Single cell type - SEC61G - The Human Protein Atlas

SEC61G

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SEC61G
Gene descriptionⁱ Full gene name according to HGNC.	SEC61 translocon subunit gamma
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.24
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SEC61G is part of cluster 77 Plasma cells - Protein processing with confidenceⁱ 1
324 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARF4	ADP ribosylation factor 4	0.7028	77
UFM1	Ubiquitin fold modifier 1	0.6568	77
OSTC	Oligosaccharyltransferase complex non-catalytic subunit	0.6148	77
TMEM167A	Transmembrane protein 167A	0.5993	29
DGUOK	Deoxyguanosine kinase	0.5902	35
SEC61B	SEC61 translocon subunit beta	0.5754	77
PDIA6	Protein disulfide isomerase family A member 6	0.5744	77
SEC13	SEC13 homolog, nuclear pore and COPII coat complex component	0.5646	77
SELENOF	Selenoprotein F	0.5644	77
PTS	6-pyruvoyltetrahydropterin synthase	0.5573	45
MYDGF	Myeloid derived growth factor	0.5566	77
MANF	Mesencephalic astrocyte derived neurotrophic factor	0.5559	77
PPIB	Peptidylprolyl isomerase B	0.5549	77
SEM1	SEM1 26S proteasome subunit	0.5548	43
CHCHD2	Coiled-coil-helix-coiled-coil-helix domain containing 2	0.5531	64

IMMUNE CELLS

SEC61G is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 0.99
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HYOU1	Hypoxia up-regulated 1	0.9762	5
FKBP2	FKBP prolyl isomerase 2	0.9762	5
SCYL3	SCY1 like pseudokinase 3	0.9524	5
ALG2	ALG2 alpha-1,3/1,6-mannosyltransferase	0.9524	13
HDDC3	HD domain containing 3	0.9524	13
SMIM19	Small integral membrane protein 19	0.9524	5
SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone	0.9524	5
TP53I13	Tumor protein p53 inducible protein 13	0.9524	5
NBDY	Negative regulator of P-body association	0.9286	5
OSTC	Oligosaccharyltransferase complex non-catalytic subunit	0.9286	8
VMAC	Vimentin type intermediate filament associated coiled-coil protein	0.9286	5
COQ4	Coenzyme Q4	0.9286	13
HSP90B1	Heat shock protein 90 beta family member 1	0.9286	5
NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit	0.9286	8
FLNB	Filamin B	0.9286	5

Adipocytes	243.7 nTPM
Breast	259.4 nTPM
Adipose tissue	228.0 nTPM

Alveolar cells type 1	288.1 nTPM
Lung	288.1 nTPM

Alveolar cells type 2	417.8 nTPM
Lung	417.8 nTPM

Astrocytes	9.9 nTPM
Brain	9.9 nTPM

B-cells	177.0 nTPM
Skin	491.2 nTPM
Adipose tissue	233.3 nTPM
Kidney	197.6 nTPM
Spleen	196.4 nTPM
Lung	185.1 nTPM
PBMC	167.8 nTPM
Stomach	167.5 nTPM
Liver	154.6 nTPM
Lymph node	147.1 nTPM
Bone marrow	135.4 nTPM
Thymus	86.4 nTPM
Salivary gland	80.3 nTPM
Esophagus	59.0 nTPM

Basal squamous epithelial cells	191.2 nTPM
Esophagus	191.2 nTPM

Ciliated cells	258.5 nTPM
Bronchus	421.6 nTPM
Endometrium	301.8 nTPM
Fallopian tube	195.1 nTPM
Lung	115.7 nTPM

Club cells	301.7 nTPM
Bronchus	631.7 nTPM
Lung	181.7 nTPM
Prostate	91.7 nTPM

Dendritic cells	605.3 nTPM
Adipose tissue	645.8 nTPM
PBMC	564.8 nTPM

Endothelial cells	212.8 nTPM
Pancreas	509.3 nTPM
Placenta	343.5 nTPM
Breast	316.4 nTPM
Skin	304.7 nTPM
Lung	231.6 nTPM
Endometrium	222.7 nTPM
Ovary	210.6 nTPM
Fallopian tube	205.4 nTPM
Skeletal muscle	201.3 nTPM
Esophagus	193.9 nTPM
Liver	191.5 nTPM
Testis	185.9 nTPM
Tongue	155.6 nTPM
Heart muscle	143.5 nTPM
Thymus	130.1 nTPM
Prostate	125.2 nTPM
Vascular	90.5 nTPM
Salivary gland	68.3 nTPM

Enteroendocrine cells	303.9 nTPM
Colon	336.5 nTPM
Rectum	290.2 nTPM
Small intestine	284.9 nTPM

Erythroid cells	237.8 nTPM
Liver	293.7 nTPM
Bone marrow	181.9 nTPM

Fibroblasts	350.3 nTPM
Pancreas	1157.4 nTPM
Placenta	591.2 nTPM
Skin	502.2 nTPM
Lung	384.8 nTPM
Adipose tissue	361.8 nTPM
Fallopian tube	326.4 nTPM
Breast	315.0 nTPM
Liver	302.4 nTPM
Skeletal muscle	275.7 nTPM
Esophagus	246.8 nTPM
Heart muscle	240.4 nTPM
Stomach	236.3 nTPM
Thymus	206.7 nTPM
Vascular	184.2 nTPM
Prostate	169.6 nTPM
Salivary gland	103.3 nTPM

Granulocytes	175.7 nTPM
Fallopian tube	227.5 nTPM
Lung	158.8 nTPM
Tongue	140.7 nTPM

Intestinal goblet cells	602.5 nTPM
Colon	900.0 nTPM
Rectum	506.8 nTPM
Small intestine	400.6 nTPM

Bipolar cells	45.5 nTPM
Eye	45.5 nTPM

Cholangiocytes	272.8 nTPM
Liver	272.8 nTPM

Collecting duct cells	245.1 nTPM
Kidney	245.1 nTPM

Cone photoreceptor cells	66.3 nTPM
Eye	66.3 nTPM

Lymphatic endothelial cells	214.2 nTPM
Ovary	234.6 nTPM
Fallopian tube	193.7 nTPM

Macrophages	244.9 nTPM
Kidney	572.6 nTPM
Pancreas	478.9 nTPM
Skin	452.4 nTPM
Spleen	324.8 nTPM
Endometrium	309.9 nTPM
Stomach	272.6 nTPM
Bone marrow	240.2 nTPM
Adipose tissue	229.3 nTPM
Skeletal muscle	220.3 nTPM
Thymus	206.6 nTPM
Breast	204.6 nTPM
Esophagus	192.7 nTPM
Testis	188.5 nTPM
Fallopian tube	187.6 nTPM
Lung	171.2 nTPM
Prostate	111.6 nTPM
Tongue	107.6 nTPM
Vascular	98.9 nTPM
Salivary gland	82.6 nTPM

Paneth cells	354.8 nTPM
Small intestine	417.9 nTPM
Rectum	328.1 nTPM
Colon	318.4 nTPM

Plasma cells	917.1 nTPM
Spleen	1524.7 nTPM
Liver	1367.4 nTPM
Stomach	1182.3 nTPM
Bone marrow	916.6 nTPM
Esophagus	795.3 nTPM
Thymus	692.6 nTPM
Fallopian tube	566.4 nTPM
Salivary gland	291.4 nTPM

Schwann cells	144.8 nTPM
Adipose tissue	252.2 nTPM
Vascular	98.2 nTPM
Esophagus	83.9 nTPM

Serous glandular cells	222.8 nTPM
Salivary gland	277.6 nTPM
Tongue	167.9 nTPM

Smooth muscle cells	236.6 nTPM
Placenta	555.4 nTPM
Skin	293.8 nTPM
Ovary	281.2 nTPM
Endometrium	274.6 nTPM
Fallopian tube	270.1 nTPM
Liver	246.7 nTPM
Breast	238.5 nTPM
Esophagus	219.8 nTPM
Lung	204.6 nTPM
Thymus	203.9 nTPM
Adipose tissue	200.6 nTPM
Prostate	194.0 nTPM
Vascular	192.0 nTPM
Skeletal muscle	177.9 nTPM
Salivary gland	119.4 nTPM
Tongue	113.2 nTPM

Suprabasal keratinocytes	408.2 nTPM
Skin	418.7 nTPM
Tongue	397.6 nTPM

T-cells	212.5 nTPM
Kidney	352.9 nTPM
Skin	340.0 nTPM
Liver	296.2 nTPM
Stomach	265.8 nTPM
Endometrium	259.2 nTPM
Spleen	259.2 nTPM
Fallopian tube	250.9 nTPM
PBMC	239.3 nTPM
Adipose tissue	232.2 nTPM
Bone marrow	230.4 nTPM
Esophagus	228.8 nTPM
Breast	215.8 nTPM
Lymph node	200.3 nTPM
Colon	171.6 nTPM
Skeletal muscle	161.4 nTPM
Prostate	152.8 nTPM
Lung	151.9 nTPM
Thymus	134.9 nTPM
Vascular	120.2 nTPM
Tongue	112.3 nTPM
Salivary gland	86.7 nTPM

Undifferentiated cells	317.1 nTPM
Small intestine	374.9 nTPM
Colon	304.7 nTPM
Rectum	271.6 nTPM

Amygdala excitatory	15.3 nTPM
Thalamus	28.6 nTPM
Cerebral cortex	15.0 nTPM
Basal ganglia	14.5 nTPM
Hippocampus	13.1 nTPM
Amygdala	12.7 nTPM
Hypothalamus	7.5 nTPM

Astrocyte	22.2 nTPM
Basal ganglia	31.9 nTPM
Medulla oblongata	28.3 nTPM
Pons	25.6 nTPM
Spinal cord	23.5 nTPM
Midbrain	23.2 nTPM
Thalamus	22.4 nTPM
Hippocampus	22.1 nTPM
Cerebellum	19.9 nTPM
Cerebral cortex	18.4 nTPM
Amygdala	15.0 nTPM
Hypothalamus	13.7 nTPM

Bergmann glia	20.1 nTPM
Pons	28.8 nTPM
Cerebellum	18.8 nTPM
Medulla oblongata	12.8 nTPM

Central nervous system macrophage	21.0 nTPM
Basal ganglia	27.5 nTPM
Medulla oblongata	27.3 nTPM
Spinal cord	25.0 nTPM
Pons	23.9 nTPM
Midbrain	21.7 nTPM
Thalamus	21.2 nTPM
Cerebral cortex	19.2 nTPM
Cerebellum	18.1 nTPM
Hippocampus	17.7 nTPM
Hypothalamus	14.9 nTPM
Amygdala	14.1 nTPM

Cerebellar inhibitory	28.2 nTPM
Pons	37.2 nTPM
Medulla oblongata	31.1 nTPM
Spinal cord	27.5 nTPM
Midbrain	24.3 nTPM
Cerebellum	20.7 nTPM

Cge interneuron	47.2 nTPM
Thalamus	72.8 nTPM
Midbrain	68.5 nTPM
Hippocampus	49.1 nTPM
Basal ganglia	45.6 nTPM
Cerebral cortex	39.3 nTPM
Amygdala	38.9 nTPM
Hypothalamus	15.9 nTPM

Choroid plexus epithelial cell	24.1 nTPM
Hippocampus	41.6 nTPM
Medulla oblongata	35.6 nTPM
Thalamus	11.0 nTPM
Basal ganglia	8.3 nTPM

Committed oligodendrocyte precursor	28.0 nTPM
Medulla oblongata	49.1 nTPM
Pons	48.7 nTPM
Cerebellum	44.4 nTPM
Basal ganglia	31.8 nTPM
Midbrain	29.4 nTPM
Spinal cord	22.1 nTPM
Thalamus	20.3 nTPM
Hippocampus	19.9 nTPM
Cerebral cortex	19.6 nTPM
Amygdala	14.1 nTPM
Hypothalamus	8.9 nTPM

Deep-layer corticothalamic and 6b	19.8 nTPM
Midbrain	26.6 nTPM
Basal ganglia	24.9 nTPM
Amygdala	22.3 nTPM
Hippocampus	20.6 nTPM
Cerebral cortex	18.3 nTPM
Hypothalamus	6.0 nTPM

Deep-layer intratelencephalic	17.9 nTPM
Basal ganglia	23.8 nTPM
Hippocampus	21.8 nTPM
Cerebral cortex	20.9 nTPM
Amygdala	16.9 nTPM
Hypothalamus	5.8 nTPM