Single cell type - NAMPT - The Human Protein Atlas

NAMPT

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NAMPT
Gene descriptionⁱ Full gene name according to HGNC.	Nicotinamide phosphoribosyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neutrophils - Degranulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Monocytes, Langerhans cells, Macrophages, Serous glandular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.44
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Endothelial cell, Leukocyte, Vascular associated smooth muscle cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Monocytes, Langerhans cells, Macrophages, Serous glandular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Endothelial cell, Leukocyte, Vascular associated smooth muscle cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NAMPT is part of cluster 74 Neutrophils - Degranulation with confidenceⁱ 1
174 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MMP25	Matrix metallopeptidase 25	0.7751	74
CXCR2	C-X-C motif chemokine receptor 2	0.7697	74
PROK2	Prokineticin 2	0.7623	74
FCGR3B	Fc gamma receptor IIIb	0.7610	74
CXCR1	C-X-C motif chemokine receptor 1	0.7505	74
TNFRSF10C	TNF receptor superfamily member 10c	0.7491	74
VNN2	Vanin 2	0.7448	74
PGLYRP1	Peptidoglycan recognition protein 1	0.7421	74
FPR1	Formyl peptide receptor 1	0.7340	74
LINC02218	Long intergenic non-protein coding RNA 2218	0.7329	74
ENSG00000258529	Novel protein	0.7242	74
NABP1	Nucleic acid binding protein 1	0.7223	74
TLR6	Toll like receptor 6	0.7127	74
ADGRG3	Adhesion G protein-coupled receptor G3	0.7060	74
BCL6	BCL6 transcription repressor	0.6979	74

IMMUNE CELLS

NAMPT is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 0.89
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000285133	Novel protein	1.0000	35
FNIP1	Folliculin interacting protein 1	1.0000	35
RESF1	Retroelement silencing factor 1	1.0000	35
STAT5B	Signal transducer and activator of transcription 5B	1.0000	35
EGLN1	Egl-9 family hypoxia inducible factor 1	1.0000	35
STAU1	Staufen double-stranded RNA binding protein 1	1.0000	35
MCM9	Minichromosome maintenance 9 homologous recombination repair factor	1.0000	35
CFLAR	CASP8 and FADD like apoptosis regulator	1.0000	35
GDPD3	Glycerophosphodiester phosphodiesterase domain containing 3	0.9762	35
PTP4A1	Protein tyrosine phosphatase 4A1	0.9762	35
TDP2	Tyrosyl-DNA phosphodiesterase 2	0.9762	35
DHRS12	Dehydrogenase/reductase 12	0.9762	35
BMX	BMX non-receptor tyrosine kinase	0.9762	35
ABHD4	Abhydrolase domain containing 4, N-acyl phospholipase B	0.9762	35
RAB36	RAB36, member RAS oncogene family	0.9762	4

Adipocytes	557.4 nTPM
Adipose tissue	954.4 nTPM
Breast	160.3 nTPM

Alveolar cells type 1	162.1 nTPM
Lung	162.1 nTPM

Alveolar cells type 2	531.2 nTPM
Lung	531.2 nTPM

Astrocytes	11.5 nTPM
Brain	11.5 nTPM

B-cells	189.1 nTPM
Skin	1014.6 nTPM
Adipose tissue	411.5 nTPM
Esophagus	159.3 nTPM
Salivary gland	155.0 nTPM
Spleen	127.0 nTPM
Lung	122.1 nTPM
Thymus	118.9 nTPM
Lymph node	88.2 nTPM
Stomach	86.5 nTPM
Liver	72.5 nTPM
Kidney	57.2 nTPM
Bone marrow	28.2 nTPM
PBMC	16.9 nTPM

Basal squamous epithelial cells	180.8 nTPM
Esophagus	180.8 nTPM

Ciliated cells	228.7 nTPM
Fallopian tube	433.5 nTPM
Bronchus	174.8 nTPM
Endometrium	171.6 nTPM
Lung	134.8 nTPM

Club cells	308.7 nTPM
Lung	392.2 nTPM
Prostate	289.6 nTPM
Bronchus	244.2 nTPM

Dendritic cells	119.4 nTPM
Adipose tissue	202.8 nTPM
PBMC	36.0 nTPM

Endothelial cells	397.3 nTPM
Lung	939.5 nTPM
Salivary gland	717.6 nTPM
Vascular	701.2 nTPM
Skin	611.4 nTPM
Skeletal muscle	601.6 nTPM
Fallopian tube	565.4 nTPM
Tongue	505.0 nTPM
Prostate	459.6 nTPM
Thymus	455.5 nTPM
Endometrium	302.4 nTPM
Liver	292.2 nTPM
Esophagus	216.8 nTPM
Ovary	175.3 nTPM
Pancreas	155.1 nTPM
Testis	125.1 nTPM
Heart muscle	120.0 nTPM
Placenta	108.4 nTPM
Breast	98.4 nTPM

Enteroendocrine cells	97.8 nTPM
Colon	165.8 nTPM
Small intestine	75.5 nTPM
Rectum	52.0 nTPM

Fibroblasts	482.5 nTPM
Lung	1110.5 nTPM
Salivary gland	939.3 nTPM
Vascular	852.1 nTPM
Skin	729.7 nTPM
Fallopian tube	717.4 nTPM
Stomach	704.7 nTPM
Thymus	630.7 nTPM
Adipose tissue	531.5 nTPM
Skeletal muscle	459.9 nTPM
Prostate	376.2 nTPM
Esophagus	216.8 nTPM
Liver	185.0 nTPM
Breast	106.2 nTPM
Pancreas	61.3 nTPM
Heart muscle	54.3 nTPM
Placenta	43.7 nTPM

Granulocytes	636.8 nTPM
Tongue	873.1 nTPM
Fallopian tube	729.1 nTPM
Lung	308.1 nTPM

Intestinal goblet cells	78.8 nTPM
Small intestine	105.1 nTPM
Colon	79.7 nTPM
Rectum	51.7 nTPM

Lymphatic endothelial cells	153.3 nTPM
Fallopian tube	279.3 nTPM
Ovary	27.3 nTPM

Bipolar cells	46.1 nTPM
Eye	46.1 nTPM

Cholangiocytes	179.3 nTPM
Liver	179.3 nTPM

Collecting duct cells	42.8 nTPM
Kidney	42.8 nTPM

Cone photoreceptor cells	23.8 nTPM
Eye	23.8 nTPM

Macrophages	1807.9 nTPM
Fallopian tube	3759.5 nTPM
Adipose tissue	3701.1 nTPM
Stomach	3238.4 nTPM
Skeletal muscle	2734.6 nTPM
Spleen	2621.5 nTPM
Salivary gland	2416.7 nTPM
Tongue	2252.4 nTPM
Vascular	1905.8 nTPM
Testis	1877.8 nTPM
Kidney	1524.0 nTPM
Thymus	1362.5 nTPM
Skin	1086.4 nTPM
Prostate	1011.4 nTPM
Endometrium	1007.9 nTPM
Lung	999.0 nTPM
Esophagus	986.4 nTPM
Breast	860.1 nTPM
Bone marrow	667.9 nTPM
Pancreas	337.1 nTPM

Paneth cells	65.1 nTPM
Colon	79.6 nTPM
Rectum	60.5 nTPM
Small intestine	55.3 nTPM

Plasma cells	221.8 nTPM
Salivary gland	603.0 nTPM
Fallopian tube	568.0 nTPM
Esophagus	145.5 nTPM
Stomach	131.9 nTPM
Liver	122.2 nTPM
Spleen	86.8 nTPM
Thymus	72.9 nTPM
Bone marrow	43.8 nTPM

Schwann cells	392.2 nTPM
Adipose tissue	816.3 nTPM
Vascular	288.4 nTPM
Esophagus	71.9 nTPM

Serous glandular cells	1795.9 nTPM
Salivary gland	2955.4 nTPM
Tongue	636.4 nTPM

Smooth muscle cells	481.4 nTPM
Tongue	1260.4 nTPM
Salivary gland	1093.0 nTPM
Skin	871.6 nTPM
Fallopian tube	813.1 nTPM
Skeletal muscle	522.3 nTPM
Lung	490.2 nTPM
Thymus	451.2 nTPM
Prostate	436.7 nTPM
Adipose tissue	404.4 nTPM
Vascular	372.8 nTPM
Liver	252.2 nTPM
Breast	173.0 nTPM
Endometrium	168.6 nTPM
Ovary	150.3 nTPM
Esophagus	145.4 nTPM
Placenta	98.0 nTPM

Suprabasal keratinocytes	380.9 nTPM
Tongue	505.8 nTPM
Skin	256.0 nTPM

T-cells	212.4 nTPM
Tongue	592.6 nTPM
Skin	478.8 nTPM
Vascular	469.1 nTPM
Adipose tissue	446.9 nTPM
Colon	342.2 nTPM
Endometrium	291.5 nTPM
Fallopian tube	219.2 nTPM
Lung	208.3 nTPM
Breast	203.2 nTPM
Skeletal muscle	182.6 nTPM
Salivary gland	180.5 nTPM
Thymus	132.5 nTPM
Stomach	123.7 nTPM
Spleen	117.7 nTPM
Esophagus	104.6 nTPM
Prostate	104.0 nTPM
Liver	96.9 nTPM
Lymph node	91.6 nTPM
Kidney	35.5 nTPM
Bone marrow	26.0 nTPM
PBMC	12.7 nTPM

Undifferentiated cells	105.6 nTPM
Small intestine	146.5 nTPM
Colon	105.1 nTPM
Rectum	65.2 nTPM

Amygdala excitatory	31.4 nTPM
Basal ganglia	36.5 nTPM
Thalamus	34.9 nTPM
Cerebral cortex	30.1 nTPM
Hippocampus	29.5 nTPM
Hypothalamus	29.5 nTPM
Amygdala	27.6 nTPM

Astrocyte	75.7 nTPM
Spinal cord	479.7 nTPM
Medulla oblongata	110.0 nTPM
Hypothalamus	55.7 nTPM
Pons	37.4 nTPM
Basal ganglia	28.4 nTPM
Amygdala	23.9 nTPM
Cerebral cortex	21.7 nTPM
Hippocampus	21.1 nTPM
Thalamus	20.3 nTPM
Midbrain	19.4 nTPM
Cerebellum	14.7 nTPM

Bergmann glia	16.0 nTPM
Medulla oblongata	21.3 nTPM
Cerebellum	18.2 nTPM
Pons	8.6 nTPM

Central nervous system macrophage	95.7 nTPM
Spinal cord	400.7 nTPM
Hypothalamus	169.1 nTPM
Medulla oblongata	88.8 nTPM
Pons	85.7 nTPM
Amygdala	64.1 nTPM
Basal ganglia	47.8 nTPM
Midbrain	43.1 nTPM
Thalamus	41.7 nTPM
Cerebellum	39.4 nTPM
Cerebral cortex	36.5 nTPM
Hippocampus	35.7 nTPM

Cerebellar inhibitory	43.2 nTPM
Pons	47.8 nTPM
Spinal cord	46.7 nTPM
Medulla oblongata	41.8 nTPM
Midbrain	40.7 nTPM
Cerebellum	39.0 nTPM

Cge interneuron	41.9 nTPM
Thalamus	51.1 nTPM
Cerebral cortex	46.1 nTPM
Midbrain	42.5 nTPM
Basal ganglia	41.4 nTPM
Amygdala	40.0 nTPM
Hippocampus	38.9 nTPM
Hypothalamus	33.3 nTPM

Choroid plexus epithelial cell	27.8 nTPM
Medulla oblongata	34.3 nTPM
Hippocampus	30.5 nTPM
Basal ganglia	29.8 nTPM
Thalamus	16.4 nTPM

Committed oligodendrocyte precursor	22.3 nTPM
Medulla oblongata	37.4 nTPM
Midbrain	26.9 nTPM
Amygdala	25.9 nTPM
Hypothalamus	25.3 nTPM
Thalamus	21.6 nTPM
Basal ganglia	19.7 nTPM
Pons	19.5 nTPM
Spinal cord	18.4 nTPM
Hippocampus	18.1 nTPM
Cerebral cortex	17.7 nTPM
Cerebellum	14.3 nTPM

Deep-layer corticothalamic and 6b	29.7 nTPM
Basal ganglia	33.5 nTPM
Hippocampus	31.7 nTPM
Amygdala	30.9 nTPM
Cerebral cortex	29.2 nTPM
Midbrain	27.7 nTPM
Hypothalamus	24.9 nTPM

Deep-layer intratelencephalic	28.3 nTPM
Basal ganglia	31.4 nTPM
Cerebral cortex	29.6 nTPM
Hippocampus	29.5 nTPM
Amygdala	28.3 nTPM
Hypothalamus	22.9 nTPM

Deep-layer near-projecting	30.5 nTPM
Hippocampus	36.1 nTPM
Cerebral cortex	32.3 nTPM
Basal ganglia	31.7 nTPM
Amygdala	28.9 nTPM
Hypothalamus	23.3 nTPM