Single cell type - NABP1 - The Human Protein Atlas

NABP1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NABP1
Gene descriptionⁱ Full gene name according to HGNC.	Nucleic acid binding protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neutrophils - Degranulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Langerhans cells, Early spermatids, Syncytiotrophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.46
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Leukocyte, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Langerhans cells, Early spermatids, Syncytiotrophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Leukocyte, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NABP1 is part of cluster 74 Neutrophils - Degranulation with confidenceⁱ 1
174 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MMP25	Matrix metallopeptidase 25	0.7616	74
IVNS1ABP	Influenza virus NS1A binding protein	0.7547	74
NAMPT	Nicotinamide phosphoribosyltransferase	0.7223	74
MBOAT7	Membrane bound O-acyltransferase domain containing 7	0.7212	74
CSF3R	Colony stimulating factor 3 receptor	0.7198	74
PROK2	Prokineticin 2	0.7181	74
FCGR3B	Fc gamma receptor IIIb	0.7162	74
CXCR1	C-X-C motif chemokine receptor 1	0.7162	74
LINC02218	Long intergenic non-protein coding RNA 2218	0.7112	74
TNFRSF10C	TNF receptor superfamily member 10c	0.7100	74
PGLYRP1	Peptidoglycan recognition protein 1	0.7095	74
CXCR2	C-X-C motif chemokine receptor 2	0.7037	74
VNN2	Vanin 2	0.6955	74
DEFA4	Defensin alpha 4	0.6848	74
CASS4	Cas scaffold protein family member 4	0.6819	74

IMMUNE CELLS

NABP1 is part of cluster 28 Neutrophils - Unknown function with confidenceⁱ 0.99
118 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TAP2	Transporter 2, ATP binding cassette subfamily B member	1.0000	28
GBP2	Guanylate binding protein 2	0.9762	28
ARMC2	Armadillo repeat containing 2	0.9762	33
PIGB	Phosphatidylinositol glycan anchor biosynthesis class B	0.9286	28
SRXN1	Sulfiredoxin 1	0.9286	28
RETREG2	Reticulophagy regulator family member 2	0.9286	28
ITGAV	Integrin subunit alpha V	0.9286	37
ECD	Ecdysoneless cell cycle regulator	0.9286	28
TNPO3	Transportin 3	0.9286	33
CPEB4	Cytoplasmic polyadenylation element binding protein 4	0.9048	28
KCNJ2	Potassium inwardly rectifying channel subfamily J member 2	0.9048	28
APOL2	Apolipoprotein L2	0.9048	28
TOR1B	Torsin family 1 member B	0.9048	28
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.9048	28
ASF1B	Anti-silencing function 1B histone chaperone	0.9048	28

Adipocytes	33.8 nTPM
Breast	40.7 nTPM
Adipose tissue	26.9 nTPM

Alveolar cells type 1	45.7 nTPM
Lung	45.7 nTPM

Alveolar cells type 2	47.2 nTPM
Lung	47.2 nTPM

Astrocytes	1.9 nTPM
Brain	1.9 nTPM

B-cells	78.1 nTPM
Skin	276.1 nTPM
Esophagus	171.1 nTPM
Lymph node	113.3 nTPM
Spleen	86.5 nTPM
Adipose tissue	60.5 nTPM
Thymus	56.4 nTPM
Salivary gland	51.1 nTPM
Stomach	47.2 nTPM
Kidney	36.4 nTPM
Bone marrow	34.1 nTPM
Liver	33.8 nTPM
Lung	33.5 nTPM
PBMC	15.4 nTPM

Ciliated cells	26.7 nTPM
Endometrium	55.9 nTPM
Fallopian tube	21.6 nTPM
Bronchus	20.5 nTPM
Lung	8.6 nTPM

Club cells	29.3 nTPM
Lung	32.1 nTPM
Bronchus	31.0 nTPM
Prostate	24.8 nTPM

Dendritic cells	22.4 nTPM
Adipose tissue	34.1 nTPM
PBMC	10.8 nTPM

Endothelial cells	19.1 nTPM
Lung	43.0 nTPM
Skeletal muscle	37.6 nTPM
Esophagus	37.5 nTPM
Skin	33.0 nTPM
Prostate	26.0 nTPM
Salivary gland	24.4 nTPM
Fallopian tube	22.6 nTPM
Vascular	21.8 nTPM
Thymus	21.5 nTPM
Tongue	20.2 nTPM
Endometrium	14.1 nTPM
Breast	8.8 nTPM
Liver	7.6 nTPM
Placenta	7.4 nTPM
Ovary	5.8 nTPM
Pancreas	5.2 nTPM
Heart muscle	4.2 nTPM
Testis	3.7 nTPM

Enteroendocrine cells	16.3 nTPM
Colon	31.8 nTPM
Small intestine	13.7 nTPM
Rectum	3.4 nTPM

Fibroblasts	49.3 nTPM
Salivary gland	114.3 nTPM
Lung	72.4 nTPM
Skeletal muscle	71.4 nTPM
Vascular	69.8 nTPM
Esophagus	68.7 nTPM
Thymus	68.3 nTPM
Stomach	54.8 nTPM
Breast	48.0 nTPM
Fallopian tube	44.5 nTPM
Skin	37.3 nTPM
Adipose tissue	36.8 nTPM
Placenta	35.7 nTPM
Pancreas	28.4 nTPM
Prostate	15.2 nTPM
Heart muscle	12.3 nTPM
Liver	10.7 nTPM

Granulocytes	110.0 nTPM
Fallopian tube	195.6 nTPM
Tongue	77.6 nTPM
Lung	57.0 nTPM

Intestinal goblet cells	15.7 nTPM
Colon	20.9 nTPM
Small intestine	19.9 nTPM
Rectum	6.2 nTPM

Lymphatic endothelial cells	19.8 nTPM
Fallopian tube	39.6 nTPM
Ovary	0.0 nTPM

Macrophages	150.8 nTPM
Fallopian tube	360.5 nTPM
Breast	301.9 nTPM
Skeletal muscle	281.0 nTPM
Esophagus	223.5 nTPM
Spleen	194.5 nTPM
Adipose tissue	168.9 nTPM
Salivary gland	152.7 nTPM
Skin	148.2 nTPM
Vascular	147.5 nTPM
Tongue	119.5 nTPM
Thymus	118.8 nTPM
Prostate	110.0 nTPM
Stomach	102.9 nTPM
Endometrium	95.3 nTPM
Bone marrow	91.2 nTPM
Testis	79.4 nTPM
Lung	71.1 nTPM
Kidney	70.8 nTPM
Pancreas	26.7 nTPM

Basal prostatic cells	22.8 nTPM
Prostate	22.8 nTPM

Basal respiratory cells	14.7 nTPM
Bronchus	14.7 nTPM

Basal squamous epithelial cells	29.5 nTPM
Esophagus	29.5 nTPM

Cholangiocytes	9.5 nTPM
Liver	9.5 nTPM

Paneth cells	36.2 nTPM
Colon	68.8 nTPM
Small intestine	24.2 nTPM
Rectum	15.8 nTPM

Plasma cells	50.5 nTPM
Fallopian tube	84.3 nTPM
Salivary gland	79.2 nTPM
Stomach	59.1 nTPM
Esophagus	46.8 nTPM
Spleen	45.9 nTPM
Thymus	41.1 nTPM
Bone marrow	25.7 nTPM
Liver	22.0 nTPM

Schwann cells	85.6 nTPM
Adipose tissue	182.3 nTPM
Esophagus	59.9 nTPM
Vascular	14.6 nTPM

Serous glandular cells	33.7 nTPM
Salivary gland	49.7 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	34.2 nTPM
Skeletal muscle	89.6 nTPM
Adipose tissue	62.6 nTPM
Breast	56.0 nTPM
Esophagus	52.9 nTPM
Skin	50.1 nTPM
Thymus	45.7 nTPM
Vascular	37.3 nTPM
Salivary gland	25.8 nTPM
Prostate	24.3 nTPM
Endometrium	23.7 nTPM
Tongue	22.2 nTPM
Fallopian tube	21.8 nTPM
Ovary	11.6 nTPM
Placenta	10.5 nTPM
Lung	9.4 nTPM
Liver	4.2 nTPM

Suprabasal keratinocytes	28.3 nTPM
Skin	39.7 nTPM
Tongue	17.0 nTPM

T-cells	91.2 nTPM
Fallopian tube	166.6 nTPM
Esophagus	165.5 nTPM
Prostate	163.4 nTPM
Breast	160.2 nTPM
Lymph node	138.4 nTPM
Vascular	132.3 nTPM
Tongue	96.4 nTPM
Skeletal muscle	83.6 nTPM
Spleen	83.1 nTPM
Endometrium	81.8 nTPM
Skin	81.7 nTPM
Thymus	81.2 nTPM
Colon	80.9 nTPM
Lung	76.1 nTPM
Adipose tissue	66.2 nTPM
Salivary gland	57.2 nTPM
Kidney	46.1 nTPM
Bone marrow	44.6 nTPM
Stomach	42.3 nTPM
Liver	38.6 nTPM
PBMC	29.7 nTPM

Undifferentiated cells	19.2 nTPM
Small intestine	28.1 nTPM
Colon	18.6 nTPM
Rectum	10.8 nTPM

Amygdala excitatory	12.8 nTPM
Hypothalamus	19.7 nTPM
Amygdala	16.3 nTPM
Hippocampus	13.0 nTPM
Basal ganglia	10.8 nTPM
Cerebral cortex	9.8 nTPM
Thalamus	7.3 nTPM

Astrocyte	2.3 nTPM
Spinal cord	3.9 nTPM
Cerebellum	2.7 nTPM
Medulla oblongata	2.5 nTPM
Hypothalamus	2.4 nTPM
Pons	2.3 nTPM
Basal ganglia	2.2 nTPM
Thalamus	2.1 nTPM
Cerebral cortex	2.0 nTPM
Amygdala	1.7 nTPM
Midbrain	1.7 nTPM
Hippocampus	1.6 nTPM

Bergmann glia	3.7 nTPM
Cerebellum	4.7 nTPM
Pons	4.3 nTPM
Medulla oblongata	2.1 nTPM

Central nervous system macrophage	115.3 nTPM
Amygdala	178.3 nTPM
Hippocampus	130.2 nTPM
Basal ganglia	120.6 nTPM
Cerebral cortex	118.9 nTPM
Hypothalamus	117.7 nTPM
Thalamus	114.0 nTPM
Midbrain	112.5 nTPM
Cerebellum	102.1 nTPM
Spinal cord	98.6 nTPM
Pons	96.5 nTPM
Medulla oblongata	79.1 nTPM

Cerebellar inhibitory	4.7 nTPM
Pons	7.0 nTPM
Midbrain	6.5 nTPM
Cerebellum	5.8 nTPM
Medulla oblongata	4.1 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	8.8 nTPM
Hippocampus	12.3 nTPM
Amygdala	11.6 nTPM
Cerebral cortex	10.2 nTPM
Basal ganglia	8.7 nTPM
Hypothalamus	7.6 nTPM
Midbrain	6.5 nTPM
Thalamus	4.5 nTPM

Choroid plexus epithelial cell	1.5 nTPM
Basal ganglia	3.7 nTPM
Medulla oblongata	2.2 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	2.8 nTPM
Thalamus	5.2 nTPM
Medulla oblongata	5.2 nTPM
Hypothalamus	4.8 nTPM
Hippocampus	4.7 nTPM
Basal ganglia	3.3 nTPM
Amygdala	2.8 nTPM
Cerebral cortex	1.9 nTPM
Pons	1.8 nTPM
Midbrain	1.7 nTPM
Cerebellum	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	14.5 nTPM
Amygdala	23.5 nTPM
Basal ganglia	15.5 nTPM
Midbrain	13.3 nTPM
Cerebral cortex	12.4 nTPM
Hippocampus	11.3 nTPM
Hypothalamus	10.8 nTPM

Deep-layer intratelencephalic	12.8 nTPM
Hippocampus	19.5 nTPM
Basal ganglia	12.6 nTPM
Hypothalamus	11.5 nTPM
Amygdala	10.6 nTPM
Cerebral cortex	9.8 nTPM

Deep-layer near-projecting	17.7 nTPM
Cerebral cortex	20.0 nTPM
Amygdala	19.3 nTPM
Basal ganglia	17.9 nTPM
Hypothalamus	16.5 nTPM
Hippocampus	14.6 nTPM

Eccentric medium spiny neuron	2.4 nTPM
Hypothalamus	2.9 nTPM
Basal ganglia	2.8 nTPM
Amygdala	2.3 nTPM
Cerebral cortex	2.3 nTPM
Hippocampus	2.1 nTPM
Thalamus	2.1 nTPM