Single cell type - TKFC - The Human Protein Atlas

TKFC

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TKFC
Gene descriptionⁱ Full gene name according to HGNC.	Triokinase and FMN cyclase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Proximal enterocytes - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Proximal enterocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.59
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Proximal enterocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TKFC is part of cluster 22 Proximal enterocytes - Digestion with confidenceⁱ 1
255 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TM6SF2	Transmembrane 6 superfamily member 2	0.9151	22
RBP2	Retinol binding protein 2	0.9132	22
FABP6	Fatty acid binding protein 6	0.9108	22
PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial	0.9085	22
DGAT1	Diacylglycerol O-acyltransferase 1	0.9060	22
ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7	0.9030	22
CCL25	C-C motif chemokine ligand 25	0.8962	22
ALDOB	Aldolase, fructose-bisphosphate B	0.8957	22
NAALADL1	N-acetylated alpha-linked acidic dipeptidase like 1	0.8893	22
MYO1A	Myosin IA	0.8887	22
TM4SF20	Transmembrane 4 L six family member 20	0.8850	22
CLDN15	Claudin 15	0.8827	22
DPEP1	Dipeptidase 1	0.8775	22
C17orf78	Chromosome 17 open reading frame 78	0.8763	22
FAM151A	Family with sequence similarity 151 member A	0.8703	22

IMMUNE CELLS

TKFC is part of cluster 13 Non-specific - Mitochondria with confidenceⁱ 0.64
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SZT2	SZT2 subunit of KICSTOR complex	1.0000	13
MRPL12	Mitochondrial ribosomal protein L12	0.9524	13
ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit	0.9524	13
PLEC	Plectin	0.9524	2
EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	0.9524	13
FSTL3	Follistatin like 3	0.9524	2
NUDT6	Nudix hydrolase 6	0.9524	13
TP53	Tumor protein p53	0.9524	13
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.9286	13
PHB2	Prohibitin 2	0.9286	13
QARS1	Glutaminyl-tRNA synthetase 1	0.9286	13
SNRPB	Small nuclear ribonucleoprotein polypeptides B and B1	0.9048	13
ATP5MC2	ATP synthase membrane subunit c locus 2	0.9048	2
SLIRP	SRA stem-loop interacting RNA binding protein	0.9048	2
DPH1	Diphthamide biosynthesis 1	0.9048	13

Adipocytes	8.5 nTPM
Breast	8.8 nTPM
Adipose tissue	8.1 nTPM

Alveolar cells type 1	10.5 nTPM
Lung	10.5 nTPM

Alveolar cells type 2	16.3 nTPM
Lung	16.3 nTPM

Astrocytes	3.7 nTPM
Brain	3.7 nTPM

B-cells	9.8 nTPM
Kidney	15.6 nTPM
Liver	14.5 nTPM
Bone marrow	13.4 nTPM
Lung	12.1 nTPM
PBMC	10.8 nTPM
Skin	10.2 nTPM
Lymph node	9.5 nTPM
Spleen	8.9 nTPM
Salivary gland	8.6 nTPM
Thymus	7.0 nTPM
Adipose tissue	6.2 nTPM
Esophagus	5.9 nTPM
Stomach	4.2 nTPM

Ciliated cells	18.2 nTPM
Lung	21.2 nTPM
Bronchus	18.3 nTPM
Fallopian tube	16.8 nTPM
Endometrium	16.2 nTPM

Club cells	12.9 nTPM
Bronchus	14.3 nTPM
Prostate	12.9 nTPM
Lung	11.4 nTPM

Endothelial cells	8.4 nTPM
Placenta	13.6 nTPM
Tongue	10.4 nTPM
Ovary	10.4 nTPM
Esophagus	9.9 nTPM
Fallopian tube	9.3 nTPM
Endometrium	9.2 nTPM
Breast	8.8 nTPM
Skin	8.4 nTPM
Vascular	8.3 nTPM
Testis	8.2 nTPM
Thymus	7.9 nTPM
Heart muscle	7.8 nTPM
Pancreas	7.8 nTPM
Skeletal muscle	7.5 nTPM
Prostate	7.2 nTPM
Liver	6.3 nTPM
Lung	6.2 nTPM
Salivary gland	4.6 nTPM

Enteroendocrine cells	26.2 nTPM
Small intestine	30.9 nTPM
Colon	24.1 nTPM
Rectum	23.5 nTPM

Fibroblasts	9.5 nTPM
Placenta	21.6 nTPM
Fallopian tube	21.3 nTPM
Breast	17.4 nTPM
Stomach	14.4 nTPM
Esophagus	10.7 nTPM
Salivary gland	8.5 nTPM
Thymus	8.5 nTPM
Vascular	8.4 nTPM
Lung	8.2 nTPM
Liver	5.9 nTPM
Prostate	5.9 nTPM
Skin	5.6 nTPM
Adipose tissue	4.9 nTPM
Pancreas	4.8 nTPM
Skeletal muscle	4.4 nTPM
Heart muscle	0.8 nTPM

Granulocytes	3.7 nTPM
Lung	7.1 nTPM
Fallopian tube	4.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	20.9 nTPM
Small intestine	35.7 nTPM
Colon	15.3 nTPM
Rectum	11.8 nTPM

Lymphatic endothelial cells	3.5 nTPM
Fallopian tube	7.0 nTPM
Ovary	0.0 nTPM

Macrophages	8.8 nTPM
Fallopian tube	14.2 nTPM
Endometrium	14.1 nTPM
Kidney	13.3 nTPM
Tongue	12.1 nTPM
Skeletal muscle	10.3 nTPM
Adipose tissue	10.3 nTPM
Breast	9.9 nTPM
Prostate	9.2 nTPM
Esophagus	9.0 nTPM
Lung	8.2 nTPM
Vascular	8.2 nTPM
Thymus	7.8 nTPM
Bone marrow	7.1 nTPM
Spleen	7.0 nTPM
Testis	6.8 nTPM
Salivary gland	6.7 nTPM
Pancreas	6.2 nTPM
Skin	4.5 nTPM
Stomach	2.6 nTPM

Paneth cells	36.3 nTPM
Small intestine	79.4 nTPM
Rectum	18.7 nTPM
Colon	10.9 nTPM

Basal prostatic cells	16.1 nTPM
Prostate	16.1 nTPM

Basal respiratory cells	13.1 nTPM
Bronchus	13.1 nTPM

Basal squamous epithelial cells	11.3 nTPM
Esophagus	11.3 nTPM

Cone photoreceptor cells	30.6 nTPM
Eye	30.6 nTPM

Plasma cells	13.0 nTPM
Thymus	20.2 nTPM
Liver	20.0 nTPM
Esophagus	15.6 nTPM
Spleen	15.6 nTPM
Stomach	12.1 nTPM
Fallopian tube	8.0 nTPM
Salivary gland	6.3 nTPM
Bone marrow	6.0 nTPM

Schwann cells	13.2 nTPM
Adipose tissue	18.7 nTPM
Esophagus	12.0 nTPM
Vascular	8.9 nTPM

Serous glandular cells	6.1 nTPM
Salivary gland	7.7 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	6.4 nTPM
Placenta	17.7 nTPM
Prostate	10.3 nTPM
Liver	10.2 nTPM
Fallopian tube	7.8 nTPM
Tongue	6.6 nTPM
Esophagus	6.0 nTPM
Ovary	6.0 nTPM
Skeletal muscle	5.9 nTPM
Thymus	5.6 nTPM
Vascular	5.2 nTPM
Endometrium	4.8 nTPM
Breast	4.6 nTPM
Salivary gland	4.4 nTPM
Skin	2.8 nTPM
Adipose tissue	2.7 nTPM
Lung	1.2 nTPM

Suprabasal keratinocytes	11.6 nTPM
Tongue	12.3 nTPM
Skin	10.9 nTPM

T-cells	6.3 nTPM
Liver	10.7 nTPM
Colon	9.7 nTPM
Stomach	9.7 nTPM
Lymph node	9.6 nTPM
Bone marrow	8.8 nTPM
PBMC	6.8 nTPM
Lung	6.3 nTPM
Endometrium	6.1 nTPM
Tongue	6.1 nTPM
Spleen	5.9 nTPM
Adipose tissue	5.8 nTPM
Skeletal muscle	5.7 nTPM
Breast	5.7 nTPM
Skin	5.6 nTPM
Vascular	5.6 nTPM
Esophagus	4.9 nTPM
Fallopian tube	4.8 nTPM
Salivary gland	4.6 nTPM
Prostate	4.3 nTPM
Thymus	3.4 nTPM
Kidney	1.8 nTPM

Undifferentiated cells	50.9 nTPM
Small intestine	110.8 nTPM
Colon	22.4 nTPM
Rectum	19.6 nTPM

Amygdala excitatory	5.1 nTPM
Basal ganglia	5.6 nTPM
Hypothalamus	5.6 nTPM
Hippocampus	5.1 nTPM
Thalamus	5.0 nTPM
Cerebral cortex	4.5 nTPM
Amygdala	4.4 nTPM

Astrocyte	6.5 nTPM
Spinal cord	9.2 nTPM
Pons	9.0 nTPM
Cerebellum	8.7 nTPM
Medulla oblongata	7.1 nTPM
Midbrain	6.2 nTPM
Thalamus	6.2 nTPM
Hippocampus	5.7 nTPM
Cerebral cortex	5.4 nTPM
Basal ganglia	4.8 nTPM
Hypothalamus	4.8 nTPM
Amygdala	4.3 nTPM

Bergmann glia	1.0 nTPM
Cerebellum	2.9 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	3.9 nTPM
Cerebral cortex	5.4 nTPM
Hippocampus	5.3 nTPM
Medulla oblongata	4.6 nTPM
Basal ganglia	4.4 nTPM
Pons	4.2 nTPM
Hypothalamus	4.0 nTPM
Thalamus	4.0 nTPM
Midbrain	3.9 nTPM
Amygdala	3.5 nTPM
Cerebellum	3.2 nTPM
Spinal cord	0.9 nTPM

Cerebellar inhibitory	4.0 nTPM
Midbrain	4.7 nTPM
Pons	4.5 nTPM
Medulla oblongata	4.2 nTPM
Cerebellum	3.9 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	4.4 nTPM
Midbrain	6.8 nTPM
Thalamus	6.2 nTPM
Basal ganglia	3.9 nTPM
Amygdala	3.6 nTPM
Cerebral cortex	3.6 nTPM
Hippocampus	3.4 nTPM
Hypothalamus	3.1 nTPM

Choroid plexus epithelial cell	3.4 nTPM
Hippocampus	5.5 nTPM
Medulla oblongata	4.4 nTPM
Basal ganglia	3.7 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	3.6 nTPM
Medulla oblongata	7.7 nTPM
Midbrain	5.9 nTPM
Hippocampus	5.2 nTPM
Amygdala	4.5 nTPM
Basal ganglia	4.4 nTPM
Cerebellum	3.2 nTPM
Pons	2.7 nTPM
Cerebral cortex	2.5 nTPM
Thalamus	2.3 nTPM
Hypothalamus	1.4 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	10.1 nTPM
Basal ganglia	14.1 nTPM
Midbrain	12.2 nTPM
Amygdala	12.1 nTPM
Cerebral cortex	9.2 nTPM
Hippocampus	7.3 nTPM
Hypothalamus	5.5 nTPM

Deep-layer intratelencephalic	7.3 nTPM
Basal ganglia	9.7 nTPM
Hippocampus	8.8 nTPM
Amygdala	6.7 nTPM
Cerebral cortex	6.0 nTPM
Hypothalamus	5.1 nTPM

Deep-layer near-projecting	7.0 nTPM
Hippocampus	8.1 nTPM
Basal ganglia	8.0 nTPM
Amygdala	7.5 nTPM
Cerebral cortex	6.0 nTPM
Hypothalamus	5.4 nTPM

Eccentric medium spiny neuron	2.8 nTPM
Hippocampus	3.7 nTPM
Hypothalamus	2.9 nTPM
Amygdala	2.7 nTPM
Thalamus	2.7 nTPM
Basal ganglia	2.5 nTPM
Cerebral cortex	2.5 nTPM

Endothelial cell	5.8 nTPM
Spinal cord	10.4 nTPM
Amygdala	7.8 nTPM
Hippocampus	6.7 nTPM
Midbrain	6.6 nTPM
Medulla oblongata	6.2 nTPM
Basal ganglia	5.6 nTPM
Cerebellum	5.4 nTPM
Pons	4.4 nTPM
Thalamus	4.0 nTPM
Hypothalamus	3.7 nTPM
Cerebral cortex	3.2 nTPM