Single cell type - SUGT1 - The Human Protein Atlas

SUGT1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SUGT1
Gene descriptionⁱ Full gene name according to HGNC.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.28
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SUGT1 is part of cluster 15 Non-specific - Mixed function with confidenceⁱ 1
295 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPP30	Ribonuclease P/MRP subunit p30	0.4983	15
SAP18	Sin3A associated protein 18	0.4894	80
IMMT	Inner membrane mitochondrial protein	0.4584	15
PPID	Peptidylprolyl isomerase D	0.4522	15
LZIC	Leucine zipper and CTNNBIP1 domain containing	0.4416	11
RTRAF	RNA transcription, translation and transport factor	0.4387	15
TCP1	T-complex 1	0.4354	15
DNAJA1	DnaJ heat shock protein family (Hsp40) member A1	0.4214	80
PSMD4	Proteasome 26S subunit ubiquitin receptor, non-ATPase 4	0.4201	15
FAM50A	Family with sequence similarity 50 member A	0.4188	58
CACYBP	Calcyclin binding protein	0.4072	80
ZCRB1	Zinc finger CCHC-type and RNA binding motif containing 1	0.4059	70
NUB1	Negative regulator of ubiquitin like proteins 1	0.4045	14
SLU7	SLU7 homolog, splicing factor	0.4011	55
PCM1	Pericentriolar material 1	0.3904	55

IMMUNE CELLS

SUGT1 is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 0.99
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MOGS	Mannosyl-oligosaccharide glucosidase	0.9762	5
SEC61G	SEC61 translocon subunit gamma	0.9524	5
SCYL3	SCY1 like pseudokinase 3	0.9524	5
TP53I13	Tumor protein p53 inducible protein 13	0.9524	5
ATP2A1	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	0.9286	13
TRAM1	Translocation associated membrane protein 1	0.9286	13
TP53RK	TP53 regulating kinase	0.9286	5
KCNAB1	Potassium voltage-gated channel subfamily A regulatory beta subunit 1	0.9286	5
ORMDL1	ORMDL sphingolipid biosynthesis regulator 1	0.9286	5
ENTPD3	Ectonucleoside triphosphate diphosphohydrolase 3	0.9286	5
FUNDC2	FUN14 domain containing 2	0.9286	8
ILF2	Interleukin enhancer binding factor 2	0.9048	5
TMED4	Transmembrane p24 trafficking protein 4	0.9048	5
MTERF3	Mitochondrial transcription termination factor 3	0.9048	8
HYOU1	Hypoxia up-regulated 1	0.9048	5

Adipocytes	76.1 nTPM
Adipose tissue	77.9 nTPM
Breast	74.3 nTPM

Alveolar cells type 1	69.6 nTPM
Lung	69.6 nTPM

Alveolar cells type 2	58.1 nTPM
Lung	58.1 nTPM

Astrocytes	21.1 nTPM
Brain	21.1 nTPM

B-cells	45.1 nTPM
Esophagus	59.0 nTPM
Lung	56.3 nTPM
Adipose tissue	55.1 nTPM
Salivary gland	53.5 nTPM
Liver	48.3 nTPM
Lymph node	46.8 nTPM
PBMC	46.2 nTPM
Thymus	45.4 nTPM
Skin	44.0 nTPM
Spleen	39.9 nTPM
Stomach	37.1 nTPM
Bone marrow	28.5 nTPM
Kidney	26.0 nTPM

Ciliated cells	90.7 nTPM
Endometrium	109.9 nTPM
Lung	97.2 nTPM
Fallopian tube	85.5 nTPM
Bronchus	70.2 nTPM

Club cells	51.8 nTPM
Prostate	57.9 nTPM
Bronchus	51.9 nTPM
Lung	45.5 nTPM

Dendritic cells	72.6 nTPM
PBMC	82.7 nTPM
Adipose tissue	62.5 nTPM

Endothelial cells	68.0 nTPM
Pancreas	100.8 nTPM
Heart muscle	87.4 nTPM
Lung	79.7 nTPM
Placenta	78.3 nTPM
Salivary gland	72.5 nTPM
Prostate	72.4 nTPM
Fallopian tube	71.5 nTPM
Skeletal muscle	68.1 nTPM
Thymus	67.8 nTPM
Breast	67.7 nTPM
Vascular	66.6 nTPM
Tongue	64.6 nTPM
Endometrium	63.8 nTPM
Ovary	62.1 nTPM
Testis	58.6 nTPM
Skin	52.0 nTPM
Liver	46.6 nTPM
Esophagus	44.0 nTPM

Enteroendocrine cells	47.7 nTPM
Colon	76.9 nTPM
Small intestine	34.3 nTPM
Rectum	31.9 nTPM

Fibroblasts	68.6 nTPM
Pancreas	111.1 nTPM
Heart muscle	104.1 nTPM
Fallopian tube	80.3 nTPM
Prostate	76.6 nTPM
Lung	71.8 nTPM
Adipose tissue	70.7 nTPM
Skeletal muscle	69.0 nTPM
Vascular	67.7 nTPM
Placenta	62.8 nTPM
Salivary gland	62.5 nTPM
Stomach	62.0 nTPM
Thymus	59.6 nTPM
Breast	59.5 nTPM
Esophagus	57.2 nTPM
Liver	42.7 nTPM
Skin	39.6 nTPM

Granulocytes	86.9 nTPM
Fallopian tube	104.5 nTPM
Lung	88.2 nTPM
Tongue	67.9 nTPM

Intestinal goblet cells	52.6 nTPM
Colon	74.1 nTPM
Rectum	43.7 nTPM
Small intestine	40.0 nTPM

Lymphatic endothelial cells	76.1 nTPM
Fallopian tube	86.8 nTPM
Ovary	65.5 nTPM

Macrophages	57.2 nTPM
Breast	91.5 nTPM
Lung	86.4 nTPM
Endometrium	70.7 nTPM
Prostate	70.6 nTPM
Adipose tissue	67.4 nTPM
Fallopian tube	62.7 nTPM
Skeletal muscle	62.6 nTPM
Vascular	58.9 nTPM
Tongue	57.5 nTPM
Thymus	57.3 nTPM
Esophagus	55.2 nTPM
Kidney	54.9 nTPM
Salivary gland	53.8 nTPM
Testis	53.3 nTPM
Spleen	42.1 nTPM
Bone marrow	36.5 nTPM
Stomach	36.0 nTPM
Pancreas	34.9 nTPM
Skin	34.5 nTPM

Basal keratinocytes	59.7 nTPM
Tongue	79.5 nTPM
Skin	39.8 nTPM

Basal prostatic cells	65.4 nTPM
Prostate	65.4 nTPM

Basal respiratory cells	65.1 nTPM
Bronchus	65.1 nTPM

Basal squamous epithelial cells	33.5 nTPM
Esophagus	33.5 nTPM

Paneth cells	47.9 nTPM
Rectum	52.2 nTPM
Small intestine	51.8 nTPM
Colon	39.8 nTPM

Plasma cells	63.3 nTPM
Thymus	84.0 nTPM
Spleen	79.9 nTPM
Liver	66.6 nTPM
Salivary gland	64.5 nTPM
Esophagus	62.4 nTPM
Stomach	52.4 nTPM
Fallopian tube	48.6 nTPM
Bone marrow	48.3 nTPM

Schwann cells	76.4 nTPM
Vascular	84.6 nTPM
Adipose tissue	72.6 nTPM
Esophagus	71.9 nTPM

Serous glandular cells	51.5 nTPM
Salivary gland	63.3 nTPM
Tongue	39.8 nTPM

Smooth muscle cells	67.0 nTPM
Ovary	84.0 nTPM
Fallopian tube	81.5 nTPM
Prostate	80.9 nTPM
Breast	76.1 nTPM
Vascular	75.7 nTPM
Adipose tissue	72.6 nTPM
Endometrium	70.7 nTPM
Tongue	67.1 nTPM
Skeletal muscle	66.5 nTPM
Salivary gland	66.0 nTPM
Placenta	64.5 nTPM
Thymus	60.8 nTPM
Skin	58.2 nTPM
Lung	55.3 nTPM
Liver	46.3 nTPM
Esophagus	45.6 nTPM

Suprabasal keratinocytes	80.1 nTPM
Tongue	118.9 nTPM
Skin	41.3 nTPM

T-cells	60.1 nTPM
Breast	111.7 nTPM
Adipose tissue	86.5 nTPM
Fallopian tube	82.8 nTPM
Prostate	76.5 nTPM
Endometrium	74.7 nTPM
Lung	73.0 nTPM
Colon	72.1 nTPM
Skeletal muscle	62.8 nTPM
Liver	55.2 nTPM
Kidney	54.1 nTPM
PBMC	54.0 nTPM
Salivary gland	52.4 nTPM
Thymus	51.3 nTPM
Tongue	49.9 nTPM
Skin	49.1 nTPM
Vascular	49.0 nTPM
Esophagus	46.2 nTPM
Spleen	45.0 nTPM
Lymph node	42.3 nTPM
Stomach	40.2 nTPM
Bone marrow	33.9 nTPM

Undifferentiated cells	64.2 nTPM
Colon	86.4 nTPM
Small intestine	55.7 nTPM
Rectum	50.3 nTPM

Amygdala excitatory	55.9 nTPM
Hypothalamus	61.9 nTPM
Hippocampus	59.3 nTPM
Basal ganglia	56.8 nTPM
Thalamus	56.7 nTPM
Amygdala	50.8 nTPM
Cerebral cortex	50.0 nTPM

Astrocyte	52.5 nTPM
Amygdala	69.4 nTPM
Hippocampus	56.4 nTPM
Basal ganglia	55.7 nTPM
Cerebellum	55.5 nTPM
Cerebral cortex	53.7 nTPM
Midbrain	53.6 nTPM
Thalamus	52.6 nTPM
Hypothalamus	50.7 nTPM
Pons	46.6 nTPM
Medulla oblongata	45.1 nTPM
Spinal cord	37.9 nTPM

Bergmann glia	58.0 nTPM
Pons	63.3 nTPM
Cerebellum	59.6 nTPM
Medulla oblongata	51.1 nTPM

Central nervous system macrophage	58.8 nTPM
Amygdala	78.9 nTPM
Midbrain	63.9 nTPM
Cerebellum	60.9 nTPM
Thalamus	60.7 nTPM
Pons	58.9 nTPM
Hippocampus	56.5 nTPM
Hypothalamus	56.5 nTPM
Basal ganglia	56.4 nTPM
Spinal cord	55.1 nTPM
Cerebral cortex	52.4 nTPM
Medulla oblongata	47.2 nTPM

Cerebellar inhibitory	51.9 nTPM
Spinal cord	57.7 nTPM
Midbrain	51.0 nTPM
Pons	50.7 nTPM
Medulla oblongata	50.6 nTPM
Cerebellum	49.2 nTPM

Cge interneuron	66.8 nTPM
Thalamus	76.9 nTPM
Hypothalamus	71.6 nTPM
Hippocampus	67.3 nTPM
Amygdala	64.2 nTPM
Midbrain	63.3 nTPM
Cerebral cortex	62.5 nTPM
Basal ganglia	62.1 nTPM

Choroid plexus epithelial cell	77.1 nTPM
Basal ganglia	106.4 nTPM
Hippocampus	86.0 nTPM
Medulla oblongata	64.0 nTPM
Thalamus	52.1 nTPM

Committed oligodendrocyte precursor	62.3 nTPM
Thalamus	79.2 nTPM
Hypothalamus	73.7 nTPM
Amygdala	72.7 nTPM
Midbrain	65.5 nTPM
Basal ganglia	65.2 nTPM
Pons	63.7 nTPM
Medulla oblongata	63.3 nTPM
Cerebral cortex	59.5 nTPM
Hippocampus	54.8 nTPM
Cerebellum	47.6 nTPM
Spinal cord	40.5 nTPM

Deep-layer corticothalamic and 6b	47.7 nTPM
Hypothalamus	57.7 nTPM
Amygdala	48.8 nTPM
Midbrain	48.8 nTPM
Hippocampus	46.2 nTPM
Cerebral cortex	44.3 nTPM
Basal ganglia	40.3 nTPM

Deep-layer intratelencephalic	50.1 nTPM
Hypothalamus	56.4 nTPM
Hippocampus	52.3 nTPM
Amygdala	49.8 nTPM
Cerebral cortex	47.6 nTPM
Basal ganglia	44.3 nTPM

Deep-layer near-projecting	57.7 nTPM
Hypothalamus	64.6 nTPM
Hippocampus	64.1 nTPM
Cerebral cortex	54.7 nTPM
Amygdala	53.5 nTPM
Basal ganglia	51.4 nTPM

Eccentric medium spiny neuron	75.3 nTPM
Hypothalamus	85.8 nTPM
Thalamus	79.5 nTPM
Hippocampus	78.3 nTPM
Basal ganglia	71.0 nTPM
Amygdala	68.8 nTPM
Cerebral cortex	68.5 nTPM