Single cell type - TPPP - The Human Protein Atlas

TPPP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPPP
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin polymerization promoting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Excitatory neurons, Horizontal cells, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.69
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons, Horizontal cells, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TPPP is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZDHHC11B	Zinc finger DHHC-type containing 11B	0.8015	51
PRR18	Proline rich 18	0.6342	51
TRIM2	Tripartite motif containing 2	0.5991	51
TMEFF2	Transmembrane protein with EGF like and two follistatin like domains 2	0.5871	51
PEX5L	Peroxisomal biogenesis factor 5 like	0.5736	51
IFT80	Intraflagellar transport 80	0.5697	51
SRCIN1	SRC kinase signaling inhibitor 1	0.5675	51
DLG1	Discs large MAGUK scaffold protein 1	0.5643	51
JAKMIP3	Janus kinase and microtubule interacting protein 3	0.5617	51
PLD1	Phospholipase D1	0.5423	51
TULP4	TUB like protein 4	0.5382	51
ACP7	Acid phosphatase 7, tartrate resistant (putative)	0.5313	51
PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	0.5275	51
NKAIN2	Sodium/potassium transporting ATPase interacting 2	0.5262	51
HS3ST5	Heparan sulfate-glucosamine 3-sulfotransferase 5	0.5260	51

Adipocytes	1.9 nTPM
Adipose tissue	2.8 nTPM
Breast	0.9 nTPM

Alveolar cells type 1	10.4 nTPM
Lung	10.4 nTPM

Alveolar cells type 2	6.2 nTPM
Lung	6.2 nTPM

Astrocytes	6.5 nTPM
Brain	6.5 nTPM

B-cells	0.9 nTPM
Adipose tissue	6.2 nTPM
Skin	5.1 nTPM
Stomach	0.4 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	26.8 nTPM
Lung	29.3 nTPM
Fallopian tube	28.1 nTPM
Endometrium	26.5 nTPM
Bronchus	23.2 nTPM

Club cells	2.5 nTPM
Lung	4.6 nTPM
Bronchus	1.8 nTPM
Prostate	1.2 nTPM

Endothelial cells	1.8 nTPM
Heart muscle	12.0 nTPM
Tongue	4.2 nTPM
Skeletal muscle	2.8 nTPM
Liver	2.5 nTPM
Skin	2.2 nTPM
Breast	1.8 nTPM
Salivary gland	1.4 nTPM
Lung	1.2 nTPM
Thymus	0.9 nTPM
Esophagus	0.8 nTPM
Vascular	0.8 nTPM
Fallopian tube	0.8 nTPM
Prostate	0.5 nTPM
Endometrium	0.3 nTPM
Ovary	0.2 nTPM
Testis	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	6.0 nTPM
Colon	9.5 nTPM
Rectum	8.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	2.6 nTPM
Heart muscle	8.5 nTPM
Skeletal muscle	4.6 nTPM
Stomach	4.3 nTPM
Fallopian tube	4.3 nTPM
Skin	4.2 nTPM
Lung	3.2 nTPM
Adipose tissue	3.0 nTPM
Liver	2.4 nTPM
Esophagus	1.5 nTPM
Vascular	1.5 nTPM
Salivary gland	1.1 nTPM
Thymus	1.0 nTPM
Placenta	0.8 nTPM
Breast	0.6 nTPM
Pancreas	0.2 nTPM
Prostate	0.0 nTPM

Granulocytes	11.7 nTPM
Tongue	29.1 nTPM
Fallopian tube	5.4 nTPM
Lung	0.5 nTPM

Intestinal goblet cells	6.3 nTPM
Colon	8.1 nTPM
Small intestine	5.8 nTPM
Rectum	4.9 nTPM

Lymphatic endothelial cells	4.8 nTPM
Fallopian tube	9.6 nTPM
Ovary	0.0 nTPM

Macrophages	1.2 nTPM
Skin	10.0 nTPM
Tongue	3.7 nTPM
Skeletal muscle	1.5 nTPM
Adipose tissue	1.3 nTPM
Esophagus	1.3 nTPM
Vascular	1.3 nTPM
Endometrium	1.2 nTPM
Lung	1.1 nTPM
Fallopian tube	1.1 nTPM
Salivary gland	0.3 nTPM
Thymus	0.2 nTPM
Breast	0.2 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Paneth cells	6.5 nTPM
Colon	10.9 nTPM
Small intestine	6.9 nTPM
Rectum	1.7 nTPM

Basal keratinocytes	12.6 nTPM
Skin	15.3 nTPM
Tongue	9.9 nTPM

Basal squamous epithelial cells	7.1 nTPM
Esophagus	7.1 nTPM

Bipolar cells	19.2 nTPM
Eye	19.2 nTPM

Endometrial stromal cells	0.7 nTPM
Endometrium	0.7 nTPM

Plasma cells	1.6 nTPM
Fallopian tube	7.1 nTPM
Salivary gland	4.5 nTPM
Liver	0.5 nTPM
Stomach	0.4 nTPM
Thymus	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	1.1 nTPM
Vascular	2.6 nTPM
Adipose tissue	0.8 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	7.0 nTPM
Tongue	13.3 nTPM
Salivary gland	0.7 nTPM

Smooth muscle cells	3.8 nTPM
Fallopian tube	8.2 nTPM
Adipose tissue	6.0 nTPM
Lung	5.9 nTPM
Vascular	5.7 nTPM
Thymus	5.6 nTPM
Skin	4.2 nTPM
Breast	4.1 nTPM
Esophagus	3.6 nTPM
Salivary gland	3.6 nTPM
Skeletal muscle	2.7 nTPM
Tongue	2.7 nTPM
Ovary	2.7 nTPM
Liver	2.5 nTPM
Prostate	2.4 nTPM
Endometrium	0.9 nTPM
Placenta	0.6 nTPM

Suprabasal keratinocytes	10.9 nTPM
Skin	16.6 nTPM
Tongue	5.3 nTPM

T-cells	5.3 nTPM
Adipose tissue	30.0 nTPM
Skin	22.8 nTPM
Tongue	11.6 nTPM
Skeletal muscle	11.3 nTPM
Fallopian tube	10.8 nTPM
Stomach	4.7 nTPM
Endometrium	4.0 nTPM
Breast	3.5 nTPM
Colon	2.9 nTPM
Esophagus	2.4 nTPM
Lung	2.4 nTPM
Vascular	1.2 nTPM
Spleen	1.0 nTPM
Thymus	0.8 nTPM
Liver	0.7 nTPM
Prostate	0.4 nTPM
Salivary gland	0.4 nTPM
Lymph node	0.3 nTPM
Bone marrow	0.3 nTPM
PBMC	0.1 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	4.5 nTPM
Small intestine	4.9 nTPM
Rectum	4.8 nTPM
Colon	3.9 nTPM

Amygdala excitatory	61.7 nTPM
Hypothalamus	83.3 nTPM
Hippocampus	59.4 nTPM
Amygdala	58.6 nTPM
Cerebral cortex	57.4 nTPM
Basal ganglia	57.2 nTPM
Thalamus	54.0 nTPM

Astrocyte	7.9 nTPM
Cerebral cortex	9.8 nTPM
Cerebellum	9.7 nTPM
Midbrain	8.8 nTPM
Thalamus	8.5 nTPM
Hypothalamus	8.2 nTPM
Spinal cord	7.5 nTPM
Hippocampus	7.3 nTPM
Pons	7.2 nTPM
Basal ganglia	7.1 nTPM
Amygdala	6.8 nTPM
Medulla oblongata	6.2 nTPM

Bergmann glia	1.7 nTPM
Cerebellum	3.7 nTPM
Pons	1.4 nTPM
Medulla oblongata	0.0 nTPM

Central nervous system macrophage	4.3 nTPM
Cerebral cortex	7.8 nTPM
Thalamus	5.8 nTPM
Hypothalamus	5.5 nTPM
Midbrain	5.4 nTPM
Hippocampus	4.6 nTPM
Pons	4.5 nTPM
Spinal cord	3.5 nTPM
Amygdala	3.3 nTPM
Cerebellum	2.5 nTPM
Basal ganglia	2.4 nTPM
Medulla oblongata	2.0 nTPM

Cerebellar inhibitory	26.2 nTPM
Spinal cord	33.0 nTPM
Midbrain	29.9 nTPM
Cerebellum	26.9 nTPM
Pons	23.7 nTPM
Medulla oblongata	17.5 nTPM

Cge interneuron	55.6 nTPM
Hypothalamus	74.3 nTPM
Thalamus	56.6 nTPM
Hippocampus	55.6 nTPM
Amygdala	54.8 nTPM
Cerebral cortex	52.6 nTPM
Basal ganglia	48.5 nTPM
Midbrain	46.4 nTPM

Choroid plexus epithelial cell	12.5 nTPM
Thalamus	19.2 nTPM
Basal ganglia	16.2 nTPM
Medulla oblongata	12.0 nTPM
Hippocampus	2.8 nTPM

Committed oligodendrocyte precursor	82.0 nTPM
Thalamus	150.8 nTPM
Hypothalamus	122.9 nTPM
Amygdala	105.4 nTPM
Spinal cord	80.9 nTPM
Basal ganglia	77.7 nTPM
Hippocampus	77.6 nTPM
Midbrain	68.0 nTPM
Cerebral cortex	67.1 nTPM
Pons	65.5 nTPM
Cerebellum	60.3 nTPM
Medulla oblongata	25.8 nTPM

Deep-layer corticothalamic and 6b	78.4 nTPM
Hypothalamus	137.0 nTPM
Amygdala	78.2 nTPM
Cerebral cortex	70.5 nTPM
Hippocampus	68.6 nTPM
Midbrain	63.2 nTPM
Basal ganglia	53.0 nTPM

Deep-layer intratelencephalic	82.5 nTPM
Hypothalamus	154.3 nTPM
Cerebral cortex	73.2 nTPM
Hippocampus	68.8 nTPM
Amygdala	66.2 nTPM
Basal ganglia	50.1 nTPM

Deep-layer near-projecting	66.1 nTPM
Hypothalamus	114.5 nTPM
Amygdala	73.9 nTPM
Cerebral cortex	63.1 nTPM
Hippocampus	42.0 nTPM
Basal ganglia	37.3 nTPM

Eccentric medium spiny neuron	76.6 nTPM
Thalamus	86.5 nTPM
Hippocampus	83.7 nTPM
Hypothalamus	82.7 nTPM
Cerebral cortex	73.4 nTPM
Basal ganglia	69.0 nTPM
Amygdala	64.2 nTPM

Endothelial cell	3.9 nTPM
Hypothalamus	7.4 nTPM
Hippocampus	6.7 nTPM
Cerebral cortex	6.4 nTPM
Midbrain	4.7 nTPM
Thalamus	4.0 nTPM
Spinal cord	3.5 nTPM
Pons	3.1 nTPM
Basal ganglia	2.8 nTPM
Amygdala	2.2 nTPM
Cerebellum	1.5 nTPM
Medulla oblongata	1.0 nTPM