Single cell type - RPS21 - The Human Protein Atlas

RPS21

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPS21
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein S21
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Ribosome (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.19
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RPS21 is part of cluster 64 Non-specific - Ribosome with confidenceⁱ 1
168 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPL37	Ribosomal protein L37	0.9078	64
RPS12	Ribosomal protein S12	0.8713	64
RPS28	Ribosomal protein S28	0.8545	64
RPS27A	Ribosomal protein S27a	0.8438	64
RPL30	Ribosomal protein L30	0.8346	64
RPL32	Ribosomal protein L32	0.8338	64
RPL28	Ribosomal protein L28	0.8293	64
RPS3A	Ribosomal protein S3A	0.8247	64
RPS23	Ribosomal protein S23	0.8183	64
RPLP1	Ribosomal protein lateral stalk subunit P1	0.8105	64
RPL39	Ribosomal protein L39	0.8091	64
RPS15A	Ribosomal protein S15a	0.8013	64
RPL35A	Ribosomal protein L35a	0.8011	64
RPL11	Ribosomal protein L11	0.7993	64
RPL18A	Ribosomal protein L18a	0.7980	64

IMMUNE CELLS

RPS21 is part of cluster 24 Non-specific - Transcription with confidenceⁱ 0.91
516 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000288645	Novel protein	0.9762	24
ACTR3C	Actin related protein 3C	0.9762	34
EEF1B2	Eukaryotic translation elongation factor 1 beta 2	0.9762	24
RPL27	Ribosomal protein L27	0.9762	34
AKT2	AKT serine/threonine kinase 2	0.9524	34
H4C6	H4 clustered histone 6	0.9524	43
MTX3	Metaxin 3	0.9524	24
RPSA	Ribosomal protein SA	0.9524	24
ZNF91	Zinc finger protein 91	0.9524	24
METTL2B	Methyltransferase 2B, methylcytidine	0.9524	34
WDR19	WD repeat domain 19	0.9524	24
HS2ST1	Heparan sulfate 2-O-sulfotransferase 1	0.9524	34
ZNF835	Zinc finger protein 835	0.9524	24
DTD2	D-aminoacyl-tRNA deacylase 2	0.9286	24
RPS10	Ribosomal protein S10	0.9286	43

Adipocytes	1683.1 nTPM
Adipose tissue	1750.2 nTPM
Breast	1616.1 nTPM

Alveolar cells type 1	1234.7 nTPM
Lung	1234.7 nTPM

Alveolar cells type 2	1643.1 nTPM
Lung	1643.1 nTPM

Astrocytes	7.4 nTPM
Brain	7.4 nTPM

B-cells	4116.6 nTPM
Adipose tissue	6718.1 nTPM
PBMC	5429.2 nTPM
Spleen	5124.8 nTPM
Lymph node	4941.1 nTPM
Liver	4410.0 nTPM
Thymus	4406.7 nTPM
Skin	4273.7 nTPM
Bone marrow	3792.1 nTPM
Stomach	3716.1 nTPM
Kidney	2849.5 nTPM
Salivary gland	2770.8 nTPM
Esophagus	2725.9 nTPM
Lung	2358.2 nTPM

Basal keratinocytes	3440.3 nTPM
Tongue	3726.7 nTPM
Skin	3153.8 nTPM

Basal squamous epithelial cells	3842.9 nTPM
Esophagus	3842.9 nTPM

Ciliated cells	789.3 nTPM
Fallopian tube	1406.9 nTPM
Endometrium	925.6 nTPM
Lung	520.8 nTPM
Bronchus	303.7 nTPM

Club cells	1224.5 nTPM
Prostate	1618.3 nTPM
Lung	1270.2 nTPM
Bronchus	785.0 nTPM

Dendritic cells	2984.1 nTPM
Adipose tissue	3248.5 nTPM
PBMC	2719.6 nTPM

Distal enterocytes	1877.3 nTPM
Rectum	2086.1 nTPM
Colon	1668.6 nTPM

Endothelial cells	1482.5 nTPM
Tongue	2958.1 nTPM
Fallopian tube	2444.6 nTPM
Skin	2031.5 nTPM
Ovary	1798.1 nTPM
Testis	1767.6 nTPM
Vascular	1749.1 nTPM
Thymus	1654.2 nTPM
Breast	1631.9 nTPM
Liver	1540.6 nTPM
Esophagus	1297.6 nTPM
Endometrium	1188.5 nTPM
Prostate	1146.9 nTPM
Lung	1101.3 nTPM
Placenta	1091.7 nTPM
Salivary gland	1049.0 nTPM
Pancreas	935.9 nTPM
Skeletal muscle	851.0 nTPM
Heart muscle	448.2 nTPM

Enteroendocrine cells	1869.9 nTPM
Colon	2170.5 nTPM
Rectum	1870.1 nTPM
Small intestine	1568.9 nTPM

Erythroid cells	3016.0 nTPM
Liver	3384.3 nTPM
Bone marrow	2647.7 nTPM

Fibroblasts	1226.2 nTPM
Fallopian tube	1916.7 nTPM
Adipose tissue	1769.2 nTPM
Placenta	1731.4 nTPM
Vascular	1710.8 nTPM
Breast	1539.0 nTPM
Pancreas	1345.2 nTPM
Lung	1258.5 nTPM
Thymus	1245.2 nTPM
Prostate	1231.6 nTPM
Skin	1164.7 nTPM
Liver	926.2 nTPM
Salivary gland	924.1 nTPM
Esophagus	896.9 nTPM
Stomach	832.9 nTPM
Skeletal muscle	698.9 nTPM
Heart muscle	427.8 nTPM

Bipolar cells	199.4 nTPM
Eye	199.4 nTPM

Cholangiocytes	1222.9 nTPM
Liver	1222.9 nTPM

Collecting duct cells	653.5 nTPM
Kidney	653.5 nTPM

Cone photoreceptor cells	229.4 nTPM
Eye	229.4 nTPM

Glandular and luminal cells	1936.6 nTPM
Endometrium	1936.6 nTPM

Granulocytes	2249.4 nTPM
Fallopian tube	2864.4 nTPM
Tongue	2177.9 nTPM
Lung	1705.7 nTPM

Intestinal goblet cells	2466.7 nTPM
Rectum	3840.7 nTPM
Colon	2147.0 nTPM
Small intestine	1412.5 nTPM

Lymphatic endothelial cells	1363.8 nTPM
Fallopian tube	1751.1 nTPM
Ovary	976.5 nTPM

Macrophages	1729.3 nTPM
Adipose tissue	3856.8 nTPM
Testis	2751.3 nTPM
Tongue	2282.1 nTPM
Endometrium	1979.0 nTPM
Fallopian tube	1964.9 nTPM
Breast	1961.3 nTPM
Kidney	1883.3 nTPM
Spleen	1652.1 nTPM
Prostate	1582.6 nTPM
Bone marrow	1516.2 nTPM
Skin	1495.4 nTPM
Salivary gland	1487.0 nTPM
Stomach	1443.0 nTPM
Skeletal muscle	1414.8 nTPM
Thymus	1315.9 nTPM
Esophagus	1275.4 nTPM
Lung	1053.6 nTPM
Vascular	1036.8 nTPM
Pancreas	904.4 nTPM

Paneth cells	2449.3 nTPM
Rectum	3610.5 nTPM
Colon	1903.4 nTPM
Small intestine	1834.0 nTPM

Plasma cells	2406.0 nTPM
Liver	3467.8 nTPM
Spleen	3355.3 nTPM
Fallopian tube	2418.7 nTPM
Bone marrow	2395.0 nTPM
Thymus	2361.3 nTPM
Stomach	2027.9 nTPM
Esophagus	1637.3 nTPM
Salivary gland	1584.3 nTPM

Schwann cells	2825.2 nTPM
Adipose tissue	7776.8 nTPM
Vascular	495.2 nTPM
Esophagus	203.7 nTPM

Serous glandular cells	1945.4 nTPM
Salivary gland	2525.2 nTPM
Tongue	1365.5 nTPM

Smooth muscle cells	1403.7 nTPM
Ovary	2821.8 nTPM
Fallopian tube	2113.5 nTPM
Liver	2106.1 nTPM
Adipose tissue	1812.2 nTPM
Breast	1717.7 nTPM
Salivary gland	1596.2 nTPM
Tongue	1463.4 nTPM
Skin	1371.4 nTPM
Vascular	1282.1 nTPM
Prostate	1111.2 nTPM
Thymus	1103.6 nTPM
Placenta	1085.3 nTPM
Endometrium	911.4 nTPM
Esophagus	737.6 nTPM
Skeletal muscle	710.8 nTPM
Lung	514.9 nTPM

Suprabasal keratinocytes	4047.3 nTPM
Tongue	4086.4 nTPM
Skin	4008.2 nTPM

T-cells	3166.4 nTPM
PBMC	6292.8 nTPM
Adipose tissue	5718.3 nTPM
Thymus	5182.7 nTPM
Lymph node	5049.6 nTPM
Fallopian tube	3721.9 nTPM
Spleen	3651.7 nTPM
Liver	3136.5 nTPM
Skin	2929.0 nTPM
Breast	2924.3 nTPM
Bone marrow	2849.8 nTPM
Vascular	2799.2 nTPM
Salivary gland	2791.3 nTPM
Stomach	2614.4 nTPM
Tongue	2600.6 nTPM
Prostate	2589.3 nTPM
Kidney	2219.4 nTPM
Esophagus	2114.8 nTPM
Lung	2066.0 nTPM
Colon	1772.5 nTPM
Skeletal muscle	1744.0 nTPM
Endometrium	1726.9 nTPM

Undifferentiated cells	3731.8 nTPM
Rectum	4820.5 nTPM
Small intestine	4115.3 nTPM
Colon	2259.7 nTPM

Amygdala excitatory	57.3 nTPM
Basal ganglia	85.8 nTPM
Cerebral cortex	75.3 nTPM
Hippocampus	68.4 nTPM
Thalamus	52.6 nTPM
Amygdala	47.8 nTPM
Hypothalamus	13.6 nTPM

Astrocyte	46.7 nTPM
Hippocampus	61.7 nTPM
Medulla oblongata	57.3 nTPM
Basal ganglia	54.4 nTPM
Cerebellum	53.7 nTPM
Pons	53.2 nTPM
Midbrain	48.9 nTPM
Cerebral cortex	45.4 nTPM
Thalamus	41.9 nTPM
Amygdala	37.5 nTPM
Spinal cord	33.8 nTPM
Hypothalamus	26.4 nTPM

Bergmann glia	41.5 nTPM
Pons	50.3 nTPM
Medulla oblongata	44.8 nTPM
Cerebellum	29.5 nTPM

Central nervous system macrophage	89.1 nTPM
Spinal cord	137.8 nTPM
Medulla oblongata	109.7 nTPM
Cerebral cortex	103.9 nTPM
Cerebellum	97.3 nTPM
Pons	91.8 nTPM
Basal ganglia	89.8 nTPM
Hippocampus	87.8 nTPM
Thalamus	83.0 nTPM
Midbrain	81.8 nTPM
Hypothalamus	51.4 nTPM
Amygdala	46.0 nTPM

Cerebellar inhibitory	64.3 nTPM
Pons	74.2 nTPM
Medulla oblongata	66.1 nTPM
Spinal cord	63.2 nTPM
Cerebellum	59.8 nTPM
Midbrain	58.2 nTPM

Cge interneuron	87.4 nTPM
Midbrain	130.5 nTPM
Basal ganglia	107.3 nTPM
Thalamus	99.8 nTPM
Hippocampus	90.0 nTPM
Cerebral cortex	88.0 nTPM
Amygdala	70.6 nTPM
Hypothalamus	25.3 nTPM

Choroid plexus epithelial cell	79.5 nTPM
Hippocampus	155.3 nTPM
Medulla oblongata	85.8 nTPM
Thalamus	60.3 nTPM
Basal ganglia	16.9 nTPM