Single cell type - SLC4A1AP - The Human Protein Atlas

SLC4A1AP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC4A1AP
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 4 member 1 adaptor protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Spermatocytes & Spermatogonia - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Spermatocytes, Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.41
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Spermatocytes, Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC4A1AP is part of cluster 79 Spermatocytes & Spermatogonia - Spermatogenesis with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UTP6	UTP6 small subunit processome component	0.4376	79
MBD1	Methyl-CpG binding domain protein 1	0.4342	31
FAM9B	Family with sequence similarity 9 member B	0.4297	79
PRR23A	Proline rich 23A	0.4273	79
ANAPC7	Anaphase promoting complex subunit 7	0.4259	12
LACTB	Lactamase beta	0.4161	58
TIPRL	TOR signaling pathway regulator	0.4145	39
SFR1	SWI5 dependent homologous recombination repair protein 1	0.4144	79
MRPS22	Mitochondrial ribosomal protein S22	0.4138	39
ZNF143	Zinc finger protein 143	0.4126	74
THAP8	THAP domain containing 8	0.4056	67
C1orf146	Chromosome 1 open reading frame 146	0.4039	79
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	0.4031	79
SF3A3	Splicing factor 3a subunit 3	0.4019	15
GDPD4	Glycerophosphodiester phosphodiesterase domain containing 4	0.3959	79

IMMUNE CELLS

SLC4A1AP is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 1
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAB37	RAB37, member RAS oncogene family	0.9762	42
SRI	Sorcin	0.9762	42
BPGM	Bisphosphoglycerate mutase	0.9762	42
MINDY3	MINDY lysine 48 deubiquitinase 3	0.9762	42
RNASEL	Ribonuclease L	0.9762	42
EMC4	ER membrane protein complex subunit 4	0.9762	42
ZNF410	Zinc finger protein 410	0.9762	42
PARP4	Poly(ADP-ribose) polymerase family member 4	0.9762	42
BLZF1	Basic leucine zipper nuclear factor 1	0.9762	42
SMAP1	Small ArfGAP 1	0.9762	42
TAX1BP1	Tax1 binding protein 1	0.9524	42
TTC33	Tetratricopeptide repeat domain 33	0.9524	42
GPKOW	G-patch domain and KOW motifs	0.9524	42
MAPRE1	Microtubule associated protein RP/EB family member 1	0.9524	42
VTI1B	Vesicle transport through interaction with t-SNAREs 1B	0.9524	42

Adipocytes	15.9 nTPM
Adipose tissue	17.4 nTPM
Breast	14.4 nTPM

Alveolar cells type 1	34.6 nTPM
Lung	34.6 nTPM

Alveolar cells type 2	23.1 nTPM
Lung	23.1 nTPM

Astrocytes	13.9 nTPM
Brain	13.9 nTPM

B-cells	15.1 nTPM
Stomach	26.2 nTPM
Salivary gland	25.3 nTPM
Bone marrow	25.0 nTPM
Thymus	23.5 nTPM
Lymph node	22.7 nTPM
PBMC	16.9 nTPM
Spleen	14.2 nTPM
Adipose tissue	12.8 nTPM
Lung	12.1 nTPM
Liver	9.7 nTPM
Esophagus	5.9 nTPM
Skin	1.7 nTPM
Kidney	0.0 nTPM

Ciliated cells	23.1 nTPM
Lung	26.7 nTPM
Fallopian tube	23.9 nTPM
Endometrium	22.0 nTPM
Bronchus	19.6 nTPM

Club cells	22.3 nTPM
Lung	23.5 nTPM
Bronchus	22.4 nTPM
Prostate	21.0 nTPM

Dendritic cells	12.7 nTPM
Adipose tissue	14.6 nTPM
PBMC	10.8 nTPM

Endothelial cells	23.1 nTPM
Heart muscle	42.8 nTPM
Pancreas	38.8 nTPM
Fallopian tube	35.0 nTPM
Thymus	26.8 nTPM
Skeletal muscle	25.2 nTPM
Vascular	24.9 nTPM
Lung	23.4 nTPM
Tongue	23.0 nTPM
Testis	22.9 nTPM
Salivary gland	22.6 nTPM
Prostate	19.0 nTPM
Ovary	18.7 nTPM
Endometrium	18.1 nTPM
Esophagus	17.7 nTPM
Breast	15.8 nTPM
Liver	15.1 nTPM
Placenta	14.8 nTPM
Skin	11.0 nTPM

Enteroendocrine cells	12.2 nTPM
Rectum	15.1 nTPM
Colon	14.7 nTPM
Small intestine	6.9 nTPM

Fibroblasts	19.4 nTPM
Pancreas	27.8 nTPM
Heart muscle	24.3 nTPM
Lung	23.1 nTPM
Liver	22.5 nTPM
Thymus	22.0 nTPM
Adipose tissue	21.6 nTPM
Salivary gland	20.8 nTPM
Skeletal muscle	20.6 nTPM
Vascular	19.3 nTPM
Fallopian tube	18.1 nTPM
Prostate	17.8 nTPM
Stomach	17.3 nTPM
Esophagus	17.2 nTPM
Placenta	15.0 nTPM
Breast	13.7 nTPM
Skin	9.9 nTPM

Granulocytes	28.4 nTPM
Lung	36.8 nTPM
Fallopian tube	33.8 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	10.7 nTPM
Colon	12.5 nTPM
Rectum	11.5 nTPM
Small intestine	8.0 nTPM

Lymphatic endothelial cells	25.4 nTPM
Fallopian tube	29.0 nTPM
Ovary	21.8 nTPM

Macrophages	20.7 nTPM
Lung	39.9 nTPM
Vascular	26.7 nTPM
Stomach	25.7 nTPM
Thymus	25.1 nTPM
Prostate	24.9 nTPM
Spleen	24.1 nTPM
Salivary gland	22.5 nTPM
Tongue	21.7 nTPM
Endometrium	21.5 nTPM
Fallopian tube	21.0 nTPM
Testis	19.8 nTPM
Skeletal muscle	19.8 nTPM
Bone marrow	19.3 nTPM
Breast	18.6 nTPM
Adipose tissue	17.7 nTPM
Kidney	15.9 nTPM
Esophagus	12.8 nTPM
Pancreas	10.3 nTPM
Skin	5.6 nTPM

Basal squamous epithelial cells	12.6 nTPM
Esophagus	12.6 nTPM

Cholangiocytes	15.3 nTPM
Liver	15.3 nTPM

Collecting duct cells	15.6 nTPM
Kidney	15.6 nTPM

Cone photoreceptor cells	10.2 nTPM
Eye	10.2 nTPM

Paneth cells	6.4 nTPM
Small intestine	10.4 nTPM
Rectum	9.0 nTPM
Colon	0.0 nTPM

Plasma cells	25.8 nTPM
Thymus	44.4 nTPM
Spleen	29.1 nTPM
Stomach	25.5 nTPM
Fallopian tube	23.8 nTPM
Liver	22.5 nTPM
Esophagus	20.8 nTPM
Salivary gland	20.6 nTPM
Bone marrow	19.6 nTPM

Schwann cells	23.2 nTPM
Esophagus	35.9 nTPM
Vascular	21.4 nTPM
Adipose tissue	12.1 nTPM

Serous glandular cells	13.4 nTPM
Salivary gland	17.9 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	19.4 nTPM
Esophagus	26.4 nTPM
Fallopian tube	25.2 nTPM
Prostate	23.1 nTPM
Lung	22.3 nTPM
Thymus	22.0 nTPM
Vascular	21.6 nTPM
Tongue	21.0 nTPM
Endometrium	20.3 nTPM
Ovary	18.8 nTPM
Skeletal muscle	17.9 nTPM
Placenta	17.4 nTPM
Adipose tissue	17.4 nTPM
Breast	16.6 nTPM
Salivary gland	16.5 nTPM
Liver	16.1 nTPM
Skin	7.9 nTPM

Suprabasal keratinocytes	29.2 nTPM
Tongue	46.5 nTPM
Skin	11.9 nTPM

T-cells	22.4 nTPM
Salivary gland	30.6 nTPM
Skeletal muscle	28.0 nTPM
Stomach	27.6 nTPM
Prostate	27.5 nTPM
Lung	27.4 nTPM
Esophagus	26.8 nTPM
Tongue	26.7 nTPM
Thymus	26.0 nTPM
Fallopian tube	25.7 nTPM
Adipose tissue	23.1 nTPM
Endometrium	22.4 nTPM
Breast	22.2 nTPM
Bone marrow	22.1 nTPM
Kidney	21.3 nTPM
Lymph node	19.5 nTPM
Liver	17.6 nTPM
Spleen	17.5 nTPM
PBMC	16.6 nTPM
Vascular	15.7 nTPM
Skin	14.4 nTPM
Colon	10.7 nTPM

Undifferentiated cells	11.6 nTPM
Colon	15.8 nTPM
Small intestine	10.5 nTPM
Rectum	8.5 nTPM

Amygdala excitatory	29.2 nTPM
Thalamus	31.8 nTPM
Hippocampus	31.5 nTPM
Amygdala	28.6 nTPM
Hypothalamus	28.6 nTPM
Cerebral cortex	28.2 nTPM
Basal ganglia	26.7 nTPM

Astrocyte	25.5 nTPM
Amygdala	30.1 nTPM
Hippocampus	28.5 nTPM
Cerebral cortex	28.0 nTPM
Midbrain	27.2 nTPM
Spinal cord	25.1 nTPM
Thalamus	24.8 nTPM
Pons	24.7 nTPM
Cerebellum	24.1 nTPM
Basal ganglia	24.0 nTPM
Hypothalamus	23.0 nTPM
Medulla oblongata	20.6 nTPM

Bergmann glia	25.8 nTPM
Pons	41.7 nTPM
Cerebellum	27.0 nTPM
Medulla oblongata	8.5 nTPM

Central nervous system macrophage	26.9 nTPM
Amygdala	32.2 nTPM
Hippocampus	30.7 nTPM
Cerebellum	30.3 nTPM
Midbrain	29.1 nTPM
Cerebral cortex	28.7 nTPM
Thalamus	28.1 nTPM
Hypothalamus	27.6 nTPM
Basal ganglia	26.0 nTPM
Pons	24.0 nTPM
Medulla oblongata	19.6 nTPM
Spinal cord	19.4 nTPM

Cerebellar inhibitory	29.1 nTPM
Cerebellum	32.3 nTPM
Pons	30.7 nTPM
Midbrain	29.9 nTPM
Medulla oblongata	27.6 nTPM
Spinal cord	24.7 nTPM

Cge interneuron	28.3 nTPM
Midbrain	30.6 nTPM
Thalamus	30.5 nTPM
Hypothalamus	28.5 nTPM
Hippocampus	27.4 nTPM
Cerebral cortex	27.1 nTPM
Amygdala	27.0 nTPM
Basal ganglia	26.9 nTPM

Choroid plexus epithelial cell	20.7 nTPM
Basal ganglia	31.5 nTPM
Medulla oblongata	23.5 nTPM
Hippocampus	19.4 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	24.3 nTPM
Amygdala	35.0 nTPM
Hypothalamus	32.1 nTPM
Hippocampus	29.8 nTPM
Thalamus	28.8 nTPM
Midbrain	25.2 nTPM
Medulla oblongata	24.5 nTPM
Cerebellum	23.8 nTPM
Pons	23.0 nTPM
Cerebral cortex	22.8 nTPM
Basal ganglia	14.8 nTPM
Spinal cord	7.4 nTPM

Deep-layer corticothalamic and 6b	28.1 nTPM
Hippocampus	30.5 nTPM
Cerebral cortex	30.1 nTPM
Basal ganglia	29.7 nTPM
Amygdala	29.1 nTPM
Hypothalamus	26.9 nTPM
Midbrain	22.2 nTPM

Deep-layer intratelencephalic	30.9 nTPM
Cerebral cortex	32.8 nTPM
Hypothalamus	32.2 nTPM
Hippocampus	30.4 nTPM
Basal ganglia	30.0 nTPM
Amygdala	29.3 nTPM

Deep-layer near-projecting	30.1 nTPM
Hypothalamus	32.3 nTPM
Cerebral cortex	31.5 nTPM
Amygdala	30.3 nTPM
Hippocampus	28.6 nTPM
Basal ganglia	27.8 nTPM

Eccentric medium spiny neuron	30.3 nTPM
Hippocampus	33.6 nTPM
Hypothalamus	33.2 nTPM
Thalamus	31.3 nTPM
Amygdala	28.5 nTPM
Basal ganglia	28.5 nTPM
Cerebral cortex	26.8 nTPM