Single cell type - PLAUR - The Human Protein Atlas

PLAUR

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLAUR
Gene descriptionⁱ Full gene name according to HGNC.	Plasminogen activator, urokinase receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes CD markers FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Monocytes, Langerhans cells, Macrophages, Hofbauer cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.59
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Leukocyte, Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Monocytes, Langerhans cells, Macrophages, Hofbauer cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Leukocyte, Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PLAUR is part of cluster 29 Monocytes - Innate immune response with confidenceⁱ 0.95
447 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL1B	Interleukin 1 beta	0.8839	29
IL1A	Interleukin 1 alpha	0.8716	29
EREG	Epiregulin	0.8629	29
BCL2A1	BCL2 related protein A1	0.8545	29
ITGAX	Integrin subunit alpha X	0.8452	29
ACOD1	Aconitate decarboxylase 1	0.8399	29
NLRP3	NLR family pyrin domain containing 3	0.8284	29
LIPN	Lipase family member N	0.8215	29
RIPK2	Receptor interacting serine/threonine kinase 2	0.8121	29
C5AR1	Complement C5a receptor 1	0.7922	29
ZNF267	Zinc finger protein 267	0.7830	29
THBS1	Thrombospondin 1	0.7807	29
SERPINB8	Serpin family B member 8	0.7697	29
STX11	Syntaxin 11	0.7636	29
CCRL2	C-C motif chemokine receptor like 2	0.7607	29

IMMUNE CELLS

PLAUR is part of cluster 7 Non-specific - Innate immune response with confidenceⁱ 1
237 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAB1B	RAB1B, member RAS oncogene family	1.0000	7
GNAI2	G protein subunit alpha i2	1.0000	7
BRI3	Brain protein I3	1.0000	7
RAC1	Rac family small GTPase 1	1.0000	7
NACC2	NACC family member 2	1.0000	7
ABHD2	Abhydrolase domain containing 2, acylglycerol lipase	0.9762	7
ENSG00000260861	Novel protein, SIRPB1-SIRPD readthrough	0.9762	7
OAZ2	Ornithine decarboxylase antizyme 2	0.9762	7
CLEC1B	C-type lectin domain family 1 member B	0.9762	7
SCLT1	Sodium channel and clathrin linker 1	0.9762	7
BIN3	Bridging integrator 3	0.9762	7
GALNS	Galactosamine (N-acetyl)-6-sulfatase	0.9762	7
MPP1	MAGUK p55 scaffold protein 1	0.9762	7
RHOT1	Ras homolog family member T1	0.9762	7
VPS18	VPS18 core subunit of CORVET and HOPS complexes	0.9762	7

Adipocytes	19.3 nTPM
Adipose tissue	20.0 nTPM
Breast	18.6 nTPM

Alveolar cells type 1	45.1 nTPM
Lung	45.1 nTPM

Alveolar cells type 2	23.8 nTPM
Lung	23.8 nTPM

Astrocytes	2.2 nTPM
Brain	2.2 nTPM

B-cells	71.4 nTPM
Skin	846.9 nTPM
Esophagus	29.5 nTPM
Lung	18.8 nTPM
Spleen	7.1 nTPM
Adipose tissue	6.6 nTPM
Kidney	5.2 nTPM
Liver	4.8 nTPM
Thymus	4.2 nTPM
Stomach	3.0 nTPM
PBMC	1.5 nTPM
Lymph node	0.5 nTPM
Salivary gland	0.4 nTPM
Bone marrow	0.0 nTPM

Basal squamous epithelial cells	158.4 nTPM
Esophagus	158.4 nTPM

Ciliated cells	89.7 nTPM
Endometrium	179.1 nTPM
Fallopian tube	84.1 nTPM
Bronchus	66.9 nTPM
Lung	28.8 nTPM

Club cells	98.3 nTPM
Bronchus	212.6 nTPM
Lung	57.2 nTPM
Prostate	25.2 nTPM

Dendritic cells	61.1 nTPM
Adipose tissue	100.6 nTPM
PBMC	21.6 nTPM

Endothelial cells	49.2 nTPM
Fallopian tube	193.4 nTPM
Tongue	109.3 nTPM
Lung	83.8 nTPM
Pancreas	75.0 nTPM
Skin	52.6 nTPM
Endometrium	51.5 nTPM
Thymus	49.9 nTPM
Esophagus	42.2 nTPM
Salivary gland	41.0 nTPM
Skeletal muscle	39.3 nTPM
Placenta	38.0 nTPM
Ovary	24.3 nTPM
Prostate	22.9 nTPM
Heart muscle	18.2 nTPM
Vascular	13.9 nTPM
Testis	12.5 nTPM
Liver	10.1 nTPM
Breast	7.0 nTPM

Enteroendocrine cells	21.1 nTPM
Colon	56.4 nTPM
Small intestine	3.4 nTPM
Rectum	3.4 nTPM

Fibroblasts	93.3 nTPM
Pancreas	394.8 nTPM
Skeletal muscle	204.9 nTPM
Fallopian tube	166.5 nTPM
Skin	132.8 nTPM
Stomach	118.2 nTPM
Thymus	101.1 nTPM
Lung	75.3 nTPM
Heart muscle	54.8 nTPM
Esophagus	52.7 nTPM
Salivary gland	39.5 nTPM
Vascular	35.0 nTPM
Adipose tissue	32.3 nTPM
Placenta	24.3 nTPM
Prostate	23.1 nTPM
Breast	21.6 nTPM
Liver	16.6 nTPM

Granulocytes	397.0 nTPM
Lung	772.9 nTPM
Tongue	237.7 nTPM
Fallopian tube	180.3 nTPM

Intestinal goblet cells	65.7 nTPM
Colon	120.6 nTPM
Small intestine	59.7 nTPM
Rectum	16.8 nTPM

Lymphatic endothelial cells	13.5 nTPM
Fallopian tube	21.5 nTPM
Ovary	5.5 nTPM

Bipolar cells	2.1 nTPM
Eye	2.1 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Cytotrophoblasts	5.1 nTPM
Placenta	5.1 nTPM

Distal enterocytes	267.7 nTPM
Colon	520.6 nTPM
Rectum	14.8 nTPM

Macrophages	885.5 nTPM
Fallopian tube	2793.5 nTPM
Adipose tissue	2398.3 nTPM
Stomach	1587.0 nTPM
Pancreas	1576.6 nTPM
Skeletal muscle	1450.4 nTPM
Spleen	1050.6 nTPM
Skin	939.3 nTPM
Tongue	759.6 nTPM
Breast	654.1 nTPM
Lung	642.2 nTPM
Esophagus	467.5 nTPM
Endometrium	466.8 nTPM
Kidney	456.7 nTPM
Vascular	435.1 nTPM
Salivary gland	369.5 nTPM
Thymus	291.6 nTPM
Testis	196.5 nTPM
Prostate	171.2 nTPM
Bone marrow	117.6 nTPM

Paneth cells	80.1 nTPM
Colon	231.6 nTPM
Rectum	5.3 nTPM
Small intestine	3.5 nTPM

Plasma cells	16.2 nTPM
Salivary gland	63.1 nTPM
Esophagus	26.0 nTPM
Fallopian tube	18.7 nTPM
Stomach	10.5 nTPM
Liver	7.0 nTPM
Thymus	3.2 nTPM
Spleen	1.4 nTPM
Bone marrow	0.0 nTPM

Schwann cells	246.5 nTPM
Adipose tissue	728.5 nTPM
Vascular	11.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	61.4 nTPM
Tongue	84.0 nTPM
Salivary gland	38.7 nTPM

Smooth muscle cells	39.9 nTPM
Skin	124.6 nTPM
Placenta	96.1 nTPM
Skeletal muscle	77.1 nTPM
Fallopian tube	69.6 nTPM
Tongue	61.7 nTPM
Endometrium	33.1 nTPM
Liver	26.7 nTPM
Salivary gland	23.6 nTPM
Thymus	22.9 nTPM
Lung	22.3 nTPM
Esophagus	21.6 nTPM
Adipose tissue	16.5 nTPM
Breast	13.1 nTPM
Vascular	11.6 nTPM
Prostate	10.3 nTPM
Ovary	7.8 nTPM

Suprabasal keratinocytes	114.8 nTPM
Tongue	182.8 nTPM
Skin	46.8 nTPM

T-cells	28.9 nTPM
Colon	188.2 nTPM
Skin	120.6 nTPM
Endometrium	38.8 nTPM
Adipose tissue	36.2 nTPM
Tongue	31.9 nTPM
Vascular	31.0 nTPM
Fallopian tube	25.4 nTPM
Breast	25.2 nTPM
Skeletal muscle	22.3 nTPM
Lung	18.7 nTPM
Esophagus	12.2 nTPM
Kidney	10.6 nTPM
Spleen	8.3 nTPM
Salivary gland	7.3 nTPM
Prostate	7.2 nTPM
Thymus	6.4 nTPM
Lymph node	4.1 nTPM
Stomach	4.0 nTPM
Liver	3.6 nTPM
PBMC	2.6 nTPM
Bone marrow	2.1 nTPM

Undifferentiated cells	14.5 nTPM
Colon	33.7 nTPM
Small intestine	5.9 nTPM
Rectum	4.0 nTPM

Amygdala excitatory	2.9 nTPM
Thalamus	6.4 nTPM
Cerebral cortex	3.0 nTPM
Hippocampus	2.7 nTPM
Basal ganglia	2.2 nTPM
Amygdala	1.8 nTPM
Hypothalamus	1.1 nTPM

Astrocyte	5.8 nTPM
Medulla oblongata	8.1 nTPM
Thalamus	7.0 nTPM
Cerebellum	6.9 nTPM
Pons	6.4 nTPM
Cerebral cortex	6.1 nTPM
Hypothalamus	5.7 nTPM
Midbrain	5.7 nTPM
Basal ganglia	5.4 nTPM
Hippocampus	5.3 nTPM
Amygdala	3.6 nTPM
Spinal cord	3.5 nTPM

Bergmann glia	10.9 nTPM
Medulla oblongata	21.3 nTPM
Cerebellum	7.2 nTPM
Pons	4.3 nTPM

Central nervous system macrophage	39.5 nTPM
Spinal cord	88.0 nTPM
Hypothalamus	45.4 nTPM
Medulla oblongata	45.1 nTPM
Pons	40.7 nTPM
Cerebellum	36.0 nTPM
Thalamus	33.0 nTPM
Amygdala	31.7 nTPM
Midbrain	31.7 nTPM
Hippocampus	31.3 nTPM
Basal ganglia	28.3 nTPM
Cerebral cortex	23.8 nTPM

Cerebellar inhibitory	6.3 nTPM
Spinal cord	8.2 nTPM
Medulla oblongata	7.5 nTPM
Cerebellum	6.5 nTPM
Pons	5.6 nTPM
Midbrain	3.7 nTPM

Cge interneuron	4.0 nTPM
Midbrain	4.9 nTPM
Cerebral cortex	4.6 nTPM
Thalamus	4.4 nTPM
Basal ganglia	4.3 nTPM
Amygdala	4.0 nTPM
Hippocampus	4.0 nTPM
Hypothalamus	1.8 nTPM

Choroid plexus epithelial cell	1.5 nTPM
Thalamus	2.7 nTPM
Basal ganglia	1.6 nTPM
Medulla oblongata	1.5 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	2.5 nTPM
Thalamus	4.1 nTPM
Spinal cord	3.7 nTPM
Hippocampus	3.6 nTPM
Cerebellum	3.2 nTPM
Basal ganglia	2.7 nTPM
Medulla oblongata	2.6 nTPM
Cerebral cortex	2.5 nTPM
Amygdala	1.7 nTPM
Hypothalamus	1.4 nTPM
Pons	0.9 nTPM
Midbrain	0.8 nTPM

Deep-layer corticothalamic and 6b	12.7 nTPM
Hypothalamus	17.7 nTPM
Basal ganglia	15.3 nTPM
Amygdala	14.9 nTPM
Hippocampus	11.8 nTPM
Cerebral cortex	8.5 nTPM
Midbrain	7.8 nTPM

Deep-layer intratelencephalic	3.7 nTPM
Hippocampus	4.1 nTPM
Basal ganglia	4.0 nTPM
Cerebral cortex	3.8 nTPM
Amygdala	3.5 nTPM
Hypothalamus	2.9 nTPM

Deep-layer near-projecting	8.6 nTPM
Basal ganglia	11.9 nTPM
Amygdala	10.2 nTPM
Cerebral cortex	7.7 nTPM
Hypothalamus	7.3 nTPM
Hippocampus	5.9 nTPM