Single cell type - IVNS1ABP - The Human Protein Atlas

IVNS1ABP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IVNS1ABP
Gene descriptionⁱ Full gene name according to HGNC.	Influenza virus NS1A binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neutrophils - Degranulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Langerhans cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Langerhans cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

IVNS1ABP is part of cluster 74 Neutrophils - Degranulation with confidenceⁱ 1
174 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CASS4	Cas scaffold protein family member 4	0.8000	74
NABP1	Nucleic acid binding protein 1	0.7547	74
MMP25	Matrix metallopeptidase 25	0.7367	74
PROK2	Prokineticin 2	0.7367	74
CXCR1	C-X-C motif chemokine receptor 1	0.7273	74
FCGR3B	Fc gamma receptor IIIb	0.7268	74
PGLYRP1	Peptidoglycan recognition protein 1	0.7226	74
LINC02218	Long intergenic non-protein coding RNA 2218	0.7182	74
RNF149	Ring finger protein 149	0.7157	74
CXCR2	C-X-C motif chemokine receptor 2	0.7128	74
LITAF	Lipopolysaccharide induced TNF factor	0.7127	74
DEFA3	Defensin alpha 3	0.7121	74
VNN2	Vanin 2	0.7114	74
CEACAM8	CEA cell adhesion molecule 8	0.7110	74
TNFRSF10C	TNF receptor superfamily member 10c	0.7083	74

IMMUNE CELLS

IVNS1ABP is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 1
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RELL1	RELT like 1	1.0000	21
PSTPIP1	Proline-serine-threonine phosphatase interacting protein 1	0.9762	21
GNG10	G protein subunit gamma 10	0.9762	21
DEFA3	Defensin alpha 3	0.9762	21
DEFA1	Defensin alpha 1	0.9762	21
MARCHF5	Membrane associated ring-CH-type finger 5	0.9762	21
ABAT	4-aminobutyrate aminotransferase	0.9762	21
TMEM43	Transmembrane protein 43	0.9762	21
RBMS1	RNA binding motif single stranded interacting protein 1	0.9762	21
FCGR2A	Fc gamma receptor IIa	0.9762	21
TSHZ3	Teashirt zinc finger homeobox 3	0.9762	21
MGRN1	Mahogunin ring finger 1	0.9762	21
SBNO2	Strawberry notch homolog 2	0.9524	21
GCA	Grancalcin	0.9524	21
SPARC	Secreted protein acidic and cysteine rich	0.9524	21

Adipocytes	150.5 nTPM
Adipose tissue	211.6 nTPM
Breast	89.5 nTPM

Alveolar cells type 1	26.1 nTPM
Lung	26.1 nTPM

Alveolar cells type 2	33.6 nTPM
Lung	33.6 nTPM

Astrocytes	13.0 nTPM
Brain	13.0 nTPM

B-cells	55.6 nTPM
Stomach	112.2 nTPM
Esophagus	106.2 nTPM
Skin	94.9 nTPM
Lymph node	82.5 nTPM
Adipose tissue	78.6 nTPM
Spleen	56.7 nTPM
Thymus	45.3 nTPM
Salivary gland	39.2 nTPM
Bone marrow	26.9 nTPM
Lung	25.5 nTPM
PBMC	24.6 nTPM
Kidney	20.8 nTPM
Liver	9.7 nTPM

Basal squamous epithelial cells	127.9 nTPM
Esophagus	127.9 nTPM

Ciliated cells	50.8 nTPM
Endometrium	82.8 nTPM
Bronchus	42.7 nTPM
Lung	41.4 nTPM
Fallopian tube	36.5 nTPM

Club cells	43.5 nTPM
Prostate	50.6 nTPM
Lung	45.2 nTPM
Bronchus	34.7 nTPM

Dendritic cells	27.9 nTPM
Adipose tissue	41.4 nTPM
PBMC	14.4 nTPM

Endothelial cells	57.7 nTPM
Skin	98.4 nTPM
Pancreas	87.9 nTPM
Salivary gland	82.8 nTPM
Prostate	73.1 nTPM
Skeletal muscle	70.9 nTPM
Endometrium	65.4 nTPM
Ovary	63.9 nTPM
Thymus	59.8 nTPM
Esophagus	57.8 nTPM
Tongue	55.4 nTPM
Vascular	52.3 nTPM
Fallopian tube	51.9 nTPM
Placenta	51.1 nTPM
Heart muscle	50.8 nTPM
Lung	48.1 nTPM
Testis	33.9 nTPM
Breast	22.0 nTPM
Liver	13.9 nTPM

Enteroendocrine cells	62.0 nTPM
Colon	87.7 nTPM
Rectum	50.3 nTPM
Small intestine	48.1 nTPM

Fibroblasts	31.8 nTPM
Stomach	59.1 nTPM
Placenta	58.5 nTPM
Skin	46.1 nTPM
Fallopian tube	43.0 nTPM
Skeletal muscle	34.0 nTPM
Esophagus	33.8 nTPM
Breast	33.5 nTPM
Heart muscle	28.2 nTPM
Lung	26.9 nTPM
Salivary gland	25.8 nTPM
Liver	24.9 nTPM
Thymus	21.7 nTPM
Prostate	21.1 nTPM
Adipose tissue	19.6 nTPM
Vascular	16.7 nTPM
Pancreas	16.6 nTPM

Granulocytes	20.7 nTPM
Fallopian tube	32.9 nTPM
Lung	14.6 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	107.4 nTPM
Small intestine	140.0 nTPM
Rectum	98.0 nTPM
Colon	84.1 nTPM

Lymphatic endothelial cells	36.9 nTPM
Fallopian tube	63.0 nTPM
Ovary	10.9 nTPM

Bipolar cells	16.0 nTPM
Eye	16.0 nTPM

Cholangiocytes	26.7 nTPM
Liver	26.7 nTPM

Collecting duct cells	101.1 nTPM
Kidney	101.1 nTPM

Cone photoreceptor cells	17.0 nTPM
Eye	17.0 nTPM

Macrophages	159.4 nTPM
Skin	347.7 nTPM
Fallopian tube	314.1 nTPM
Adipose tissue	284.3 nTPM
Stomach	252.1 nTPM
Spleen	240.6 nTPM
Skeletal muscle	239.8 nTPM
Esophagus	215.8 nTPM
Vascular	147.5 nTPM
Thymus	127.3 nTPM
Lung	126.9 nTPM
Salivary gland	125.1 nTPM
Tongue	121.4 nTPM
Breast	118.3 nTPM
Endometrium	75.0 nTPM
Prostate	68.0 nTPM
Testis	63.9 nTPM
Kidney	59.3 nTPM
Pancreas	53.4 nTPM
Bone marrow	47.6 nTPM

Paneth cells	52.6 nTPM
Rectum	86.9 nTPM
Colon	39.8 nTPM
Small intestine	31.1 nTPM

Plasma cells	39.4 nTPM
Esophagus	98.8 nTPM
Salivary gland	39.4 nTPM
Fallopian tube	38.9 nTPM
Thymus	38.6 nTPM
Stomach	35.6 nTPM
Spleen	32.7 nTPM
Liver	19.0 nTPM
Bone marrow	12.1 nTPM

Schwann cells	51.1 nTPM
Adipose tissue	83.9 nTPM
Esophagus	47.9 nTPM
Vascular	21.4 nTPM

Serous glandular cells	96.7 nTPM
Salivary gland	144.8 nTPM
Tongue	48.6 nTPM

Smooth muscle cells	28.9 nTPM
Salivary gland	66.4 nTPM
Esophagus	50.5 nTPM
Skin	49.2 nTPM
Skeletal muscle	39.3 nTPM
Endometrium	38.4 nTPM
Breast	32.9 nTPM
Adipose tissue	24.9 nTPM
Thymus	23.8 nTPM
Tongue	21.6 nTPM
Placenta	20.5 nTPM
Prostate	18.9 nTPM
Liver	17.8 nTPM
Fallopian tube	16.3 nTPM
Ovary	16.0 nTPM
Lung	12.9 nTPM
Vascular	12.3 nTPM

Suprabasal keratinocytes	110.1 nTPM
Skin	181.4 nTPM
Tongue	38.8 nTPM

T-cells	113.5 nTPM
Adipose tissue	241.5 nTPM
Endometrium	213.8 nTPM
Stomach	185.9 nTPM
Breast	168.7 nTPM
Fallopian tube	159.2 nTPM
Colon	152.1 nTPM
Skin	144.0 nTPM
Esophagus	114.4 nTPM
Skeletal muscle	113.8 nTPM
Vascular	104.9 nTPM
Spleen	104.4 nTPM
Tongue	99.1 nTPM
Lymph node	94.9 nTPM
Lung	83.7 nTPM
Thymus	82.8 nTPM
Salivary gland	81.7 nTPM
Bone marrow	74.3 nTPM
Prostate	57.9 nTPM
Liver	37.7 nTPM
Kidney	35.5 nTPM
PBMC	32.4 nTPM

Undifferentiated cells	66.6 nTPM
Small intestine	87.0 nTPM
Rectum	69.9 nTPM
Colon	42.8 nTPM

Amygdala excitatory	21.1 nTPM
Thalamus	27.7 nTPM
Basal ganglia	22.6 nTPM
Hypothalamus	21.9 nTPM
Cerebral cortex	19.4 nTPM
Hippocampus	18.7 nTPM
Amygdala	16.5 nTPM

Astrocyte	22.5 nTPM
Thalamus	31.3 nTPM
Cerebellum	29.9 nTPM
Midbrain	29.7 nTPM
Pons	28.3 nTPM
Basal ganglia	21.7 nTPM
Spinal cord	20.2 nTPM
Medulla oblongata	19.8 nTPM
Hypothalamus	17.9 nTPM
Amygdala	16.7 nTPM
Hippocampus	16.3 nTPM
Cerebral cortex	15.7 nTPM

Bergmann glia	25.2 nTPM
Pons	34.5 nTPM
Cerebellum	23.9 nTPM
Medulla oblongata	17.0 nTPM

Central nervous system macrophage	81.4 nTPM
Amygdala	99.5 nTPM
Basal ganglia	86.0 nTPM
Hypothalamus	85.7 nTPM
Cerebellum	85.5 nTPM
Pons	83.3 nTPM
Midbrain	81.1 nTPM
Thalamus	80.1 nTPM
Hippocampus	77.9 nTPM
Cerebral cortex	75.8 nTPM
Spinal cord	72.4 nTPM
Medulla oblongata	67.8 nTPM

Cerebellar inhibitory	39.1 nTPM
Midbrain	47.9 nTPM
Pons	38.7 nTPM
Medulla oblongata	36.8 nTPM
Cerebellum	36.2 nTPM
Spinal cord	35.7 nTPM

Cge interneuron	22.1 nTPM
Thalamus	27.4 nTPM
Basal ganglia	24.0 nTPM
Amygdala	22.0 nTPM
Midbrain	20.8 nTPM
Cerebral cortex	20.5 nTPM
Hippocampus	20.3 nTPM
Hypothalamus	19.4 nTPM

Choroid plexus epithelial cell	28.0 nTPM
Hippocampus	30.5 nTPM
Basal ganglia	30.3 nTPM
Medulla oblongata	26.6 nTPM
Thalamus	24.7 nTPM

Committed oligodendrocyte precursor	54.6 nTPM
Hypothalamus	71.0 nTPM
Amygdala	64.8 nTPM
Midbrain	62.2 nTPM
Spinal cord	58.9 nTPM
Cerebral cortex	53.8 nTPM
Thalamus	53.8 nTPM
Basal ganglia	52.0 nTPM
Hippocampus	48.6 nTPM
Pons	46.9 nTPM
Medulla oblongata	45.2 nTPM
Cerebellum	42.8 nTPM

Deep-layer corticothalamic and 6b	37.1 nTPM
Basal ganglia	52.2 nTPM
Amygdala	39.4 nTPM
Midbrain	38.8 nTPM
Cerebral cortex	35.1 nTPM
Hypothalamus	32.2 nTPM
Hippocampus	25.1 nTPM

Deep-layer intratelencephalic	18.9 nTPM
Basal ganglia	21.7 nTPM
Amygdala	21.1 nTPM
Cerebral cortex	19.8 nTPM
Hippocampus	16.1 nTPM
Hypothalamus	15.8 nTPM

Deep-layer near-projecting	21.6 nTPM
Amygdala	27.1 nTPM
Basal ganglia	24.5 nTPM
Cerebral cortex	21.3 nTPM
Hypothalamus	19.9 nTPM
Hippocampus	15.0 nTPM