Single cell type - RMI2 - The Human Protein Atlas

RMI2

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RMI2
Gene descriptionⁱ Full gene name according to HGNC.	RecQ mediated genome instability 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Spermatogonia, Syncytiotrophoblasts, Spermatocytes, Peritubular cells, Erythroid cells, Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.72
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (memory B-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Spermatogonia, Syncytiotrophoblasts, Spermatocytes, Peritubular cells, Erythroid cells, Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (memory B-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RMI2 is part of cluster 24 Cytotrophoblasts - Mitochondria with confidenceⁱ 1
235 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.8350	24
SOX14	SRY-box transcription factor 14	0.7873	24
PAGE4	PAGE family member 4	0.7852	24
FOXO4	Forkhead box O4	0.7799	24
L1TD1	LINE1 type transposase domain containing 1	0.7788	24
FBN2	Fibrillin 2	0.7753	24
MAGEA8	MAGE family member A8	0.7730	24
SMAGP	Small cell adhesion glycoprotein	0.7620	24
MBNL3	Muscleblind like splicing regulator 3	0.7589	24
MCM2	Minichromosome maintenance complex component 2	0.7576	52
HPDL	4-hydroxyphenylpyruvate dioxygenase like	0.7494	24
GSDME	Gasdermin E	0.7489	24
XAGE3	X antigen family member 3	0.7412	24
IFI6	Interferon alpha inducible protein 6	0.7358	24
VGLL1	Vestigial like family member 1	0.7288	24

IMMUNE CELLS

RMI2 is part of cluster 43 Non-specific - Transcription & Translation with confidenceⁱ 0.77
433 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	1.0000	43
ARHGEF35	Rho guanine nucleotide exchange factor 35	1.0000	43
AFAP1L2	Actin filament associated protein 1 like 2	1.0000	43
H3C11	H3 clustered histone 11	0.9762	43
ARHGEF5	Rho guanine nucleotide exchange factor 5	0.9762	43
ZNF726	Zinc finger protein 726	0.9762	43
SUCLG2	Succinate-CoA ligase GDP-forming subunit beta	0.9762	43
CCDC141	Coiled-coil domain containing 141	0.9762	43
SGCB	Sarcoglycan beta	0.9762	16
FBXO44	F-box protein 44	0.9762	43
RHBDL1	Rhomboid like 1	0.9762	43
WDR76	WD repeat domain 76	0.9762	43
ZFP37	ZFP37 zinc finger protein	0.9524	43
CARF	Calcium responsive transcription factor	0.9524	16
CSGALNACT1	Chondroitin sulfate N-acetylgalactosaminyltransferase 1	0.9524	43

Adipocytes	1.2 nTPM
Adipose tissue	1.6 nTPM
Breast	0.9 nTPM

Alveolar cells type 1	0.9 nTPM
Lung	0.9 nTPM

Alveolar cells type 2	5.4 nTPM
Lung	5.4 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	5.1 nTPM
Lung	17.4 nTPM
Skin	10.2 nTPM
PBMC	6.2 nTPM
Thymus	5.9 nTPM
Kidney	5.2 nTPM
Spleen	4.3 nTPM
Salivary gland	4.3 nTPM
Bone marrow	4.1 nTPM
Adipose tissue	3.7 nTPM
Lymph node	2.8 nTPM
Stomach	1.7 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	0.6 nTPM
Lung	1.5 nTPM
Endometrium	0.7 nTPM
Fallopian tube	0.3 nTPM
Bronchus	0.1 nTPM

Club cells	3.6 nTPM
Lung	5.3 nTPM
Prostate	4.9 nTPM
Bronchus	0.6 nTPM

Endothelial cells	2.2 nTPM
Placenta	10.8 nTPM
Testis	9.8 nTPM
Tongue	3.5 nTPM
Skin	3.4 nTPM
Endometrium	3.0 nTPM
Ovary	2.1 nTPM
Esophagus	1.8 nTPM
Skeletal muscle	1.3 nTPM
Prostate	1.0 nTPM
Thymus	0.9 nTPM
Vascular	0.8 nTPM
Lung	0.6 nTPM
Heart muscle	0.5 nTPM
Salivary gland	0.4 nTPM
Fallopian tube	0.4 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	3.3 nTPM
Colon	6.6 nTPM
Rectum	3.4 nTPM
Small intestine	0.0 nTPM

Fibroblasts	5.6 nTPM
Placenta	57.1 nTPM
Esophagus	8.6 nTPM
Pancreas	6.5 nTPM
Breast	3.8 nTPM
Skin	2.8 nTPM
Adipose tissue	2.1 nTPM
Vascular	1.5 nTPM
Stomach	1.4 nTPM
Prostate	1.3 nTPM
Liver	1.2 nTPM
Fallopian tube	1.2 nTPM
Skeletal muscle	0.8 nTPM
Thymus	0.8 nTPM
Salivary gland	0.7 nTPM
Heart muscle	0.5 nTPM
Lung	0.0 nTPM

Granulocytes	1.6 nTPM
Lung	4.0 nTPM
Fallopian tube	0.6 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	7.8 nTPM
Colon	11.3 nTPM
Rectum	7.9 nTPM
Small intestine	4.0 nTPM

Lymphatic endothelial cells	2.9 nTPM
Ovary	5.5 nTPM
Fallopian tube	0.4 nTPM

Macrophages	2.1 nTPM
Testis	9.3 nTPM
Endometrium	4.9 nTPM
Pancreas	4.1 nTPM
Bone marrow	4.1 nTPM
Tongue	3.7 nTPM
Lung	1.9 nTPM
Prostate	1.7 nTPM
Fallopian tube	1.5 nTPM
Breast	1.4 nTPM
Adipose tissue	1.3 nTPM
Esophagus	1.3 nTPM
Skeletal muscle	1.2 nTPM
Skin	1.1 nTPM
Kidney	0.9 nTPM
Vascular	0.5 nTPM
Salivary gland	0.3 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	3.7 nTPM
Rectum	7.5 nTPM
Small intestine	3.5 nTPM
Colon	0.0 nTPM

Basal squamous epithelial cells	7.3 nTPM
Esophagus	7.3 nTPM

Bipolar cells	0.2 nTPM
Eye	0.2 nTPM

Collecting duct cells	5.8 nTPM
Kidney	5.8 nTPM

Distal tubular cells	6.1 nTPM
Kidney	6.1 nTPM

Plasma cells	2.7 nTPM
Spleen	5.3 nTPM
Thymus	5.3 nTPM
Liver	5.0 nTPM
Bone marrow	4.5 nTPM
Stomach	0.8 nTPM
Fallopian tube	0.6 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	0.8 nTPM
Adipose tissue	2.0 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.2 nTPM
Salivary gland	0.3 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.1 nTPM
Placenta	20.3 nTPM
Endometrium	3.3 nTPM
Liver	3.0 nTPM
Ovary	2.2 nTPM
Esophagus	1.2 nTPM
Skin	1.0 nTPM
Skeletal muscle	0.9 nTPM
Adipose tissue	0.7 nTPM
Thymus	0.6 nTPM
Tongue	0.3 nTPM
Vascular	0.3 nTPM
Breast	0.3 nTPM
Fallopian tube	0.3 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM

T-cells	1.7 nTPM
Liver	4.8 nTPM
Kidney	4.4 nTPM
Lymph node	3.6 nTPM
Skin	3.2 nTPM
Bone marrow	2.7 nTPM
Thymus	2.4 nTPM
Spleen	2.2 nTPM
PBMC	2.1 nTPM
Endometrium	1.9 nTPM
Skeletal muscle	1.9 nTPM
Tongue	1.5 nTPM
Lung	1.3 nTPM
Colon	1.0 nTPM
Salivary gland	0.6 nTPM
Breast	0.6 nTPM
Adipose tissue	0.5 nTPM
Fallopian tube	0.5 nTPM
Stomach	0.4 nTPM
Vascular	0.4 nTPM
Prostate	0.2 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	23.1 nTPM
Colon	34.8 nTPM
Rectum	21.4 nTPM
Small intestine	13.1 nTPM

Amygdala excitatory	4.7 nTPM
Cerebral cortex	6.0 nTPM
Hippocampus	5.6 nTPM
Amygdala	5.5 nTPM
Hypothalamus	5.0 nTPM
Basal ganglia	3.2 nTPM
Thalamus	3.2 nTPM

Astrocyte	1.8 nTPM
Pons	2.3 nTPM
Spinal cord	2.3 nTPM
Medulla oblongata	2.2 nTPM
Basal ganglia	1.9 nTPM
Hypothalamus	1.9 nTPM
Cerebral cortex	1.8 nTPM
Cerebellum	1.6 nTPM
Hippocampus	1.6 nTPM
Midbrain	1.6 nTPM
Amygdala	1.4 nTPM
Thalamus	1.0 nTPM

Bergmann glia	1.3 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	1.9 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	1.8 nTPM
Spinal cord	3.2 nTPM
Cerebellum	2.2 nTPM
Medulla oblongata	2.2 nTPM
Pons	1.9 nTPM
Basal ganglia	1.8 nTPM
Cerebral cortex	1.8 nTPM
Hypothalamus	1.6 nTPM
Midbrain	1.5 nTPM
Hippocampus	1.4 nTPM
Amygdala	1.3 nTPM
Thalamus	1.2 nTPM

Cerebellar inhibitory	4.2 nTPM
Midbrain	6.8 nTPM
Cerebellum	5.7 nTPM
Pons	5.2 nTPM
Medulla oblongata	3.3 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	1.6 nTPM
Hypothalamus	2.1 nTPM
Basal ganglia	1.9 nTPM
Amygdala	1.8 nTPM
Cerebral cortex	1.8 nTPM
Hippocampus	1.7 nTPM
Thalamus	1.2 nTPM
Midbrain	0.7 nTPM

Choroid plexus epithelial cell	1.3 nTPM
Medulla oblongata	3.8 nTPM
Basal ganglia	1.3 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.7 nTPM
Basal ganglia	1.6 nTPM
Cerebellum	1.6 nTPM
Cerebral cortex	1.3 nTPM
Medulla oblongata	1.3 nTPM
Hippocampus	0.8 nTPM
Hypothalamus	0.7 nTPM
Thalamus	0.5 nTPM
Amygdala	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	4.6 nTPM
Basal ganglia	6.3 nTPM
Hypothalamus	5.0 nTPM
Cerebral cortex	4.7 nTPM
Amygdala	4.3 nTPM
Hippocampus	4.0 nTPM
Midbrain	3.3 nTPM

Deep-layer intratelencephalic	4.7 nTPM
Basal ganglia	6.5 nTPM
Hypothalamus	4.8 nTPM
Amygdala	4.2 nTPM
Cerebral cortex	4.2 nTPM
Hippocampus	3.8 nTPM

Deep-layer near-projecting	3.6 nTPM
Basal ganglia	4.2 nTPM
Hippocampus	3.6 nTPM
Hypothalamus	3.6 nTPM
Amygdala	3.4 nTPM
Cerebral cortex	3.2 nTPM

Eccentric medium spiny neuron	3.3 nTPM
Amygdala	4.8 nTPM
Cerebral cortex	4.0 nTPM
Basal ganglia	3.4 nTPM
Hypothalamus	3.2 nTPM
Thalamus	2.8 nTPM
Hippocampus	1.7 nTPM

Endothelial cell	3.5 nTPM
Cerebellum	6.2 nTPM
Thalamus	6.2 nTPM
Basal ganglia	4.7 nTPM
Midbrain	3.8 nTPM
Hippocampus	3.5 nTPM
Amygdala	3.4 nTPM
Cerebral cortex	3.2 nTPM
Hypothalamus	2.5 nTPM
Pons	2.5 nTPM
Medulla oblongata	2.1 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	1.0 nTPM
Midbrain	2.5 nTPM
Thalamus	2.0 nTPM
Basal ganglia	1.7 nTPM
Medulla oblongata	1.3 nTPM
Hippocampus	0.8 nTPM
Amygdala	0.6 nTPM
Pons	0.4 nTPM
Hypothalamus	0.0 nTPM
Spinal cord	0.0 nTPM