Single cell type - MX1 - The Human Protein Atlas

MX1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MX1
Gene descriptionⁱ Full gene name according to HGNC.	MX dynamin like GTPase 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	36

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Adipocytes & Endothelial cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Dendritic cells, Adipocytes, Extravillous trophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.45
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Dendritic cells, Adipocytes, Extravillous trophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MX1 is part of cluster 41 Adipocytes & Endothelial cells - Mixed function with confidenceⁱ 1
325 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OAS3	2'-5'-oligoadenylate synthetase 3	0.8092	41
IFIT3	Interferon induced protein with tetratricopeptide repeats 3	0.7623	58
XAF1	XIAP associated factor 1	0.6957	41
IFI44L	Interferon induced protein 44 like	0.6926	41
IFIT1	Interferon induced protein with tetratricopeptide repeats 1	0.6653	41
OAS2	2'-5'-oligoadenylate synthetase 2	0.6346	58
IFI44	Interferon induced protein 44	0.6158	41
CCDC194	Coiled-coil domain containing 194	0.5899	6
GPIHBP1	Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	0.5868	41
PARP12	Poly(ADP-ribose) polymerase family member 12	0.5655	58
C1QTNF9	C1q and TNF related 9	0.5579	41
AVPR2	Arginine vasopressin receptor 2	0.5575	41
IFIT2	Interferon induced protein with tetratricopeptide repeats 2	0.5506	41
PPARG	Peroxisome proliferator activated receptor gamma	0.5456	58
SAMD9L	Sterile alpha motif domain containing 9 like	0.5436	58

IMMUNE CELLS

MX1 is part of cluster 13 Non-specific - Mitochondria with confidenceⁱ 0.65
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TREX1	Three prime repair exonuclease 1	0.9762	2
FSTL3	Follistatin like 3	0.9762	2
SMCR8	SMCR8-C9orf72 complex subunit	0.9524	13
KLC4	Kinesin light chain 4	0.9286	13
NHLRC1	NHL repeat containing E3 ubiquitin protein ligase 1	0.9286	38
BRAT1	BRCA1 associated ATM activator 1	0.9286	33
PLEKHM2	Pleckstrin homology and RUN domain containing M2	0.9048	2
ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit	0.9048	13
SETD7	SET domain containing 7, histone lysine methyltransferase	0.9048	33
TKFC	Triokinase and FMN cyclase	0.9048	13
SLC25A6	Solute carrier family 25 member 6	0.9048	13
TRPS1	Transcriptional repressor GATA binding 1	0.9048	38
PLEC	Plectin	0.9048	2
SZT2	SZT2 subunit of KICSTOR complex	0.9048	13
TRMT1	TRNA methyltransferase 1	0.8810	13

Adipocytes	107.4 nTPM
Breast	121.9 nTPM
Adipose tissue	92.9 nTPM

Alveolar cells type 1	14.9 nTPM
Lung	14.9 nTPM

Alveolar cells type 2	14.2 nTPM
Lung	14.2 nTPM

Astrocytes	2.5 nTPM
Brain	2.5 nTPM

B-cells	43.8 nTPM
Bone marrow	80.8 nTPM
Lung	61.7 nTPM
Salivary gland	60.4 nTPM
Lymph node	54.7 nTPM
PBMC	53.9 nTPM
Thymus	52.9 nTPM
Spleen	52.7 nTPM
Stomach	38.4 nTPM
Esophagus	35.4 nTPM
Adipose tissue	29.6 nTPM
Skin	23.7 nTPM
Kidney	20.8 nTPM
Liver	4.8 nTPM

Ciliated cells	25.8 nTPM
Bronchus	33.7 nTPM
Fallopian tube	26.6 nTPM
Lung	24.5 nTPM
Endometrium	18.1 nTPM

Club cells	30.5 nTPM
Prostate	42.1 nTPM
Lung	26.3 nTPM
Bronchus	23.1 nTPM

Dendritic cells	122.5 nTPM
Adipose tissue	137.1 nTPM
PBMC	107.9 nTPM

Endothelial cells	70.4 nTPM
Skeletal muscle	210.6 nTPM
Ovary	166.2 nTPM
Fallopian tube	108.7 nTPM
Heart muscle	90.9 nTPM
Tongue	87.5 nTPM
Salivary gland	85.2 nTPM
Testis	84.5 nTPM
Thymus	72.9 nTPM
Vascular	64.0 nTPM
Skin	57.5 nTPM
Esophagus	47.9 nTPM
Endometrium	37.8 nTPM
Lung	36.1 nTPM
Prostate	35.4 nTPM
Pancreas	25.9 nTPM
Breast	22.8 nTPM
Placenta	22.7 nTPM
Liver	11.3 nTPM

Enteroendocrine cells	6.1 nTPM
Small intestine	13.7 nTPM
Colon	2.9 nTPM
Rectum	1.7 nTPM

Fibroblasts	16.9 nTPM
Stomach	34.6 nTPM
Esophagus	26.1 nTPM
Breast	26.1 nTPM
Liver	24.9 nTPM
Fallopian tube	22.5 nTPM
Skeletal muscle	21.2 nTPM
Heart muscle	18.8 nTPM
Skin	18.5 nTPM
Salivary gland	17.1 nTPM
Prostate	13.2 nTPM
Adipose tissue	12.1 nTPM
Vascular	11.3 nTPM
Thymus	10.4 nTPM
Lung	9.9 nTPM
Pancreas	3.8 nTPM
Placenta	0.5 nTPM

Granulocytes	10.7 nTPM
Tongue	19.4 nTPM
Fallopian tube	7.1 nTPM
Lung	5.5 nTPM

Intestinal goblet cells	29.0 nTPM
Small intestine	70.4 nTPM
Colon	8.6 nTPM
Rectum	8.0 nTPM

Lymphatic endothelial cells	58.6 nTPM
Ovary	76.4 nTPM
Fallopian tube	40.7 nTPM

Macrophages	42.9 nTPM
Lung	144.8 nTPM
Fallopian tube	97.5 nTPM
Testis	65.1 nTPM
Esophagus	52.7 nTPM
Skeletal muscle	50.9 nTPM
Endometrium	45.5 nTPM
Breast	41.6 nTPM
Spleen	41.1 nTPM
Kidney	37.2 nTPM
Vascular	37.2 nTPM
Bone marrow	36.5 nTPM
Stomach	36.0 nTPM
Adipose tissue	31.7 nTPM
Tongue	29.9 nTPM
Thymus	22.7 nTPM
Salivary gland	15.5 nTPM
Prostate	14.9 nTPM
Skin	8.9 nTPM
Pancreas	6.2 nTPM

Basal keratinocytes	31.4 nTPM
Tongue	58.2 nTPM
Skin	4.5 nTPM

Basal prostatic cells	16.1 nTPM
Prostate	16.1 nTPM

Basal respiratory cells	12.3 nTPM
Bronchus	12.3 nTPM

Basal squamous epithelial cells	17.5 nTPM
Esophagus	17.5 nTPM

Paneth cells	9.1 nTPM
Small intestine	20.7 nTPM
Colon	3.6 nTPM
Rectum	2.9 nTPM

Plasma cells	30.5 nTPM
Spleen	48.4 nTPM
Fallopian tube	45.0 nTPM
Stomach	44.8 nTPM
Bone marrow	25.7 nTPM
Thymus	25.7 nTPM
Salivary gland	25.1 nTPM
Esophagus	15.6 nTPM
Liver	14.0 nTPM

Schwann cells	36.8 nTPM
Adipose tissue	46.8 nTPM
Esophagus	35.9 nTPM
Vascular	27.7 nTPM

Serous glandular cells	17.5 nTPM
Tongue	26.5 nTPM
Salivary gland	8.5 nTPM

Smooth muscle cells	21.7 nTPM
Skeletal muscle	67.1 nTPM
Ovary	58.2 nTPM
Breast	27.6 nTPM
Esophagus	25.2 nTPM
Tongue	25.1 nTPM
Liver	25.0 nTPM
Skin	21.1 nTPM
Vascular	16.8 nTPM
Adipose tissue	16.5 nTPM
Fallopian tube	14.0 nTPM
Lung	11.8 nTPM
Thymus	9.1 nTPM
Placenta	9.0 nTPM
Endometrium	7.3 nTPM
Salivary gland	7.3 nTPM
Prostate	6.7 nTPM

Suprabasal keratinocytes	45.9 nTPM
Tongue	88.6 nTPM
Skin	3.2 nTPM

T-cells	34.1 nTPM
Fallopian tube	55.1 nTPM
Salivary gland	48.4 nTPM
Lymph node	43.4 nTPM
Esophagus	41.4 nTPM
Thymus	41.2 nTPM
Breast	40.7 nTPM
Adipose tissue	40.3 nTPM
PBMC	38.9 nTPM
Tongue	37.4 nTPM
Skeletal muscle	34.0 nTPM
Spleen	33.3 nTPM
Bone marrow	32.1 nTPM
Prostate	31.4 nTPM
Endometrium	31.0 nTPM
Colon	29.2 nTPM
Stomach	29.0 nTPM
Lung	28.3 nTPM
Kidney	24.8 nTPM
Vascular	20.5 nTPM
Liver	18.2 nTPM
Skin	17.9 nTPM

Undifferentiated cells	8.5 nTPM
Small intestine	20.1 nTPM
Colon	3.5 nTPM
Rectum	2.0 nTPM

Amygdala excitatory	7.1 nTPM
Basal ganglia	11.6 nTPM
Hippocampus	6.9 nTPM
Thalamus	6.8 nTPM
Cerebral cortex	5.9 nTPM
Amygdala	5.8 nTPM
Hypothalamus	5.8 nTPM

Astrocyte	11.5 nTPM
Medulla oblongata	18.6 nTPM
Spinal cord	16.7 nTPM
Cerebellum	15.0 nTPM
Pons	13.3 nTPM
Midbrain	11.5 nTPM
Thalamus	11.1 nTPM
Hypothalamus	10.6 nTPM
Basal ganglia	10.1 nTPM
Amygdala	7.1 nTPM
Hippocampus	7.1 nTPM
Cerebral cortex	5.3 nTPM

Bergmann glia	4.3 nTPM
Medulla oblongata	8.5 nTPM
Cerebellum	3.1 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	61.3 nTPM
Basal ganglia	100.2 nTPM
Spinal cord	75.4 nTPM
Medulla oblongata	75.3 nTPM
Thalamus	72.4 nTPM
Midbrain	59.6 nTPM
Amygdala	56.6 nTPM
Pons	54.3 nTPM
Cerebral cortex	49.3 nTPM
Cerebellum	48.0 nTPM
Hippocampus	43.5 nTPM
Hypothalamus	39.9 nTPM

Cerebellar inhibitory	20.6 nTPM
Spinal cord	24.7 nTPM
Midbrain	23.6 nTPM
Pons	20.4 nTPM
Medulla oblongata	18.0 nTPM
Cerebellum	16.2 nTPM

Cge interneuron	6.2 nTPM
Cerebral cortex	8.1 nTPM
Hippocampus	7.0 nTPM
Basal ganglia	6.9 nTPM
Hypothalamus	5.7 nTPM
Thalamus	5.5 nTPM
Amygdala	5.1 nTPM
Midbrain	4.7 nTPM

Choroid plexus epithelial cell	15.4 nTPM
Basal ganglia	17.6 nTPM
Thalamus	16.4 nTPM
Hippocampus	13.9 nTPM
Medulla oblongata	13.6 nTPM

Committed oligodendrocyte precursor	5.3 nTPM
Medulla oblongata	10.3 nTPM
Pons	8.9 nTPM
Hypothalamus	6.8 nTPM
Thalamus	6.8 nTPM
Basal ganglia	6.0 nTPM
Midbrain	5.0 nTPM
Cerebellum	4.8 nTPM
Spinal cord	3.7 nTPM
Cerebral cortex	2.5 nTPM
Hippocampus	2.1 nTPM
Amygdala	1.1 nTPM

Deep-layer corticothalamic and 6b	6.0 nTPM
Hippocampus	9.7 nTPM
Midbrain	8.9 nTPM
Hypothalamus	7.2 nTPM
Amygdala	4.2 nTPM
Cerebral cortex	3.1 nTPM
Basal ganglia	3.0 nTPM

Deep-layer intratelencephalic	8.3 nTPM
Hippocampus	9.5 nTPM
Hypothalamus	9.2 nTPM
Cerebral cortex	8.5 nTPM
Basal ganglia	7.7 nTPM
Amygdala	6.7 nTPM

Deep-layer near-projecting	7.9 nTPM
Cerebral cortex	9.9 nTPM
Hippocampus	9.4 nTPM
Amygdala	8.4 nTPM
Basal ganglia	6.8 nTPM
Hypothalamus	4.9 nTPM

Eccentric medium spiny neuron	10.8 nTPM
Hypothalamus	16.2 nTPM
Cerebral cortex	12.6 nTPM
Amygdala	9.8 nTPM
Thalamus	9.8 nTPM
Basal ganglia	9.2 nTPM
Hippocampus	7.0 nTPM