Single cell type - OGFRL1 - The Human Protein Atlas

OGFRL1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OGFRL1
Gene descriptionⁱ Full gene name according to HGNC.	Opioid growth factor receptor like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Schwann cells, Macrophages, Langerhans cells, Astrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Schwann cells, Macrophages, Langerhans cells, Astrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

OGFRL1 is part of cluster 58 Macrophages - Innate immune response with confidenceⁱ 1
420 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TCHH	Trichohyalin	0.7165	58
GGTA1	Glycoprotein alpha-galactosyltransferase 1 (inactive)	0.6884	75
GAL3ST4	Galactose-3-O-sulfotransferase 4	0.6484	58
TLR5	Toll like receptor 5	0.6295	58
VENTX	VENT homeobox	0.5936	29
EGR2	Early growth response 2	0.5858	58
FCGR2C	Fc gamma receptor IIc (gene/pseudogene)	0.5766	58
SAP30	Sin3A associated protein 30	0.5759	29
FCGR2A	Fc gamma receptor IIa	0.5747	58
MS4A4E	Membrane spanning 4-domains A4E	0.5747	58
SLC31A2	Solute carrier family 31 member 2	0.5704	75
FGL2	Fibrinogen like 2	0.5667	29
JDP2	Jun dimerization protein 2	0.5662	53
SLC37A2	Solute carrier family 37 member 2	0.5556	58
NAMPT	Nicotinamide phosphoribosyltransferase	0.5483	74

IMMUNE CELLS

OGFRL1 is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 0.53
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
H2AC19	H2A clustered histone 19	1.0000	38
FAM131A	Family with sequence similarity 131 member A	0.9762	38
CYSTM1	Cysteine rich transmembrane module containing 1	0.9762	35
SPAG9	Sperm associated antigen 9	0.9762	21
GLT1D1	Glycosyltransferase 1 domain containing 1	0.9524	38
IL27	Interleukin 27	0.9524	38
PCP2	Purkinje cell protein 2	0.9524	35
MTX1	Metaxin 1	0.9524	38
CCR1	C-C motif chemokine receptor 1	0.9524	35
ITGA5	Integrin subunit alpha 5	0.9524	21
ANO10	Anoctamin 10	0.9524	38
C18orf25	Chromosome 18 open reading frame 25	0.9524	38
MPZL2	Myelin protein zero like 2	0.9524	38
NPEPPS	Aminopeptidase puromycin sensitive	0.9524	38
DHX34	DExH-box helicase 34	0.9524	38

Adipocytes	39.0 nTPM
Breast	39.0 nTPM
Adipose tissue	38.9 nTPM

Alveolar cells type 1	14.6 nTPM
Lung	14.6 nTPM

Alveolar cells type 2	24.5 nTPM
Lung	24.5 nTPM

B-cells	26.1 nTPM
Skin	72.8 nTPM
Adipose tissue	49.8 nTPM
Lung	37.6 nTPM
Salivary gland	36.5 nTPM
Esophagus	29.5 nTPM
Thymus	25.5 nTPM
Lymph node	16.5 nTPM
Kidney	15.6 nTPM
PBMC	13.9 nTPM
Stomach	13.9 nTPM
Spleen	10.8 nTPM
Liver	9.7 nTPM
Bone marrow	7.5 nTPM

Basal keratinocytes	62.3 nTPM
Tongue	85.0 nTPM
Skin	39.6 nTPM

Ciliated cells	6.4 nTPM
Endometrium	7.9 nTPM
Fallopian tube	7.2 nTPM
Bronchus	5.2 nTPM
Lung	5.1 nTPM

Club cells	18.9 nTPM
Lung	27.3 nTPM
Prostate	15.1 nTPM
Bronchus	14.2 nTPM

Dendritic cells	31.6 nTPM
PBMC	32.4 nTPM
Adipose tissue	30.8 nTPM

Endothelial cells	22.3 nTPM
Heart muscle	71.4 nTPM
Tongue	44.3 nTPM
Salivary gland	32.7 nTPM
Vascular	29.1 nTPM
Skeletal muscle	26.0 nTPM
Testis	21.4 nTPM
Breast	21.1 nTPM
Skin	18.3 nTPM
Thymus	17.7 nTPM
Prostate	17.1 nTPM
Endometrium	16.9 nTPM
Esophagus	16.7 nTPM
Lung	15.1 nTPM
Fallopian tube	13.9 nTPM
Pancreas	12.9 nTPM
Ovary	9.6 nTPM
Placenta	9.1 nTPM
Liver	7.6 nTPM

Enteroendocrine cells	4.7 nTPM
Rectum	10.1 nTPM
Colon	4.0 nTPM
Small intestine	0.0 nTPM

Fibroblasts	45.7 nTPM
Adipose tissue	173.8 nTPM
Skeletal muscle	96.4 nTPM
Salivary gland	66.8 nTPM
Skin	58.0 nTPM
Esophagus	52.9 nTPM
Heart muscle	43.0 nTPM
Breast	41.5 nTPM
Vascular	34.4 nTPM
Thymus	32.1 nTPM
Fallopian tube	29.0 nTPM
Lung	27.4 nTPM
Pancreas	23.3 nTPM
Prostate	19.1 nTPM
Placenta	15.4 nTPM
Liver	9.5 nTPM
Stomach	8.6 nTPM

Granulocytes	16.3 nTPM
Tongue	24.3 nTPM
Lung	15.1 nTPM
Fallopian tube	9.4 nTPM

Intestinal goblet cells	2.6 nTPM
Rectum	4.1 nTPM
Colon	3.2 nTPM
Small intestine	0.6 nTPM

Lymphatic endothelial cells	14.6 nTPM
Fallopian tube	18.3 nTPM
Ovary	10.9 nTPM

Macrophages	183.3 nTPM
Prostate	386.2 nTPM
Tongue	343.2 nTPM
Testis	311.2 nTPM
Adipose tissue	301.2 nTPM
Salivary gland	297.7 nTPM
Fallopian tube	274.9 nTPM
Breast	218.8 nTPM
Vascular	209.8 nTPM
Esophagus	178.5 nTPM
Skeletal muscle	171.6 nTPM
Lung	126.6 nTPM
Endometrium	118.1 nTPM
Kidney	92.0 nTPM
Stomach	87.5 nTPM
Thymus	87.5 nTPM
Spleen	87.2 nTPM
Pancreas	84.3 nTPM
Bone marrow	54.7 nTPM
Skin	52.4 nTPM

Astrocytes	166.3 nTPM
Brain	166.3 nTPM

Bipolar cells	39.3 nTPM
Eye	39.3 nTPM

Cholangiocytes	11.4 nTPM
Liver	11.4 nTPM

Collecting duct cells	11.7 nTPM
Kidney	11.7 nTPM

Paneth cells	3.6 nTPM
Rectum	7.0 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Plasma cells	20.8 nTPM
Fallopian tube	77.8 nTPM
Salivary gland	38.9 nTPM
Thymus	15.1 nTPM
Liver	10.0 nTPM
Stomach	9.2 nTPM
Spleen	7.7 nTPM
Bone marrow	7.6 nTPM
Esophagus	0.0 nTPM

Schwann cells	183.9 nTPM
Vascular	335.4 nTPM
Adipose tissue	120.6 nTPM
Esophagus	95.8 nTPM

Serous glandular cells	140.7 nTPM
Salivary gland	188.6 nTPM
Tongue	92.8 nTPM

Smooth muscle cells	33.1 nTPM
Adipose tissue	133.6 nTPM
Salivary gland	99.3 nTPM
Skeletal muscle	63.4 nTPM
Tongue	54.2 nTPM
Vascular	29.6 nTPM
Breast	22.5 nTPM
Thymus	20.4 nTPM
Prostate	17.0 nTPM
Endometrium	14.2 nTPM
Skin	13.3 nTPM
Fallopian tube	13.0 nTPM
Placenta	12.7 nTPM
Esophagus	10.8 nTPM
Liver	9.8 nTPM
Lung	9.4 nTPM
Ovary	6.9 nTPM

Suprabasal keratinocytes	61.5 nTPM
Tongue	78.9 nTPM
Skin	44.1 nTPM

T-cells	26.0 nTPM
Tongue	78.5 nTPM
Prostate	60.6 nTPM
Vascular	54.3 nTPM
Adipose tissue	53.5 nTPM
Lung	47.7 nTPM
Thymus	34.6 nTPM
Salivary gland	33.2 nTPM
Fallopian tube	32.5 nTPM
Skeletal muscle	30.2 nTPM
Breast	20.6 nTPM
Skin	15.8 nTPM
Liver	12.8 nTPM
Endometrium	12.3 nTPM
Esophagus	12.2 nTPM
Spleen	9.1 nTPM
PBMC	8.6 nTPM
Bone marrow	8.4 nTPM
Colon	7.8 nTPM
Stomach	6.5 nTPM
Lymph node	4.0 nTPM
Kidney	3.5 nTPM

Undifferentiated cells	6.4 nTPM
Colon	7.2 nTPM
Rectum	7.2 nTPM
Small intestine	4.8 nTPM

Amygdala excitatory	43.3 nTPM
Thalamus	52.6 nTPM
Basal ganglia	45.6 nTPM
Hypothalamus	45.1 nTPM
Amygdala	44.7 nTPM
Hippocampus	38.9 nTPM
Cerebral cortex	33.0 nTPM

Astrocyte	408.4 nTPM
Pons	577.3 nTPM
Medulla oblongata	509.1 nTPM
Spinal cord	493.0 nTPM
Cerebellum	477.7 nTPM
Thalamus	426.7 nTPM
Midbrain	413.8 nTPM
Hypothalamus	387.9 nTPM
Basal ganglia	348.7 nTPM
Hippocampus	345.8 nTPM
Cerebral cortex	263.1 nTPM
Amygdala	248.9 nTPM

Bergmann glia	148.5 nTPM
Pons	198.5 nTPM
Cerebellum	144.7 nTPM
Medulla oblongata	102.3 nTPM

Central nervous system macrophage	337.2 nTPM
Hypothalamus	399.2 nTPM
Spinal cord	390.1 nTPM
Amygdala	372.2 nTPM
Medulla oblongata	353.9 nTPM
Cerebellum	344.4 nTPM
Thalamus	331.4 nTPM
Hippocampus	330.0 nTPM
Pons	321.9 nTPM
Cerebral cortex	304.1 nTPM
Midbrain	284.9 nTPM
Basal ganglia	277.4 nTPM

Cerebellar inhibitory	127.6 nTPM
Midbrain	143.4 nTPM
Cerebellum	135.4 nTPM
Spinal cord	134.7 nTPM
Medulla oblongata	114.7 nTPM
Pons	109.7 nTPM

Cge interneuron	48.6 nTPM
Thalamus	62.6 nTPM
Midbrain	49.6 nTPM
Amygdala	48.2 nTPM
Hippocampus	47.4 nTPM
Basal ganglia	45.4 nTPM
Cerebral cortex	43.9 nTPM
Hypothalamus	43.3 nTPM

Choroid plexus epithelial cell	11.1 nTPM
Medulla oblongata	14.0 nTPM
Thalamus	13.7 nTPM
Basal ganglia	11.1 nTPM
Hippocampus	5.5 nTPM

Committed oligodendrocyte precursor	25.0 nTPM
Medulla oblongata	37.4 nTPM
Basal ganglia	33.4 nTPM
Cerebellum	30.1 nTPM
Pons	30.1 nTPM
Midbrain	26.9 nTPM
Spinal cord	22.1 nTPM
Hypothalamus	21.2 nTPM
Cerebral cortex	20.9 nTPM
Hippocampus	18.9 nTPM
Thalamus	18.5 nTPM
Amygdala	15.2 nTPM

Deep-layer corticothalamic and 6b	59.7 nTPM
Hippocampus	66.3 nTPM
Basal ganglia	65.0 nTPM
Midbrain	63.2 nTPM
Amygdala	60.1 nTPM
Cerebral cortex	55.9 nTPM
Hypothalamus	47.9 nTPM

Deep-layer intratelencephalic	42.2 nTPM
Basal ganglia	46.0 nTPM
Cerebral cortex	42.7 nTPM
Hypothalamus	42.2 nTPM
Hippocampus	41.4 nTPM
Amygdala	38.6 nTPM

Deep-layer near-projecting	62.0 nTPM
Hippocampus	68.3 nTPM
Hypothalamus	67.6 nTPM
Amygdala	62.5 nTPM
Cerebral cortex	57.6 nTPM
Basal ganglia	53.8 nTPM

Eccentric medium spiny neuron	42.4 nTPM
Thalamus	45.4 nTPM
Hypothalamus	43.0 nTPM
Amygdala	42.7 nTPM
Cerebral cortex	42.5 nTPM
Hippocampus	40.6 nTPM
Basal ganglia	40.1 nTPM