Single cell type - GLCE - The Human Protein Atlas

GLCE

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLCE
Gene descriptionⁱ Full gene name according to HGNC.	Glucuronic acid epimerase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.46
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Upper rhombic lip)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Upper rhombic lip)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GLCE is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZDHHC11B	Zinc finger DHHC-type containing 11B	0.5808	51
RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing	0.5490	51
DLG2	Discs large MAGUK scaffold protein 2	0.5463	51
TMEFF2	Transmembrane protein with EGF like and two follistatin like domains 2	0.5452	51
MFSD6	Major facilitator superfamily domain containing 6	0.5451	3
PEX5L	Peroxisomal biogenesis factor 5 like	0.5317	51
DLG1	Discs large MAGUK scaffold protein 1	0.5131	51
AK5	Adenylate kinase 5	0.4924	51
NKAIN2	Sodium/potassium transporting ATPase interacting 2	0.4757	51
FANCL	FA complementation group L	0.4755	51
JAKMIP3	Janus kinase and microtubule interacting protein 3	0.4735	51
TPPP	Tubulin polymerization promoting protein	0.4715	51
ZC3H12B	Zinc finger CCCH-type containing 12B	0.4653	69
NIPAL2	NIPA like domain containing 2	0.4582	34
SEC14L5	SEC14 like lipid binding 5	0.4574	51

IMMUNE CELLS

GLCE is part of cluster 2 Dendritic cells - Unknown function with confidenceⁱ 0.63
342 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM86A	Transmembrane protein 86A	1.0000	2
DHRS4L2	Dehydrogenase/reductase 4 like 2	0.9762	2
SAT2	Spermidine/spermine N1-acetyltransferase family member 2	0.9762	2
ZBTB46	Zinc finger and BTB domain containing 46	0.9762	13
FRMD4B	FERM domain containing 4B	0.9762	2
DHRS4	Dehydrogenase/reductase 4	0.9524	2
ATP5MC3	ATP synthase membrane subunit c locus 3	0.9524	13
EHF	ETS homologous factor	0.9524	2
CD4	CD4 molecule	0.9524	2
PPY	Pancreatic polypeptide	0.9286	2
COX7A2L	Cytochrome c oxidase subunit 7A2 like	0.9286	13
RASA4	RAS p21 protein activator 4	0.9286	2
GYS1	Glycogen synthase 1	0.9286	13
EIF3L	Eukaryotic translation initiation factor 3 subunit L	0.9286	13
CRAT	Carnitine O-acetyltransferase	0.9286	33

Adipocytes	17.0 nTPM
Breast	19.4 nTPM
Adipose tissue	14.6 nTPM

Alveolar cells type 1	4.1 nTPM
Lung	4.1 nTPM

Alveolar cells type 2	16.1 nTPM
Lung	16.1 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	5.8 nTPM
Skin	15.2 nTPM
Lung	9.4 nTPM
Esophagus	5.9 nTPM
Stomach	5.5 nTPM
Lymph node	5.4 nTPM
Bone marrow	5.3 nTPM
Spleen	5.3 nTPM
Thymus	5.3 nTPM
Kidney	5.2 nTPM
Adipose tissue	4.9 nTPM
PBMC	4.6 nTPM
Salivary gland	3.7 nTPM
Liver	0.0 nTPM

Ciliated cells	10.1 nTPM
Lung	14.3 nTPM
Bronchus	12.1 nTPM
Fallopian tube	9.2 nTPM
Endometrium	4.8 nTPM

Club cells	14.7 nTPM
Bronchus	17.5 nTPM
Lung	16.6 nTPM
Prostate	10.0 nTPM

Dendritic cells	20.1 nTPM
PBMC	21.6 nTPM
Adipose tissue	18.7 nTPM

Endothelial cells	22.6 nTPM
Heart muscle	60.8 nTPM
Endometrium	38.1 nTPM
Liver	32.8 nTPM
Lung	28.5 nTPM
Skeletal muscle	26.4 nTPM
Tongue	24.0 nTPM
Vascular	20.0 nTPM
Placenta	19.3 nTPM
Ovary	19.1 nTPM
Salivary gland	18.8 nTPM
Thymus	18.1 nTPM
Skin	17.1 nTPM
Esophagus	16.7 nTPM
Testis	15.9 nTPM
Pancreas	15.5 nTPM
Prostate	15.2 nTPM
Fallopian tube	14.9 nTPM
Breast	5.3 nTPM

Enteroendocrine cells	24.8 nTPM
Colon	33.8 nTPM
Small intestine	20.6 nTPM
Rectum	20.1 nTPM

Fibroblasts	15.4 nTPM
Lung	27.4 nTPM
Skeletal muscle	21.0 nTPM
Adipose tissue	20.6 nTPM
Stomach	20.2 nTPM
Salivary gland	18.9 nTPM
Esophagus	17.5 nTPM
Thymus	16.3 nTPM
Breast	14.6 nTPM
Liver	14.2 nTPM
Prostate	13.9 nTPM
Heart muscle	13.0 nTPM
Placenta	10.0 nTPM
Skin	10.0 nTPM
Fallopian tube	9.9 nTPM
Vascular	9.8 nTPM
Pancreas	8.5 nTPM

Granulocytes	12.6 nTPM
Tongue	24.3 nTPM
Fallopian tube	7.1 nTPM
Lung	6.6 nTPM

Intestinal goblet cells	37.5 nTPM
Small intestine	57.3 nTPM
Rectum	30.8 nTPM
Colon	24.6 nTPM

Lymphatic endothelial cells	8.9 nTPM
Ovary	10.9 nTPM
Fallopian tube	6.9 nTPM

Macrophages	11.8 nTPM
Tongue	17.8 nTPM
Skeletal muscle	17.0 nTPM
Bone marrow	16.2 nTPM
Spleen	16.0 nTPM
Kidney	15.0 nTPM
Testis	13.6 nTPM
Esophagus	12.8 nTPM
Breast	12.6 nTPM
Vascular	11.5 nTPM
Prostate	11.4 nTPM
Lung	10.8 nTPM
Salivary gland	10.8 nTPM
Stomach	10.3 nTPM
Thymus	9.7 nTPM
Endometrium	9.2 nTPM
Skin	8.9 nTPM
Adipose tissue	8.4 nTPM
Fallopian tube	7.7 nTPM
Pancreas	4.1 nTPM

Basal respiratory cells	19.0 nTPM
Bronchus	19.0 nTPM

Basal squamous epithelial cells	25.3 nTPM
Esophagus	25.3 nTPM

Bipolar cells	8.0 nTPM
Eye	8.0 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Paneth cells	28.8 nTPM
Small intestine	51.8 nTPM
Rectum	27.4 nTPM
Colon	7.2 nTPM

Plasma cells	6.5 nTPM
Esophagus	10.4 nTPM
Salivary gland	8.5 nTPM
Spleen	7.0 nTPM
Liver	6.5 nTPM
Stomach	5.4 nTPM
Thymus	4.8 nTPM
Fallopian tube	4.8 nTPM
Bone marrow	4.5 nTPM

Schwann cells	9.6 nTPM
Esophagus	12.0 nTPM
Adipose tissue	9.4 nTPM
Vascular	7.3 nTPM

Serous glandular cells	31.0 nTPM
Tongue	48.6 nTPM
Salivary gland	13.3 nTPM

Smooth muscle cells	7.1 nTPM
Liver	16.1 nTPM
Prostate	13.4 nTPM
Adipose tissue	8.9 nTPM
Tongue	8.4 nTPM
Skeletal muscle	7.9 nTPM
Lung	7.1 nTPM
Salivary gland	6.5 nTPM
Skin	6.0 nTPM
Ovary	5.9 nTPM
Fallopian tube	5.8 nTPM
Breast	5.7 nTPM
Thymus	5.5 nTPM
Endometrium	5.2 nTPM
Vascular	5.2 nTPM
Placenta	2.9 nTPM
Esophagus	2.4 nTPM

Suprabasal keratinocytes	19.7 nTPM
Tongue	23.4 nTPM
Skin	16.1 nTPM

T-cells	7.4 nTPM
Skin	16.5 nTPM
Tongue	12.7 nTPM
Esophagus	12.2 nTPM
Prostate	10.4 nTPM
Breast	9.5 nTPM
Stomach	8.6 nTPM
Adipose tissue	7.9 nTPM
Spleen	7.5 nTPM
Lymph node	6.8 nTPM
Thymus	6.8 nTPM
Salivary gland	6.6 nTPM
Skeletal muscle	6.4 nTPM
Lung	5.5 nTPM
Kidney	5.3 nTPM
Liver	5.3 nTPM
Vascular	5.2 nTPM
Fallopian tube	5.0 nTPM
Endometrium	4.8 nTPM
Bone marrow	4.6 nTPM
Colon	3.9 nTPM
PBMC	3.4 nTPM

Undifferentiated cells	27.5 nTPM
Small intestine	33.8 nTPM
Rectum	27.2 nTPM
Colon	21.3 nTPM

Amygdala excitatory	119.3 nTPM
Thalamus	193.3 nTPM
Amygdala	151.9 nTPM
Basal ganglia	113.4 nTPM
Cerebral cortex	103.1 nTPM
Hippocampus	82.0 nTPM
Hypothalamus	72.3 nTPM

Astrocyte	11.7 nTPM
Hypothalamus	15.5 nTPM
Amygdala	14.0 nTPM
Medulla oblongata	12.8 nTPM
Basal ganglia	12.5 nTPM
Thalamus	12.5 nTPM
Cerebral cortex	10.9 nTPM
Hippocampus	10.6 nTPM
Spinal cord	10.3 nTPM
Cerebellum	10.0 nTPM
Pons	9.7 nTPM
Midbrain	9.4 nTPM

Bergmann glia	18.2 nTPM
Cerebellum	21.1 nTPM
Medulla oblongata	19.2 nTPM
Pons	14.4 nTPM

Central nervous system macrophage	248.2 nTPM
Amygdala	319.4 nTPM
Hypothalamus	292.1 nTPM
Basal ganglia	259.0 nTPM
Midbrain	257.3 nTPM
Thalamus	255.3 nTPM
Pons	249.4 nTPM
Hippocampus	242.8 nTPM
Medulla oblongata	227.6 nTPM
Cerebral cortex	226.1 nTPM
Cerebellum	219.1 nTPM
Spinal cord	182.5 nTPM

Cerebellar inhibitory	348.6 nTPM
Midbrain	465.3 nTPM
Medulla oblongata	458.1 nTPM
Pons	284.7 nTPM
Spinal cord	283.2 nTPM
Cerebellum	251.4 nTPM

Cge interneuron	89.9 nTPM
Hypothalamus	137.7 nTPM
Amygdala	114.5 nTPM
Basal ganglia	105.6 nTPM
Cerebral cortex	83.9 nTPM
Hippocampus	76.4 nTPM
Midbrain	63.5 nTPM
Thalamus	47.8 nTPM

Choroid plexus epithelial cell	88.4 nTPM
Hippocampus	102.6 nTPM
Thalamus	95.9 nTPM
Medulla oblongata	77.6 nTPM
Basal ganglia	77.5 nTPM

Committed oligodendrocyte precursor	81.7 nTPM
Hypothalamus	129.0 nTPM
Cerebellum	109.4 nTPM
Thalamus	107.2 nTPM
Medulla oblongata	90.4 nTPM
Amygdala	89.1 nTPM
Basal ganglia	73.9 nTPM
Pons	68.2 nTPM
Spinal cord	62.5 nTPM
Cerebral cortex	60.8 nTPM
Midbrain	54.6 nTPM
Hippocampus	53.3 nTPM

Deep-layer corticothalamic and 6b	190.8 nTPM
Amygdala	241.8 nTPM
Basal ganglia	226.7 nTPM
Cerebral cortex	193.6 nTPM
Hypothalamus	182.2 nTPM
Midbrain	166.4 nTPM
Hippocampus	133.9 nTPM

Deep-layer intratelencephalic	105.3 nTPM
Amygdala	169.5 nTPM
Cerebral cortex	95.9 nTPM
Hypothalamus	93.4 nTPM
Basal ganglia	91.8 nTPM
Hippocampus	76.1 nTPM

Deep-layer near-projecting	72.0 nTPM
Basal ganglia	113.3 nTPM
Hypothalamus	101.9 nTPM
Amygdala	54.2 nTPM
Cerebral cortex	49.3 nTPM
Hippocampus	41.3 nTPM

Eccentric medium spiny neuron	306.5 nTPM
Amygdala	336.3 nTPM
Hypothalamus	325.5 nTPM
Cerebral cortex	301.9 nTPM
Hippocampus	299.3 nTPM
Thalamus	290.9 nTPM
Basal ganglia	285.4 nTPM