Single cell type - HSPE1-MOB4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSPE1-MOB4
Gene descriptionⁱ Full gene name according to HGNC.	HSPE1-MOB4 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Chaperones and protein folding (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Tuft cells, Conjunctival goblet cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.57
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

HSPE1-MOB4 is part of cluster 75 Non-specific - Chaperones and protein folding with confidenceⁱ 1
37 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSPH1	Heat shock protein family H (Hsp110) member 1	0.7578	75
DNAJB1	DnaJ heat shock protein family (Hsp40) member B1	0.6417	75
NKRF	NFKB repressing factor	0.6222	75
HSPD1	Heat shock protein family D (Hsp60) member 1	0.6218	75
BAG3	BAG cochaperone 3	0.6121	75
FBXL14	F-box and leucine rich repeat protein 14	0.5953	75
CLK1	CDC like kinase 1	0.5721	75
HSP90AA1	Heat shock protein 90 alpha family class A member 1	0.5613	75
USPL1	Ubiquitin specific peptidase like 1	0.5265	75
CGAS	Cyclic GMP-AMP synthase	0.5255	75
MRPL18	Mitochondrial ribosomal protein L18	0.5126	75
NOX3	NADPH oxidase 3	0.5123	58
KLHL25	Kelch like family member 25	0.5109	76
CACYBP	Calcyclin binding protein	0.5000	75
DNAJB6	DnaJ heat shock protein family (Hsp40) member B6	0.4972	75

IMMUNE CELLS

HSPE1-MOB4 is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.9
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXN3	Forkhead box N3	1.0000	42
MFAP1	Microfibril associated protein 1	1.0000	42
TXNDC9	Thioredoxin domain containing 9	1.0000	42
PIGG	Phosphatidylinositol glycan anchor biosynthesis class G	0.9762	42
ASTE1	Asteroid homolog 1	0.9762	42
ZNF394	Zinc finger protein 394	0.9762	42
POPDC2	Popeye domain containing 2	0.9762	42
RIC8B	RIC8 guanine nucleotide exchange factor B	0.9762	42
CNOT2	CCR4-NOT transcription complex subunit 2	0.9762	42
ISOC1	Isochorismatase domain containing 1	0.9762	5
CRBN	Cereblon	0.9524	42
CDADC1	Cytidine and dCMP deaminase domain containing 1	0.9524	42
EIF2B2	Eukaryotic translation initiation factor 2B subunit beta	0.9524	42
SOCS2	Suppressor of cytokine signaling 2	0.9524	42
GMCL1	Germ cell-less 1, spermatogenesis associated	0.9524	42