Single cell type - XK - The Human Protein Atlas

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	XK
Gene descriptionⁱ Full gene name according to HGNC.	X-linked Kx blood group antigen, Kell and VPS13A binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Blood group antigen proteins Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Erythroid cells, Distal enterocytes, Proximal enterocytes, Gastric mucus-secreting cells, Enteroendocrine cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.75
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (basophil, eosinophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Erythroid cells, Distal enterocytes, Proximal enterocytes, Gastric mucus-secreting cells, Enteroendocrine cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (basophil, eosinophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

XK is part of cluster 1 Erythroid cells - Oxygen transport with confidenceⁱ 1
138 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CA1	Carbonic anhydrase 1	0.6915	1
FOXH1	Forkhead box H1	0.6894	1
ABCB10	ATP binding cassette subfamily B member 10	0.6514	1
TRIM10	Tripartite motif containing 10	0.6487	1
RHD	Rh blood group D antigen	0.6294	1
SLC25A21	Solute carrier family 25 member 21	0.6071	1
GYPE	Glycophorin E (MNS blood group)	0.6007	1
BOLA2	BolA family member 2	0.5966	1
HBQ1	Hemoglobin subunit theta 1	0.5919	1
GYPB	Glycophorin B (MNS blood group)	0.5740	1
HBM	Hemoglobin subunit mu	0.5735	1
GYPA	Glycophorin A (MNS blood group)	0.5717	1
EPB42	Erythrocyte membrane protein band 4.2	0.5715	1
KLF1	KLF transcription factor 1	0.5693	1
BLVRB	Biliverdin reductase B	0.5684	1

IMMUNE CELLS

XK is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 1
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RABGAP1	RAB GTPase activating protein 1	1.0000	22
LCAT	Lecithin-cholesterol acyltransferase	1.0000	22
SERPINB2	Serpin family B member 2	1.0000	22
PLAAT5	Phospholipase A and acyltransferase 5	1.0000	22
ASRGL1	Asparaginase and isoaspartyl peptidase 1	1.0000	22
CDK15	Cyclin dependent kinase 15	1.0000	22
HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	1.0000	22
IL5RA	Interleukin 5 receptor subunit alpha	1.0000	22
KMT2E	Lysine methyltransferase 2E (inactive)	1.0000	22
CLC	Charcot-Leyden crystal galectin	0.9762	22
PIP5K1B	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta	0.9762	22
FBXL20	F-box and leucine rich repeat protein 20	0.9762	22
AREG	Amphiregulin	0.9762	22
RCOR3	REST corepressor 3	0.9762	22
KIAA1614	KIAA1614	0.9762	22

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.3 nTPM
Lung	0.3 nTPM

Alveolar cells type 2	2.5 nTPM
Lung	2.5 nTPM

Astrocytes	2.5 nTPM
Brain	2.5 nTPM

B-cells	0.3 nTPM
Lung	1.3 nTPM
Adipose tissue	1.2 nTPM
Thymus	0.8 nTPM
Salivary gland	0.4 nTPM
Spleen	0.3 nTPM
Lymph node	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	4.4 nTPM
Fallopian tube	7.9 nTPM
Endometrium	4.7 nTPM
Lung	3.1 nTPM
Bronchus	1.9 nTPM

Club cells	0.8 nTPM
Prostate	1.5 nTPM
Lung	0.5 nTPM
Bronchus	0.2 nTPM

Endothelial cells	0.2 nTPM
Tongue	0.7 nTPM
Salivary gland	0.6 nTPM
Heart muscle	0.5 nTPM
Esophagus	0.5 nTPM
Endometrium	0.2 nTPM
Ovary	0.2 nTPM
Lung	0.1 nTPM
Vascular	0.1 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	13.7 nTPM
Colon	15.6 nTPM
Small intestine	13.7 nTPM
Rectum	11.7 nTPM

Fibroblasts	0.4 nTPM
Heart muscle	3.0 nTPM
Lung	1.2 nTPM
Vascular	1.1 nTPM
Placenta	0.4 nTPM
Salivary gland	0.3 nTPM
Thymus	0.2 nTPM
Fallopian tube	0.2 nTPM
Skeletal muscle	0.1 nTPM
Esophagus	0.1 nTPM
Breast	0.1 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.2 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	9.9 nTPM
Rectum	15.2 nTPM
Small intestine	7.8 nTPM
Colon	6.6 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	0.2 nTPM
Lung	1.1 nTPM
Salivary gland	0.7 nTPM
Endometrium	0.6 nTPM
Tongue	0.5 nTPM
Fallopian tube	0.3 nTPM
Vascular	0.2 nTPM
Breast	0.2 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	10.0 nTPM
Rectum	15.8 nTPM
Colon	7.2 nTPM
Small intestine	6.9 nTPM

Cone photoreceptor cells	5.1 nTPM
Eye	5.1 nTPM

Early spermatids	1.4 nTPM
Testis	1.4 nTPM

Plasma cells	2.6 nTPM
Fallopian tube	5.1 nTPM
Stomach	5.0 nTPM
Salivary gland	3.6 nTPM
Liver	3.5 nTPM
Bone marrow	1.5 nTPM
Spleen	1.2 nTPM
Thymus	1.1 nTPM
Esophagus	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	2.2 nTPM
Salivary gland	4.4 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.6 nTPM
Salivary gland	4.5 nTPM
Ovary	3.3 nTPM
Prostate	3.0 nTPM
Vascular	2.3 nTPM
Breast	2.2 nTPM
Adipose tissue	1.6 nTPM
Thymus	1.5 nTPM
Skeletal muscle	1.2 nTPM
Esophagus	1.2 nTPM
Lung	1.2 nTPM
Fallopian tube	1.2 nTPM
Skin	1.1 nTPM
Tongue	0.6 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM

T-cells	0.5 nTPM
Esophagus	2.4 nTPM
Colon	1.9 nTPM
Skeletal muscle	0.8 nTPM
Fallopian tube	0.8 nTPM
Bone marrow	0.6 nTPM
Stomach	0.6 nTPM
Prostate	0.5 nTPM
PBMC	0.4 nTPM
Adipose tissue	0.4 nTPM
Liver	0.3 nTPM
Spleen	0.3 nTPM
Thymus	0.3 nTPM
Breast	0.3 nTPM
Endometrium	0.2 nTPM
Lymph node	0.2 nTPM
Kidney	0.0 nTPM
Skin	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	12.8 nTPM
Rectum	14.6 nTPM
Small intestine	13.9 nTPM
Colon	10.0 nTPM

Amygdala excitatory	18.9 nTPM
Hypothalamus	20.4 nTPM
Amygdala	20.2 nTPM
Hippocampus	20.2 nTPM
Thalamus	18.6 nTPM
Cerebral cortex	18.0 nTPM
Basal ganglia	16.2 nTPM

Astrocyte	4.3 nTPM
Spinal cord	7.1 nTPM
Pons	7.0 nTPM
Cerebellum	6.8 nTPM
Hypothalamus	6.3 nTPM
Medulla oblongata	5.6 nTPM
Midbrain	4.6 nTPM
Thalamus	3.4 nTPM
Basal ganglia	2.2 nTPM
Hippocampus	1.8 nTPM
Cerebral cortex	1.7 nTPM
Amygdala	1.1 nTPM

Bergmann glia	0.4 nTPM
Cerebellum	1.1 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	0.6 nTPM
Pons	1.2 nTPM
Cerebral cortex	1.1 nTPM
Thalamus	1.0 nTPM
Hypothalamus	0.6 nTPM
Amygdala	0.5 nTPM
Cerebellum	0.5 nTPM
Hippocampus	0.5 nTPM
Medulla oblongata	0.5 nTPM
Midbrain	0.5 nTPM
Basal ganglia	0.4 nTPM
Spinal cord	0.0 nTPM

Cerebellar inhibitory	17.0 nTPM
Medulla oblongata	20.6 nTPM
Cerebellum	20.2 nTPM
Midbrain	17.1 nTPM
Pons	16.2 nTPM
Spinal cord	11.0 nTPM

Cge interneuron	18.6 nTPM
Hypothalamus	21.7 nTPM
Amygdala	19.5 nTPM
Thalamus	19.3 nTPM
Midbrain	18.2 nTPM
Hippocampus	17.5 nTPM
Cerebral cortex	17.1 nTPM
Basal ganglia	16.7 nTPM

Choroid plexus epithelial cell	8.1 nTPM
Hippocampus	13.9 nTPM
Thalamus	11.0 nTPM
Basal ganglia	5.1 nTPM
Medulla oblongata	2.4 nTPM

Committed oligodendrocyte precursor	29.8 nTPM
Cerebral cortex	54.5 nTPM
Midbrain	52.1 nTPM
Pons	47.8 nTPM
Amygdala	41.7 nTPM
Hippocampus	38.3 nTPM
Cerebellum	23.8 nTPM
Basal ganglia	20.8 nTPM
Hypothalamus	18.4 nTPM
Spinal cord	11.0 nTPM
Thalamus	10.6 nTPM
Medulla oblongata	9.0 nTPM

Deep-layer corticothalamic and 6b	17.6 nTPM
Amygdala	22.0 nTPM
Hypothalamus	21.8 nTPM
Cerebral cortex	17.4 nTPM
Hippocampus	16.9 nTPM
Midbrain	14.4 nTPM
Basal ganglia	13.4 nTPM

Deep-layer intratelencephalic	16.4 nTPM
Hypothalamus	20.8 nTPM
Hippocampus	18.0 nTPM
Amygdala	15.6 nTPM
Cerebral cortex	14.6 nTPM
Basal ganglia	13.2 nTPM

Deep-layer near-projecting	21.2 nTPM
Hypothalamus	27.8 nTPM
Amygdala	21.9 nTPM
Cerebral cortex	19.8 nTPM
Basal ganglia	18.7 nTPM
Hippocampus	17.9 nTPM

Eccentric medium spiny neuron	21.6 nTPM
Amygdala	23.0 nTPM
Cerebral cortex	22.1 nTPM
Hypothalamus	22.0 nTPM
Hippocampus	21.6 nTPM
Thalamus	21.3 nTPM
Basal ganglia	19.6 nTPM

Endothelial cell	0.6 nTPM
Amygdala	2.2 nTPM
Pons	1.2 nTPM
Thalamus	1.1 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.8 nTPM
Cerebral cortex	0.6 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	3.6 nTPM
Amygdala	5.7 nTPM
Thalamus	4.0 nTPM
Pons	3.9 nTPM
Midbrain	3.8 nTPM
Basal ganglia	3.5 nTPM
Hippocampus	3.4 nTPM
Medulla oblongata	3.1 nTPM
Hypothalamus	2.7 nTPM
Spinal cord	1.9 nTPM