Single cell type - CSE1L - The Human Protein Atlas

CSE1L

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CSE1L
Gene descriptionⁱ Full gene name according to HGNC.	Chromosome segregation 1 like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cell proliferation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Spermatocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.38
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Spermatocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CSE1L is part of cluster 52 Non-specific - Cell proliferation with confidenceⁱ 1
248 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PARS2	Prolyl-tRNA synthetase 2, mitochondrial	0.5002	67
XRCC6	X-ray repair cross complementing 6	0.4895	39
KNL1	Kinetochore scaffold 1	0.4635	79
RMI2	RecQ mediated genome instability 2	0.4592	24
UBAC1	UBA domain containing 1	0.4582	1
CENPH	Centromere protein H	0.4567	52
TEX30	Testis expressed 30	0.4565	31
USP5	Ubiquitin specific peptidase 5	0.4493	39
EME1	Essential meiotic structure-specific endonuclease 1	0.4427	52
TIPIN	TIMELESS interacting protein	0.4418	79
YEATS4	YEATS domain containing 4	0.4414	31
CCDC15	Coiled-coil domain containing 15	0.4380	31
PCNA	Proliferating cell nuclear antigen	0.4374	52
ORC6	Origin recognition complex subunit 6	0.4357	52
POTED	POTE ankyrin domain family member D	0.4320	31

IMMUNE CELLS

CSE1L is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.98
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WDR3	WD repeat domain 3	1.0000	33
DDX3Y	DEAD-box helicase 3 Y-linked	0.9762	33
ZNF408	Zinc finger protein 408	0.9762	33
ZMYM2	Zinc finger MYM-type containing 2	0.9762	33
CCT4	Chaperonin containing TCP1 subunit 4	0.9524	33
TPRG1	Tumor protein p63 regulated 1	0.9524	33
IQCG	IQ motif containing G	0.9524	33
HSPA9	Heat shock protein family A (Hsp70) member 9	0.9524	33
ACOT13	Acyl-CoA thioesterase 13	0.9524	33
ZNF862	Zinc finger protein 862	0.9524	33
DOP1A	DOP1 leucine zipper like protein A	0.9524	33
VEZT	Vezatin, adherens junctions transmembrane protein	0.9286	33
POLR1B	RNA polymerase I subunit B	0.9286	33
EMC1	ER membrane protein complex subunit 1	0.9286	33
POMT1	Protein O-mannosyltransferase 1	0.9286	33

Adipocytes	15.3 nTPM
Breast	16.5 nTPM
Adipose tissue	14.2 nTPM

Alveolar cells type 1	34.5 nTPM
Lung	34.5 nTPM

Alveolar cells type 2	30.9 nTPM
Lung	30.9 nTPM

Astrocytes	7.7 nTPM
Brain	7.7 nTPM

B-cells	18.4 nTPM
Bone marrow	25.9 nTPM
Spleen	24.8 nTPM
Esophagus	23.6 nTPM
Thymus	22.0 nTPM
Kidney	20.8 nTPM
Lymph node	20.8 nTPM
Skin	18.6 nTPM
Stomach	17.7 nTPM
Lung	16.1 nTPM
Salivary gland	15.9 nTPM
PBMC	15.4 nTPM
Liver	9.7 nTPM
Adipose tissue	7.4 nTPM

Ciliated cells	19.0 nTPM
Fallopian tube	22.2 nTPM
Lung	20.9 nTPM
Bronchus	17.5 nTPM
Endometrium	15.5 nTPM

Club cells	21.1 nTPM
Bronchus	23.9 nTPM
Lung	22.4 nTPM
Prostate	16.9 nTPM

Dendritic cells	17.5 nTPM
PBMC	18.0 nTPM
Adipose tissue	17.0 nTPM

Endothelial cells	22.6 nTPM
Lung	35.8 nTPM
Placenta	34.6 nTPM
Testis	25.9 nTPM
Thymus	24.6 nTPM
Vascular	24.4 nTPM
Heart muscle	24.1 nTPM
Tongue	23.7 nTPM
Fallopian tube	22.9 nTPM
Esophagus	21.9 nTPM
Prostate	21.4 nTPM
Pancreas	20.7 nTPM
Skin	20.7 nTPM
Endometrium	20.2 nTPM
Skeletal muscle	19.4 nTPM
Ovary	19.4 nTPM
Liver	17.6 nTPM
Breast	14.9 nTPM
Salivary gland	14.7 nTPM

Enteroendocrine cells	12.0 nTPM
Colon	19.0 nTPM
Rectum	13.4 nTPM
Small intestine	3.4 nTPM

Fibroblasts	21.1 nTPM
Pancreas	43.2 nTPM
Placenta	38.5 nTPM
Thymus	23.6 nTPM
Lung	23.4 nTPM
Vascular	21.2 nTPM
Skin	21.0 nTPM
Skeletal muscle	20.5 nTPM
Fallopian tube	19.8 nTPM
Prostate	18.5 nTPM
Liver	17.8 nTPM
Adipose tissue	17.3 nTPM
Salivary gland	16.2 nTPM
Esophagus	15.7 nTPM
Stomach	14.4 nTPM
Heart muscle	13.3 nTPM
Breast	13.3 nTPM

Granulocytes	13.1 nTPM
Lung	16.1 nTPM
Fallopian tube	13.3 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	12.2 nTPM
Colon	14.3 nTPM
Small intestine	11.3 nTPM
Rectum	11.1 nTPM

Lymphatic endothelial cells	20.1 nTPM
Fallopian tube	23.8 nTPM
Ovary	16.4 nTPM

Macrophages	19.8 nTPM
Lung	26.9 nTPM
Bone marrow	26.4 nTPM
Testis	24.8 nTPM
Skin	23.4 nTPM
Esophagus	23.1 nTPM
Tongue	22.5 nTPM
Thymus	21.8 nTPM
Vascular	21.8 nTPM
Kidney	21.2 nTPM
Prostate	21.2 nTPM
Salivary gland	20.7 nTPM
Pancreas	18.5 nTPM
Spleen	17.0 nTPM
Fallopian tube	16.5 nTPM
Skeletal muscle	16.1 nTPM
Adipose tissue	16.0 nTPM
Stomach	12.9 nTPM
Endometrium	12.3 nTPM
Breast	12.2 nTPM

Basal keratinocytes	37.9 nTPM
Tongue	44.8 nTPM
Skin	31.0 nTPM

Basal prostatic cells	20.6 nTPM
Prostate	20.6 nTPM

Basal respiratory cells	28.1 nTPM
Bronchus	28.1 nTPM

Basal squamous epithelial cells	29.3 nTPM
Esophagus	29.3 nTPM

Paneth cells	7.6 nTPM
Rectum	16.0 nTPM
Small intestine	6.9 nTPM
Colon	0.0 nTPM

Plasma cells	29.9 nTPM
Thymus	59.6 nTPM
Spleen	44.5 nTPM
Bone marrow	42.3 nTPM
Liver	39.1 nTPM
Salivary gland	20.1 nTPM
Stomach	11.7 nTPM
Fallopian tube	11.3 nTPM
Esophagus	10.4 nTPM

Schwann cells	32.6 nTPM
Esophagus	59.9 nTPM
Vascular	21.4 nTPM
Adipose tissue	16.4 nTPM

Serous glandular cells	31.4 nTPM
Tongue	39.8 nTPM
Salivary gland	23.1 nTPM

Smooth muscle cells	20.7 nTPM
Placenta	37.7 nTPM
Esophagus	25.2 nTPM
Thymus	22.8 nTPM
Fallopian tube	22.4 nTPM
Adipose tissue	20.3 nTPM
Salivary gland	19.9 nTPM
Vascular	19.8 nTPM
Ovary	19.7 nTPM
Liver	19.5 nTPM
Endometrium	19.5 nTPM
Prostate	19.5 nTPM
Tongue	18.6 nTPM
Skin	18.4 nTPM
Breast	16.8 nTPM
Skeletal muscle	15.5 nTPM
Lung	15.3 nTPM

Suprabasal keratinocytes	41.5 nTPM
Tongue	46.4 nTPM
Skin	36.7 nTPM

T-cells	17.4 nTPM
Skin	26.3 nTPM
Bone marrow	23.7 nTPM
Stomach	22.5 nTPM
Spleen	21.5 nTPM
Thymus	20.8 nTPM
Lymph node	19.8 nTPM
Kidney	19.5 nTPM
Prostate	17.7 nTPM
Vascular	17.7 nTPM
PBMC	17.3 nTPM
Fallopian tube	17.1 nTPM
Esophagus	17.0 nTPM
Adipose tissue	16.9 nTPM
Liver	16.1 nTPM
Lung	15.4 nTPM
Tongue	14.4 nTPM
Breast	13.6 nTPM
Endometrium	12.9 nTPM
Colon	12.7 nTPM
Skeletal muscle	12.5 nTPM
Salivary gland	10.4 nTPM

Undifferentiated cells	35.1 nTPM
Colon	52.3 nTPM
Rectum	28.8 nTPM
Small intestine	24.3 nTPM

Amygdala excitatory	33.9 nTPM
Thalamus	40.4 nTPM
Basal ganglia	35.2 nTPM
Hypothalamus	33.0 nTPM
Amygdala	32.0 nTPM
Hippocampus	32.0 nTPM
Cerebral cortex	30.6 nTPM

Astrocyte	22.8 nTPM
Spinal cord	25.1 nTPM
Hypothalamus	24.8 nTPM
Amygdala	24.5 nTPM
Cerebellum	24.4 nTPM
Thalamus	22.3 nTPM
Medulla oblongata	22.0 nTPM
Hippocampus	21.9 nTPM
Midbrain	21.9 nTPM
Basal ganglia	21.6 nTPM
Cerebral cortex	21.2 nTPM
Pons	21.2 nTPM

Bergmann glia	22.8 nTPM
Cerebellum	27.7 nTPM
Medulla oblongata	27.7 nTPM
Pons	12.9 nTPM

Central nervous system macrophage	51.7 nTPM
Amygdala	60.6 nTPM
Spinal cord	55.1 nTPM
Basal ganglia	54.9 nTPM
Hypothalamus	52.7 nTPM
Midbrain	52.3 nTPM
Hippocampus	51.4 nTPM
Cerebellum	51.0 nTPM
Thalamus	50.0 nTPM
Pons	49.8 nTPM
Cerebral cortex	48.4 nTPM
Medulla oblongata	42.6 nTPM

Cerebellar inhibitory	36.5 nTPM
Spinal cord	49.5 nTPM
Cerebellum	34.6 nTPM
Medulla oblongata	34.2 nTPM
Midbrain	33.0 nTPM
Pons	31.3 nTPM

Cge interneuron	41.6 nTPM
Thalamus	48.4 nTPM
Midbrain	43.1 nTPM
Amygdala	42.8 nTPM
Basal ganglia	42.6 nTPM
Cerebral cortex	39.2 nTPM
Hypothalamus	38.9 nTPM
Hippocampus	35.9 nTPM

Choroid plexus epithelial cell	27.9 nTPM
Medulla oblongata	34.4 nTPM
Basal ganglia	30.4 nTPM
Hippocampus	25.0 nTPM
Thalamus	21.9 nTPM

Committed oligodendrocyte precursor	41.5 nTPM
Hypothalamus	58.0 nTPM
Cerebral cortex	48.8 nTPM
Midbrain	44.5 nTPM
Thalamus	44.1 nTPM
Basal ganglia	42.7 nTPM
Hippocampus	40.9 nTPM
Spinal cord	40.5 nTPM
Medulla oblongata	38.7 nTPM
Amygdala	37.8 nTPM
Cerebellum	30.1 nTPM
Pons	30.1 nTPM

Deep-layer corticothalamic and 6b	37.5 nTPM
Basal ganglia	40.9 nTPM
Hypothalamus	37.3 nTPM
Amygdala	37.1 nTPM
Hippocampus	37.0 nTPM
Midbrain	36.6 nTPM
Cerebral cortex	35.9 nTPM

Deep-layer intratelencephalic	35.5 nTPM
Amygdala	38.8 nTPM
Hypothalamus	36.3 nTPM
Hippocampus	34.4 nTPM
Basal ganglia	34.3 nTPM
Cerebral cortex	33.8 nTPM

Deep-layer near-projecting	36.5 nTPM
Amygdala	39.1 nTPM
Basal ganglia	38.8 nTPM
Cerebral cortex	37.4 nTPM
Hypothalamus	37.0 nTPM
Hippocampus	30.2 nTPM

Eccentric medium spiny neuron	32.8 nTPM
Hypothalamus	35.9 nTPM
Amygdala	34.5 nTPM
Basal ganglia	32.7 nTPM
Thalamus	32.5 nTPM
Cerebral cortex	31.1 nTPM
Hippocampus	30.3 nTPM