Single cell type - SETD7 - The Human Protein Atlas

SETD7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SETD7
Gene descriptionⁱ Full gene name according to HGNC.	SET domain containing 7, histone lysine methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle cells - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.36
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SETD7 is part of cluster 32 Smooth muscle cells - Muscle contraction with confidenceⁱ 1
236 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SHLD2	Shieldin complex subunit 2	0.4913	39
ELN	Elastin	0.4880	32
DDR2	Discoidin domain receptor tyrosine kinase 2	0.4874	32
LRP1	LDL receptor related protein 1	0.4795	53
FHIP2A	FHF complex subunit HOOK interacting protein 2A	0.4754	78
UBE4A	Ubiquitination factor E4A	0.4725	55
PTGIS	Prostaglandin I2 synthase	0.4714	53
ZC3H7A	Zinc finger CCCH-type containing 7A	0.4691	55
TBC1D2B	TBC1 domain family member 2B	0.4683	53
LTBP2	Latent transforming growth factor beta binding protein 2	0.4610	32
OMD	Osteomodulin	0.4564	53
GHR	Growth hormone receptor	0.4529	8
ITGBL1	Integrin subunit beta like 1	0.4521	32
C1R	Complement C1r	0.4518	53
GOLM2	Golgi membrane protein 2	0.4514	40

IMMUNE CELLS

SETD7 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.86
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CIBAR1	CBY1 interacting BAR domain containing 1	0.9762	33
PUDP	Pseudouridine 5'-phosphatase	0.9762	33
PEPD	Peptidase D	0.9762	33
ASB13	Ankyrin repeat and SOCS box containing 13	0.9524	26
SLC25A3	Solute carrier family 25 member 3	0.9524	33
ENO1	Enolase 1	0.9286	33
NUDT14	Nudix hydrolase 14	0.9286	33
SMCR8	SMCR8-C9orf72 complex subunit	0.9286	13
TUBGCP2	Tubulin gamma complex associated protein 2	0.9286	33
WRAP73	WD repeat containing, antisense to TP73	0.9286	33
SIAE	Sialic acid acetylesterase	0.9286	38
SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	0.9286	33
ORC1	Origin recognition complex subunit 1	0.9286	33
FSTL3	Follistatin like 3	0.9286	2
BRAT1	BRCA1 associated ATM activator 1	0.9048	33

Adipocytes	28.6 nTPM
Adipose tissue	30.3 nTPM
Breast	26.9 nTPM

Alveolar cells type 1	22.3 nTPM
Lung	22.3 nTPM

Alveolar cells type 2	35.2 nTPM
Lung	35.2 nTPM

Astrocytes	16.4 nTPM
Brain	16.4 nTPM

B-cells	9.0 nTPM
Adipose tissue	19.8 nTPM
Lymph node	13.8 nTPM
Skin	13.6 nTPM
Stomach	13.1 nTPM
Spleen	11.3 nTPM
Lung	10.7 nTPM
Salivary gland	10.7 nTPM
Thymus	10.1 nTPM
Esophagus	5.9 nTPM
PBMC	4.6 nTPM
Bone marrow	3.5 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM

Ciliated cells	9.8 nTPM
Bronchus	22.5 nTPM
Lung	8.1 nTPM
Fallopian tube	6.3 nTPM
Endometrium	2.5 nTPM

Club cells	16.5 nTPM
Bronchus	20.0 nTPM
Lung	17.9 nTPM
Prostate	11.5 nTPM

Endothelial cells	30.0 nTPM
Fallopian tube	39.4 nTPM
Prostate	37.3 nTPM
Vascular	37.2 nTPM
Salivary gland	36.8 nTPM
Liver	36.5 nTPM
Endometrium	34.1 nTPM
Pancreas	33.6 nTPM
Heart muscle	33.5 nTPM
Tongue	33.3 nTPM
Lung	32.1 nTPM
Thymus	32.1 nTPM
Esophagus	30.2 nTPM
Breast	26.4 nTPM
Skeletal muscle	26.1 nTPM
Testis	20.5 nTPM
Skin	20.5 nTPM
Placenta	17.0 nTPM
Ovary	13.6 nTPM

Enteroendocrine cells	6.9 nTPM
Small intestine	10.3 nTPM
Colon	5.3 nTPM
Rectum	5.0 nTPM

Fibroblasts	45.1 nTPM
Heart muscle	86.5 nTPM
Skeletal muscle	70.1 nTPM
Vascular	69.6 nTPM
Fallopian tube	58.9 nTPM
Adipose tissue	55.2 nTPM
Esophagus	54.6 nTPM
Liver	48.6 nTPM
Salivary gland	46.5 nTPM
Skin	39.4 nTPM
Thymus	39.1 nTPM
Stomach	36.0 nTPM
Lung	31.8 nTPM
Breast	29.6 nTPM
Prostate	24.4 nTPM
Pancreas	22.6 nTPM
Placenta	9.1 nTPM

Granulocytes	3.3 nTPM
Tongue	4.9 nTPM
Fallopian tube	4.0 nTPM
Lung	1.0 nTPM

Intestinal goblet cells	12.5 nTPM
Rectum	18.7 nTPM
Colon	12.3 nTPM
Small intestine	6.3 nTPM

Lymphatic endothelial cells	29.2 nTPM
Fallopian tube	42.1 nTPM
Ovary	16.4 nTPM

Macrophages	23.8 nTPM
Vascular	53.4 nTPM
Stomach	33.4 nTPM
Adipose tissue	32.5 nTPM
Thymus	30.3 nTPM
Spleen	30.1 nTPM
Fallopian tube	27.7 nTPM
Tongue	26.2 nTPM
Lung	25.7 nTPM
Salivary gland	25.1 nTPM
Bone marrow	24.3 nTPM
Skeletal muscle	23.0 nTPM
Esophagus	19.3 nTPM
Prostate	19.1 nTPM
Skin	16.7 nTPM
Kidney	15.9 nTPM
Testis	14.9 nTPM
Endometrium	14.8 nTPM
Breast	11.8 nTPM
Pancreas	8.2 nTPM

Paneth cells	3.8 nTPM
Rectum	11.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal keratinocytes	21.9 nTPM
Tongue	26.8 nTPM
Skin	16.9 nTPM

Basal respiratory cells	14.2 nTPM
Bronchus	14.2 nTPM

Bipolar cells	5.1 nTPM
Eye	5.1 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Plasma cells	16.6 nTPM
Salivary gland	36.7 nTPM
Fallopian tube	35.1 nTPM
Stomach	21.4 nTPM
Esophagus	10.4 nTPM
Thymus	10.4 nTPM
Liver	9.0 nTPM
Spleen	8.7 nTPM
Bone marrow	1.5 nTPM

Schwann cells	26.4 nTPM
Adipose tissue	44.1 nTPM
Vascular	23.0 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	15.0 nTPM
Salivary gland	21.0 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	27.8 nTPM
Vascular	63.4 nTPM
Tongue	36.5 nTPM
Liver	31.4 nTPM
Adipose tissue	30.1 nTPM
Skeletal muscle	27.9 nTPM
Placenta	27.6 nTPM
Salivary gland	27.6 nTPM
Esophagus	26.4 nTPM
Lung	25.9 nTPM
Prostate	24.9 nTPM
Thymus	24.8 nTPM
Endometrium	24.2 nTPM
Fallopian tube	21.1 nTPM
Breast	20.4 nTPM
Skin	18.3 nTPM
Ovary	13.8 nTPM

Suprabasal keratinocytes	31.1 nTPM
Tongue	42.4 nTPM
Skin	19.8 nTPM

T-cells	12.6 nTPM
Adipose tissue	46.5 nTPM
Tongue	29.0 nTPM
Fallopian tube	24.2 nTPM
Vascular	21.3 nTPM
Prostate	15.1 nTPM
Salivary gland	15.1 nTPM
Thymus	15.1 nTPM
Stomach	14.4 nTPM
Skeletal muscle	12.1 nTPM
Skin	11.6 nTPM
Breast	10.8 nTPM
Endometrium	9.6 nTPM
Lung	7.4 nTPM
Colon	6.8 nTPM
Liver	5.9 nTPM
Esophagus	4.9 nTPM
Kidney	4.4 nTPM
Spleen	3.5 nTPM
Lymph node	3.4 nTPM
PBMC	2.1 nTPM
Bone marrow	1.8 nTPM

Undifferentiated cells	10.9 nTPM
Rectum	13.9 nTPM
Colon	11.6 nTPM
Small intestine	7.3 nTPM

Amygdala excitatory	32.6 nTPM
Hypothalamus	52.9 nTPM
Thalamus	37.7 nTPM
Basal ganglia	27.2 nTPM
Cerebral cortex	27.2 nTPM
Hippocampus	27.2 nTPM
Amygdala	23.7 nTPM

Astrocyte	35.8 nTPM
Spinal cord	74.9 nTPM
Pons	40.9 nTPM
Medulla oblongata	38.8 nTPM
Hypothalamus	37.6 nTPM
Midbrain	35.3 nTPM
Thalamus	32.0 nTPM
Cerebellum	31.6 nTPM
Hippocampus	29.1 nTPM
Amygdala	27.5 nTPM
Basal ganglia	24.3 nTPM
Cerebral cortex	21.2 nTPM

Bergmann glia	17.6 nTPM
Medulla oblongata	19.2 nTPM
Pons	18.7 nTPM
Cerebellum	14.9 nTPM

Central nervous system macrophage	37.0 nTPM
Amygdala	50.1 nTPM
Thalamus	39.0 nTPM
Cerebellum	38.9 nTPM
Hippocampus	38.9 nTPM
Hypothalamus	37.7 nTPM
Midbrain	37.6 nTPM
Basal ganglia	36.6 nTPM
Pons	32.8 nTPM
Cerebral cortex	32.0 nTPM
Medulla oblongata	31.7 nTPM
Spinal cord	31.5 nTPM

Cerebellar inhibitory	35.5 nTPM
Medulla oblongata	39.0 nTPM
Pons	38.3 nTPM
Midbrain	35.1 nTPM
Spinal cord	33.0 nTPM
Cerebellum	32.2 nTPM

Cge interneuron	33.9 nTPM
Thalamus	54.5 nTPM
Midbrain	40.5 nTPM
Amygdala	29.3 nTPM
Hippocampus	29.2 nTPM
Hypothalamus	29.1 nTPM
Basal ganglia	27.6 nTPM
Cerebral cortex	26.8 nTPM

Choroid plexus epithelial cell	42.7 nTPM
Basal ganglia	66.4 nTPM
Thalamus	43.8 nTPM
Hippocampus	33.3 nTPM
Medulla oblongata	27.4 nTPM

Committed oligodendrocyte precursor	24.1 nTPM
Thalamus	34.0 nTPM
Amygdala	32.1 nTPM
Hypothalamus	31.4 nTPM
Cerebral cortex	30.4 nTPM
Medulla oblongata	23.2 nTPM
Pons	23.0 nTPM
Hippocampus	21.0 nTPM
Cerebellum	20.6 nTPM
Basal ganglia	18.6 nTPM
Midbrain	16.0 nTPM
Spinal cord	14.7 nTPM

Deep-layer corticothalamic and 6b	32.6 nTPM
Amygdala	38.0 nTPM
Midbrain	35.5 nTPM
Cerebral cortex	33.3 nTPM
Hypothalamus	32.6 nTPM
Basal ganglia	28.9 nTPM
Hippocampus	27.2 nTPM

Deep-layer intratelencephalic	21.6 nTPM
Hypothalamus	24.5 nTPM
Amygdala	24.4 nTPM
Cerebral cortex	22.0 nTPM
Basal ganglia	18.7 nTPM
Hippocampus	18.4 nTPM

Deep-layer near-projecting	20.2 nTPM
Cerebral cortex	22.4 nTPM
Hippocampus	21.5 nTPM
Amygdala	20.2 nTPM
Hypothalamus	18.8 nTPM
Basal ganglia	17.9 nTPM

Eccentric medium spiny neuron	18.2 nTPM
Thalamus	24.5 nTPM
Basal ganglia	22.7 nTPM
Hippocampus	18.2 nTPM
Amygdala	16.5 nTPM
Cerebral cortex	15.4 nTPM
Hypothalamus	12.0 nTPM

Endothelial cell	61.1 nTPM
Amygdala	72.7 nTPM
Hippocampus	65.4 nTPM
Hypothalamus	64.5 nTPM
Cerebral cortex	63.3 nTPM
Cerebellum	62.7 nTPM
Basal ganglia	62.5 nTPM
Spinal cord	60.4 nTPM
Thalamus	59.9 nTPM
Pons	58.0 nTPM
Midbrain	57.6 nTPM
Medulla oblongata	45.1 nTPM