Single cell type - SLU7 - The Human Protein Atlas

SLU7

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLU7
Gene descriptionⁱ Full gene name according to HGNC.	SLU7 homolog, splicing factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.28
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLU7 is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CIR1	Corepressor interacting with RBPJ, CIR1	0.6051	39
GGNBP2	Gametogenetin binding protein 2	0.5928	70
ARL14EP	ADP ribosylation factor like GTPase 14 effector protein	0.5610	70
STAG2	Stromal antigen 2	0.5354	55
TTF1	Transcription termination factor 1	0.5265	55
USP8	Ubiquitin specific peptidase 8	0.5245	55
LARP7	La ribonucleoprotein 7, transcriptional regulator	0.5216	39
RNF20	Ring finger protein 20	0.4867	70
ANKRD11	Ankyrin repeat domain containing 11	0.4835	28
ROCK1	Rho associated coiled-coil containing protein kinase 1	0.4833	32
RSF1	Remodeling and spacing factor 1	0.4813	55
ZNF766	Zinc finger protein 766	0.4744	55
GCC2	GRIP and coiled-coil domain containing 2	0.4682	55
SH3GLB1	SH3 domain containing GRB2 like, endophilin B1	0.4669	70
COPS4	COP9 signalosome subunit 4	0.4642	39

IMMUNE CELLS

SLU7 is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 1
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF267	Zinc finger protein 267	1.0000	35
RAF1	Raf-1 proto-oncogene, serine/threonine kinase	0.9762	35
IRF9	Interferon regulatory factor 9	0.9762	35
ZNF281	Zinc finger protein 281	0.9762	35
USP15	Ubiquitin specific peptidase 15	0.9762	35
TACC3	Transforming acidic coiled-coil containing protein 3	0.9762	35
H2BC11	H2B clustered histone 11	0.9762	35
STK17B	Serine/threonine kinase 17b	0.9762	35
CCDC28A	Coiled-coil domain containing 28A	0.9762	35
HTATIP2	HIV-1 Tat interactive protein 2	0.9524	35
MED31	Mediator complex subunit 31	0.9524	35
VRK3	VRK serine/threonine kinase 3	0.9524	35
MAP1LC3A	Microtubule associated protein 1 light chain 3 alpha	0.9524	35
KIAA0319	KIAA0319	0.9524	20
GTF2B	General transcription factor IIB	0.9524	35

Adipocytes	39.2 nTPM
Adipose tissue	46.1 nTPM
Breast	32.4 nTPM

Alveolar cells type 1	29.9 nTPM
Lung	29.9 nTPM

Alveolar cells type 2	36.0 nTPM
Lung	36.0 nTPM

Astrocytes	9.3 nTPM
Brain	9.3 nTPM

B-cells	49.0 nTPM
Adipose tissue	86.0 nTPM
PBMC	66.2 nTPM
Salivary gland	63.7 nTPM
Kidney	57.2 nTPM
Liver	53.1 nTPM
Lung	52.3 nTPM
Thymus	51.7 nTPM
Lymph node	51.3 nTPM
Stomach	41.8 nTPM
Spleen	35.1 nTPM
Bone marrow	31.7 nTPM
Skin	28.8 nTPM
Esophagus	17.7 nTPM

Ciliated cells	37.6 nTPM
Lung	41.2 nTPM
Endometrium	39.9 nTPM
Fallopian tube	35.7 nTPM
Bronchus	33.4 nTPM

Club cells	45.5 nTPM
Bronchus	52.4 nTPM
Prostate	46.4 nTPM
Lung	37.8 nTPM

Dendritic cells	118.5 nTPM
Adipose tissue	161.5 nTPM
PBMC	75.5 nTPM

Endothelial cells	46.1 nTPM
Heart muscle	73.2 nTPM
Skeletal muscle	62.7 nTPM
Testis	61.0 nTPM
Salivary gland	50.3 nTPM
Prostate	50.2 nTPM
Vascular	47.8 nTPM
Ovary	47.5 nTPM
Tongue	47.0 nTPM
Fallopian tube	41.6 nTPM
Thymus	41.5 nTPM
Endometrium	41.2 nTPM
Placenta	40.3 nTPM
Breast	39.5 nTPM
Pancreas	38.8 nTPM
Lung	38.0 nTPM
Esophagus	37.6 nTPM
Skin	36.6 nTPM
Liver	35.3 nTPM

Enteroendocrine cells	32.1 nTPM
Colon	35.1 nTPM
Small intestine	30.9 nTPM
Rectum	30.2 nTPM

Fibroblasts	44.0 nTPM
Heart muscle	123.4 nTPM
Salivary gland	53.8 nTPM
Skeletal muscle	52.7 nTPM
Adipose tissue	52.7 nTPM
Prostate	48.8 nTPM
Vascular	47.8 nTPM
Pancreas	42.9 nTPM
Fallopian tube	35.2 nTPM
Esophagus	33.5 nTPM
Skin	32.9 nTPM
Thymus	32.9 nTPM
Placenta	30.9 nTPM
Lung	30.9 nTPM
Breast	30.6 nTPM
Stomach	28.8 nTPM
Liver	26.1 nTPM

Granulocytes	58.8 nTPM
Tongue	63.1 nTPM
Fallopian tube	61.5 nTPM
Lung	51.9 nTPM

Intestinal goblet cells	36.1 nTPM
Colon	39.4 nTPM
Rectum	36.5 nTPM
Small intestine	32.3 nTPM

Lymphatic endothelial cells	37.5 nTPM
Fallopian tube	58.6 nTPM
Ovary	16.4 nTPM

Macrophages	49.4 nTPM
Adipose tissue	98.1 nTPM
Fallopian tube	82.8 nTPM
Lung	77.7 nTPM
Testis	54.6 nTPM
Vascular	54.1 nTPM
Prostate	53.7 nTPM
Salivary gland	52.8 nTPM
Tongue	52.0 nTPM
Pancreas	49.3 nTPM
Skeletal muscle	49.0 nTPM
Endometrium	47.4 nTPM
Spleen	42.1 nTPM
Kidney	41.6 nTPM
Thymus	41.2 nTPM
Breast	32.6 nTPM
Bone marrow	32.4 nTPM
Skin	27.9 nTPM
Stomach	25.7 nTPM
Esophagus	24.4 nTPM

Basal keratinocytes	45.2 nTPM
Tongue	46.7 nTPM
Skin	43.8 nTPM

Basal respiratory cells	53.9 nTPM
Bronchus	53.9 nTPM

Basal squamous epithelial cells	22.6 nTPM
Esophagus	22.6 nTPM

Bipolar cells	61.8 nTPM
Eye	61.8 nTPM

Paneth cells	49.0 nTPM
Small intestine	69.1 nTPM
Colon	39.8 nTPM
Rectum	38.1 nTPM

Plasma cells	35.3 nTPM
Fallopian tube	51.8 nTPM
Esophagus	46.8 nTPM
Salivary gland	42.1 nTPM
Liver	37.6 nTPM
Thymus	34.5 nTPM
Stomach	33.5 nTPM
Spleen	26.9 nTPM
Bone marrow	9.1 nTPM

Schwann cells	50.7 nTPM
Adipose tissue	88.2 nTPM
Vascular	63.7 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	40.4 nTPM
Salivary gland	63.0 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	43.7 nTPM
Prostate	63.3 nTPM
Skeletal muscle	58.4 nTPM
Vascular	57.2 nTPM
Tongue	53.6 nTPM
Ovary	50.2 nTPM
Liver	48.0 nTPM
Placenta	46.9 nTPM
Salivary gland	43.4 nTPM
Adipose tissue	40.1 nTPM
Lung	38.8 nTPM
Fallopian tube	38.5 nTPM
Breast	34.8 nTPM
Skin	33.4 nTPM
Endometrium	32.8 nTPM
Thymus	30.8 nTPM
Esophagus	28.8 nTPM

Suprabasal keratinocytes	49.5 nTPM
Tongue	55.3 nTPM
Skin	43.7 nTPM

T-cells	55.3 nTPM
Adipose tissue	85.9 nTPM
Prostate	84.8 nTPM
Fallopian tube	78.5 nTPM
Tongue	71.1 nTPM
Liver	65.5 nTPM
Colon	65.3 nTPM
PBMC	65.1 nTPM
Lung	64.5 nTPM
Salivary gland	60.5 nTPM
Skeletal muscle	57.5 nTPM
Thymus	54.9 nTPM
Kidney	54.1 nTPM
Vascular	51.1 nTPM
Endometrium	48.9 nTPM
Breast	45.1 nTPM
Lymph node	42.7 nTPM
Skin	40.0 nTPM
Stomach	37.3 nTPM
Spleen	35.1 nTPM
Bone marrow	32.6 nTPM
Esophagus	21.9 nTPM

Undifferentiated cells	34.5 nTPM
Rectum	36.4 nTPM
Colon	34.5 nTPM
Small intestine	32.5 nTPM

Amygdala excitatory	18.7 nTPM
Hippocampus	23.9 nTPM
Cerebral cortex	20.2 nTPM
Basal ganglia	20.1 nTPM
Amygdala	17.3 nTPM
Thalamus	16.3 nTPM
Hypothalamus	14.3 nTPM

Astrocyte	12.6 nTPM
Cerebral cortex	14.0 nTPM
Amygdala	13.9 nTPM
Cerebellum	13.7 nTPM
Thalamus	13.7 nTPM
Medulla oblongata	13.0 nTPM
Hippocampus	12.9 nTPM
Midbrain	12.7 nTPM
Hypothalamus	11.9 nTPM
Pons	11.7 nTPM
Basal ganglia	11.4 nTPM
Spinal cord	9.8 nTPM

Bergmann glia	16.6 nTPM
Medulla oblongata	21.3 nTPM
Pons	14.4 nTPM
Cerebellum	14.1 nTPM

Central nervous system macrophage	26.5 nTPM
Amygdala	29.8 nTPM
Thalamus	29.1 nTPM
Cerebral cortex	28.7 nTPM
Midbrain	26.8 nTPM
Cerebellum	26.6 nTPM
Medulla oblongata	26.6 nTPM
Basal ganglia	26.4 nTPM
Hippocampus	25.9 nTPM
Hypothalamus	24.3 nTPM
Pons	24.1 nTPM
Spinal cord	23.6 nTPM

Cerebellar inhibitory	20.4 nTPM
Pons	24.9 nTPM
Cerebellum	24.3 nTPM
Midbrain	23.6 nTPM
Medulla oblongata	18.2 nTPM
Spinal cord	11.0 nTPM

Cge interneuron	29.7 nTPM
Thalamus	39.1 nTPM
Basal ganglia	30.7 nTPM
Midbrain	29.8 nTPM
Hippocampus	29.1 nTPM
Cerebral cortex	28.9 nTPM
Amygdala	27.0 nTPM
Hypothalamus	23.2 nTPM

Choroid plexus epithelial cell	15.3 nTPM
Thalamus	19.2 nTPM
Basal ganglia	16.4 nTPM
Medulla oblongata	14.5 nTPM
Hippocampus	11.1 nTPM

Committed oligodendrocyte precursor	17.2 nTPM
Hypothalamus	25.3 nTPM
Pons	22.1 nTPM
Amygdala	20.9 nTPM
Thalamus	20.5 nTPM
Midbrain	16.8 nTPM
Cerebral cortex	16.5 nTPM
Cerebellum	15.9 nTPM
Hippocampus	15.5 nTPM
Spinal cord	14.7 nTPM
Basal ganglia	13.1 nTPM
Medulla oblongata	7.7 nTPM

Deep-layer corticothalamic and 6b	21.7 nTPM
Midbrain	24.4 nTPM
Cerebral cortex	22.7 nTPM
Hippocampus	21.9 nTPM
Basal ganglia	21.6 nTPM
Amygdala	20.6 nTPM
Hypothalamus	19.0 nTPM

Deep-layer intratelencephalic	22.8 nTPM
Cerebral cortex	27.8 nTPM
Hippocampus	23.9 nTPM
Basal ganglia	23.5 nTPM
Hypothalamus	20.2 nTPM
Amygdala	18.7 nTPM

Deep-layer near-projecting	21.6 nTPM
Cerebral cortex	26.0 nTPM
Basal ganglia	24.0 nTPM
Amygdala	21.1 nTPM
Hippocampus	18.5 nTPM
Hypothalamus	18.4 nTPM

Eccentric medium spiny neuron	25.1 nTPM
Hypothalamus	31.8 nTPM
Thalamus	28.9 nTPM
Basal ganglia	24.6 nTPM
Hippocampus	22.4 nTPM
Cerebral cortex	21.9 nTPM
Amygdala	21.2 nTPM