Single cell type - BCL2A1 - The Human Protein Atlas

BCL2A1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCL2A1
Gene descriptionⁱ Full gene name according to HGNC.	BCL2 related protein A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Monocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.80
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Leukocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (neutrophil, non-classical monocyte, eosinophil, intermediate monocyte)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Monocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Leukocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (neutrophil, non-classical monocyte, eosinophil, intermediate monocyte)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

BCL2A1 is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 0.95
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LIPN	Lipase family member N	0.9274	29
ITGAX	Integrin subunit alpha X	0.8732	29
IL1B	Interleukin 1 beta	0.8606	29
PLAUR	Plasminogen activator, urokinase receptor	0.8545	29
C5AR1	Complement C5a receptor 1	0.8472	29
ACOD1	Aconitate decarboxylase 1	0.8366	29
EREG	Epiregulin	0.8297	29
IL1A	Interleukin 1 alpha	0.8083	29
FCAR	Fc alpha receptor	0.7919	29
PPIF	Peptidylprolyl isomerase F	0.7848	29
AMPD2	Adenosine monophosphate deaminase 2	0.7804	29
MEFV	MEFV innate immuity regulator, pyrin	0.7733	29
C9orf72	C9orf72-SMCR8 complex subunit	0.7693	29
RNF19B	Ring finger protein 19B	0.7680	29
FPR2	Formyl peptide receptor 2	0.7643	74

IMMUNE CELLS

BCL2A1 is part of cluster 37 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 0.64
275 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CATSPERG	Cation channel sperm associated auxiliary subunit gamma	1.0000	37
RAB2A	RAB2A, member RAS oncogene family	1.0000	37
STK40	Serine/threonine kinase 40	0.9762	37
FGR	FGR proto-oncogene, Src family tyrosine kinase	0.9762	37
TUBA1A	Tubulin alpha 1a	0.9762	37
DEDD2	Death effector domain containing 2	0.9762	37
TIAM2	TIAM Rac1 associated GEF 2	0.9762	37
LYST	Lysosomal trafficking regulator	0.9762	37
IFITM3	Interferon induced transmembrane protein 3	0.9762	37
RAB35	RAB35, member RAS oncogene family	0.9762	37
DENND3	DENN domain containing 3	0.9762	37
SGTA	Small glutamine rich tetratricopeptide repeat co-chaperone alpha	0.9762	37
USB1	U6 snRNA biogenesis phosphodiesterase 1	0.9762	37
CHFR	Checkpoint with forkhead and ring finger domains	0.9762	37
CMTM6	CKLF like MARVEL transmembrane domain containing 6	0.9524	37

Adipocytes	4.0 nTPM
Breast	7.6 nTPM
Adipose tissue	0.4 nTPM

Alveolar cells type 1	2.7 nTPM
Lung	2.7 nTPM

Alveolar cells type 2	2.3 nTPM
Lung	2.3 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	160.0 nTPM
Adipose tissue	410.7 nTPM
Spleen	282.2 nTPM
Stomach	224.0 nTPM
Skin	211.7 nTPM
Lymph node	207.6 nTPM
Esophagus	206.5 nTPM
Bone marrow	108.5 nTPM
Lung	104.6 nTPM
Thymus	96.6 nTPM
PBMC	80.0 nTPM
Salivary gland	77.7 nTPM
Liver	43.5 nTPM
Kidney	26.0 nTPM

Ciliated cells	15.3 nTPM
Fallopian tube	20.4 nTPM
Lung	14.5 nTPM
Bronchus	13.8 nTPM
Endometrium	12.3 nTPM

Club cells	22.7 nTPM
Bronchus	39.2 nTPM
Lung	28.5 nTPM
Prostate	0.4 nTPM

Endothelial cells	3.1 nTPM
Liver	10.1 nTPM
Lung	10.1 nTPM
Tongue	8.2 nTPM
Salivary gland	4.8 nTPM
Endometrium	4.3 nTPM
Thymus	3.2 nTPM
Fallopian tube	3.0 nTPM
Skin	2.5 nTPM
Placenta	2.3 nTPM
Heart muscle	2.2 nTPM
Vascular	1.9 nTPM
Skeletal muscle	1.4 nTPM
Prostate	0.7 nTPM
Esophagus	0.5 nTPM
Ovary	0.1 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	3.9 nTPM
Lung	15.5 nTPM
Pancreas	13.1 nTPM
Stomach	7.2 nTPM
Salivary gland	5.3 nTPM
Fallopian tube	4.5 nTPM
Vascular	3.4 nTPM
Skin	2.7 nTPM
Liver	2.4 nTPM
Thymus	2.3 nTPM
Placenta	1.9 nTPM
Skeletal muscle	1.1 nTPM
Breast	1.0 nTPM
Esophagus	0.8 nTPM
Prostate	0.7 nTPM
Heart muscle	0.5 nTPM
Adipose tissue	0.2 nTPM

Granulocytes	145.9 nTPM
Fallopian tube	267.1 nTPM
Tongue	106.7 nTPM
Lung	64.0 nTPM

Intestinal goblet cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	2.0 nTPM
Fallopian tube	4.0 nTPM
Ovary	0.0 nTPM

Macrophages	585.2 nTPM
Fallopian tube	2049.2 nTPM
Adipose tissue	1801.7 nTPM
Spleen	1106.8 nTPM
Stomach	995.4 nTPM
Endometrium	766.9 nTPM
Breast	525.8 nTPM
Pancreas	499.5 nTPM
Lung	498.6 nTPM
Skeletal muscle	491.7 nTPM
Esophagus	364.8 nTPM
Kidney	323.0 nTPM
Salivary gland	310.6 nTPM
Bone marrow	268.6 nTPM
Vascular	264.9 nTPM
Tongue	238.1 nTPM
Prostate	212.6 nTPM
Skin	161.6 nTPM
Testis	137.6 nTPM
Thymus	102.1 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal keratinocytes	6.5 nTPM
Tongue	8.8 nTPM
Skin	4.1 nTPM

Basal prostatic cells	3.6 nTPM
Prostate	3.6 nTPM

Basal respiratory cells	56.6 nTPM
Bronchus	56.6 nTPM

Cytotrophoblasts	1.2 nTPM
Placenta	1.2 nTPM

Plasma cells	9.3 nTPM
Bone marrow	15.1 nTPM
Spleen	10.8 nTPM
Esophagus	10.4 nTPM
Stomach	10.1 nTPM
Fallopian tube	10.0 nTPM
Salivary gland	8.1 nTPM
Liver	5.5 nTPM
Thymus	4.5 nTPM

Schwann cells	92.6 nTPM
Adipose tissue	277.2 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	38.7 nTPM
Salivary gland	59.7 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	2.1 nTPM
Thymus	5.4 nTPM
Endometrium	3.4 nTPM
Skin	3.3 nTPM
Breast	3.0 nTPM
Fallopian tube	2.9 nTPM
Esophagus	2.4 nTPM
Lung	2.4 nTPM
Placenta	2.3 nTPM
Salivary gland	2.2 nTPM
Vascular	2.1 nTPM
Skeletal muscle	1.4 nTPM
Tongue	0.9 nTPM
Liver	0.8 nTPM
Prostate	0.6 nTPM
Ovary	0.4 nTPM
Adipose tissue	0.2 nTPM

T-cells	50.5 nTPM
Colon	188.2 nTPM
Spleen	124.5 nTPM
Endometrium	67.2 nTPM
Lymph node	65.1 nTPM
Fallopian tube	57.2 nTPM
Vascular	53.9 nTPM
Lung	49.9 nTPM
Thymus	48.3 nTPM
Adipose tissue	43.9 nTPM
Prostate	40.5 nTPM
Stomach	39.6 nTPM
Kidney	38.1 nTPM
Breast	35.9 nTPM
Bone marrow	33.6 nTPM
Liver	33.4 nTPM
Salivary gland	30.9 nTPM
PBMC	28.8 nTPM
Skin	26.6 nTPM
Skeletal muscle	23.1 nTPM
Tongue	19.9 nTPM
Esophagus	12.2 nTPM

Undifferentiated cells	0.1 nTPM
Colon	0.1 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	0.1 nTPM
Thalamus	0.5 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Basal ganglia	0.0 nTPM
Hypothalamus	0.0 nTPM

Astrocyte	0.1 nTPM
Cerebral cortex	0.3 nTPM
Cerebellum	0.2 nTPM
Pons	0.2 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.1 nTPM
Medulla oblongata	0.1 nTPM
Midbrain	0.1 nTPM
Thalamus	0.1 nTPM
Amygdala	0.0 nTPM
Spinal cord	0.0 nTPM

Bergmann glia	0.0 nTPM
Cerebellum	0.1 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	4.3 nTPM
Basal ganglia	10.6 nTPM
Spinal cord	7.9 nTPM
Pons	5.6 nTPM
Medulla oblongata	5.2 nTPM
Midbrain	4.1 nTPM
Cerebellum	3.5 nTPM
Hippocampus	3.3 nTPM
Thalamus	3.3 nTPM
Hypothalamus	2.5 nTPM
Amygdala	1.0 nTPM
Cerebral cortex	0.8 nTPM

Cerebellar inhibitory	0.1 nTPM
Medulla oblongata	0.4 nTPM
Cerebellum	0.1 nTPM
Pons	0.1 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.1 nTPM
Midbrain	0.2 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Amygdala	0.0 nTPM
Hypothalamus	0.0 nTPM
Thalamus	0.0 nTPM

Choroid plexus epithelial cell	0.1 nTPM
Basal ganglia	0.1 nTPM
Medulla oblongata	0.1 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.3 nTPM
Pons	0.9 nTPM
Midbrain	0.8 nTPM
Basal ganglia	0.5 nTPM
Hippocampus	0.5 nTPM
Thalamus	0.2 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.1 nTPM
Amygdala	0.2 nTPM
Cerebral cortex	0.2 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Amygdala	0.0 nTPM
Hypothalamus	0.0 nTPM

Deep-layer near-projecting	0.0 nTPM
Basal ganglia	0.1 nTPM
Amygdala	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM

Eccentric medium spiny neuron	0.1 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Thalamus	0.0 nTPM

Endothelial cell	0.0 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM

Ependymal cell	0.1 nTPM
Pons	0.4 nTPM
Hippocampus	0.1 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM