Single cell type - ZMAT4 - The Human Protein Atlas

ZMAT4

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZMAT4
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger matrin-type 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Inhibitory neurons, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.91
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Midbrain-derived inhibitory)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (NK-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Inhibitory neurons, Excitatory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Midbrain-derived inhibitory)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (NK-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZMAT4 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HAPLN4	Hyaluronan and proteoglycan link protein 4	0.9453	8
CNTN5	Contactin 5	0.9297	65
DEFB131B	Defensin beta 131B	0.9200	8
KCNC2	Potassium voltage-gated channel subfamily C member 2	0.8999	65
KCNJ3	Potassium inwardly rectifying channel subfamily J member 3	0.8805	8
KAZN	Kazrin, periplakin interacting protein	0.8776	65
GRIA1	Glutamate ionotropic receptor AMPA type subunit 1	0.8760	65
DLGAP1	DLG associated protein 1	0.8708	8
TMEM151B	Transmembrane protein 151B	0.8667	65
BIVM-ERCC5	BIVM-ERCC5 readthrough	0.8661	8
CACNG2	Calcium voltage-gated channel auxiliary subunit gamma 2	0.8552	8
FBXL17	F-box and leucine rich repeat protein 17	0.8437	8
HCN1	Hyperpolarization activated cyclic nucleotide gated potassium channel 1	0.8418	8
KLHL29	Kelch like family member 29	0.8416	8
OVCH1	Ovochymase 1	0.8376	8

IMMUNE CELLS

ZMAT4 is part of cluster 15 NK-cells - Unknown function with confidenceⁱ 1
158 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
XCL2	X-C motif chemokine ligand 2	1.0000	15
TBXT	T-box transcription factor T	1.0000	15
ZNF333	Zinc finger protein 333	1.0000	15
TMSB15A	Thymosin beta 15A	1.0000	15
ITGAD	Integrin subunit alpha D	1.0000	15
COX6A2	Cytochrome c oxidase subunit 6A2	1.0000	15
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1	1.0000	15
KLRF1	Killer cell lectin like receptor F1	1.0000	15
NCAM1	Neural cell adhesion molecule 1	1.0000	15
CDHR1	Cadherin related family member 1	1.0000	15
STYK1	Serine/threonine/tyrosine kinase 1	1.0000	15
XCL1	X-C motif chemokine ligand 1	1.0000	15
KLRC1	Killer cell lectin like receptor C1	1.0000	15
KLRD1	Killer cell lectin like receptor D1	1.0000	15
RAMP1	Receptor activity modifying protein 1	1.0000	15

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	1.9 nTPM
Brain	1.9 nTPM

B-cells	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	0.1 nTPM
Lung	0.4 nTPM
Endometrium	0.0 nTPM
Bronchus	0.0 nTPM
Fallopian tube	0.0 nTPM

Club cells	0.1 nTPM
Lung	0.3 nTPM
Prostate	0.1 nTPM
Bronchus	0.0 nTPM

Endothelial cells	0.0 nTPM
Lung	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.6 nTPM
Rectum	1.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Fibroblasts	0.4 nTPM
Prostate	2.0 nTPM
Placenta	1.5 nTPM
Stomach	1.4 nTPM
Skin	0.2 nTPM
Thymus	0.2 nTPM
Breast	0.2 nTPM
Pancreas	0.1 nTPM
Vascular	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.2 nTPM
Fallopian tube	0.6 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	5.6 nTPM
Ovary	10.9 nTPM
Fallopian tube	0.4 nTPM

Macrophages	0.0 nTPM
Vascular	0.5 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Bipolar cells	6.7 nTPM
Eye	6.7 nTPM

Cone photoreceptor cells	3.4 nTPM
Eye	3.4 nTPM

Early spermatids	9.9 nTPM
Testis	9.9 nTPM

Plasma cells	0.1 nTPM
Stomach	0.4 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.2 nTPM
Placenta	2.4 nTPM
Endometrium	0.2 nTPM
Adipose tissue	0.2 nTPM
Thymus	0.1 nTPM
Vascular	0.1 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.1 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM
Breast	0.0 nTPM

T-cells	0.4 nTPM
Kidney	3.5 nTPM
Liver	1.5 nTPM
Skeletal muscle	0.8 nTPM
PBMC	0.5 nTPM
Skin	0.4 nTPM
Spleen	0.4 nTPM
Salivary gland	0.4 nTPM
Bone marrow	0.2 nTPM
Tongue	0.2 nTPM
Stomach	0.1 nTPM
Breast	0.1 nTPM
Fallopian tube	0.1 nTPM
Colon	0.0 nTPM
Endometrium	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	110.9 nTPM
Cerebral cortex	190.5 nTPM
Hippocampus	171.8 nTPM
Amygdala	106.0 nTPM
Basal ganglia	98.5 nTPM
Hypothalamus	62.7 nTPM
Thalamus	35.8 nTPM

Astrocyte	6.4 nTPM
Thalamus	17.7 nTPM
Medulla oblongata	14.9 nTPM
Basal ganglia	8.5 nTPM
Hypothalamus	6.0 nTPM
Cerebellum	5.5 nTPM
Cerebral cortex	4.7 nTPM
Pons	4.6 nTPM
Amygdala	2.6 nTPM
Midbrain	2.5 nTPM
Hippocampus	2.2 nTPM
Spinal cord	1.6 nTPM

Bergmann glia	0.4 nTPM
Cerebellum	1.1 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	4.3 nTPM
Thalamus	19.5 nTPM
Cerebral cortex	5.5 nTPM
Pons	4.6 nTPM
Hypothalamus	3.4 nTPM
Medulla oblongata	2.9 nTPM
Basal ganglia	2.5 nTPM
Hippocampus	2.5 nTPM
Midbrain	2.1 nTPM
Amygdala	1.8 nTPM
Cerebellum	1.4 nTPM
Spinal cord	0.9 nTPM

Cerebellar inhibitory	32.5 nTPM
Pons	82.3 nTPM
Medulla oblongata	40.5 nTPM
Midbrain	24.0 nTPM
Cerebellum	13.2 nTPM
Spinal cord	2.7 nTPM

Cge interneuron	517.3 nTPM
Thalamus	624.9 nTPM
Hypothalamus	608.8 nTPM
Midbrain	604.9 nTPM
Cerebral cortex	527.9 nTPM
Amygdala	466.9 nTPM
Basal ganglia	395.7 nTPM
Hippocampus	391.7 nTPM

Choroid plexus epithelial cell	2.1 nTPM
Medulla oblongata	4.7 nTPM
Thalamus	2.7 nTPM
Basal ganglia	0.8 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	30.6 nTPM
Thalamus	139.1 nTPM
Medulla oblongata	52.9 nTPM
Pons	25.7 nTPM
Basal ganglia	24.1 nTPM
Hypothalamus	18.4 nTPM
Midbrain	17.6 nTPM
Spinal cord	14.7 nTPM
Cerebral cortex	14.6 nTPM
Hippocampus	12.2 nTPM
Amygdala	11.3 nTPM
Cerebellum	6.3 nTPM

Deep-layer corticothalamic and 6b	108.4 nTPM
Midbrain	214.1 nTPM
Cerebral cortex	174.5 nTPM
Basal ganglia	118.7 nTPM
Hypothalamus	67.0 nTPM
Amygdala	47.7 nTPM
Hippocampus	28.0 nTPM

Deep-layer intratelencephalic	111.7 nTPM
Cerebral cortex	173.6 nTPM
Hypothalamus	169.5 nTPM
Basal ganglia	110.7 nTPM
Hippocampus	53.2 nTPM
Amygdala	51.3 nTPM

Deep-layer near-projecting	17.0 nTPM
Cerebral cortex	26.9 nTPM
Amygdala	25.0 nTPM
Hippocampus	22.8 nTPM
Hypothalamus	6.8 nTPM
Basal ganglia	3.4 nTPM

Eccentric medium spiny neuron	33.8 nTPM
Cerebral cortex	67.0 nTPM
Amygdala	42.2 nTPM
Hippocampus	27.8 nTPM
Hypothalamus	24.5 nTPM
Thalamus	24.3 nTPM
Basal ganglia	16.9 nTPM

Endothelial cell	3.9 nTPM
Thalamus	15.2 nTPM
Cerebral cortex	5.1 nTPM
Basal ganglia	4.7 nTPM
Amygdala	4.5 nTPM
Spinal cord	3.5 nTPM
Midbrain	2.8 nTPM
Hippocampus	1.6 nTPM
Cerebellum	1.5 nTPM
Hypothalamus	1.2 nTPM
Pons	1.2 nTPM
Medulla oblongata	1.0 nTPM

Ependymal cell	6.6 nTPM
Medulla oblongata	14.0 nTPM
Thalamus	9.7 nTPM
Basal ganglia	9.2 nTPM
Pons	8.2 nTPM
Midbrain	5.7 nTPM
Amygdala	4.6 nTPM
Hypothalamus	4.5 nTPM
Hippocampus	2.0 nTPM
Spinal cord	1.9 nTPM