Single cell type - TOMM20 - The Human Protein Atlas

TOMM20

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOMM20
Gene descriptionⁱ Full gene name according to HGNC.	Translocase of outer mitochondrial membrane 20
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Ribosome (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.19
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TOMM20 is part of cluster 64 Non-specific - Ribosome with confidenceⁱ 1
168 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NSA2	NSA2 ribosome biogenesis factor	0.6503	64
EIF4B	Eukaryotic translation initiation factor 4B	0.6256	64
RPL7A	Ribosomal protein L7a	0.6238	64
TPT1	Tumor protein, translationally-controlled 1	0.6073	64
RPL14	Ribosomal protein L14	0.5936	64
NACA	Nascent polypeptide associated complex subunit alpha	0.5795	64
PABPC1	Poly(A) binding protein cytoplasmic 1	0.5716	64
RPL13	Ribosomal protein L13	0.5708	64
RPL5	Ribosomal protein L5	0.5691	64
EEF1A1	Eukaryotic translation elongation factor 1 alpha 1	0.5658	64
RPL29	Ribosomal protein L29	0.5655	64
EEF1B2	Eukaryotic translation elongation factor 1 beta 2	0.5628	64
RPL6	Ribosomal protein L6	0.5498	64
RPL19	Ribosomal protein L19	0.5491	64
RPS21	Ribosomal protein S21	0.5412	64

IMMUNE CELLS

TOMM20 is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 1
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PCBP2	Poly(rC) binding protein 2	1.0000	30
RPLP0	Ribosomal protein lateral stalk subunit P0	0.9762	30
MYBBP1A	MYB binding protein 1a	0.9762	30
RPS24	Ribosomal protein S24	0.9762	30
MMAB	Metabolism of cobalamin associated B	0.9762	30
ZNF621	Zinc finger protein 621	0.9762	30
HSD17B12	Hydroxysteroid 17-beta dehydrogenase 12	0.9762	30
MIX23	Mitochondrial matrix import factor 23	0.9762	30
KMT2B	Lysine methyltransferase 2B	0.9524	30
ZNF839	Zinc finger protein 839	0.9524	30
SMIM26	Small integral membrane protein 26	0.9524	30
LYRM4	LYR motif containing 4	0.9524	18
TMEM231	Transmembrane protein 231	0.9524	18
ANKMY1	Ankyrin repeat and MYND domain containing 1	0.9524	18
MTAP	Methylthioadenosine phosphorylase	0.9524	30

Adipocytes	157.0 nTPM
Breast	166.7 nTPM
Adipose tissue	147.3 nTPM

Alveolar cells type 1	198.6 nTPM
Lung	198.6 nTPM

Alveolar cells type 2	224.8 nTPM
Lung	224.8 nTPM

Astrocytes	23.8 nTPM
Brain	23.8 nTPM

B-cells	193.1 nTPM
Adipose tissue	313.2 nTPM
Lung	241.5 nTPM
Salivary gland	239.5 nTPM
Thymus	238.5 nTPM
PBMC	223.2 nTPM
Lymph node	179.1 nTPM
Spleen	178.2 nTPM
Stomach	170.8 nTPM
Liver	169.1 nTPM
Esophagus	153.4 nTPM
Skin	145.7 nTPM
Kidney	135.2 nTPM
Bone marrow	122.4 nTPM

Basal squamous epithelial cells	263.9 nTPM
Esophagus	263.9 nTPM

Ciliated cells	147.0 nTPM
Fallopian tube	194.0 nTPM
Endometrium	174.8 nTPM
Lung	144.3 nTPM
Bronchus	74.9 nTPM

Club cells	173.2 nTPM
Prostate	223.1 nTPM
Lung	193.5 nTPM
Bronchus	102.9 nTPM

Dendritic cells	270.9 nTPM
Adipose tissue	318.9 nTPM
PBMC	223.0 nTPM

Endothelial cells	153.9 nTPM
Fallopian tube	270.5 nTPM
Breast	181.9 nTPM
Tongue	174.4 nTPM
Vascular	173.7 nTPM
Pancreas	173.2 nTPM
Testis	173.1 nTPM
Salivary gland	172.6 nTPM
Thymus	165.7 nTPM
Endometrium	160.0 nTPM
Prostate	159.6 nTPM
Lung	156.3 nTPM
Skin	133.0 nTPM
Esophagus	131.6 nTPM
Skeletal muscle	124.9 nTPM
Ovary	119.4 nTPM
Liver	114.6 nTPM
Placenta	112.4 nTPM
Heart muscle	72.9 nTPM

Enteroendocrine cells	162.2 nTPM
Colon	221.9 nTPM
Rectum	134.2 nTPM
Small intestine	130.5 nTPM

Erythroid cells	153.2 nTPM
Bone marrow	173.6 nTPM
Liver	132.9 nTPM

Fibroblasts	147.2 nTPM
Fallopian tube	266.9 nTPM
Prostate	210.6 nTPM
Vascular	188.6 nTPM
Adipose tissue	187.7 nTPM
Lung	184.8 nTPM
Salivary gland	173.0 nTPM
Pancreas	168.2 nTPM
Placenta	134.8 nTPM
Breast	134.0 nTPM
Thymus	132.5 nTPM
Skeletal muscle	126.2 nTPM
Esophagus	108.4 nTPM
Skin	96.8 nTPM
Heart muscle	87.3 nTPM
Stomach	77.8 nTPM
Liver	77.1 nTPM

Granulocytes	284.1 nTPM
Fallopian tube	322.3 nTPM
Lung	287.4 nTPM
Tongue	242.5 nTPM

Intestinal goblet cells	193.6 nTPM
Rectum	272.5 nTPM
Colon	185.3 nTPM
Small intestine	123.1 nTPM

Bipolar cells	48.5 nTPM
Eye	48.5 nTPM

Cholangiocytes	146.9 nTPM
Liver	146.9 nTPM

Collecting duct cells	46.7 nTPM
Kidney	46.7 nTPM

Cone photoreceptor cells	90.1 nTPM
Eye	90.1 nTPM

Lymphatic endothelial cells	171.1 nTPM
Fallopian tube	249.5 nTPM
Ovary	92.7 nTPM

Macrophages	173.5 nTPM
Adipose tissue	305.7 nTPM
Testis	251.1 nTPM
Lung	239.9 nTPM
Fallopian tube	213.2 nTPM
Prostate	211.9 nTPM
Endometrium	184.5 nTPM
Salivary gland	183.2 nTPM
Skeletal muscle	181.4 nTPM
Tongue	181.3 nTPM
Breast	168.5 nTPM
Vascular	152.0 nTPM
Kidney	146.9 nTPM
Spleen	142.4 nTPM
Bone marrow	133.8 nTPM
Stomach	128.6 nTPM
Thymus	123.2 nTPM
Pancreas	121.3 nTPM
Esophagus	118.2 nTPM
Skin	110.3 nTPM

Paneth cells	180.3 nTPM
Rectum	268.3 nTPM
Colon	144.7 nTPM
Small intestine	127.8 nTPM

Plasma cells	190.6 nTPM
Fallopian tube	295.3 nTPM
Salivary gland	211.3 nTPM
Esophagus	187.1 nTPM
Spleen	181.1 nTPM
Liver	171.7 nTPM
Thymus	169.4 nTPM
Stomach	166.7 nTPM
Bone marrow	141.9 nTPM

Schwann cells	233.0 nTPM
Adipose tissue	386.5 nTPM
Vascular	192.8 nTPM
Esophagus	119.8 nTPM

Serous glandular cells	368.9 nTPM
Salivary gland	486.0 nTPM
Tongue	251.9 nTPM

Smooth muscle cells	202.5 nTPM
Fallopian tube	308.5 nTPM
Salivary gland	275.1 nTPM
Ovary	268.0 nTPM
Vascular	256.6 nTPM
Prostate	243.3 nTPM
Breast	225.1 nTPM
Adipose tissue	216.7 nTPM
Lung	196.3 nTPM
Endometrium	189.0 nTPM
Tongue	184.4 nTPM
Skin	158.7 nTPM
Liver	152.4 nTPM
Thymus	151.9 nTPM
Skeletal muscle	147.8 nTPM
Placenta	134.0 nTPM
Esophagus	132.1 nTPM

Suprabasal keratinocytes	277.6 nTPM
Tongue	286.6 nTPM
Skin	268.6 nTPM

T-cells	198.4 nTPM
Adipose tissue	310.1 nTPM
Fallopian tube	302.7 nTPM
Thymus	300.3 nTPM
PBMC	281.3 nTPM
Salivary gland	274.2 nTPM
Prostate	261.5 nTPM
Lung	224.5 nTPM
Colon	219.4 nTPM
Breast	215.8 nTPM
Lymph node	206.4 nTPM
Tongue	191.4 nTPM
Vascular	191.4 nTPM
Skin	162.3 nTPM
Endometrium	162.1 nTPM
Skeletal muscle	149.7 nTPM
Spleen	147.5 nTPM
Stomach	137.9 nTPM
Liver	120.4 nTPM
Bone marrow	109.9 nTPM
Esophagus	104.6 nTPM
Kidney	94.0 nTPM

Undifferentiated cells	260.5 nTPM
Rectum	302.7 nTPM
Small intestine	249.3 nTPM
Colon	229.5 nTPM

Amygdala excitatory	94.9 nTPM
Hippocampus	117.4 nTPM
Thalamus	111.2 nTPM
Basal ganglia	96.7 nTPM
Hypothalamus	83.4 nTPM
Cerebral cortex	83.1 nTPM
Amygdala	77.4 nTPM

Astrocyte	27.0 nTPM
Thalamus	31.6 nTPM
Cerebral cortex	31.3 nTPM
Hippocampus	27.8 nTPM
Midbrain	27.3 nTPM
Hypothalamus	27.2 nTPM
Amygdala	26.5 nTPM
Basal ganglia	26.5 nTPM
Medulla oblongata	25.7 nTPM
Pons	25.5 nTPM
Cerebellum	25.0 nTPM
Spinal cord	22.8 nTPM

Bergmann glia	28.5 nTPM
Pons	34.5 nTPM
Medulla oblongata	27.7 nTPM
Cerebellum	23.3 nTPM

Central nervous system macrophage	37.7 nTPM
Cerebral cortex	42.8 nTPM
Thalamus	42.5 nTPM
Hypothalamus	40.4 nTPM
Pons	39.7 nTPM
Medulla oblongata	38.7 nTPM
Spinal cord	38.6 nTPM
Basal ganglia	37.7 nTPM
Midbrain	35.2 nTPM
Hippocampus	35.1 nTPM
Amygdala	33.4 nTPM
Cerebellum	31.2 nTPM

Cerebellar inhibitory	72.4 nTPM
Medulla oblongata	85.3 nTPM
Midbrain	72.2 nTPM
Pons	70.9 nTPM
Cerebellum	70.5 nTPM
Spinal cord	63.2 nTPM

Cge interneuron	99.4 nTPM
Hippocampus	113.8 nTPM
Thalamus	108.8 nTPM
Midbrain	105.2 nTPM
Amygdala	98.8 nTPM
Basal ganglia	97.1 nTPM
Cerebral cortex	88.8 nTPM
Hypothalamus	83.1 nTPM

Choroid plexus epithelial cell	52.1 nTPM
Hippocampus	63.8 nTPM
Thalamus	57.5 nTPM
Medulla oblongata	46.1 nTPM
Basal ganglia	40.8 nTPM

Committed oligodendrocyte precursor	56.8 nTPM
Basal ganglia	69.5 nTPM
Medulla oblongata	63.3 nTPM
Cerebellum	60.3 nTPM
Thalamus	59.7 nTPM
Pons	59.3 nTPM
Cerebral cortex	57.0 nTPM
Hippocampus	56.4 nTPM
Hypothalamus	54.6 nTPM
Midbrain	53.8 nTPM
Amygdala	50.7 nTPM
Spinal cord	40.5 nTPM

Deep-layer corticothalamic and 6b	106.4 nTPM
Hypothalamus	117.0 nTPM
Basal ganglia	112.9 nTPM
Midbrain	108.7 nTPM
Hippocampus	102.7 nTPM
Cerebral cortex	100.8 nTPM
Amygdala	96.0 nTPM

Deep-layer intratelencephalic	100.6 nTPM
Hippocampus	116.6 nTPM
Hypothalamus	113.9 nTPM
Cerebral cortex	97.2 nTPM
Basal ganglia	94.0 nTPM
Amygdala	81.2 nTPM