Single cell type - PCBP2 - The Human Protein Atlas

PCBP2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PCBP2
Gene descriptionⁱ Full gene name according to HGNC.	Poly(rC) binding protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Ribosome (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.17
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PCBP2 is part of cluster 64 Non-specific - Ribosome with confidenceⁱ 1
168 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPIL3	Peptidylprolyl isomerase like 3	0.6438	15
EIF3CL	Eukaryotic translation initiation factor 3 subunit C like	0.6338	15
SUMO2	Small ubiquitin like modifier 2	0.6018	15
ATP5MC2	ATP synthase membrane subunit c locus 2	0.6007	64
MDP1	Magnesium dependent phosphatase 1	0.5777	49
SNRPA	Small nuclear ribonucleoprotein polypeptide A	0.5752	15
EIF3E	Eukaryotic translation initiation factor 3 subunit E	0.5667	64
ESD	Esterase D	0.5567	15
CCNG1	Cyclin G1	0.5357	64
RPL22	Ribosomal protein L22	0.5324	64
FBXO4	F-box protein 4	0.5321	15
RPL39	Ribosomal protein L39	0.5283	64
EEF1A1	Eukaryotic translation elongation factor 1 alpha 1	0.5232	64
RPL17	Ribosomal protein L17	0.5224	49
RPS23	Ribosomal protein S23	0.5198	64

IMMUNE CELLS

PCBP2 is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 1
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TOMM20	Translocase of outer mitochondrial membrane 20	1.0000	30
RPLP0	Ribosomal protein lateral stalk subunit P0	0.9762	30
MYBBP1A	MYB binding protein 1a	0.9762	30
RPS24	Ribosomal protein S24	0.9762	30
MMAB	Metabolism of cobalamin associated B	0.9762	30
ZNF621	Zinc finger protein 621	0.9762	30
HSD17B12	Hydroxysteroid 17-beta dehydrogenase 12	0.9762	30
MIX23	Mitochondrial matrix import factor 23	0.9762	30
KMT2B	Lysine methyltransferase 2B	0.9524	30
ZNF839	Zinc finger protein 839	0.9524	30
SMIM26	Small integral membrane protein 26	0.9524	30
LYRM4	LYR motif containing 4	0.9524	18
TMEM231	Transmembrane protein 231	0.9524	18
ANKMY1	Ankyrin repeat and MYND domain containing 1	0.9524	18
MTAP	Methylthioadenosine phosphorylase	0.9524	30

Adipocytes	266.5 nTPM
Adipose tissue	282.7 nTPM
Breast	250.3 nTPM

Alveolar cells type 1	216.6 nTPM
Lung	216.6 nTPM

Alveolar cells type 2	249.5 nTPM
Lung	249.5 nTPM

Astrocytes	61.6 nTPM
Brain	61.6 nTPM

B-cells	377.3 nTPM
Lymph node	613.6 nTPM
Spleen	560.1 nTPM
Skin	509.9 nTPM
Stomach	502.4 nTPM
Bone marrow	465.9 nTPM
Esophagus	383.5 nTPM
Adipose tissue	372.4 nTPM
Kidney	358.8 nTPM
PBMC	335.6 nTPM
Lung	222.7 nTPM
Liver	212.5 nTPM
Salivary gland	199.9 nTPM
Thymus	167.8 nTPM

Basal squamous epithelial cells	547.1 nTPM
Esophagus	547.1 nTPM

Ciliated cells	173.5 nTPM
Endometrium	230.4 nTPM
Lung	170.7 nTPM
Bronchus	150.8 nTPM
Fallopian tube	142.2 nTPM

Club cells	195.1 nTPM
Bronchus	201.5 nTPM
Prostate	196.0 nTPM
Lung	187.8 nTPM

Dendritic cells	390.4 nTPM
Adipose tissue	421.1 nTPM
PBMC	359.7 nTPM

Endothelial cells	255.1 nTPM
Esophagus	444.8 nTPM
Liver	395.5 nTPM
Skin	379.1 nTPM
Fallopian tube	297.7 nTPM
Breast	277.7 nTPM
Vascular	276.2 nTPM
Endometrium	263.1 nTPM
Testis	255.8 nTPM
Salivary gland	255.2 nTPM
Placenta	241.8 nTPM
Prostate	236.7 nTPM
Tongue	225.7 nTPM
Ovary	225.1 nTPM
Skeletal muscle	219.4 nTPM
Thymus	189.1 nTPM
Lung	181.7 nTPM
Pancreas	155.1 nTPM
Heart muscle	73.1 nTPM

Enteroendocrine cells	170.0 nTPM
Colon	179.4 nTPM
Rectum	172.8 nTPM
Small intestine	157.9 nTPM

Erythroid cells	430.5 nTPM
Bone marrow	644.3 nTPM
Liver	216.8 nTPM

Fibroblasts	251.8 nTPM
Placenta	545.8 nTPM
Esophagus	365.1 nTPM
Skin	343.8 nTPM
Adipose tissue	318.1 nTPM
Vascular	304.9 nTPM
Stomach	296.9 nTPM
Prostate	239.6 nTPM
Salivary gland	218.9 nTPM
Skeletal muscle	214.7 nTPM
Breast	211.8 nTPM
Pancreas	207.7 nTPM
Fallopian tube	193.6 nTPM
Lung	181.3 nTPM
Liver	167.2 nTPM
Thymus	154.9 nTPM
Heart muscle	64.1 nTPM

Granulocytes	171.3 nTPM
Lung	193.1 nTPM
Tongue	169.8 nTPM
Fallopian tube	151.2 nTPM

Intestinal goblet cells	212.6 nTPM
Rectum	290.8 nTPM
Small intestine	193.7 nTPM
Colon	153.3 nTPM

Bipolar cells	82.1 nTPM
Eye	82.1 nTPM

Cholangiocytes	223.2 nTPM
Liver	223.2 nTPM

Collecting duct cells	280.1 nTPM
Kidney	280.1 nTPM

Cone photoreceptor cells	124.0 nTPM
Eye	124.0 nTPM

Lymphatic endothelial cells	228.1 nTPM
Fallopian tube	281.7 nTPM
Ovary	174.6 nTPM

Macrophages	330.4 nTPM
Adipose tissue	610.0 nTPM
Spleen	587.5 nTPM
Stomach	475.9 nTPM
Bone marrow	474.3 nTPM
Esophagus	435.4 nTPM
Kidney	386.8 nTPM
Skin	371.1 nTPM
Skeletal muscle	329.5 nTPM
Fallopian tube	309.4 nTPM
Tongue	285.9 nTPM
Testis	267.8 nTPM
Lung	259.0 nTPM
Prostate	246.9 nTPM
Vascular	243.2 nTPM
Salivary gland	235.9 nTPM
Endometrium	218.9 nTPM
Breast	212.3 nTPM
Thymus	191.9 nTPM
Pancreas	135.7 nTPM

Paneth cells	226.1 nTPM
Rectum	277.1 nTPM
Small intestine	238.3 nTPM
Colon	162.8 nTPM

Plasma cells	350.5 nTPM
Stomach	600.6 nTPM
Spleen	540.3 nTPM
Bone marrow	447.0 nTPM
Esophagus	421.0 nTPM
Salivary gland	253.4 nTPM
Liver	211.3 nTPM
Fallopian tube	202.6 nTPM
Thymus	127.7 nTPM

Schwann cells	363.6 nTPM
Adipose tissue	752.3 nTPM
Esophagus	179.7 nTPM
Vascular	158.8 nTPM

Serous glandular cells	187.9 nTPM
Salivary gland	296.2 nTPM
Tongue	79.5 nTPM

Smooth muscle cells	235.9 nTPM
Esophagus	320.7 nTPM
Placenta	319.1 nTPM
Skin	296.6 nTPM
Ovary	283.2 nTPM
Adipose tissue	249.2 nTPM
Liver	247.9 nTPM
Prostate	245.1 nTPM
Vascular	241.4 nTPM
Endometrium	232.7 nTPM
Fallopian tube	232.4 nTPM
Breast	229.9 nTPM
Skeletal muscle	222.7 nTPM
Tongue	222.1 nTPM
Salivary gland	201.0 nTPM
Lung	121.1 nTPM
Thymus	109.8 nTPM

Suprabasal keratinocytes	304.9 nTPM
Skin	386.2 nTPM
Tongue	223.6 nTPM

T-cells	280.5 nTPM
Lymph node	558.4 nTPM
Spleen	473.7 nTPM
Bone marrow	438.8 nTPM
Stomach	429.4 nTPM
Adipose tissue	363.5 nTPM
PBMC	347.8 nTPM
Esophagus	318.8 nTPM
Skin	287.7 nTPM
Colon	268.1 nTPM
Kidney	246.5 nTPM
Skeletal muscle	208.7 nTPM
Tongue	208.6 nTPM
Thymus	207.5 nTPM
Endometrium	201.7 nTPM
Salivary gland	200.1 nTPM
Breast	199.9 nTPM
Vascular	199.8 nTPM
Liver	194.9 nTPM
Prostate	184.5 nTPM
Fallopian tube	181.4 nTPM
Lung	169.9 nTPM

Undifferentiated cells	288.7 nTPM
Small intestine	334.3 nTPM
Rectum	325.4 nTPM
Colon	206.5 nTPM

Amygdala excitatory	72.6 nTPM
Hippocampus	79.6 nTPM
Cerebral cortex	74.7 nTPM
Hypothalamus	74.5 nTPM
Amygdala	72.2 nTPM
Basal ganglia	67.7 nTPM
Thalamus	66.7 nTPM

Astrocyte	121.8 nTPM
Hippocampus	163.0 nTPM
Spinal cord	138.8 nTPM
Cerebral cortex	138.0 nTPM
Cerebellum	129.3 nTPM
Amygdala	128.3 nTPM
Pons	113.4 nTPM
Medulla oblongata	111.8 nTPM
Basal ganglia	104.9 nTPM
Hypothalamus	104.5 nTPM
Midbrain	104.3 nTPM
Thalamus	103.0 nTPM

Bergmann glia	138.5 nTPM
Cerebellum	149.3 nTPM
Pons	142.4 nTPM
Medulla oblongata	123.6 nTPM

Central nervous system macrophage	161.8 nTPM
Hippocampus	192.2 nTPM
Midbrain	173.8 nTPM
Cerebellum	173.0 nTPM
Spinal cord	172.8 nTPM
Basal ganglia	166.6 nTPM
Amygdala	161.3 nTPM
Cerebral cortex	157.3 nTPM
Pons	156.8 nTPM
Thalamus	146.8 nTPM
Hypothalamus	140.1 nTPM
Medulla oblongata	139.2 nTPM

Cerebellar inhibitory	117.4 nTPM
Spinal cord	137.5 nTPM
Midbrain	132.8 nTPM
Pons	111.7 nTPM
Cerebellum	110.1 nTPM
Medulla oblongata	95.0 nTPM

Cge interneuron	88.4 nTPM
Thalamus	114.2 nTPM
Midbrain	99.8 nTPM
Hypothalamus	90.0 nTPM
Amygdala	82.7 nTPM
Basal ganglia	79.1 nTPM
Hippocampus	78.9 nTPM
Cerebral cortex	73.9 nTPM

Choroid plexus epithelial cell	175.1 nTPM
Thalamus	189.1 nTPM
Medulla oblongata	188.1 nTPM
Basal ganglia	176.2 nTPM
Hippocampus	147.0 nTPM

Committed oligodendrocyte precursor	123.1 nTPM
Cerebellum	150.6 nTPM
Hippocampus	144.6 nTPM
Thalamus	129.7 nTPM
Pons	126.6 nTPM
Amygdala	123.5 nTPM
Spinal cord	121.4 nTPM
Hypothalamus	117.4 nTPM
Cerebral cortex	116.5 nTPM
Basal ganglia	112.2 nTPM
Midbrain	110.9 nTPM
Medulla oblongata	100.7 nTPM

Deep-layer corticothalamic and 6b	68.9 nTPM
Hypothalamus	77.5 nTPM
Midbrain	72.1 nTPM
Hippocampus	69.9 nTPM
Cerebral cortex	67.3 nTPM
Amygdala	64.7 nTPM
Basal ganglia	61.7 nTPM

Deep-layer intratelencephalic	73.9 nTPM
Amygdala	77.3 nTPM
Hypothalamus	76.0 nTPM
Cerebral cortex	73.4 nTPM
Hippocampus	72.1 nTPM
Basal ganglia	70.6 nTPM