Single cell type - ENOX1 - The Human Protein Atlas

ENOX1

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENOX1
Gene descriptionⁱ Full gene name according to HGNC.	Ecto-NOX disulfide-thiol exchanger 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Late spermatids, Astrocytes, Early spermatids, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.85
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Late spermatids, Astrocytes, Early spermatids, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENOX1 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RASGRF2	Ras protein specific guanine nucleotide releasing factor 2	0.8230	8
GRID1	Glutamate ionotropic receptor delta type subunit 1	0.7935	65
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	0.7732	8
SUPT3H	SPT3 homolog, SAGA and STAGA complex component	0.7724	8
DOCK3	Dedicator of cytokinesis 3	0.7677	65
IL1RAPL1	Interleukin 1 receptor accessory protein like 1	0.7533	65
KIRREL3	Kirre like nephrin family adhesion molecule 3	0.7528	65
IGSF11	Immunoglobulin superfamily member 11	0.7481	65
KCNC2	Potassium voltage-gated channel subfamily C member 2	0.7441	65
LRRC8B	Leucine rich repeat containing 8 VRAC subunit B	0.7427	65
RAD52	RAD52 homolog, DNA repair protein	0.7304	8
ZMAT4	Zinc finger matrin-type 4	0.7281	8
SAMD12	Sterile alpha motif domain containing 12	0.7270	51
HSPE1-MOB4	HSPE1-MOB4 readthrough	0.7241	8
GAS2	Growth arrest specific 2	0.7139	8

Adipocytes	1.2 nTPM
Breast	1.3 nTPM
Adipose tissue	1.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

B-cells	0.7 nTPM
Skin	8.5 nTPM
Thymus	0.4 nTPM
Spleen	0.2 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

Basal keratinocytes	0.4 nTPM
Skin	0.6 nTPM
Tongue	0.2 nTPM

Ciliated cells	1.9 nTPM
Lung	4.8 nTPM
Fallopian tube	2.5 nTPM
Bronchus	0.4 nTPM
Endometrium	0.1 nTPM

Club cells	0.4 nTPM
Prostate	0.8 nTPM
Lung	0.3 nTPM
Bronchus	0.1 nTPM

Endothelial cells	0.3 nTPM
Heart muscle	1.6 nTPM
Skeletal muscle	1.1 nTPM
Ovary	0.8 nTPM
Esophagus	0.5 nTPM
Tongue	0.5 nTPM
Testis	0.3 nTPM
Prostate	0.2 nTPM
Thymus	0.2 nTPM
Fallopian tube	0.2 nTPM
Endometrium	0.1 nTPM
Vascular	0.1 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	2.4 nTPM
Placenta	5.2 nTPM
Pancreas	5.1 nTPM
Esophagus	4.6 nTPM
Skeletal muscle	3.4 nTPM
Stomach	2.9 nTPM
Fallopian tube	2.9 nTPM
Thymus	2.5 nTPM
Lung	2.3 nTPM
Prostate	2.0 nTPM
Adipose tissue	1.9 nTPM
Breast	1.8 nTPM
Skin	1.6 nTPM
Salivary gland	1.6 nTPM
Vascular	1.1 nTPM
Heart muscle	0.2 nTPM
Liver	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.1 nTPM
Fallopian tube	0.2 nTPM
Ovary	0.0 nTPM

Macrophages	0.4 nTPM
Testis	1.9 nTPM
Kidney	0.9 nTPM
Skeletal muscle	0.8 nTPM
Adipose tissue	0.8 nTPM
Breast	0.6 nTPM
Tongue	0.5 nTPM
Fallopian tube	0.5 nTPM
Thymus	0.4 nTPM
Salivary gland	0.3 nTPM
Vascular	0.1 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	164.4 nTPM
Brain	164.4 nTPM

Distal tubular cells	6.1 nTPM
Kidney	6.1 nTPM

Plasma cells	0.0 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	6.2 nTPM
Adipose tissue	17.6 nTPM
Vascular	1.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.1 nTPM
Salivary gland	0.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	3.8 nTPM
Adipose tissue	11.6 nTPM
Skeletal muscle	8.4 nTPM
Esophagus	8.4 nTPM
Thymus	7.1 nTPM
Placenta	6.9 nTPM
Lung	5.9 nTPM
Vascular	2.8 nTPM
Fallopian tube	2.1 nTPM
Salivary gland	1.9 nTPM
Breast	1.8 nTPM
Ovary	1.5 nTPM
Endometrium	1.4 nTPM
Prostate	0.6 nTPM
Tongue	0.6 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM

T-cells	0.2 nTPM
Skin	1.4 nTPM
Skeletal muscle	0.8 nTPM
Lymph node	0.6 nTPM
Adipose tissue	0.2 nTPM
Stomach	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.1 nTPM
Colon	0.3 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	738.3 nTPM
Hypothalamus	981.9 nTPM
Basal ganglia	759.8 nTPM
Amygdala	714.9 nTPM
Cerebral cortex	689.9 nTPM
Thalamus	679.7 nTPM
Hippocampus	603.4 nTPM

Astrocyte	338.9 nTPM
Spinal cord	424.7 nTPM
Amygdala	398.3 nTPM
Medulla oblongata	387.8 nTPM
Thalamus	380.9 nTPM
Midbrain	362.8 nTPM
Basal ganglia	361.7 nTPM
Hippocampus	358.1 nTPM
Pons	347.3 nTPM
Cerebral cortex	264.3 nTPM
Cerebellum	255.0 nTPM
Hypothalamus	187.6 nTPM

Bergmann glia	110.9 nTPM
Medulla oblongata	117.2 nTPM
Pons	110.8 nTPM
Cerebellum	104.9 nTPM

Central nervous system macrophage	16.0 nTPM
Hypothalamus	26.0 nTPM
Thalamus	23.0 nTPM
Amygdala	19.8 nTPM
Cerebral cortex	18.9 nTPM
Hippocampus	17.8 nTPM
Pons	15.4 nTPM
Spinal cord	13.5 nTPM
Midbrain	12.4 nTPM
Basal ganglia	10.3 nTPM
Cerebellum	9.3 nTPM
Medulla oblongata	9.2 nTPM

Cerebellar inhibitory	477.6 nTPM
Spinal cord	660.0 nTPM
Medulla oblongata	500.3 nTPM
Cerebellum	456.4 nTPM
Midbrain	453.8 nTPM
Pons	317.6 nTPM

Cge interneuron	595.0 nTPM
Thalamus	758.3 nTPM
Hypothalamus	665.5 nTPM
Amygdala	617.6 nTPM
Hippocampus	597.2 nTPM
Midbrain	570.2 nTPM
Cerebral cortex	518.1 nTPM
Basal ganglia	437.9 nTPM

Choroid plexus epithelial cell	26.5 nTPM
Thalamus	82.2 nTPM
Basal ganglia	14.2 nTPM
Medulla oblongata	9.6 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	347.6 nTPM
Thalamus	930.9 nTPM
Hypothalamus	746.3 nTPM
Amygdala	625.9 nTPM
Basal ganglia	318.7 nTPM
Cerebral cortex	256.5 nTPM
Pons	213.4 nTPM
Midbrain	203.3 nTPM
Hippocampus	176.7 nTPM
Medulla oblongata	164.0 nTPM
Cerebellum	111.0 nTPM
Spinal cord	77.3 nTPM

Deep-layer corticothalamic and 6b	419.1 nTPM
Midbrain	500.3 nTPM
Basal ganglia	457.6 nTPM
Hypothalamus	455.4 nTPM
Hippocampus	449.6 nTPM
Cerebral cortex	349.9 nTPM
Amygdala	301.9 nTPM

Deep-layer intratelencephalic	784.9 nTPM
Amygdala	1308.4 nTPM
Basal ganglia	831.5 nTPM
Hypothalamus	746.6 nTPM
Cerebral cortex	596.2 nTPM
Hippocampus	441.7 nTPM

Deep-layer near-projecting	685.7 nTPM
Amygdala	838.1 nTPM
Hypothalamus	807.8 nTPM
Cerebral cortex	667.4 nTPM
Basal ganglia	619.0 nTPM
Hippocampus	496.0 nTPM

Eccentric medium spiny neuron	790.4 nTPM
Cerebral cortex	911.2 nTPM
Basal ganglia	847.0 nTPM
Hypothalamus	841.4 nTPM
Amygdala	756.7 nTPM
Thalamus	730.9 nTPM
Hippocampus	655.3 nTPM

Endothelial cell	18.7 nTPM
Basal ganglia	28.0 nTPM
Hypothalamus	26.1 nTPM
Hippocampus	22.8 nTPM
Amygdala	22.4 nTPM
Cerebral cortex	21.7 nTPM
Midbrain	19.8 nTPM
Thalamus	19.2 nTPM
Medulla oblongata	15.4 nTPM
Pons	13.7 nTPM
Spinal cord	10.4 nTPM
Cerebellum	6.2 nTPM

Ependymal cell	108.0 nTPM
Amygdala	160.4 nTPM
Medulla oblongata	146.2 nTPM
Pons	114.7 nTPM
Basal ganglia	107.1 nTPM
Hypothalamus	102.6 nTPM
Midbrain	97.1 nTPM
Hippocampus	86.4 nTPM
Spinal cord	86.2 nTPM
Thalamus	71.3 nTPM