Single cell type - DOP1A - The Human Protein Atlas

DOP1A

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DOP1A
Gene descriptionⁱ Full gene name according to HGNC.	DOP1 leucine zipper like protein A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.54
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DOP1A is part of cluster 69 Neurons - Neuronal signaling with confidenceⁱ 1
331 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZC3H12B	Zinc finger CCCH-type containing 12B	0.7560	69
ARMCX5-GPRASP2	ARMCX5-GPRASP2 readthrough	0.6862	69
SORCS3	Sortilin related VPS10 domain containing receptor 3	0.6844	34
PPFIA2	PTPRF interacting protein alpha 2	0.6720	34
LARGE1	LARGE xylosyl- and glucuronyltransferase 1	0.6677	34
THRB	Thyroid hormone receptor beta	0.6673	69
FAM185A	Family with sequence similarity 185 member A	0.6671	69
LINGO2	Leucine rich repeat and Ig domain containing 2	0.6637	34
CSRNP3	Cysteine and serine rich nuclear protein 3	0.6612	69
CACNA1E	Calcium voltage-gated channel subunit alpha1 E	0.6574	34
CSMD1	CUB and Sushi multiple domains 1	0.6545	34
NEXMIF	Neurite extension and migration factor	0.6513	69
ANKS1B	Ankyrin repeat and sterile alpha motif domain containing 1B	0.6512	34
LRRC7	Leucine rich repeat containing 7	0.6486	65
CHRM3	Cholinergic receptor muscarinic 3	0.6458	34

IMMUNE CELLS

DOP1A is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.94
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF408	Zinc finger protein 408	0.9762	33
HSPD1	Heat shock protein family D (Hsp60) member 1	0.9762	33
MAU2	MAU2 sister chromatid cohesion factor	0.9762	33
DDX3Y	DEAD-box helicase 3 Y-linked	0.9762	33
SARS2	Seryl-tRNA synthetase 2, mitochondrial	0.9762	33
ZMYM2	Zinc finger MYM-type containing 2	0.9762	33
ZNF862	Zinc finger protein 862	0.9524	33
EMC1	ER membrane protein complex subunit 1	0.9524	33
POLR1B	RNA polymerase I subunit B	0.9524	33
CSE1L	Chromosome segregation 1 like	0.9524	33
RARS1	Arginyl-tRNA synthetase 1	0.9524	33
WDR3	WD repeat domain 3	0.9524	33
ERCC8	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	0.9524	33
HSPA9	Heat shock protein family A (Hsp70) member 9	0.9286	33
VPS50	VPS50 subunit of EARP/GARPII complex	0.9286	33

Adipocytes	9.7 nTPM
Adipose tissue	10.5 nTPM
Breast	9.0 nTPM

Alveolar cells type 1	9.2 nTPM
Lung	9.2 nTPM

Alveolar cells type 2	8.1 nTPM
Lung	8.1 nTPM

B-cells	10.7 nTPM
Lymph node	16.4 nTPM
Bone marrow	15.3 nTPM
Stomach	13.9 nTPM
Salivary gland	13.3 nTPM
Adipose tissue	13.2 nTPM
Spleen	12.8 nTPM
Thymus	11.9 nTPM
Esophagus	11.8 nTPM
PBMC	9.2 nTPM
Skin	6.8 nTPM
Kidney	5.2 nTPM
Liver	4.8 nTPM
Lung	4.0 nTPM

Basal keratinocytes	11.0 nTPM
Skin	13.6 nTPM
Tongue	8.4 nTPM

Ciliated cells	13.0 nTPM
Bronchus	18.7 nTPM
Fallopian tube	11.9 nTPM
Lung	11.5 nTPM
Endometrium	9.9 nTPM

Club cells	9.6 nTPM
Bronchus	11.0 nTPM
Prostate	9.2 nTPM
Lung	8.7 nTPM

Dendritic cells	11.9 nTPM
Adipose tissue	13.0 nTPM
PBMC	10.8 nTPM

Endothelial cells	7.4 nTPM
Heart muscle	21.1 nTPM
Salivary gland	11.1 nTPM
Skeletal muscle	8.9 nTPM
Prostate	8.7 nTPM
Thymus	8.0 nTPM
Vascular	8.0 nTPM
Pancreas	7.8 nTPM
Esophagus	6.9 nTPM
Lung	6.7 nTPM
Endometrium	6.6 nTPM
Tongue	6.6 nTPM
Ovary	6.6 nTPM
Testis	6.1 nTPM
Fallopian tube	6.1 nTPM
Breast	5.3 nTPM
Liver	3.8 nTPM
Skin	3.3 nTPM
Placenta	1.7 nTPM

Enteroendocrine cells	10.8 nTPM
Small intestine	13.7 nTPM
Rectum	11.7 nTPM
Colon	7.0 nTPM

Fibroblasts	7.8 nTPM
Heart muscle	13.7 nTPM
Esophagus	12.7 nTPM
Skeletal muscle	11.8 nTPM
Breast	10.9 nTPM
Fallopian tube	10.4 nTPM
Adipose tissue	8.6 nTPM
Prostate	8.6 nTPM
Salivary gland	8.2 nTPM
Vascular	7.9 nTPM
Thymus	6.4 nTPM
Stomach	5.8 nTPM
Lung	5.0 nTPM
Skin	4.9 nTPM
Placenta	4.2 nTPM
Liver	3.6 nTPM
Pancreas	2.5 nTPM

Granulocytes	7.4 nTPM
Fallopian tube	9.8 nTPM
Lung	7.6 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	7.5 nTPM
Small intestine	13.1 nTPM
Rectum	7.6 nTPM
Colon	2.0 nTPM

Lymphatic endothelial cells	12.3 nTPM
Ovary	16.4 nTPM
Fallopian tube	8.2 nTPM

Macrophages	7.5 nTPM
Skeletal muscle	14.0 nTPM
Fallopian tube	11.8 nTPM
Endometrium	10.5 nTPM
Salivary gland	10.5 nTPM
Adipose tissue	9.7 nTPM
Breast	9.7 nTPM
Lung	9.2 nTPM
Prostate	9.2 nTPM
Esophagus	9.0 nTPM
Bone marrow	8.1 nTPM
Tongue	7.7 nTPM
Testis	7.4 nTPM
Thymus	6.0 nTPM
Kidney	5.3 nTPM
Vascular	5.0 nTPM
Spleen	4.0 nTPM
Skin	3.3 nTPM
Stomach	2.6 nTPM
Pancreas	0.0 nTPM

Astrocytes	73.7 nTPM
Brain	73.7 nTPM

Bipolar cells	27.0 nTPM
Eye	27.0 nTPM

Cholangiocytes	1.9 nTPM
Liver	1.9 nTPM

Collecting duct cells	1.9 nTPM
Kidney	1.9 nTPM

Paneth cells	12.6 nTPM
Colon	18.1 nTPM
Rectum	12.9 nTPM
Small intestine	6.9 nTPM

Plasma cells	5.8 nTPM
Spleen	10.6 nTPM
Salivary gland	9.0 nTPM
Fallopian tube	8.4 nTPM
Thymus	7.4 nTPM
Stomach	6.3 nTPM
Bone marrow	3.0 nTPM
Liver	2.0 nTPM
Esophagus	0.0 nTPM

Schwann cells	14.1 nTPM
Adipose tissue	21.5 nTPM
Esophagus	12.0 nTPM
Vascular	8.9 nTPM

Serous glandular cells	15.8 nTPM
Tongue	17.7 nTPM
Salivary gland	14.0 nTPM

Smooth muscle cells	8.3 nTPM
Adipose tissue	12.0 nTPM
Prostate	10.9 nTPM
Skeletal muscle	10.3 nTPM
Salivary gland	10.3 nTPM
Thymus	9.7 nTPM
Ovary	9.6 nTPM
Breast	9.4 nTPM
Endometrium	8.9 nTPM
Vascular	8.9 nTPM
Esophagus	8.4 nTPM
Tongue	7.8 nTPM
Fallopian tube	7.6 nTPM
Lung	7.1 nTPM
Liver	5.5 nTPM
Placenta	3.5 nTPM
Skin	3.3 nTPM

T-cells	9.2 nTPM
Vascular	15.3 nTPM
Adipose tissue	12.7 nTPM
Bone marrow	12.3 nTPM
Skeletal muscle	12.1 nTPM
Salivary gland	12.1 nTPM
Fallopian tube	12.1 nTPM
Endometrium	10.2 nTPM
Lymph node	10.0 nTPM
Thymus	9.9 nTPM
Breast	9.8 nTPM
Spleen	9.6 nTPM
Stomach	9.2 nTPM
Tongue	9.0 nTPM
Prostate	8.9 nTPM
Colon	8.8 nTPM
Lung	7.6 nTPM
PBMC	7.3 nTPM
Liver	6.7 nTPM
Skin	3.9 nTPM
Kidney	3.5 nTPM
Esophagus	2.4 nTPM

Undifferentiated cells	6.2 nTPM
Rectum	8.1 nTPM
Small intestine	7.9 nTPM
Colon	2.7 nTPM

Amygdala excitatory	248.0 nTPM
Amygdala	258.4 nTPM
Hypothalamus	255.6 nTPM
Thalamus	255.5 nTPM
Hippocampus	249.3 nTPM
Cerebral cortex	237.2 nTPM
Basal ganglia	232.0 nTPM

Astrocyte	138.9 nTPM
Amygdala	192.4 nTPM
Hypothalamus	155.7 nTPM
Hippocampus	143.1 nTPM
Cerebral cortex	139.3 nTPM
Thalamus	138.4 nTPM
Basal ganglia	137.7 nTPM
Midbrain	134.5 nTPM
Spinal cord	130.6 nTPM
Pons	127.9 nTPM
Medulla oblongata	117.7 nTPM
Cerebellum	110.9 nTPM

Bergmann glia	139.8 nTPM
Pons	146.7 nTPM
Cerebellum	142.7 nTPM
Medulla oblongata	130.0 nTPM

Central nervous system macrophage	230.7 nTPM
Amygdala	340.8 nTPM
Hypothalamus	279.4 nTPM
Hippocampus	240.5 nTPM
Midbrain	238.1 nTPM
Thalamus	225.8 nTPM
Basal ganglia	219.6 nTPM
Pons	218.5 nTPM
Cerebellum	212.3 nTPM
Cerebral cortex	191.7 nTPM
Spinal cord	190.5 nTPM
Medulla oblongata	179.9 nTPM

Cerebellar inhibitory	199.9 nTPM
Spinal cord	220.0 nTPM
Cerebellum	203.1 nTPM
Medulla oblongata	199.8 nTPM
Midbrain	198.8 nTPM
Pons	177.8 nTPM

Cge interneuron	208.4 nTPM
Amygdala	234.5 nTPM
Hypothalamus	224.2 nTPM
Midbrain	208.0 nTPM
Basal ganglia	203.0 nTPM
Thalamus	201.8 nTPM
Cerebral cortex	194.8 nTPM
Hippocampus	192.4 nTPM

Choroid plexus epithelial cell	201.8 nTPM
Medulla oblongata	251.5 nTPM
Basal ganglia	249.9 nTPM
Thalamus	156.2 nTPM
Hippocampus	149.8 nTPM

Committed oligodendrocyte precursor	165.3 nTPM
Amygdala	215.4 nTPM
Hypothalamus	189.1 nTPM
Midbrain	174.7 nTPM
Hippocampus	174.6 nTPM
Cerebral cortex	170.4 nTPM
Thalamus	166.4 nTPM
Pons	155.8 nTPM
Basal ganglia	151.7 nTPM
Cerebellum	147.5 nTPM
Medulla oblongata	147.2 nTPM
Spinal cord	125.1 nTPM

Deep-layer corticothalamic and 6b	230.5 nTPM
Amygdala	253.3 nTPM
Hippocampus	238.5 nTPM
Cerebral cortex	234.4 nTPM
Hypothalamus	220.7 nTPM
Basal ganglia	218.5 nTPM
Midbrain	217.4 nTPM

Deep-layer intratelencephalic	237.2 nTPM
Amygdala	283.1 nTPM
Hippocampus	232.8 nTPM
Hypothalamus	225.8 nTPM
Cerebral cortex	224.9 nTPM
Basal ganglia	219.5 nTPM

Deep-layer near-projecting	218.5 nTPM
Amygdala	254.6 nTPM
Hypothalamus	230.3 nTPM
Cerebral cortex	216.5 nTPM
Basal ganglia	210.4 nTPM
Hippocampus	180.5 nTPM

Eccentric medium spiny neuron	296.4 nTPM
Amygdala	324.6 nTPM
Thalamus	312.3 nTPM
Hypothalamus	310.5 nTPM
Hippocampus	280.2 nTPM
Cerebral cortex	278.4 nTPM
Basal ganglia	272.7 nTPM

Endothelial cell	144.9 nTPM
Hypothalamus	217.1 nTPM
Amygdala	177.7 nTPM
Hippocampus	154.8 nTPM
Spinal cord	150.2 nTPM
Basal ganglia	141.7 nTPM
Thalamus	139.5 nTPM
Cerebral cortex	138.1 nTPM
Cerebellum	137.8 nTPM
Midbrain	128.5 nTPM
Pons	116.7 nTPM
Medulla oblongata	91.3 nTPM