Single cell type - DLG2 - The Human Protein Atlas

DLG2

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DLG2
Gene descriptionⁱ Full gene name according to HGNC.	Discs large MAGUK scaffold protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	32

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.77
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DLG2 is part of cluster 51 Oligodendrocytes - Unknown function with confidenceⁱ 1
302 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CADM2	Cell adhesion molecule 2	0.9035	69
NALCN	Sodium leak channel, non-selective	0.8777	69
ANKS1B	Ankyrin repeat and sterile alpha motif domain containing 1B	0.8250	34
SHISA7	Shisa family member 7	0.8199	34
AK5	Adenylate kinase 5	0.8094	51
ZC3H12B	Zinc finger CCCH-type containing 12B	0.7902	69
INSYN2B	Inhibitory synaptic factor family member 2B	0.7648	51
FAM131B	Family with sequence similarity 131 member B	0.7541	51
NCAM2	Neural cell adhesion molecule 2	0.7403	69
CLASP2	Cytoplasmic linker associated protein 2	0.7196	51
OTUD7A	OTU deubiquitinase 7A	0.7141	51
PEX5L	Peroxisomal biogenesis factor 5 like	0.7080	51
SLC7A14	Solute carrier family 7 member 14	0.7074	69
SCN2A	Sodium voltage-gated channel alpha subunit 2	0.6952	69
SYT14	Synaptotagmin 14	0.6885	69

Adipocytes	5.4 nTPM
Breast	5.7 nTPM
Adipose tissue	4.9 nTPM

Alveolar cells type 1	0.6 nTPM
Lung	0.6 nTPM

Alveolar cells type 2	5.3 nTPM
Lung	5.3 nTPM

Astrocytes	704.4 nTPM
Brain	704.4 nTPM

B-cells	1.3 nTPM
Liver	4.8 nTPM
PBMC	3.1 nTPM
Salivary gland	2.2 nTPM
Lymph node	1.8 nTPM
Adipose tissue	1.6 nTPM
Spleen	1.3 nTPM
Lung	1.3 nTPM
Thymus	0.8 nTPM
Kidney	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	2.3 nTPM
Fallopian tube	5.5 nTPM
Lung	1.6 nTPM
Endometrium	1.5 nTPM
Bronchus	0.4 nTPM

Club cells	1.3 nTPM
Prostate	2.7 nTPM
Lung	1.2 nTPM
Bronchus	0.1 nTPM

Endothelial cells	3.7 nTPM
Skeletal muscle	10.5 nTPM
Prostate	7.9 nTPM
Breast	7.0 nTPM
Tongue	5.2 nTPM
Ovary	5.1 nTPM
Salivary gland	4.6 nTPM
Heart muscle	4.0 nTPM
Vascular	3.8 nTPM
Esophagus	3.1 nTPM
Skin	2.7 nTPM
Fallopian tube	2.6 nTPM
Endometrium	2.5 nTPM
Testis	2.4 nTPM
Thymus	2.1 nTPM
Placenta	1.7 nTPM
Lung	1.1 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	1.4 nTPM
Rectum	3.4 nTPM
Colon	0.8 nTPM
Small intestine	0.0 nTPM

Fibroblasts	6.4 nTPM
Esophagus	16.8 nTPM
Skeletal muscle	13.2 nTPM
Prostate	9.2 nTPM
Heart muscle	7.8 nTPM
Breast	7.3 nTPM
Vascular	7.2 nTPM
Fallopian tube	6.4 nTPM
Salivary gland	6.1 nTPM
Stomach	5.8 nTPM
Adipose tissue	5.5 nTPM
Lung	4.4 nTPM
Placenta	4.2 nTPM
Skin	3.9 nTPM
Thymus	3.6 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Granulocytes	0.9 nTPM
Fallopian tube	2.1 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.5 nTPM
Colon	1.2 nTPM
Rectum	0.3 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	13.0 nTPM
Ovary	21.8 nTPM
Fallopian tube	4.2 nTPM

Macrophages	0.9 nTPM
Breast	5.1 nTPM
Prostate	2.7 nTPM
Testis	2.5 nTPM
Tongue	1.6 nTPM
Skeletal muscle	1.5 nTPM
Salivary gland	1.4 nTPM
Bone marrow	1.0 nTPM
Vascular	0.8 nTPM
Fallopian tube	0.4 nTPM
Adipose tissue	0.2 nTPM
Thymus	0.2 nTPM
Lung	0.1 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal prostatic cells	12.0 nTPM
Prostate	12.0 nTPM

Basal squamous epithelial cells	6.0 nTPM
Esophagus	6.0 nTPM

Bipolar cells	278.4 nTPM
Eye	278.4 nTPM

Cholangiocytes	1.9 nTPM
Liver	1.9 nTPM

Plasma cells	0.7 nTPM
Fallopian tube	3.2 nTPM
Liver	0.5 nTPM
Thymus	0.5 nTPM
Stomach	0.4 nTPM
Salivary gland	0.4 nTPM
Spleen	0.2 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	7.4 nTPM
Esophagus	12.0 nTPM
Vascular	9.4 nTPM
Adipose tissue	0.8 nTPM

Serous glandular cells	4.3 nTPM
Tongue	4.4 nTPM
Salivary gland	4.2 nTPM

Smooth muscle cells	5.3 nTPM
Breast	10.9 nTPM
Skeletal muscle	7.3 nTPM
Salivary gland	6.9 nTPM
Tongue	6.9 nTPM
Fallopian tube	6.9 nTPM
Adipose tissue	6.7 nTPM
Vascular	6.2 nTPM
Ovary	6.0 nTPM
Esophagus	4.8 nTPM
Thymus	4.8 nTPM
Prostate	4.3 nTPM
Lung	3.5 nTPM
Skin	3.3 nTPM
Endometrium	2.8 nTPM
Liver	2.1 nTPM
Placenta	1.1 nTPM

Suprabasal keratinocytes	11.6 nTPM
Tongue	13.0 nTPM
Skin	10.1 nTPM

T-cells	1.8 nTPM
Breast	5.5 nTPM
Skeletal muscle	4.9 nTPM
Prostate	4.0 nTPM
Endometrium	3.0 nTPM
Kidney	2.7 nTPM
Fallopian tube	2.3 nTPM
Tongue	2.1 nTPM
Salivary gland	1.9 nTPM
Lymph node	1.6 nTPM
Skin	1.4 nTPM
Adipose tissue	1.4 nTPM
PBMC	1.2 nTPM
Vascular	1.2 nTPM
Colon	1.0 nTPM
Thymus	1.0 nTPM
Bone marrow	0.8 nTPM
Spleen	0.5 nTPM
Lung	0.5 nTPM
Liver	0.3 nTPM
Stomach	0.1 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	0.4 nTPM
Rectum	0.5 nTPM
Colon	0.3 nTPM
Small intestine	0.2 nTPM

Amygdala excitatory	5409.9 nTPM
Hypothalamus	6200.2 nTPM
Amygdala	5619.5 nTPM
Basal ganglia	5516.1 nTPM
Hippocampus	5482.2 nTPM
Cerebral cortex	5326.7 nTPM
Thalamus	4315.1 nTPM

Astrocyte	1122.7 nTPM
Amygdala	2031.1 nTPM
Hippocampus	1640.0 nTPM
Hypothalamus	1426.9 nTPM
Cerebral cortex	1421.6 nTPM
Basal ganglia	1410.7 nTPM
Thalamus	993.4 nTPM
Midbrain	812.4 nTPM
Spinal cord	726.0 nTPM
Pons	652.0 nTPM
Medulla oblongata	650.5 nTPM
Cerebellum	584.9 nTPM

Bergmann glia	1922.9 nTPM
Cerebellum	2235.9 nTPM
Pons	1789.6 nTPM
Medulla oblongata	1743.2 nTPM

Central nervous system macrophage	308.9 nTPM
Amygdala	460.9 nTPM
Hypothalamus	411.1 nTPM
Thalamus	343.8 nTPM
Hippocampus	341.4 nTPM
Cerebral cortex	334.9 nTPM
Midbrain	303.5 nTPM
Basal ganglia	282.4 nTPM
Pons	244.9 nTPM
Cerebellum	230.3 nTPM
Spinal cord	227.9 nTPM
Medulla oblongata	216.9 nTPM

Cerebellar inhibitory	1671.1 nTPM
Spinal cord	2397.8 nTPM
Cerebellum	1585.7 nTPM
Midbrain	1539.1 nTPM
Medulla oblongata	1510.5 nTPM
Pons	1322.2 nTPM

Cge interneuron	3574.5 nTPM
Hypothalamus	4460.7 nTPM
Amygdala	4269.3 nTPM
Basal ganglia	3470.4 nTPM
Hippocampus	3447.1 nTPM
Midbrain	3269.4 nTPM
Cerebral cortex	3114.4 nTPM
Thalamus	2990.5 nTPM

Choroid plexus epithelial cell	274.3 nTPM
Thalamus	600.1 nTPM
Basal ganglia	184.7 nTPM
Medulla oblongata	165.4 nTPM
Hippocampus	147.0 nTPM

Committed oligodendrocyte precursor	2418.5 nTPM
Hypothalamus	4477.8 nTPM
Thalamus	4169.2 nTPM
Amygdala	4129.1 nTPM
Cerebral cortex	2352.2 nTPM
Basal ganglia	2296.3 nTPM
Hippocampus	2192.2 nTPM
Midbrain	1694.3 nTPM
Cerebellum	1461.9 nTPM
Pons	1374.1 nTPM
Medulla oblongata	1301.3 nTPM
Spinal cord	1155.3 nTPM

Deep-layer corticothalamic and 6b	5393.0 nTPM
Amygdala	6023.0 nTPM
Hypothalamus	5789.0 nTPM
Hippocampus	5646.9 nTPM
Cerebral cortex	5413.3 nTPM
Midbrain	5030.0 nTPM
Basal ganglia	4455.9 nTPM

Deep-layer intratelencephalic	5432.6 nTPM
Amygdala	6666.1 nTPM
Hypothalamus	6114.3 nTPM
Hippocampus	5552.4 nTPM
Cerebral cortex	4474.6 nTPM
Basal ganglia	4355.5 nTPM

Deep-layer near-projecting	3515.2 nTPM
Hypothalamus	4803.4 nTPM
Amygdala	4059.8 nTPM
Cerebral cortex	3239.1 nTPM
Basal ganglia	2781.9 nTPM
Hippocampus	2691.7 nTPM

Eccentric medium spiny neuron	5529.7 nTPM
Amygdala	6787.6 nTPM
Hypothalamus	6109.1 nTPM
Cerebral cortex	5830.0 nTPM
Thalamus	5130.8 nTPM
Basal ganglia	4748.9 nTPM
Hippocampus	4572.1 nTPM

Endothelial cell	519.8 nTPM
Basal ganglia	738.2 nTPM
Hypothalamus	655.1 nTPM
Amygdala	617.0 nTPM
Hippocampus	587.0 nTPM
Midbrain	528.3 nTPM
Thalamus	503.8 nTPM
Cerebral cortex	471.8 nTPM
Cerebellum	447.6 nTPM
Pons	441.3 nTPM
Spinal cord	374.5 nTPM
Medulla oblongata	352.8 nTPM