxidase chaperone
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.27
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PET100 is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ROMO1	Reactive oxygen species modulator 1	0.6661	45
ATP5MK	ATP synthase membrane subunit k	0.6546	39
UQCR11	Ubiquinol-cytochrome c reductase, complex III subunit XI	0.6541	39
NDUFV2	NADH:ubiquinone oxidoreductase core subunit V2	0.5872	45
NDUFA7	NADH:ubiquinone oxidoreductase subunit A7	0.5871	16
TRIM54	Tripartite motif containing 54	0.5867	45
VNN1	Vanin 1	0.5801	45
ANXA10	Annexin A10	0.5733	45
COX17	Cytochrome c oxidase copper chaperone COX17	0.5680	45
TBC1D3D	TBC1 domain family member 3D	0.5653	45
CLDN14	Claudin 14	0.5623	45
TFF1	Trefoil factor 1	0.5616	45
LAMC2	Laminin subunit gamma 2	0.5598	45
C22orf39	Chromosome 22 open reading frame 39	0.5498	39
DUOX2	Dual oxidase 2	0.5479	45

IMMUNE CELLS

PET100 is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 0.98
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARL17B	ADP ribosylation factor like GTPase 17B	1.0000	22
RABAC1	Rab acceptor 1	1.0000	22
CLC	Charcot-Leyden crystal galectin	0.9762	22
ZKSCAN4	Zinc finger with KRAB and SCAN domains 4	0.9762	41
DGUOK	Deoxyguanosine kinase	0.9762	41
DEPDC5	DEP domain containing 5, GATOR1 subcomplex subunit	0.9524	22
PCBD2	Pterin-4 alpha-carbinolamine dehydratase 2	0.9524	22
ANKRD11	Ankyrin repeat domain containing 11	0.9524	41
NUDC	Nuclear distribution C, dynein complex regulator	0.9286	41
IL5RA	Interleukin 5 receptor subunit alpha	0.9286	22
HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.9286	22
KMT2E	Lysine methyltransferase 2E (inactive)	0.9286	22
PLD3	Phospholipase D family member 3	0.9286	41
XK	X-linked Kx blood group antigen, Kell and VPS13A binding protein	0.9286	22
CNTN1	Contactin 1	0.9286	22

Adipocytes	88.7 nTPM
Adipose tissue	101.4 nTPM
Breast	76.0 nTPM

Alveolar cells type 1	62.2 nTPM
Lung	62.2 nTPM

Alveolar cells type 2	59.7 nTPM
Lung	59.7 nTPM

Astrocytes	5.9 nTPM
Brain	5.9 nTPM

B-cells	98.9 nTPM
Skin	145.7 nTPM
Adipose tissue	135.4 nTPM
Liver	130.4 nTPM
Stomach	129.1 nTPM
Spleen	120.0 nTPM
Bone marrow	118.1 nTPM
PBMC	115.5 nTPM
Lymph node	88.5 nTPM
Kidney	88.4 nTPM
Thymus	74.0 nTPM
Lung	49.6 nTPM
Salivary gland	49.2 nTPM
Esophagus	41.3 nTPM

Ciliated cells	105.0 nTPM
Bronchus	132.5 nTPM
Fallopian tube	122.7 nTPM
Endometrium	107.5 nTPM
Lung	57.3 nTPM

Club cells	86.6 nTPM
Bronchus	151.4 nTPM
Prostate	60.1 nTPM
Lung	48.2 nTPM

Dendritic cells	162.8 nTPM
PBMC	176.3 nTPM
Adipose tissue	149.3 nTPM

Endothelial cells	93.8 nTPM
Pancreas	235.3 nTPM
Heart muscle	191.6 nTPM
Liver	168.8 nTPM
Ovary	129.5 nTPM
Breast	117.8 nTPM
Placenta	113.5 nTPM
Testis	100.4 nTPM
Tongue	89.0 nTPM
Esophagus	77.6 nTPM
Skin	70.9 nTPM
Fallopian tube	64.8 nTPM
Endometrium	56.8 nTPM
Thymus	54.1 nTPM
Lung	51.1 nTPM
Prostate	50.6 nTPM
Vascular	44.0 nTPM
Skeletal muscle	40.4 nTPM
Salivary gland	33.1 nTPM

Enteroendocrine cells	199.5 nTPM
Small intestine	291.8 nTPM
Rectum	202.9 nTPM
Colon	103.8 nTPM

Erythroid cells	169.6 nTPM
Liver	230.7 nTPM
Bone marrow	108.5 nTPM

Fibroblasts	92.0 nTPM
Liver	182.6 nTPM
Pancreas	162.9 nTPM
Heart muscle	161.6 nTPM
Placenta	154.5 nTPM
Adipose tissue	118.8 nTPM
Stomach	96.6 nTPM
Fallopian tube	93.5 nTPM
Breast	87.6 nTPM
Skin	82.8 nTPM
Esophagus	78.5 nTPM
Prostate	68.0 nTPM
Vascular	45.1 nTPM
Thymus	44.1 nTPM
Lung	36.2 nTPM
Skeletal muscle	30.7 nTPM
Salivary gland	29.2 nTPM

Granulocytes	81.9 nTPM
Fallopian tube	109.5 nTPM
Tongue	77.6 nTPM
Lung	58.5 nTPM

Intestinal goblet cells	233.4 nTPM
Small intestine	315.9 nTPM
Rectum	257.0 nTPM
Colon	127.5 nTPM

Lymphatic endothelial cells	163.4 nTPM
Ovary	218.2 nTPM
Fallopian tube	108.6 nTPM

Basal keratinocytes	79.1 nTPM
Tongue	100.0 nTPM
Skin	58.2 nTPM

Basal prostatic cells	91.3 nTPM
Prostate	91.3 nTPM

Basal respiratory cells	188.9 nTPM
Bronchus	188.9 nTPM

Basal squamous epithelial cells	82.7 nTPM
Esophagus	82.7 nTPM

Macrophages	121.6 nTPM
Kidney	310.6 nTPM
Pancreas	310.4 nTPM
Stomach	177.5 nTPM
Spleen	173.4 nTPM
Bone marrow	171.3 nTPM
Adipose tissue	162.0 nTPM
Skin	127.0 nTPM
Fallopian tube	121.2 nTPM
Esophagus	100.2 nTPM
Testis	99.2 nTPM
Endometrium	88.6 nTPM
Breast	79.4 nTPM
Thymus	74.3 nTPM
Lung	66.8 nTPM
Vascular	56.5 nTPM
Tongue	50.7 nTPM
Skeletal muscle	49.7 nTPM
Prostate	48.2 nTPM
Salivary gland	43.3 nTPM

Paneth cells	221.6 nTPM
Small intestine	310.8 nTPM
Rectum	223.7 nTPM
Colon	130.3 nTPM

Plasma cells	199.3 nTPM
Liver	362.0 nTPM
Spleen	244.7 nTPM
Stomach	221.1 nTPM
Fallopian tube	214.5 nTPM
Bone marrow	203.9 nTPM
Esophagus	150.7 nTPM
Thymus	123.0 nTPM
Salivary gland	74.8 nTPM

Schwann cells	73.5 nTPM
Adipose tissue	127.3 nTPM
Esophagus	47.9 nTPM
Vascular	45.4 nTPM

Serous glandular cells	75.2 nTPM
Salivary gland	84.2 nTPM
Tongue	66.3 nTPM

Smooth muscle cells	76.1 nTPM
Liver	125.7 nTPM
Ovary	122.8 nTPM
Esophagus	118.9 nTPM
Placenta	113.3 nTPM
Adipose tissue	102.9 nTPM
Fallopian tube	84.4 nTPM
Skin	71.6 nTPM
Breast	59.8 nTPM
Prostate	59.0 nTPM
Salivary gland	56.9 nTPM
Vascular	56.7 nTPM
Endometrium	55.7 nTPM
Thymus	52.1 nTPM
Tongue	50.6 nTPM
Lung	47.0 nTPM
Skeletal muscle	40.2 nTPM

Suprabasal keratinocytes	114.4 nTPM
Tongue	157.8 nTPM
Skin	70.9 nTPM

T-cells	110.1 nTPM
Liver	182.2 nTPM
Adipose tissue	180.5 nTPM
Fallopian tube	165.3 nTPM
Kidney	164.0 nTPM
Spleen	153.6 nTPM
Bone marrow	152.0 nTPM
Stomach	144.5 nTPM
PBMC	130.4 nTPM
Skin	110.1 nTPM
Colon	108.2 nTPM
Lymph node	104.9 nTPM
Thymus	99.7 nTPM
Breast	86.2 nTPM
Prostate	82.8 nTPM
Tongue	79.2 nTPM
Esophagus	77.9 nTPM
Endometrium	75.9 nTPM
Lung	70.8 nTPM
Vascular	57.1 nTPM
Salivary gland	48.0 nTPM
Skeletal muscle	39.3 nTPM

Undifferentiated cells	166.2 nTPM
Rectum	207.9 nTPM
Small intestine	198.1 nTPM
Colon	92.7 nTPM

Amygdala excitatory	5.4 nTPM
Thalamus	12.3 nTPM
Basal ganglia	7.5 nTPM
Hippocampus	5.3 nTPM
Cerebral cortex	3.7 nTPM
Amygdala	3.0 nTPM
Hypothalamus	0.8 nTPM

Astrocyte	8.2 nTPM
Cerebellum	14.5 nTPM
Basal ganglia	12.0 nTPM
Midbrain	10.4 nTPM
Medulla oblongata	9.4 nTPM
Pons	9.2 nTPM
Hippocampus	8.5 nTPM
Thalamus	8.3 nTPM
Cerebral cortex	6.4 nTPM
Spinal cord	6.1 nTPM
Hypothalamus	2.8 nTPM
Amygdala	2.7 nTPM

Bergmann glia	8.4 nTPM
Medulla oblongata	12.8 nTPM
Cerebellum	6.8 nTPM
Pons	5.8 nTPM

Central nervous system macrophage	9.7 nTPM
Medulla oblongata	17.7 nTPM
Basal ganglia	13.9 nTPM
Spinal cord	13.2 nTPM
Midbrain	10.0 nTPM
Pons	9.8 nTPM
Thalamus	9.8 nTPM
Cerebellum	9.6 nTPM
Cerebral cortex	7.7 nTPM
Hippocampus	7.6 nTPM
Hypothalamus	4.2 nTPM
Amygdala	3.1 nTPM

Cerebellar inhibitory	18.9 nTPM
Medulla oblongata	27.6 nTPM
Pons	24.3 nTPM
Spinal cord	19.2 nTPM
Midbrain	11.8 nTPM
Cerebellum	11.6 nTPM

Cge interneuron	14.5 nTPM
Thalamus	25.2 nTPM
Midbrain	22.5 nTPM
Basal ganglia	15.8 nTPM
Hippocampus	12.9 nTPM
Amygdala	10.8 nTPM
Cerebral cortex	10.4 nTPM
Hypothalamus	3.8 nTPM

Choroid plexus epithelial cell	10.2 nTPM
Medulla oblongata	17.0 nTPM
Hippocampus	11.1 nTPM
Thalamus	11.0 nTPM
Basal ganglia	1.7 nTPM

Committed oligodendrocyte precursor	11.7 nTPM
Medulla oblongata	29.7 nTPM
Cerebellum	20.6 nTPM
Basal ganglia	14.8 nTPM
Midbrain	11.8 nTPM
Spinal cord	11.0 nTPM
Hippocampus	10.6 nTPM
Pons	10.6 nTPM
Cerebral cortex	8.2 nTPM
Thalamus	7.4 nTPM
Hypothalamus	2.7 nTPM
Amygdala	1.7 nTPM

Deep-layer corticothalamic and 6b	7.3 nTPM
Basal ganglia	13.1 nTPM
Midbrain	10.0 nTPM
Amygdala	7.0 nTPM
Cerebral cortex	6.3 nTPM
Hippocampus	6.2 nTPM
Hypothalamus	1.2 nTPM

Deep-layer intratelencephalic	6.4 nTPM
Basal ganglia	10.1 nTPM
Hippocampus	8.1 nTPM
Cerebral cortex	6.9 nTPM
Amygdala	5.9 nTPM
Hypothalamus	0.9 nTPM

Deep-layer near-projecting	8.4 nTPM
Hippocampus	16.6 nTPM
Basal ganglia	11.2 nTPM
Amygdala	7.0 nTPM
Cerebral cortex	6.4 nTPM
Hypothalamus	1.1 nTPM