Single cell type - RAMP2 - The Human Protein Atlas

RAMP2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RAMP2
Gene descriptionⁱ Full gene name according to HGNC.	Receptor activity modifying protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	FDA approved drug targets Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphatic endothelial cells - Lymph vessel development (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Adipocytes, Lymphatic endothelial cells, Endothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.75
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (plasmacytoid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Adipocytes, Lymphatic endothelial cells, Endothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (plasmacytoid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RAMP2 is part of cluster 54 Lymphatic endothelial cells - Lymph vessel development with confidenceⁱ 1
108 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLDN5	Claudin 5	0.8691	54
KANK3	KN motif and ankyrin repeat domains 3	0.8329	54
DIPK2B	Divergent protein kinase domain 2B	0.8280	54
TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1	0.7930	54
HYAL2	Hyaluronidase 2	0.7908	54
ECSCR	Endothelial cell surface expressed chemotaxis and apoptosis regulator	0.7719	54
ADCY4	Adenylate cyclase 4	0.7712	41
EGFL7	EGF like domain multiple 7	0.7681	41
TM4SF18	Transmembrane 4 L six family member 18	0.7502	54
HSPA12B	Heat shock protein family A (Hsp70) member 12B	0.7199	41
CCM2L	CCM2 like scaffold protein	0.7092	41
ROBO4	Roundabout guidance receptor 4	0.7089	41
GJD3	Gap junction protein delta 3	0.7047	54
RASIP1	Ras interacting protein 1	0.6977	41
BCL6B	BCL6B transcription repressor	0.6932	41

Adipocytes	1017.0 nTPM
Breast	1132.4 nTPM
Adipose tissue	901.6 nTPM

Alveolar cells type 1	5.9 nTPM
Lung	5.9 nTPM

Alveolar cells type 2	2.8 nTPM
Lung	2.8 nTPM

Astrocytes	1.5 nTPM
Brain	1.5 nTPM

B-cells	6.4 nTPM
Kidney	36.4 nTPM
Skin	23.7 nTPM
Thymus	8.6 nTPM
Adipose tissue	7.0 nTPM
Salivary gland	5.1 nTPM
Lung	1.3 nTPM
Lymph node	0.7 nTPM
Spleen	0.4 nTPM
Stomach	0.4 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	8.6 nTPM
Endometrium	18.1 nTPM
Fallopian tube	9.0 nTPM
Lung	7.1 nTPM
Bronchus	0.1 nTPM

Club cells	5.5 nTPM
Lung	11.5 nTPM
Prostate	4.3 nTPM
Bronchus	0.7 nTPM

Endothelial cells	571.8 nTPM
Placenta	1758.2 nTPM
Breast	1295.3 nTPM
Esophagus	861.9 nTPM
Skeletal muscle	816.0 nTPM
Skin	780.3 nTPM
Lung	708.9 nTPM
Endometrium	575.3 nTPM
Fallopian tube	543.8 nTPM
Thymus	509.3 nTPM
Ovary	446.4 nTPM
Testis	378.2 nTPM
Pancreas	359.4 nTPM
Salivary gland	348.7 nTPM
Vascular	321.6 nTPM
Tongue	219.3 nTPM
Prostate	188.3 nTPM
Liver	158.7 nTPM
Heart muscle	22.7 nTPM

Enteroendocrine cells	1.2 nTPM
Rectum	3.4 nTPM
Colon	0.3 nTPM
Small intestine	0.0 nTPM

Fibroblasts	164.7 nTPM
Adipose tissue	588.1 nTPM
Salivary gland	566.4 nTPM
Liver	303.6 nTPM
Stomach	260.8 nTPM
Thymus	223.1 nTPM
Skeletal muscle	144.7 nTPM
Breast	113.8 nTPM
Esophagus	103.0 nTPM
Vascular	89.2 nTPM
Fallopian tube	70.4 nTPM
Prostate	61.4 nTPM
Skin	56.0 nTPM
Placenta	24.5 nTPM
Lung	17.2 nTPM
Pancreas	9.3 nTPM
Heart muscle	3.5 nTPM

Granulocytes	3.2 nTPM
Lung	5.5 nTPM
Fallopian tube	4.2 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	952.3 nTPM
Ovary	1249.3 nTPM
Fallopian tube	655.3 nTPM

Macrophages	4.8 nTPM
Thymus	15.2 nTPM
Skin	11.1 nTPM
Skeletal muscle	10.4 nTPM
Breast	10.1 nTPM
Esophagus	9.0 nTPM
Vascular	6.4 nTPM
Bone marrow	6.1 nTPM
Fallopian tube	4.4 nTPM
Tongue	4.0 nTPM
Endometrium	3.1 nTPM
Stomach	2.6 nTPM
Testis	2.5 nTPM
Lung	1.7 nTPM
Salivary gland	1.5 nTPM
Adipose tissue	1.4 nTPM
Prostate	1.4 nTPM
Kidney	0.9 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal keratinocytes	9.9 nTPM
Tongue	10.0 nTPM
Skin	9.7 nTPM

Basal respiratory cells	1.0 nTPM
Bronchus	1.0 nTPM

Basal squamous epithelial cells	4.7 nTPM
Esophagus	4.7 nTPM

Bipolar cells	0.2 nTPM
Eye	0.2 nTPM

Plasma cells	16.5 nTPM
Fallopian tube	76.9 nTPM
Esophagus	15.6 nTPM
Salivary gland	15.2 nTPM
Stomach	10.9 nTPM
Thymus	6.7 nTPM
Liver	5.5 nTPM
Bone marrow	1.5 nTPM
Spleen	0.0 nTPM

Schwann cells	0.7 nTPM
Vascular	2.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	8.8 nTPM
Salivary gland	17.6 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	67.1 nTPM
Liver	367.2 nTPM
Skeletal muscle	209.2 nTPM
Tongue	145.2 nTPM
Adipose tissue	131.2 nTPM
Placenta	89.5 nTPM
Breast	33.5 nTPM
Thymus	16.5 nTPM
Skin	15.5 nTPM
Lung	14.1 nTPM
Endometrium	12.8 nTPM
Fallopian tube	11.4 nTPM
Vascular	8.7 nTPM
Prostate	7.9 nTPM
Ovary	6.2 nTPM
Salivary gland	4.1 nTPM
Esophagus	0.0 nTPM

T-cells	3.2 nTPM
Skin	13.0 nTPM
Breast	10.3 nTPM
Endometrium	9.4 nTPM
Lung	7.5 nTPM
Esophagus	4.9 nTPM
Salivary gland	4.2 nTPM
Vascular	4.0 nTPM
Skeletal muscle	3.8 nTPM
Liver	3.3 nTPM
Fallopian tube	1.9 nTPM
Prostate	1.5 nTPM
Tongue	1.3 nTPM
Kidney	0.9 nTPM
Lymph node	0.7 nTPM
Thymus	0.5 nTPM
Adipose tissue	0.2 nTPM
Stomach	0.2 nTPM
Colon	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	0.5 nTPM
Rectum	0.9 nTPM
Colon	0.2 nTPM
Small intestine	0.2 nTPM

Amygdala excitatory	0.7 nTPM
Thalamus	1.8 nTPM
Hippocampus	0.9 nTPM
Amygdala	0.8 nTPM
Cerebral cortex	0.5 nTPM
Hypothalamus	0.2 nTPM
Basal ganglia	0.0 nTPM

Astrocyte	3.3 nTPM
Cerebellum	5.9 nTPM
Medulla oblongata	5.7 nTPM
Pons	5.4 nTPM
Midbrain	3.9 nTPM
Basal ganglia	3.4 nTPM
Spinal cord	3.1 nTPM
Hypothalamus	2.7 nTPM
Hippocampus	1.9 nTPM
Thalamus	1.9 nTPM
Cerebral cortex	1.7 nTPM
Amygdala	1.0 nTPM

Bergmann glia	9.2 nTPM
Medulla oblongata	14.9 nTPM
Pons	7.2 nTPM
Cerebellum	5.6 nTPM

Central nervous system macrophage	0.7 nTPM
Medulla oblongata	2.4 nTPM
Hippocampus	1.0 nTPM
Spinal cord	0.9 nTPM
Basal ganglia	0.7 nTPM
Hypothalamus	0.6 nTPM
Midbrain	0.4 nTPM
Pons	0.4 nTPM
Cerebellum	0.3 nTPM
Cerebral cortex	0.3 nTPM
Thalamus	0.3 nTPM
Amygdala	0.2 nTPM

Cerebellar inhibitory	0.3 nTPM
Pons	1.0 nTPM
Medulla oblongata	0.6 nTPM
Cerebellum	0.2 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	5.3 nTPM
Basal ganglia	7.0 nTPM
Midbrain	6.5 nTPM
Thalamus	6.4 nTPM
Hippocampus	5.7 nTPM
Cerebral cortex	4.9 nTPM
Amygdala	4.4 nTPM
Hypothalamus	2.2 nTPM

Choroid plexus epithelial cell	2.9 nTPM
Hippocampus	5.5 nTPM
Medulla oblongata	3.5 nTPM
Basal ganglia	2.4 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	4.6 nTPM
Spinal cord	18.4 nTPM
Midbrain	8.4 nTPM
Basal ganglia	4.4 nTPM
Medulla oblongata	3.9 nTPM
Cerebral cortex	3.8 nTPM
Hippocampus	3.6 nTPM
Pons	2.7 nTPM
Amygdala	2.3 nTPM
Cerebellum	1.6 nTPM
Thalamus	0.9 nTPM
Hypothalamus	0.7 nTPM

Deep-layer corticothalamic and 6b	0.4 nTPM
Basal ganglia	1.1 nTPM
Cerebral cortex	0.5 nTPM
Hippocampus	0.5 nTPM
Amygdala	0.3 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.9 nTPM
Basal ganglia	1.2 nTPM
Hippocampus	1.2 nTPM
Cerebral cortex	0.9 nTPM
Amygdala	0.8 nTPM
Hypothalamus	0.2 nTPM

Deep-layer near-projecting	0.2 nTPM
Hippocampus	0.7 nTPM
Basal ganglia	0.2 nTPM
Cerebral cortex	0.2 nTPM
Amygdala	0.0 nTPM
Hypothalamus	0.0 nTPM

Eccentric medium spiny neuron	0.5 nTPM
Hippocampus	0.8 nTPM
Thalamus	0.6 nTPM
Amygdala	0.5 nTPM
Cerebral cortex	0.4 nTPM
Hypothalamus	0.4 nTPM
Basal ganglia	0.2 nTPM

Endothelial cell	400.5 nTPM
Medulla oblongata	735.3 nTPM
Pons	513.7 nTPM
Thalamus	474.4 nTPM
Cerebellum	463.8 nTPM
Spinal cord	395.2 nTPM
Midbrain	394.1 nTPM
Cerebral cortex	393.2 nTPM
Hippocampus	362.6 nTPM
Basal ganglia	257.3 nTPM
Amygdala	222.4 nTPM
Hypothalamus	193.5 nTPM

Ependymal cell	9.9 nTPM
Midbrain	19.7 nTPM
Pons	17.3 nTPM
Hypothalamus	12.5 nTPM
Amygdala	11.4 nTPM
Thalamus	10.5 nTPM
Medulla oblongata	7.5 nTPM
Hippocampus	6.6 nTPM
Basal ganglia	3.6 nTPM
Spinal cord	0.0 nTPM