Single cell type - RYR2 - The Human Protein Atlas

RYR2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RYR2
Gene descriptionⁱ Full gene name according to HGNC.	Ryanodine receptor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes FDA approved drug targets Human disease related genes Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Cardiomyocytes, Excitatory neurons, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.88
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Cardiomyocytes, Excitatory neurons, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RYR2 is part of cluster 68 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
262 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RBM20	RNA binding motif protein 20	0.8500	68
SLC8A1	Solute carrier family 8 member A1	0.7417	34
GPR22	G protein-coupled receptor 22	0.6781	68
NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1	0.6755	68
ASB14	Ankyrin repeat and SOCS box containing 14	0.6496	68
OXCT1	3-oxoacid CoA-transferase 1	0.6401	68
ATP5PD	ATP synthase peripheral stalk subunit d	0.6372	68
ADAM11	ADAM metallopeptidase domain 11	0.6326	34
FBXO40	F-box protein 40	0.6320	68
SGCG	Sarcoglycan gamma	0.6316	68
TECRL	Trans-2,3-enoyl-CoA reductase like	0.6247	68
MYBPC3	Myosin binding protein C3	0.6246	68
LRRC10	Leucine rich repeat containing 10	0.6236	68
LYNX1	Ly6/neurotoxin 1	0.6228	68
ATP5ME	ATP synthase membrane subunit e	0.6206	68

Adipocytes	0.3 nTPM
Breast	0.6 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	16.1 nTPM
Brain	16.1 nTPM

B-cells	0.0 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	0.1 nTPM
Fallopian tube	0.3 nTPM
Lung	0.2 nTPM
Endometrium	0.1 nTPM
Bronchus	0.0 nTPM

Club cells	0.0 nTPM
Lung	0.1 nTPM
Bronchus	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	3.9 nTPM
Heart muscle	49.2 nTPM
Endometrium	10.8 nTPM
Breast	3.5 nTPM
Placenta	2.8 nTPM
Ovary	1.0 nTPM
Skin	0.8 nTPM
Tongue	0.8 nTPM
Esophagus	0.5 nTPM
Thymus	0.4 nTPM
Prostate	0.3 nTPM
Skeletal muscle	0.2 nTPM
Salivary gland	0.2 nTPM
Vascular	0.2 nTPM
Fallopian tube	0.2 nTPM
Lung	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	24.5 nTPM
Heart muscle	376.8 nTPM
Lung	6.7 nTPM
Esophagus	1.5 nTPM
Placenta	1.4 nTPM
Prostate	1.3 nTPM
Vascular	1.3 nTPM
Fallopian tube	1.2 nTPM
Skin	0.6 nTPM
Thymus	0.4 nTPM
Skeletal muscle	0.1 nTPM
Breast	0.1 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	3.2 nTPM
Fallopian tube	6.3 nTPM
Ovary	0.0 nTPM

Macrophages	0.2 nTPM
Esophagus	2.6 nTPM
Salivary gland	0.7 nTPM
Endometrium	0.6 nTPM
Tongue	0.2 nTPM
Vascular	0.2 nTPM
Breast	0.2 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Bipolar cells	73.2 nTPM
Eye	73.2 nTPM

Collecting duct cells	1.9 nTPM
Kidney	1.9 nTPM

Cone photoreceptor cells	6.8 nTPM
Eye	6.8 nTPM

Early spermatids	20.6 nTPM
Testis	20.6 nTPM

Plasma cells	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.2 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	2.9 nTPM
Salivary gland	5.8 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	14.1 nTPM
Endometrium	31.8 nTPM
Vascular	31.7 nTPM
Skin	24.6 nTPM
Lung	23.5 nTPM
Breast	21.7 nTPM
Thymus	16.7 nTPM
Esophagus	15.6 nTPM
Ovary	12.3 nTPM
Prostate	12.2 nTPM
Salivary gland	10.6 nTPM
Fallopian tube	8.5 nTPM
Skeletal muscle	5.5 nTPM
Adipose tissue	5.3 nTPM
Placenta	3.7 nTPM
Tongue	2.1 nTPM
Liver	0.4 nTPM

T-cells	0.2 nTPM
Kidney	0.9 nTPM
Tongue	0.9 nTPM
Endometrium	0.5 nTPM
Spleen	0.5 nTPM
Skeletal muscle	0.4 nTPM
Lung	0.3 nTPM
PBMC	0.2 nTPM
Adipose tissue	0.2 nTPM
Bone marrow	0.2 nTPM
Salivary gland	0.2 nTPM
Stomach	0.1 nTPM
Fallopian tube	0.1 nTPM
Colon	0.0 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Small intestine	0.1 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	1916.4 nTPM
Amygdala	2921.0 nTPM
Hypothalamus	2194.4 nTPM
Cerebral cortex	1980.1 nTPM
Hippocampus	1861.1 nTPM
Basal ganglia	1582.1 nTPM
Thalamus	959.7 nTPM

Astrocyte	22.9 nTPM
Hypothalamus	52.0 nTPM
Amygdala	43.4 nTPM
Basal ganglia	42.4 nTPM
Cerebral cortex	27.0 nTPM
Hippocampus	18.9 nTPM
Thalamus	14.9 nTPM
Medulla oblongata	14.5 nTPM
Pons	12.9 nTPM
Midbrain	9.7 nTPM
Cerebellum	8.4 nTPM
Spinal cord	7.5 nTPM

Bergmann glia	8.0 nTPM
Cerebellum	11.9 nTPM
Medulla oblongata	6.4 nTPM
Pons	5.8 nTPM

Central nervous system macrophage	22.5 nTPM
Cerebral cortex	49.7 nTPM
Hypothalamus	45.4 nTPM
Amygdala	32.6 nTPM
Hippocampus	31.6 nTPM
Basal ganglia	23.6 nTPM
Thalamus	20.9 nTPM
Pons	11.5 nTPM
Medulla oblongata	10.7 nTPM
Cerebellum	10.0 nTPM
Midbrain	8.6 nTPM
Spinal cord	2.4 nTPM

Cerebellar inhibitory	893.4 nTPM
Pons	1117.4 nTPM
Midbrain	1110.1 nTPM
Cerebellum	883.8 nTPM
Medulla oblongata	803.2 nTPM
Spinal cord	552.7 nTPM

Cge interneuron	364.3 nTPM
Thalamus	447.5 nTPM
Amygdala	381.7 nTPM
Hippocampus	374.8 nTPM
Midbrain	369.7 nTPM
Hypothalamus	363.0 nTPM
Cerebral cortex	314.2 nTPM
Basal ganglia	299.3 nTPM

Choroid plexus epithelial cell	29.4 nTPM
Medulla oblongata	45.2 nTPM
Hippocampus	33.3 nTPM
Basal ganglia	19.8 nTPM
Thalamus	19.2 nTPM

Committed oligodendrocyte precursor	185.6 nTPM
Amygdala	384.6 nTPM
Hypothalamus	351.0 nTPM
Basal ganglia	255.1 nTPM
Medulla oblongata	210.4 nTPM
Pons	170.9 nTPM
Thalamus	170.6 nTPM
Midbrain	147.0 nTPM
Cerebellum	118.9 nTPM
Hippocampus	114.3 nTPM
Cerebral cortex	103.9 nTPM
Spinal cord	14.7 nTPM

Deep-layer corticothalamic and 6b	2180.7 nTPM
Hypothalamus	2561.4 nTPM
Cerebral cortex	2532.8 nTPM
Hippocampus	2361.5 nTPM
Amygdala	2057.5 nTPM
Midbrain	1977.0 nTPM
Basal ganglia	1594.0 nTPM

Deep-layer intratelencephalic	2354.0 nTPM
Hypothalamus	3208.5 nTPM
Hippocampus	2595.2 nTPM
Cerebral cortex	2194.8 nTPM
Basal ganglia	1910.1 nTPM
Amygdala	1861.5 nTPM

Deep-layer near-projecting	2024.2 nTPM
Hypothalamus	2413.0 nTPM
Amygdala	2296.4 nTPM
Cerebral cortex	2208.4 nTPM
Basal ganglia	1670.7 nTPM
Hippocampus	1532.5 nTPM

Eccentric medium spiny neuron	3128.5 nTPM
Thalamus	3796.5 nTPM
Basal ganglia	3586.5 nTPM
Hypothalamus	3346.4 nTPM
Cerebral cortex	3063.5 nTPM
Amygdala	2851.5 nTPM
Hippocampus	2126.9 nTPM

Endothelial cell	35.0 nTPM
Hypothalamus	117.9 nTPM
Amygdala	59.2 nTPM
Hippocampus	34.3 nTPM
Basal ganglia	32.6 nTPM
Cerebral cortex	30.7 nTPM
Medulla oblongata	23.6 nTPM
Pons	21.2 nTPM
Midbrain	18.9 nTPM
Cerebellum	17.0 nTPM
Spinal cord	15.5 nTPM
Thalamus	14.1 nTPM

Ependymal cell	24.3 nTPM
Amygdala	54.0 nTPM
Hypothalamus	50.9 nTPM
Basal ganglia	36.5 nTPM
Hippocampus	20.4 nTPM
Midbrain	19.0 nTPM
Thalamus	12.1 nTPM
Pons	10.6 nTPM
Medulla oblongata	9.0 nTPM
Spinal cord	5.7 nTPM